New evidence proves that hair loss is NOT caused by a tight scalp
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- Опубликовано: 2 окт 2024
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Sources:
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6. Nordström RE. Synchronous balding of scalp and hair-bearing grafts of scalp transplanted to the skin of the arm in male pattern baldness. Acta Derm Venereol. 1979;59(3):266-268.
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9. Brodsky MA, Swope DM, Grimes D. Diffusion of Botulinum Toxins. Tremor Other Hyperkinet Mov (N Y). 2012;2:tre-02-85-417-1. Accessed January 15, 2024. www.ncbi.nlm.n...
10. Samira B, Meriem D, Oumkeltoum E, Driss E, Yassine B, Saloua E. Cutis verticis gyrata primitif essentiel, une affection cutanée rare: cas clinique et revue de la littérature. Pan Afr Med J. 2014;19:345. doi:10.11604/pamj.2014.19.345.5729
11. Tellez-Segura R. Involvement of Mechanical Stress in Androgenetic Alopecia. Int J Trichology. 2015;7(3):95-99. doi:10.4103/0974-7753.167468
12. Shon U, Kim MH, Lee DY, Kim SH, Park BC. The effect of intradermal botulinum toxin on androgenetic alopecia and its possible mechanism. J Am Acad Dermatol. 2020;83(6):1838-1839. doi:10.1016/j.jaad.2020.04.082
13. Magnusson MR. Commentary on: The Change of Plane of the Supratrochlear and Supraorbital Arteries in the Forehead-An Ultrasound-Based Investigation. Aesthetic Surgery Journal. 2021;41(11):NP1599-NP1602. doi:10.1093/asj/sjab077
14. Naik PP. Utilities of Botulinum Toxins in Dermatology and Cosmetology. CCID. 2021;Volume 14:1319-1330. doi:10.2147/CCID.S332247
15. Deng Z, Chen M, Liu F, et al. Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia. Journal of Investigative Dermatology. 2022;142(8):2088-2099.e9. doi:10.1016/j.jid.2022.01.003
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18. Agorgianitis L, Panagouli E, Tsakotos G, Tsoucalas G, Filippou D. The Supratrochlear Artery Revisited: An Anatomic Review in Favor of Modern Cosmetic Applications in the Area. Cureus. 12(2):e7141. doi:10.7759/cureus.7141
Kevin. You and Derrick saved my hair. 5 months in min and fin and I've gotten back most of what i lost and seeing new growth constantly. Zero sides and my depression is gone. Thank you sir
Thanks, choom! Honoured to have given you some inspiration in your battle against the slaphead curse!
@@haircafekevinAnother scalp Saved
Based
@@haircafekevinCan Finasteride cause breast cancer?
Damn good for you, man. It's crazy to me how little someone can take and see such a turnaround in such a short time when I'm on a nuclear stack for almost 2 years and still losing!! 🙏 It turns around
Rob English punching air rn
Blüttflew !
Baldflow
Rob England**
All my homies hate bludflew
@@shortkeys73see that’s how much I dont take the guy seriously to the point where I dont even recall his surname 🤣
Great video. I will definitely share this video, especially if I hear someone use the blutflew theory. Also, I wonder what the blutfew theorists' explanation is for why men are far more likely to have pattern hair loss due to tight scalps while women do not suffer from the same pattern baldness as much as men and why finasteride stops the hair loss.
Women that go the trans route also are under the risk of getting male pattern baldness, not because they are increasing their scalp tension, but due to the hormonal changes.
@@LorenzoValentino-le7rs Yeah, I have heard that as well.
Kevin Mann the slayer of scalptensioncels 🔥🔥🔥🔥
Hey Kevin! Can you please make a video on a Trichologist named William Gaunitz... He promotes a lot of unscientific claims about scalp massaging, nutrients treatment of any kind of hair loss, Saw Palmetto etc.
So true
Yeah, the products he sells are a joke
9:54
I dont see how people could believe the outcome of scalp tension theory
You would still have the same 5AR density and sensitivity. The supposed increase in blood flow would just bring more free T to the area and still AGA would progress. More oxygen wouldnt prevent 5AR from doing its job on T
Yo it's KWXK!!
KYLEEEEE
Been a year on 5AR blockers and minox and im getting that hair back baby. I thank you a lot Kevin for helping me take the big leap, you da Mann!
My scalp feels extra tight when I eat broccoli
tight tight tight sniff
Yes... do botox on scalp ( fix tightness fix hairloss and botox is safe 😊)
Hello Kevin, my hairloss has been halted for 9 months now. I feel like i have a 2nd chance in life. Thank you for encouraging me to start fin.
Thank fucking god I found you. Made it my mission to get my hair back after struggling with the mental shit that comes with losing your hair. 7 years into my hair loss journey and I'm finally fighting it. Had another Cafe help me to cope, now I'm switching Cafes to fight.
Let's go!
Hey Kevin whats ur thoughts on a 21 year old who is a Norwood 2 and has been on treatment finasteride and minoxidil for two years on getting a hair transplant. Should l wait till l'm 25 or consider getting one now, or add dutasteride into the stack once a week. Whats ur take on this? Btw ur advice has been life changing and has enhanced the quality of life of so many people just by fighting to save our hair. Keep doing what you're doing Kevin
Honestly, I'd say go ahead and get a transplant right now. A Norwood 2 will only need like 1200 grafts or so so you'll easily have enough donor hair for future procedures, especially with treatments like verteporfin on the horizon that will likely be able to help you recover some donor hair with future procedures.
You've been on treatment long enough that you've probably come close to maxing out regrowth from pharmaceuticals. You may get a tiny bit more regrowth if you go nuclear but there is no guarantee and I'd be hesitant to recommend changes when the treatment seems to be working for you.
Go ahead and do it, dude. You don't want to spend 4 more years in your prime with a hairline you don't like.
@haircafekevin holy shit that was a good answer. You save more men than just about anyone. I feel incredible and confident keeping my hair. 35 and people still think I'm in my mid 20s because I still got my hair. Ty sir
I'm a 20 year old guy, hairloss started at 18. I'm still nw1 so it wasn't horrible, but I saw the writing on the wall. Also losing shitloads of hair every shower. Finally started 1mg/day finasteride a month ago. I figured I'd have to wait a few months for it to work, but man. It's already started working, shedding has reduced significantly and I dont have any side effects. Fuck man, its like a big mental weight is finally gone. Fantastic drug.
apart from yelling bludflow Infront of the mirror try calf raises 7 times a week. it's really a game changer
Had to take a quick diversion to consider why all men were wearing hats in the past.
General conclusion is that it was all social signalling which has been replaced by the car you drive.
I neither wear a hat or own a car.
Hi Kevin! I would like to ask you about nutrition. I watched one of your videos about high protein diet and hairloss. I've been thinking about reducing my meat intake considerably.
Nutrition is such a confusing and contradictory field. I'm trying to build muscle because I'm a walking skeleton, and Paul Saladino said meat intake is optimal for us as a species. Jordan Peterson and Joe rogan also talked about that.
However, Harvard edu has meat as a high inflamatory food, among others things like sugar, gluten, etc
I understand you are a vegan. Do you take supplements? I sufer from ibs and I read gluthamine can help, but I'm afraid it could be just a scam, and as I mentioned before, I'm training and trying to build muscle
Also, thank You for this new video!
Yeah, I. take vitamin B-12. At the very least make sure you take that as it can't practically be obtained from plant based sources.
I don't care about the carnivore vs vegan thing. It's a culture war battle that doesn't interest me and you have charlatans on both sides.
I’m also hitting gym for hypertrophy quite regularly, I’m unable to fulfil my protein intake as I’m a vegetarian due to ethical and religious reasons, I get around 40g of high quality protein only in a day. Other protein sources are either incomplete in amino acids or are dairy. I want to become vegan but I’m stuck. Fake meat and vegan meat is not available here in my country, I could take multiple whey supplement during the day but that will make me go broke 😂
@@prav077 oh damn! Sorry man, that sounds hard!
The area which balds seems like it’s precisely that which has no muscle beneath it and where the skin sits directly on the bone. Maybe androgens cause balding by catabolizing whatever fat you have in your scalp, therefore interfering with some essential process(es) for hair growth? This seems more likely than androgens ”destroying” head hairs (how?) which all happen to be within this specific anatomical area while sparing the rest
Those specific areas where we go bald have increased DHT in the hair follicles. High DHT levels shut down the WNT pathway which is essential for hair growth. You can induce hair loss in mice just by injecting DHT in their skin. You can stunt isolated hair follicle growth in cell cultures just by adding DHT. There is no fat or anything else involved in cultured hair follicles. There are just the follicles and DHT at high levels destroys them. If you read the medical literature on androgenic alopecia, the mechanism behind it is well understood. The downstream effects of DHT that harm hair growth have been well worked out. It is not as mysterious as you make it out to be.
Roberto Englandia: Art of the Grift
I have cvg and male pattern baldness feels bad man
Rob English is inviting you for dinner.
Who is Rob English?
There was a new paper called "Minoxidil sulfotransferase enzymatical activity in plants" where they used extracts to increase minoxidil results. Can you please cover that in a video?
Hmm. Hadn't seen that one. Looks interesting. I'll give it a read and see if it's worth reporting on.
@@haircafekevin Thank you! And there are also several papers about minoxidil nanocarriers for follicle targeting that need a bit of your spotlight!
I have actually forgotten how to say blöódflúõ because of listening to Kevin.
Kevin, your channel is pure gold.
I have had so many doctors and ht surgeons tell me half truths and falsehoods.
I am glad your channel properly informed me (and saved me thousands).
Once Verteporfin becomes commonplacr, I may opt for a ht.
1 of these days you will say blüdfow in a private conversation and people will look at you weird :D
It has already happened.
it's crazy this is even still a question somehow. even on videos on social media about balding people either say, "stop wearing hats" or "just shave it bro, nothing can stop it." it's so sad! i try to help but people just don't wanna hear it. crazy stuff. keep fighting the good fight, Kevin. I admire your patience.
Yeah that Rob English is a real snake.
Erm, just to be clear Kev, I can get myself some expensive headphones and they won't contribute to hair loss right? 😅
Yeah, that's no problem. There is such a thing as traction alopecia where people who pull their hair for long periods of time can experience temporary hair loss. That happens more with things like tight braiding though.
Just so long as they headphones aren't pulling really hard against the hair for hours then it shouldn't be an issue.
whenever i read some shit informations about finasteride side effects, i come here and easy my mind by watching kevins videos 👌 thanks for that ❤️
Saying blowdflu in the middle of a scientific presentation is just killing me man 🤣
Thanks papa Kevin ❤
Hey Kevin, I was wondering, what is the average cost for good hair transplants in the US? For lets say 1000-2000 grafts? I am thinking about it but I found a wide range of prices online.
For FUT, 4 dollars. For an FUE, 8 to 9 dollars.
@@haircafekevin Damn I guess quality does cost more. Significantly so lol. Thanks.
Rob England has nothing of value to add to the world of hairloss
Rob Scamglish never stops, I don't know why, but I always receive emails from him and his latest fancy "bludbluw" machine, showing fake pictures of balding people and then having more hair than any afro. By the way, does it matter what type of shampoo and conditioner one uses for hairloss or is part of all the scam? Best
Yeah, I really wish Rob would drop this scalp tension bullshit. Every time he promotes it I have people coming to my channel asking about it so it's not like I can just ignore it.
Shampoo isn't going to do anything to stop hair loss. Even if the active ingredient has some scientific evidence behind it, shampoos don't stay on the scalp long enough for it to matter much.
If you have dermatitis though, Nizoral is great. It may also be good to pair it with a pyrithione zinc shampoo like head and shoulders since using nizoral daily will fry your hair.
@@haircafekevin Alright, Thanks.
Hello Haircafe
Ive watched ur video in finasteride and alzheimer. In 13:15 u stated that the concentration used in the study was 3-10x less than seen in serum levels in humans. Calculating the dose used in the study it comes down to 37ng/ml.
The peak serum concentration after finasteride is as well around that.
We know finastasteride accumulates in the body especially in the tissue. Although finasteride prime target is the type 2 enzyme it doesn’t necessarily mean that fin cant accumulate in the brain. Or how donu see that please clarify?
Also in this video u talked about the correlation of serum and brain csf allopregnenolone levels. In the study from europe there was a decline in serum allopregnenolone which got greater within every month even with the dose of 1mg. Which kind of makes sense since serum allopregnenolone is synthezied in the adrenal gland with the type 2 enzyme too.
With youre explanation trying to say serum and brain allo levels dont correlate. U showed the case of durring an epilepsy brain allo levels plunge but serum allo stays the same.
I dont think that this is the ultimate proove that u can reduce serum allo without affecting the brain.
Since allopregnenolone isnt a paracrine hormone like dht.
I also came across some papers claiming that via the periphal nervous system theres is some mechanism how the brain balances serum and brain allo levels. Low serum levels of allo after all are accoiciated with depression.
Please help me clarify this i indeed dont belive fin causes depression ulimatley but the stuff i preseted also doesnt sit well with me at all.
Especially for young felleas like me like under 25were the prefrontal cortex isnt matured this is something that prevents me from getting on treatment. Also the fact that we dont know for sure the effect on srd5a3.
Listen to that segment again. I said that the concentration in the study was 3 to 10 times HIGHER than the blood concentrations seen in finasteride users. A concentration of 37 ng/ml is about 3 to 10 times higher than the range of peak finasteride concentrations described in the propecia package insert, which was 4.9-13.7 ng/ml. The point of that part of the video was that the suppression of brain 5ar activity was due to finasteride's weak type 1 isoenzyme blocking effect. The fact that MK386 which only suppresses the type 1 isoenzyme completely blocked brain 5ar activity means that there can't be any type 2 activity in the brain tissue, because that would not have been blocked by a specific type 1 blocker. We know from other studies that the IC50 of finasteride for the type 2 isoenzyme is 0.16 nM and for the type 1 isoenzyme it is 81.0 nM, so finasteride is a much weaker type 1 than type 2 isoenzyme blocker, about 500 times weaker. So it really has negligible type 1 effects. Also, the finasteride drug information sheet states it does not accumulate in the CSF, "The volume of distribution is 76 L at steady state, ranging from 44 to 96 L. Finasteride has been shown to cross the blood brain barrier but does not appear to distribute preferentially to the CSF."
The Czech studies on serum allo with finasteride are based on few patients. The first study was small, just 20 or so men, and there was no control group, which I think is important because we don't know if serum allo levels fluctuate over time spontaneously. If you look at the graphs in their second study of only 12 men, the neurosteroid hormone responses are quite different among all the ones they looked at. Some neurosteroids go down then, up, some bounce around between going up or down. It almost looks random if you look at all their data. The results from the Czech group haven't been duplicated by any other center. Finally, allo is synthesized directly in the brain where it acts directly on GABA receptors. Articles such as this one, www.ncbi.nlm.nih.gov/pmc/articles/PMC3356145/ do refer to its actions as paracrine/autocrine. Given finasteride's weak type 1 effects, and the fact that the 5ar isoenzyme in the brain is the type 1 isoenzyme, and the fact that allo acts as a paracrine hormone in the brain, finasteride should not have neurological effects mediated by neurosteroids.
I did a video on the type 3 isoenzyme. It isn't involved in the same reactions as the type 1 and type 2. Here is that video, ruclips.net/video/Tzu_yWBR_rU/видео.html
I understand you are concerned, about starting finasteride, but there is a lot of misinformation out there especially about effects on the brain. All I can do is present the studies as I see them, and ultimately you need to decide for yourself if you are comfortable taking the drug.
@@haircafekevin really do appreciate the answer. But does tissue concentration as well peak similarly as serum or is it lower? Otherwise those concentration as used in the in vivo study could eventually as well have an effect on the type 1 enzyme? Do u have anything backing this up or can we say since serum dht doesnt change more than 70% that the tissue concentration as well is safe?
Kevın ı can't thank you enough. I was already a ugly young male and scared to use finasteride.
If ı didn't stop my balding ı would most likely rope.
You saved my life witcher.
Thank you.
Could you make a video about topical valproic acid for hair growth?
Yeah, not a bad idea. It has been a while since I have made a " does X help with hair loss?"
@@haircafekevin I’ve used it before with a combination of minoxidil and some other things. Got great results but it might of just been from the minoxidil. I only cut out the acid because I know oral valproic acid has some nasty side effects and was afraid topical might eventually too
@@haircafekevin btw, it’d be cool to have some new “worst of the hairloss industry” videos too eventually. 😂
This channel should be huge, like Jay-z massive
24:45 WAIT, if DHT is the only (?) cause and finasteride is ur favorite drug, why does Minoxidil also works huh? Answer that
Minoxidil is a general growth stimulant. It will increase hair growth even if you have normal hair. If you take it orally you can grow hair in places that didn't have hair already, which is called hirsutism. It doesn't correct the underlying problem which is DHT in androgenic alopecia, but it still will stimulate hair growth and help some, but not as much as finasteride.
My doctors keep telling me finasteride caused my ed. But tbh I believe you over them.
There are so many causes for ED and more people report increased libido on finasteride than any negative side effects.
Try titration of the med you could be the very unluck 1out of 1000 use less mg of fin and fix your life style
Hey, finesteride did cause it, finasteride is a dangerous drug. Bcareful who u believe
Im confused. How does minoxidil work/help?
It opens a specific potassium channel that stimulates hair growth.
Imagine the amount of dudes who'd get their heads RIP'd by trying to massage their hair back if we didn't have good channels out keeping the peace.
I'm sure people have been trying these wacky cures for hundreds of years and of course they never work. All our treatments for hairloss that actually work were discovered on accident
This is painful. Regardless of the mechanism of mpb, which we still dont know the full picture, you cannot deny the studies which mapped the tension of the galea in regards to the typical shape of mpb. Whether it’s down to actual blood flow or not (which wouldn’t minoxidil prove this being it’s a vasodilator and can increase hair growth wherever applied??) the tension over the skull has SOME component in the pattern of mpb. You just sound bitter lmao
Nothing for me to be bitter about. The scalp tensions computer study is just one study that attempted to form a 2D computer model of scalp tension and then claim that the model was similar to the most common, but not the only pattern of AGA. The study did not actually measure scalp tension in the human scalp. It is based on a 2D, not 3D model of the scalp and it is based on a number of prior assumptions that may have been tweaked to produce the pattern that they got. It has never been shown that there is more scalp tension in the areas of the model than in other areas, and the model doesn't account for atypical patterns of AGA like DUPA and retrograde alopecia. So you are basing too much on this one simulation study that has not been verified by other research.
As far as minoxidil goes, its mechanism of action is not known, but it probably relates to opening a specific potassium ion channel in the hair follicles and it has nothing to do with increasing blood flow. Otherwise all vasodilators would cause hair growth, but they don't.
I agree we don't know every single last detail of the molecular mechanisms of AGA, but it is clear it ultimately stems from an excess of DHT in a pattern that is determined genetically and not by extrinsic factors like blood flow or scalp tension.
@@haircafekevin it makes sense though, genetics determine skull shape. And to account for atypical patterns, skull shape would play a huge role in that. DUPA and retrograde alopecia are a lot rarer and there aren’t enough studies on them, and most people with them don’t respond to finasteride. there is no doubt that DHT is obviously involved with hair loss, but it’s simply the fact that there absolutely is more to it than we know, otherwise we would have solved this by now. There are problems with a lot of studies but there’s also many more years that minoxidil and finasteride have been around. Also people with hair transplants are still advised to use finasteride as transplanted hair DOES eventually miniaturize. The point is we don’t have the full picture, we have a few decent chunks, but not the whole thing. I agree more studies have to be carried out to understand the full picture. The truth is there’s too much money in NOT curing hair loss. I think the full picture of why it happens is very complicated and we don’t know enough.
@@aross5234 You're making this more complicated than it is. Why do you have to have genetics determine skull shape and then have the skull shape determine hair loss? If genetics can determine skull shape, genetics can also just directly determine the pattern of distribution of the 5AR enzyme in the hair follicles of the scalp. There have been 100s of genetic abnormalities found in people with androgenic alopecia, and they have to do with things that affect the hair cycle and androgens, not bone growth.
Men with hair transplants still take finasteride to avoid hair loss in the vertex area and because even donor hair can have some degree of susceptibility to DHT, as you can see in men with retrograde alopecia.
As far as people making more money not curing diseases, that's an old conspiracy theory that goes against human nature. First of all if someone did have a better cure for hair loss, they'd make tons of money from it. Secondly, I've heard people say the same thing about cancer. Like, doctors know how to cure cancer, but they'd lose business if they revealed the cure. So yeah, tell me about these doctors who would let their kids die of cancer before their eyes just so they could protect their profits.
It doesn't add much to say that not everything is known about the mechanisms behind hair loss. You can say that about anything in science. Of course not everything is known and there is always more research to be done. However what we do know supports the androgenic theory and there is no need to defy Occam's Razor and bring in ancient obsolete theories like skull shape, blood flow or scalp tension.
Hey Kevin, just wanted to say thanks for your shedding video, I’m 3 months on oral fin and am going through a nasty shed rn, but I’m gonna stick with it
You've got this. Just think of it as a positive thing since it proves the drug is working. Shitty telogen hairs are falling out to make way for stronger, Chad anagen hairs.
@@haircafekevinis it normal to shed 3 months in on fin? for some reason i assumed sheds would occur in the initial weeks after starting the medication or are shed just able to happen whenever :o
Hey Chump, any update on hair cloning for HT? are you in contact with Bryan Johnson, if so why he is wasting his time with laser and not investing in something like CRISPR😅?
Did a video on it not too long ago. ruclips.net/video/ofMacocWHTU/видео.html
No, I'm not in contact with Bryan Johnson.
I have CVG and am a victim of the Norwood reaper. :(
But Kevin! You've just ruined my last hope for the botox injections as an alternative means.. (I am a great fan of yours and bought some fenasterid which is not a prescription drug in my country, yet I'm gonna consult before taking it).
"Did you hear about that guy Hairguard mentioned who held his arm up over his head for 40 years and it withered! What do you have to say about that, Kevin!?"
Glad to have you here, choom.
It's not exactly that the tight scalp causes reduced "blud flow" and that leads to hair thinning. The tight scalp causes micro inflammations, and as a result dht arrives to deal with this inflammation. Over time, collagen and scar tissue forms and that reduces the blood flow on the scalp, making the hair thin and weaker. If you look at male pattern baldness, the areas that lose hair first are the areas of maximum strain, then as the baldness progresses, the intermediate strain areas lose hair and finally those with the lowest. The phases of baldness match almost perfectly the stress areas, and makes a very compelling argument.
First of all, the stress on the scalp has not been measured. You are referring to a computer model that has never been validated with real measurements. Also, if stress were the initiating factor, everyone would have hair loss in the supposed stress pattern. Your theory doesn't account for the fact that many people don't get hair loss at all, and others get patterns that don't match this supposed stress pattern, including female pattern hair loss, DUPA, and retrograde alopecia. You also don't account for the fact that hair follicles from balding regions versus normal regions have increased 5AR, increased DHT and increased androgen receptors. There's no reason all this would happen as a response to inflammation. Finally your theory doesn't account for the over 250 genetic differences seen in men with AGA versus men without it. These abnormal genes include genes for the androgen receptors among many others. And you totally ignore the point from the video that the typical pattern of MPH develops in men with weirdly redundant scalps that can't possible have the same stress pattern as a normal scalp.
@@haircafekevin Thanks for taking the time to give such a detailed answer, I didn't watch the whole video before I wrote this. Like you, I'm looking for the truth :)
You’re my favorite person on RUclips, period. Thank you, God bless you Papa Choom.
What i dont understand is, if everything in this vid is true why does finasteride not work for everyone (if that is genuinely the actual cause). Why doesn't it work for men that went bald years ago? why topical finasteride doesn't work in a lot of men? Also, why cant 'they' take a follicle from the back of the head that never goes through miniaturisation and one from a balding area that does and just compare the difference, surely the difference would be glaringly obvious....After years and years or research and billions spent they cant do this? It seems to me there is another underlying cause that hasn't been thought of yet.
Finasteride only suppresses about 40% of scalp DHT. Dutasteride can suppress more, but we have nothing that can completely suppress scalp DHT. So you wouldn't expect it to work on everyone, especially people who have waited too long and have irreversible changes in their hair follicles that nothing will reverse.
Also the follicles from the balding and non-balding areas have been studied. The follicles from the balding area have more 5AR, more DHT, and more androgen receptors. There is just different gene expression in the balding areas. This hasn't been a mystery for many years now.
@@haircafekevin What about derma-rolling/stamp? a lot of people have had great results with that. What does DHT have to do with that? surely that is blud flew lol
@@paulh4826 There aren't good studies proving dermarolling helps by itself. The data suggests it helps with absorption of minoxidil, most likely just by poking holes through the stratum corneum to allow the drug into the skin. Anecdotes that some people get great results don't prove anything, because people can get results even with a placebo treatment.
Since years, for me the open question about MPB is the presence of scar tissue around the follicle as baldness progresses throughout the years. Why is it happening at all? Normally scarring occurs when damage is detected via neurons. So why cell damage is happening around the follicle? DHT causes cell damage that the body tries to "heal" with scarring? Or maybe unidentified protein/acid whatsoever that haven't been marked with radiofluorescence? in the end, the dermal papilla ejects at around 7 years from being dormant because of DHT, and thats the point of no return for that paticular follicle, but there is still no clear question why scarring is happening. And interestingly prostaglandin D2 is also present, which is known to be an immune response for damage or allergical reaction. Might be connected but haven't seen study to clarify these 2 facts.
Every year more and more details of the biochemistry are being worked out. Like you said, there is no doubt that DHT is triggering downstream effects, but exactly how miniaturization works and how scarring forms is still being investigated. I think the Deng paper I cited is a major step in understanding miniaturization and I'm confident all the steps from start to finish will be worked out in the next few years.
Yea Kevin It never ceases to amaze me that new generations believe in this crap .you'd think we sqashed this out dated unproven theory. Scalp messages, rosemary oil etc
Hi kev, what do you think about mixing ecklonia cava extract (powder) in the minoxidil? Also L-carnitine L-Tartrate? Can you please make a video on this?
He already did a Carnitine video
Thanks to you and to your word " just pop the pill and forget about it, go about your day" I started finasteride 6 month ago, didn't give myself nocebo effect, which is so hard not to do with all the scams and manipulation across the internet
Love your channel! Could you make a video on the safety of e171 titanium dioxide? It is used in tablets of a variety of medicine including finasteride.
The amount found in finasteride is trivial so it shouldn't matter, but it might be worth covering as I do get asked about this a lot.
Hi Kevin, I want to get a ht (I'm Norwood 2) but I'm afraid I can't comb my hair forward anymore.
1200 or so grafts should probably do it.
Turns out scalp massages don't magically grow hair by rubbing your head, who would've guessed? They still feel nice though.
Hi Kevin,
Has any study ever shown that finasteride has any effect whatsoever on the brain? (such as on mental speed, clarity and ability to focus)
Cheers Kev
Just rat brains, and the drug has different effects on the 5AR isoenzymes in rodents versus humans. Also, the doses are much higher than in humans, adjusted for body weight. But there are no studies showing any adverse effects directly in human brains. There are database studies claiming there are side effects like brain fog with finasteride, but these studies are based on self-reported side effects and can't rule out a nocebo effect, which is very likely given forums that claim finasteride causes these effects.
*FLOODBLOW*
Yoyo sir
In youre video in depression you cited this study * (Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role)
They summarize all of the current claims on how finasteride causes depression or alteration of neurosteroids. It seems its somewhat well written and reading this gave me chill.
Why did u cite this without even adressing the study in the video?
It's a terrible, fear-mongering review article that doesn't contribute any new data to the debate. It clearly has an agenda, talking repeatedly about finasteride's "demasculinizing and feminizing effects." It accepts PFS as real without any analysis of the shoddy PFS studies. It accepts the various rodent studies of finasteride on brain function as relevant to humans without mentioning that finasteride is a strong type 1 isoenzyme blocker in rodents while it is a very weak blocker in humans, which is relevant because most of the 5ar in the brain is type 1. Not to mention the article is sexist: "they report an increase in female-typical symptoms and disorders-anxiety and depression." It is full of anecdotal information like, "one of our patients with catamenial epilepsy nearly succumbed to intractable seizures when her uncle, a dermatologist, prescribed finasteride for off-label use." Otherwise the studies the article mentions are studies that I addressed in my videos on neurosteroids and depression. So the article is biased and in my opinion poorly presents the data without any critique of the flaws of the studies it presents.
I LOVE YOU KEVIN
Kevin. Let’s say one was loosing their hairs in their teens years that’s a diffused thinner. Aggressive AGA. Is it possible for that person to still be balding if they decided to take 2.5 mg of oral dutasteride?
Very unlikely. 2.5 MG of dutasteride is extremely powerful, suppresses twice as much scalp DHT as 1 MG of finasteride in fact.
It is the most nuclear thing you can use that is safe.
Another finasteride banger
Yoo Kev, what is your current opinion on Stemoxydine and Alfatradiol if Fin or even Dut arent enough in completely regrowing or stopping hair loss? I dont really like Minoxidil since its kind of like a "temporary boost" whereas things like Fin actually go after the source. Minox really would be my last resort. But then where does this leave Alfa and Stem? Are they worth the buy? Are their mechanisms of action similar to Minoxidil? From what Ive seen and read at least Alfa seems to inhibit certain androgens, so its more similar in action to Fin than Minox I guess. And then what about Stem? Would you perhaps even then really recommend Minox over these two?
Stemoxydine is a growth stimulant, but it doesn't work like minoxidil so it can even be stacked with it. I actually talk a bit stemoxydine in this video and explain how it works. I have an older video going over it too.
ruclips.net/video/R27yKMo0r7E/видео.html
Alfatradiol is a 5AR inhibitor albeit a weaker one than finasteride. They're both better as adjunctive therapies although neither will be as effective as minoxidil.
If you are already on fin or dut then they are worth a try if you want more hair growth. They are pricier than minoxidil though.
@@haircafekevinThank you so much, just one more question: so if you stop taking Fin or Alfa, it will only make the hair loss continue once again. But if you stop Minox, you literally lose all you've gained, quite rapidly too. What is Stemoxydine closer to? I wonder if the potential "boost" Stem gives is far more long-term
@@G.J.Fokkink I think it is likely you'd eventually lose the additional benefits from stemoxydine and alfatradiol too. It's just not as noticeable as with minoxidil since they don't regrow as much hair as minoxidil.
@@haircafekevin I have to send you a question again since sth just popped up: due to the different mechanisms for Alfa, Stem and Minox, would you expect Alfa and/or Stem to give more hair gains than Minox in the long run?
@@G.J.Fokkink No, minoxidil is significantly more powerful than both of them. Even 2 percent minoxidil is more powerful.
Minoxidil's gains last long term so long as you use it with a 5AR inhibitor.
Bro fr thought baldness was gonna be cured by botox injections 💀
I took finasteride for 20 years, hair loss doesnt stop. I did scalp massage for 3 weeks. My hair became thicker, more shiny, more dark.
Uh-huh.
Great video champ.
Kevin I need your help my guy - Ever since I started taking finasteride I've been a lot of tired and sleepy throughout the day - is there any supplement you recommend I take or anything other than caffeine to stay awake throughout the day without having to take naps and sleep? I'm 25.
Do you take it oral ? Switch to topical and reduce the dose you can add an antiandrogen like alfatradiol high dose 2x the amount what you should use and take dutasteride topical every 2 weeks
How is your sleep schedule? I would make sure you're getting enough sleep before making adjustments to your treatment protocol.
@@haircafekevin My sleep schedule has been the same for many years now and for probably like a decade - nothing else has changed in my life expect starting finasteride around 5 months ago.
I bought Merck Propecia Finasteride and that's what I take (split the 1mg tablet into 4 pieces taking 1 piece every day EOD).
After a few weeks of starting Finasteride a few months ago I started being unable to function with my normal energy levels throughout the day and find myself very tired and sleepy having to take naps and sleep throughout the day.
@@haircafekevin hey Kevin Could you please make a video about Trichoxidil and capronium chloride, these two together are the best growth agents. (Not Trioxidil)
Bludfloo 😂
Everything is nova.
Hi Kevin, I started 1 mg of finasteride yesterday and I'm already expereincing a struggle in having an erection. Is this a normal expereince after the first tablet? Should I stop taking it?
Something that happens that fast is almost certainly a nocebo effect. There are different approaches you could take. One approach would be to stop the drug, wait a week, make sure you are feeling fine, and then restart it at a lower dose, like 0.5 mg every other day. Later you can raise the dose back up as long as you are feeling fine.
@@haircafekevin my Dr. from Keeps said the same exact thing. Thank you so much!
The last guy that i found is called "Aesthetic Primal" he claimed that DHT does not cause Hair Loss and that it is a Super Hormone...
Funnily Enough , he got very famous lately because of his e-book called "Skyscraper Method" claiming that it can make you grow 2 to 4 inches a year after puberty (his entire e-Book is pure broscience BS)..
Ps : I also used to believe in false Hair Loss theory and i even made a thread on r/tressless called "the galea theory and why it make sense" , i realise how dumb i was and thanks to Kevin , i am now 100% sure that Science does not lie and DHT is Trash after 18..
Ps number 2 : Just shave it brOoo
LOL! What does he recommend? Breaking your legs so they heal and grow back taller? That's what they literally do in height lengthening surgery. You can't lengthen the diaphysis of a bone once the epiphyseal plates have fused. What an absolute grifter.
@@haircafekevin he unironically recommend to do :
1-Cycling with raised seats..
2-Sleeping with Weights on your ankles
3-A lot of jumps to "grow"
it's very funny because i did some research and just like hair loss being caused by Bludflow , the "microfractures" theory was debunked a long time ago and was proven to be Extremely dangerous...
This is not a normal debunking video.... this was A FUNERAL... the theory dies here, forever.... ⚰️
Thanks, I sure hope so.
is spraying minoxidl only on the effected areas effective e.g only temples for temple recession but no balding or thinning elsewhere
Yes. It works locally.
A Guy named Hans Amato made a video "Is your DHT ideal for your age?" recently if you need a laugh.
what a fool, Hans - he actually believes we need DHT in our bodies?
Kevin you are the best !! One question ,from what I understand, injecting Botox into the skin can be helpful because it decreases TGF-beta 1. Is that the only reason it can be beneficial? Does it have anything to do with blocking DHT in the scalp or reducing tension?
Scalp tension doesn't cause hair loss, so the relaxing effect of Botox won't affect hair loss. There's no effect on DHT either. It appears that the best explanation is the effect on TGF-beta 1.
Ingesting ejaculate is very technically better than scalp massages. Relaxin is a hormone inside of ejaculate that does have minor anti-inflammatory properties, serelaxin is a synthetic version of this hormone used for heart stuff and autoimmune stuff. Connor Murphy was onto something, i bet microneedling and topical application of ejaculate would do more than scalp massages.
Micro needle jizz into your scalp , I swear I see an extra hair !
Hey Kevin, thanks for the video, hope you ascend to Biblically accurate angel status soon! Question though, I’ve been on fin 1.25 mg EOD for a year now (almost exactly), and was wondering how can I tell between baby hairs that symbolize regrowth, vs baby hairs that are just naturally there? I think I’m starting to see regrowth, but I’m not quite sure!
I think you just have to wait and see. If it is new growth, it will become apparent over time. But I bet it's not your imagination!
@@haircafekevin thank you senpai!
Decreased blood flow lacks oxygen and in such environments Test converts more to DHT rather than to estradiol. Balding actually is a result of low estrogen in a scalp tissue.
That's why youngsters usually don't have problems with hair loss. Test is super high but thanks to still properly functioning blood circulation, scalp tissue has enough estradiol to counter balance DHT. That's why Minoxidil and botox work. They both indeed lower DHT but indirectly.
No.
1) Male children have low testosterone levels, much lower than teenage and adult males.
2) There is no evidence that low oxygen environments convert more testosterone to DHT as opposed to estrogen. That was pure speculation in the Goldman article on low pO2 in the scalp without any research to back it up.
3) The current theory is that minoxidil works by opening a specific potassium channel that promotes hair growth. Botox directly affects hair growth factors independent of effects on muscle contraction. In any case, the effect on vascular tone is not a factor, since other drugs that lower vascular tone and improve blood flow, like calcium channel blockers, alpha-blockers, and ACE inhibitors have zero effect on hair growth.
Sorry, you're just spouting bro-science.
Hi Kevin,
I started finasteride a few weeks back and I thought I was experiencing brain fog and a weird light headedness and feeling like I was less present. I stopped finasteride and the sides went away. I started again on the same dose(0.5 mg every day) as I thought it could be placebo. I experienced the same sides. I then stopped again. Yesterday I started 0.25mg and today I feel the exact same way and I am convinced it isn’t nocebo. Do you think it is my body adjusting to the drug as I haven’t been on it for more than 1 week consecutively? Do you think my body could adapt to it if I stayed on longer?
Cheers Kev
Yes, give it a couple of months. Any side effects will likely go away on their own.
If not, try 0.1 MG daily. That is the smallest dose you can use that still works.
Hi Kevin. Any tips to grow long hair as a man? Also is there any way of speeding hair growth rate. Thanks
Both finasteride and minoxidil lengthen the growth cycle, so you will get longer hair on them.
Kevin i have a question regarding dutasteride (0.5mg a day versus 2.5mg a day) :
Some people say that anything more than 0.5mg is useless since the study didn't last longer than 6 months (the dutasteride 2.5mg study) and that basically, perhaps the larger dose just reached a steady state faster.
So their assumption is that if the 2.5mg dutasteride study lasted for a longer period of time, we would see about the same scalp DHT reduction for both 0.5mg and 2.5mg..
What do you think about that ?
The differences between 0.5 mg and 2.5 mg in DHT aren't huge, but they were apparent by week 6 and continued through week 24 without any change. So I think the difference is real but not dramatic and the dose response curve is getting pretty flat by the time you reach 2.5 mg daily. By 6 months you probably have reached a steady state given the half life of dutasteride.
@haircafekevin
Thanks Kevin !
So the 2.5mg dutasteride study is a serious one i guess.
It means 2.5mg dutasteride a day is kinda the maximum power you can get out of dutasteride just like finasteride doesn't really get better above 1mg a day.
But if we talk about scalp DHT reduction : 2.5mg dutasteride is much much better than finasteride 1mg (twice as much scalp DHT reduction)
And also still better than 0.5mg dutasteride anyway.
Am i correct ?
I wish they did more research on dutasteride cause I'm sure there is much more to learn about it .
@@exactly1176I’m trying to push to 2,5mg right now
@@exactly1176 I think you summed it up perfectly. I agree that more research on dutasteride would be great. I think that since the drug company unfortunately didn't seek FDA approval for the hair loss indication, there isn't a lot of funding coming from the company to support dutasteride hair loss research. It's too bad that the system is so driven by drug company money.
@@Bartholome3101 The dutasteride master race amongst the dutasteride master race.
That ending was powerful
I love the constant hate for Blūd flow people.
Do u change how u say bloodflow? Im at 1:22 and I cant take the sound anymore.
It's a meme that dates back to my feud with Hairguard. Sorry if you find it annoying, but it is kind of tradition on my channel.
6:32 enough is enough.
@@nemiw4429 A shame, it's a really good video. Wish you would push through.
24:15 holy based
Hey Kevin, you mentioned Pea and Hemp protein are what you recommend to prevent hairloss but I was wondering if Vegan protein is fine also. Also, do you think creatine can accelerate hairloss?
Yeah, pea and hemp are both vegan protein sources. If something is labelled as vegan protein it usually means it has a combination of plant source. They're all fine.
Check out my video on creatine.
ruclips.net/video/CEqwrYIMM1c/видео.html
Kevin! when you claim that the best is yet, to come!! you generally mean after the 1st year stage or later?
Yeah, things peak by the first to second year.
does he pronounce "blood flow" that way because he's making fun of the british dude from HG, or because he has no testosterone left?
That's how it's actually pronounced because bludflow is a meme.
I’ve been on finasteride for about 4 years now. When I first started, I noticed that my hair felt super strong, scalp inflammation/pain eliminated and my skin was dry. Now, it feels like finasteride has stopped working - hair is thinner, scalp feels a bit more inflamed and I’m producing a lot more sebum. Why is this happening? I didn’t think that finasteride would ever become ineffective??
You may just need stronger 5AR inhibition. Maybe try dutasteride. You can use 0.5 or even 2.5 mg of dutasteride for double the scalp dht suppression of finasteride.
@@haircafekevin I’m concerned about doing dut. I have considered doing it topically but not sure about its efficacy. What are your thoughts on RU58441?
@@dababydagoat1380 Dut has been shown to be as safe as finasteride. Check out my video "the truth about dutasteride's side effects."
RU58841 on the other hand has no clinical data.
I took 1mg fin for one day and a few hours later i got that left ball pain and tingly nips, stopped for a few weekd went away. Should i try .5? I was tryn to do it 3x a week.
Sure, try 0.5 mg 3x per week.
@@haircafekevin should i do anything for the left testi pain and tingly nips? Or could it just go away after taking the med for awhile
If increased blood flaw its Irelevant with androgenic alopecia then there is no need to use Microneedling Devices or is it..
@user-nl3nv9dd3d Microneedling is useless, check out my recent video on it.
Kevin where exactly do you keep your Proscar pieces ? Do you keep them inside the pill-cutter itself ?
Did you pop a 1/4 of Proscar this morning ?
I keep them in an old prescription bottle. I usually take my Proscar in the middle of the day.
@@haircafekevinhow many tablets do you cut up at once?
I have ehlers danlos syndrome, and you inspired me to start fin. Many people with eds actually look younger than they are for whatever reason. My skin has a doughy texture and doesn't wrinkle
I need help I had started finasteride a couple of months with 0 signs of hairloss but after a month or so of taking it I lost complete libido I couldn’t get it up with my girlfriend, I powered through it for 2 more months with no luck whatsoever. So I stopped and 2 weeks after stopping my libido came back at full force but currently I’m shedding hairs everywhere this has never happened to be before like litteraly everywhere. I was in class and my notebook was full of hair follicles
Have you tried using a lower dose? You can try 0.5 or 0.2 MG daily or every other day. If need be you can even go as low as 0.1 MG daily. I talk about it in my optimal dose of finasteride video.
@@haircafekevin yes i was taking 0.25mg every other day. It is really pissing me off cuz I wanna sleep knowing my hair is safe. Not taking finasteride is like being out in the jungle
@@selimabouleila3562 You can try topical finasteride or 0.1 MG of oral finasteride daily. Also, maybe consider a low dose of Cialis, like 2.5 MG per day. It will easily deal take care of any erection issues you have.
@@haircafekevin ok will try that
@@haircafekevin I’m so sorry to bother you but the issue is I’m in France and I cannot procure myself topical finasteride.
I can cut finasteride to at most 0.25mg but beyond that it turns into dust.
I was on 0.25mg every other day with side effects
I have also tried CIALIS and it works but it’s quite expensive here in France 113 euros for 28 pills which means over the course of a year I’ll have to pay maybe 300-400 euros just for cialis which isn’t huge but if I can avoid it would be better
Should I maybe do 0.25mg every 3 or 4 days or what is the solution
That said, I might be able to procure cialis from a third world country for 5% of the price which is promising
(UPDATE)
I've been on 5mg(1pill everday)of Fin and 5%minoxidil(5x a week) for ALMOST a year I'm on the 10th or 11th month as of right now at this point and I've seen soooo much improvement of the darkening of my scalp. the areas I want to be filled in have darkened SIGNIFICANTLY and the horseshoe/balding patterns have almost completely vanished but right now I'm going through a bit of a shedding phase where it's easy to pull off the hair on my scalp and hairline but even with that my hair still looks dark and almost going back to normal in terms of where my hairline used to be it barely looks like I'm balding to me atleast
So far, libido side effects or gyno or depression for that matter, even
once again, THANK YOU SO FVCKING MUCH KEVIN ❤❤❤
you did what MPMD couldn't get me to do, and you are a MASSIVE reason I have my confidence back..
It's been awesome seeing your feedback on my channel leading up to this glorious day. Thank you for sharing your experience and inspiring others to stick with it. Especially when people panic and assume a treatment isn't working after the first treatment shed.
Your patience paid off big time and you've earned your hair!
Congrats hair loss Witcher!
a hair loss company KESHAH says it is about sclap tension and inflammation, hmmm
Let's all trust some scam hair loss company trying to justify selling a bogus product rather than published scientific research.
Kevin with a beard...This, I like.
But... My blůdfloo 😭
Cant wait to get on fin and min, atm im broke with no income
Look into quartering Proscar tablets. That is what I do and it is super cheap.
@@haircafekevin thank you for the tip and encouragement! In sweden ive heard about a few who does this, but it seems to be more common to get denied access to this type over regular oral fin here :) apprecate the shi out of your channel keep it up!!
@@haircafekevin also tretinoin is not allowed here in my freedom individualistic liberal country, so i gotta hope that im a responder to minox once i get to try it😂
@@dasitmane7590 Odds are in your favour that you will be a good responder. If for some reason you're not you could also try 10 or 15 percent minoxidil (if you can get your hands on it). It works in non responders to 5 percent minoxidil. I talk about it here.
ruclips.net/video/YUNdv782Byo/видео.html
fyi, rob also said reduced blood flow is the consequence of mpb
He's also had to adjust his theories to the facts over time. He still promotes non-medical treatments like scalp massage on his site though.
@@haircafekevin can you really say he's a scammer though?
He said depending on the severity and rate of your hair loss, you should go/skip the scalp massage as a treatment for mpb
I dont think he said people with mpb should go directly to the scalp massages
He also said scalp massages have poor quality data
He's laying out all the + and - of scalp massages and leaving the choice up to us, if we wanna go that route or not.
He also said scalp massages also rank amongst the lowest in his heirchy of evidence,
Why would a scammer who chooses to sell a programme would lay out so many - of what he's trying to sell?
And also personally I tried doing scalp massages myself, I swear it reduced my hairfall, idk why maybe its just a psychological phenomenon
@@rebelxd2019 Rob is clever because he posts lots of information pro and con approaches like scalp massage in an attempt to appear like he doesn't have an agenda, but he clearly does since he is selling subs and puts drug treatments and non-drug treatments on an equal footing on his website. That way he can deflect criticism by saying he doesn't think the evidence for scalp massage is good if he is challenged on the science. He says that he's just laying out the evidence and letting people choose. That would be like a doctor saying you have a bacterial pneumonia, and you can either take an antibiotic or use acupuncture, and the evidence for acupuncture working for pneumonia is bad, but it's your choice. Rob has a vested interest in selling subs, and no one is going to subscribe just to hear him say take finasteride, so he has to make it seem like scalp massage is a viable option.
I don't doubt your personal experience with scalp massage, but it's just subjective and there is a placebo effect when you think you are doing something positive for your hair. The placebo effect has been shown to affect hormone levels and brain neurotransmitters, so just because you had a response doesn't mean it was the scalp massage that did it. Scalp massage hasn't been shown to work in a properly designed randomized controlled study.
Is it best to use finasteride first and wait to see that hair loss has slowed, then incorporate regrowth agents? Like minoxidil and Stemoxydine?
I’m also considering a once weekly dutasteride tablet but I will wait to see if finasteride alone is enough
Thanks for all you do (in case you didn’t see my shed comment)
If you start treatment before losing ground or have just barely starting losing ground then yes, finasteride alone is probably all you'll ever need. If you're getting into the game late, say you're a Norwood 2 or beyond then I would start with finasteride or dutasteride and a growth stimulant like topical minoxidil right away.
Once weekly dutasteride is a great way to dip your toes into extra DHT inhibition too. I know Killian from The Hair Chemist did that and I have a video on it too.
ruclips.net/video/y-jp7oKK2SU/видео.html
Nice work, my dude! Stumbled upon your videos after the What I've Learned thing. I got convinced after you debunked the 💩 out of the bloodflow theory.
Glad to have you here, choom! What I've Learned should take that video down.
Rupert Angletérre