I'm so glad a popular RUclipsr made this video! I've been telling people about Zebrafish studies benefits, and everyone just looks at me like I'm crazy like "wtf we're totally different from a little fish" hopefully some of them will see this video
There's another big motivation for researchers to use zebrafish. They don't have any limitations on bioethics like mice have. Either way, zebrafish, fruit fly larvae and C. elegans are our modern medicine heroes.
***WATCH BEFORE READING*** What if I were to tell you there was a quiz on this video? How well would you do? I always wondered what type of retention these videos had. Here are a few questions I pulled from the information in this video, if you would like to try. **QUESTIONS** 1. What is the most common mutation in relation to melanoma? 2. What is the scientific name for zebrafish? 3. What is the name of the compound when enhanced increased the amount of hematopoietic (or blood) stem cells? 4. What percentage of zebrafish's protein-coding genes are similar to humans? 5. What is the name of the gene found to accelerate melanoma formation in Zebrafish? 6. What do zebrafish lack devoiding them of being the perfect test subjects for human disease? 7. What organ tissue can zebrafish regenerate after being damaged?
I got none. retention is poor. I watch because of interest. not because I can remember the figures or terminology. the presenter speaks to quickly for that.
If I were watching to legitimately learn and do stuff about this whilst seriously interacting with other people about this, I would be watching some RUclips video, yes, but I'd be doing *_much_* more. Like Xavior Lawless, I do it for the interest, sure some facts will stick to my mind for a while, but it's not like I'm gonna do anything with them; I just watch it because I love science in general.
Done honestly : 1. BRAF 6000 something 2. Dunno 3. PGE2 which is well known in human metabolism btw 4. Around 70% or 80 not sure 5. Don't remember. 6. They don't have neither lungs nor breasts. 7. The heart Interesting matter I believe, retention is mostly partial in every lecture/videos we attend but your questions should be oriented towards general messages rather than details such as the percentage, the scientific name or the name of the mutations to really seek for useful retention (none will remember those details but the usefullness in melanoma treatment/potential heart repair/bone marrow regrowth help; they might). That's actually something that could be looked up to see the impact of internet scientific vulgarisation which is the point of SciShow.
I'm surprised he didn't mention Glofish, which are fluorescent zebrafish that were originally used in research, but then became commercialized. They're the first GMO animal you can own as a pet and they're found in big pet stores and local fish stores.
I appreciate the content as always, in addition, I quite like the lighting in this episode, have you all done something different, or am I just having another stroke?
That was a bit more scientific than the average technicality of your usual episodes...and I watched just about all of them ^^ Interesting all the same though.
Nine blinks in 4 minutes and 32 seconds. I know there's cuts and editing, but it's still impressive. Impressive enough to trigger my brain into asking whether or not you blinked at all.
I knew this already because I have some in a tank beside me and I did lots of research on them... just because. Cute, fairly hardy and active fishies. And fearless; they'll nibble my fingers.
I think that using animals to understand and discover new ways to treat a person health is important. There are so many animals out there in the world that we have no idea why they exist or what benefits they provide to the environment. Well one of them is the zebrafish or Danio rerio. Genetic testing of these fish could provide humans with a solution to some medical issues, specifically diseases. With the similarities between humans and the zebra fish, scientists can possibly develop a better understanding of how certain diseases work and how they are passed on. Such things can be vital to patients that may be suffering from a disease that doesn't necessarily have a cure or fix at this time. By using animals and conducting research on them, I think it creates a whole new avenue for medical knowledge and discovery to follow.
Now I can't but hope that someone remembers to buy more 'host flakes' to sprinkle into the tank to keep them fed. No one wants to have to be the one to flush a host who goes belly up.
my son has a one of a kind genetic mutation. because of the lack of a second person being diagnosed with the same disorder. Doctors have made zebra fish that have the same genetic mutation as him so they can learn more about it.
News like this, CRISPR, etc, wow. Growth of technology is rapidly outpacing the growth of common sense and scientific literacy. What could possibly go wrong...
Hey sci show, while creeping around my house at night to grab a midnight snack I was tiptoeing to try and not disturb anyone. while I did this I first thought "why does, no matter how softly I plant my foot, does it always my noise?". Then I remembered that any two objects field of electrons prevent them from ever really touching which brought up a second question " why does two objects that never really touch coming together make noise and why would slowing the speed of the objects lessen it?" Could you please answer on or both of these questions for me?
probably over 10 years ago now, back when I was in junior high, the school organized some special project where the students were paired with researchers (all were biologist of different sorts if i recall correctly) and required to make a presentation about the research subject. I was paired with a researcher that was injecting zebra fish with some weird genetic material that would light up the area it affected with either bright green or red color (depending which was used) into egg cells . The goal was to find which gene in the fish was responsible for the development of nervous cells to find a way to help Alzheimer patients and the like.
a few years ago during my undergrad I applied to be part of a research team looking into zebrafish neurophysiology, too bad I was a bio major and it was a psych study so they rejected me :( would have been really cool to be a part of it
Zebrafish also regenerate their retinas. So sight decline isn't a thing for them. Would love to learn a way to regenerate the lens though. Presbyopia has no cure. And I don't know if we even know why the lens stiffens.
0:26-0:31 "because we have a common designer" is also a good explanation. Better infact, considering the flaws in nearly all of the "pillars" of evolution.
Oh you idiot. Evolution is a fact. Now one can believe that some greater being influenced where it wound up, but no, evolution is a documented, reliable fact. Yes we call it a theory but it is a theory the way gravity is a theory. Something that it is impossible to ever completely and totally prove, but we can easily document the effects of.
gravity is a fact - evolution is a hypothesis at best. Even that is flattering considering the blatant errors on it's end and the tons of lacking evidence and failed predictions, not to mention the ways it's hindered science...
Красимир Геджов Gravity is still considered a theory, but like any scientific theory it is treated as fact. The theory of relativity is another example. We can never definitively prove either things, however it dictates how things behave and we can objectively observe how it impacts things, just like with evolution. We can see the fossil record changing over time as animals evolved. They did not magically come into being. Or do you believe the devil put them there? What about the Galapagos finches, which are being studied still and we have actual records of them changing, showing how evolution works. Or the fact that we can genetically study the similarities between animals and ourselves. We can see how they relate and where the genes came from. You're denying reality with these claims, evolution has greatly helped science, not hindered it. You have no proof.
riff5fki I don't wanna get into a debate here, but you should study the difference between micro and macro evolution. Adaptation is not macroevolution, we're yet to see one case of it being so, even with the fossil record which you can't even hope to place your hopes on, because it's the best example for a global catastrophy like the flood of Noah. Not to mention dating methods are flawed, "change" is arbitrarily assigned to fossils without real proof, even when there is UNCHANGED species that are the same from allegedly 200+ milion years. Evolution does not stop - mutations always happen - that's what drives evolution. Nothing can stay the same. And oh yeah, mutations - it's obvious that mutations are losing of information, not gainig. The evolutionary side of academia and science is yet to produce a discovery which shows otherwise for how many decades now since we know about DNA? We would've even known more about it sooner if it wasn't called "mostly junk" by unproven evolutionary assumptions. I know all your points and arguments - they simply don't work the way you think you do. Research some creationist papers, articles, documentaries, lectures at conferences. Real scientists - not "fossil are made by the devil" people. All that information is out there, no need to flood the comments with a most definately fruitless debate.
1:17 "Zebra fish still aren't the perfect model for disease as they don't have lungs or mammary glands" and Oh. I don't know... mabye the fact that they are FREAKING FISH!!!!!
never underestimate the power of model organisms. we've learned a ridiculous amount from fruit flies. the Nobel prize for medicine went out today to a guy working on yeast cells.
I'm confused. Do we have similar genome because we have a common ancestor or do we share a common ancestor because we have a similar genome? Is this circular reasoning? I'm confused.
This is amazing. Human intelligence on the cusp of evolving us into immortal martian fish people. The future is now.
Gotta admit, this isn't as stupid as half the BS MIRI claims.
And you just had to add the cheesy "The future is now"..smh
Unless you identify as an immortal martian fish person, in which case humanity is appropriating your genome.
I don't get why people don't perceive this sarcasm.
For all those who blindly believe the so called evolution theory I recommend u watch dr.iad qnaiby series for more enlightenment
Can you do one on cerebral aneurysms? I had one rupture at 19 and would love to learn more!
Bob Le get off this site for everyone's sake.
Everybody like this so it gets to the top of the comments
ask on patreon or stop asking
Don't listen! You will be the next litojonny
do you have a genetics problem with your collagen?
I'm so glad a popular RUclipsr made this video! I've been telling people about Zebrafish studies benefits, and everyone just looks at me like I'm crazy like "wtf we're totally different from a little fish"
hopefully some of them will see this video
Visiclear is in the eye supplement I use, Fantastic things will be learned
Why do you only have 13 likes on this?
If you want to cure cancer, just delete the youtube comments section.
That only cures RUclips Cancer
Not (I wish i can type every single cancer but that'll take forever)
Just delete the internet, that should fix it
once you notice his hands, you cannot unsee them.
crud
Cr42yguy notice he doesnt blink at all
Cr42yguy now thats truly evil :D
I hadn't noticed the blinking thing... Argh! Thank you so much :-)
Jump cuts
the title looks like a clickbait ad on an illegal live streaming site
This is the fish none of the doctors want you to know about
Doctor's love this fish
This fish is better than viagra!
Top Ten SHOCKING facts about the Zebrafish!
You'll never believe number 9!
This fish is a cheap and effective secret drug
The heroes whe need, but not the ones we deserve.
Huh... I just finished setting up my LC/MS assay for prostaglandin E2 levels when I watched this video. Good timing scishow!
There's another big motivation for researchers to use zebrafish. They don't have any limitations on bioethics like mice have. Either way, zebrafish, fruit fly larvae and C. elegans are our modern medicine heroes.
***WATCH BEFORE READING***
What if I were to tell you there was a quiz on this video? How well would you do? I always wondered what type of retention these videos had. Here are a few questions I pulled from the information in this video, if you would like to try.
**QUESTIONS**
1. What is the most common mutation in relation to melanoma?
2. What is the scientific name for zebrafish?
3. What is the name of the compound when enhanced increased the amount of hematopoietic (or blood) stem cells?
4. What percentage of zebrafish's protein-coding genes are similar to humans?
5. What is the name of the gene found to accelerate melanoma formation in Zebrafish?
6. What do zebrafish lack devoiding them of being the perfect test subjects for human disease?
7. What organ tissue can zebrafish regenerate after being damaged?
I got none. retention is poor.
I watch because of interest.
not because I can remember the figures or terminology.
the presenter speaks to quickly for that.
Mammary glands baby.
It's too early in the morning for the hippo-campus to be working like this, man.(Aus)
If I were watching to legitimately learn and do stuff about this whilst seriously interacting with other people about this, I would be watching some RUclips video, yes, but I'd be doing *_much_* more. Like Xavior Lawless, I do it for the interest, sure some facts will stick to my mind for a while, but it's not like I'm gonna do anything with them; I just watch it because I love science in general.
Done honestly :
1. BRAF 6000 something
2. Dunno
3. PGE2 which is well known in human metabolism btw
4. Around 70% or 80 not sure
5. Don't remember.
6. They don't have neither lungs nor breasts.
7. The heart
Interesting matter I believe, retention is mostly partial in every lecture/videos we attend but your questions should be oriented towards general messages rather than details such as the percentage, the scientific name or the name of the mutations to really seek for useful retention (none will remember those details but the usefullness in melanoma treatment/potential heart repair/bone marrow regrowth help; they might).
That's actually something that could be looked up to see the impact of internet scientific vulgarisation which is the point of SciShow.
Mate, we need more such comments around here. Thank you for making us think. :)
I'm glad that Michael isn't just a sound engineer anymore
Awesome little fish! Why can't all fish be this cool?!
All fish are cool though, they keep the Ocean's ecosystem in check and other living organisms.
yes sir!
Nice new lighting setup SciShow. It looks great with the greenscreen!
Michael! Back at it again with that apple watch
I'm surprised he didn't mention Glofish, which are fluorescent zebrafish that were originally used in research, but then became commercialized. They're the first GMO animal you can own as a pet and they're found in big pet stores and local fish stores.
I have these as pets!
Heeeeeeeey, I'm working in a D. Rerio lab right now waiting for my embryos to permeabilize! Yay Scishow shoutouts! :D
I appreciate the content as always, in addition, I quite like the lighting in this episode, have you all done something different, or am I just having another stroke?
wow...that is amazing, i came to this vid while searching for ways to extract stem cells from fish and glad i stuck around for the whole vid.
I like this guy
no homo
Aah masculinity is so weak
a Hugh Mongous one?
ILYES
or two :D
Nah I am good
I prefer people with boobs not balls. I am pretty confident with my sexuality... I think.
That was a bit more scientific than the average technicality of your usual episodes...and I watched just about all of them ^^
Interesting all the same though.
Nine blinks in 4 minutes and 32 seconds. I know there's cuts and editing, but it's still impressive. Impressive enough to trigger my brain into asking whether or not you blinked at all.
is that a SciShow smartwatch to go with your handsome SciShow hoodie?
Oh my god that last pun at the end there really had me laughing. Tiny fish, big way.. Hooooly hell,, I just can't stop myself..
That's pretty exciting! Thanks.
Nice job, Michael!
I knew this already because I have some in a tank beside me and I did lots of research on them... just because. Cute, fairly hardy and active fishies. And fearless; they'll nibble my fingers.
I think that using animals to understand and discover new ways to treat a person health is important. There are so many animals out there in the world that we have no idea why they exist or what benefits they provide to the environment. Well one of them is the zebrafish or Danio rerio. Genetic testing of these fish could provide humans with a solution to some medical issues, specifically diseases. With the similarities between humans and the zebra fish, scientists can possibly develop a better understanding of how certain diseases work and how they are passed on. Such things can be vital to patients that may be suffering from a disease that doesn't necessarily have a cure or fix at this time. By using animals and conducting research on them, I think it creates a whole new avenue for medical knowledge and discovery to follow.
so the message of SciShow is if humanity can make it another 50 years we will live forever.
That teleprompter is the real MVP of this video lol. There is no way somebody is remember all of this haha
fish are cool
Dude i have those same zebra danios in my turtle tank and I love em
Cool we are doing a study in our university with zebra fish
Very smart
I use to have these.
I just had a lecture about this earlier today. bouky as
I have some of these guys in my tanks
You have SciShow hosts in a tank? You psychopath!
The video background is blue, so they most likely film inside their tanks.
Now I can't but hope that someone remembers to buy more 'host flakes' to sprinkle into the tank to keep them fed. No one wants to have to be the one to flush a host who goes belly up.
Love this channel
Aranda 2016! Love this guy.
my son has a one of a kind genetic mutation. because of the lack of a second person being diagnosed with the same disorder. Doctors have made zebra fish that have the same genetic mutation as him so they can learn more about it.
How's your son
Make a vídeo about colesterol
News like this, CRISPR, etc, wow. Growth of technology is rapidly outpacing the growth of common sense and scientific literacy. What could possibly go wrong...
My students just learned about zebrafish being used by scientists to test muscle damage in space!
I have a Zebra Fish, It's kinda' cool to know they are helping science, I guess.
Hey sci show, while creeping around my house at night to grab a midnight snack I was tiptoeing to try and not disturb anyone. while I did this I first thought "why does, no matter how softly I plant my foot, does it always my noise?". Then I remembered that any two objects field of electrons prevent them from ever really touching which brought up a second question " why does two objects that never really touch coming together make noise and why would slowing the speed of the objects lessen it?" Could you please answer on or both of these questions for me?
probably over 10 years ago now, back when I was in junior high, the school organized some special project where the students were paired with researchers (all were biologist of different sorts if i recall correctly) and required to make a presentation about the research subject. I was paired with a researcher that was injecting zebra fish with some weird genetic material that would light up the area it affected with either bright green or red color (depending which was used) into egg cells . The goal was to find which gene in the fish was responsible for the development of nervous cells to find a way to help Alzheimer patients and the like.
a few years ago during my undergrad I applied to be part of a research team looking into zebrafish neurophysiology, too bad I was a bio major and it was a psych study so they rejected me :( would have been really cool to be a part of it
Wow, 34 seconds after the video was published :D
Somehow I read it as "The Modern Fish That's Changing Tiny Medicine."
Woot HSCT! Maybe i will get that new medication when i go :/
Zebrafish also regenerate their retinas. So sight decline isn't a thing for them. Would love to learn a way to regenerate the lens though. Presbyopia has no cure. And I don't know if we even know why the lens stiffens.
In the wild are zebrafish prey for the lionfish?
Master Therion I sea what you did there!
Yes, I believe it's one of those things in the Circle of Life.
Only in SciShow will I see hosts breaking stereotypes
Zebrafish are also extremely hardy.
i want to thank you sci show for not changing. even the hair :)
please talk about acrylamide in French fries! 🍟
Why do snails bubble when you pour salt on them?
0:26-0:31 "because we have a common designer" is also a good explanation. Better infact, considering the flaws in nearly all of the "pillars" of evolution.
Oh you idiot. Evolution is a fact. Now one can believe that some greater being influenced where it wound up, but no, evolution is a documented, reliable fact. Yes we call it a theory but it is a theory the way gravity is a theory. Something that it is impossible to ever completely and totally prove, but we can easily document the effects of.
gravity is a fact - evolution is a hypothesis at best. Even that is flattering considering the blatant errors on it's end and the tons of lacking evidence and failed predictions, not to mention the ways it's hindered science...
Красимир Геджов Gravity is still considered a theory, but like any scientific theory it is treated as fact. The theory of relativity is another example. We can never definitively prove either things, however it dictates how things behave and we can objectively observe how it impacts things, just like with evolution. We can see the fossil record changing over time as animals evolved. They did not magically come into being. Or do you believe the devil put them there? What about the Galapagos finches, which are being studied still and we have actual records of them changing, showing how evolution works. Or the fact that we can genetically study the similarities between animals and ourselves. We can see how they relate and where the genes came from. You're denying reality with these claims, evolution has greatly helped science, not hindered it. You have no proof.
riff5fki I don't wanna get into a debate here, but you should study the difference between micro and macro evolution. Adaptation is not macroevolution, we're yet to see one case of it being so, even with the fossil record which you can't even hope to place your hopes on, because it's the best example for a global catastrophy like the flood of Noah. Not to mention dating methods are flawed, "change" is arbitrarily assigned to fossils without real proof, even when there is UNCHANGED species that are the same from allegedly 200+ milion years. Evolution does not stop - mutations always happen - that's what drives evolution. Nothing can stay the same. And oh yeah, mutations - it's obvious that mutations are losing of information, not gainig. The evolutionary side of academia and science is yet to produce a discovery which shows otherwise for how many decades now since we know about DNA? We would've even known more about it sooner if it wasn't called "mostly junk" by unproven evolutionary assumptions.
I know all your points and arguments - they simply don't work the way you think you do. Research some creationist papers, articles, documentaries, lectures at conferences. Real scientists - not "fossil are made by the devil" people.
All that information is out there, no need to flood the comments with a most definately fruitless debate.
If you hate science so much and believe in some vast global conspiracies why on earth are you watching a science show?
What do they taste like?
and happen to be one of the best freshwater aquarium fish in the world!
IT'S SO CUTE!~
Huh, the humble yet nippy zebra danio, who woulda' thunk it
Thank you tiny fish for allowing us to further our knowlege of things! I hope you dont mind the sciencing.
I have them they're called Edward Pesca Charles Alina and Delta (R.I.P Lars)
What chemicals can induce skin cancer in zebrafish in 1-2 weeks for dissertation purposes???
SciShow have you done a video about deafness?
The see-through adult zebrafish are called Casper mutants :)
Are you guys going to make the sweatshirt Michael is wearing for the store?
thatd be cool, i suppose
Kilroy was here
Spread him to every video you go to
Truly an old meme
I swear I've seen this video uploaded multiple times now...
Yeah
I saw the title and immeditely thought "babel fish"...
I'd like to see a transparent Human, more so a transparent politician.
So if you eat lots of zebra fish you'll live forever? What about real zebras should we eat them too?
huldu I appreciate your humor
For safety, I say yes. Save one for me.
It couldn't /hurt/
+huldu Eating animals doesn't give you their abilities.
it does too, fish ate zebras and now you've got zebra fish.
I dunno, there's something fishy about this
So promising 💜
Dang.. I was hoping it was about the babelfish.
I WANT HIS HOODIE
so giant danio..... i had about 10 of them
i had those pet fish!
1:17 "Zebra fish still aren't the perfect model for disease as they don't have lungs or mammary glands" and Oh. I don't know... mabye the fact that they are FREAKING FISH!!!!!
never underestimate the power of model organisms. we've learned a ridiculous amount from fruit flies. the Nobel prize for medicine went out today to a guy working on yeast cells.
i swear he didnt even blink once in the video, illuminati confirmed
Why do i shiver after i pee?
Michael, do you stick a lot of make up on for these videos or is your skin just that good?
Inquiring minds want to know.
Why can too many scovile units kill people?
I keep thinking of zebrafish wearing a pair of jeans.
This fish is just one step closer to the mindless regenerating zombie monsters we'll one day be overtaken by
Heh heh, so funny. Im helping the world in medicine!
Drug companies are now charging $600 for a zebrafish.
***** its a joke
I've got a few hundred for free(they bred)
They would if they could
Yes, all that stuff the fish has we can put in us, and soon we will be healthy, and we can breath underwater also. A win win solution.
When a fish is more transparent than your government...
Zebra fish "Those researchers gave me cancer"
I'm confused. Do we have similar genome because we have a common ancestor or do we share a common ancestor because we have a similar genome? Is this circular reasoning? I'm confused.
Wow
i have that in my fish tank o_o woohoo?
Anyone else noticing the thumbnails not being correctly stretched for mobile?
I have 3 zebra danios and 3 leopard danios.
Can I have that hoodie? Why can't I have?
Im early for once woo hoo!
Me too!
whoa, thats complex medicated...😵