Non Steroidal Anti Inflammatory Drug | NSAIDs (Part-03) | Mechanism of Action of NSAID | NSAIDs

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Prostaglandins are a family of chemicals that are produced by the cells of the body and have several important functions. They promote inflammation that is necessary for healing, but also results in pain, and fever; support the blood clotting function of platelets, and protect the lining of the stomach from the damaging effects of acid. Prostaglandins are produced within the body's cells by the enzyme cyclooxygenase (COX). There are two COX enzymes, COX-1 and COX-2. Both enzymes produce prostaglandins that promote inflammation, pain, and fever. However, only COX-1 produces prostaglandins that support platelets and protect the stomach. Nonsteroidal anti-inflammatory drugs (NSAIDs) block the COX enzymes and reduce prostaglandins throughout the body. As a consequence, ongoing inflammation, pain, and fever are reduced. Since the prostaglandins that protect the stomach and support platelets and blood clotting also are reduced, NSAIDs can cause ulcers in the stomach and promote bleeding.
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I want to ask a question! If all NSAIDs decrease the platelets aggregation then why we used paracetamol in dengue ?

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Not all mainly non selective and in higher dose

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Sir mujhe NSAID ke notes apke page pharmacy solution pr nhi mile.. Kya aap meri help kr skte ho... Mujhe baki to notes mile pr NSAID KE NOTES NHI MILE...

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Have been following your all videos and loved them.
But I don't know why in NSAID series things seem to be messed up a lot. Understanding has become difficult particularly in NSAID series. That basic Cox 1 and Cox 2 chart or something related to that is missing. 🙁

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Process of anti inflammatory is understandable but not as much as how I used to understand other topics

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We have many videos as animation which cover cox 1 and cox 2 role. Even we have uploaded mnemonic on it

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Sir , why we need anti- inflammation action , if inflammation cause ingest to the antigen.

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If there is increase in Ab-Ag interaction it will cause pain and swelling. Thas why we have to reduce it.

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Sir Lekin anti inflammatory drug use krne se antigen kaise kill hoga

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Antigen ??

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Zaheer Alam NSAID antigen ko kill nahi karta

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sir ,plz 4&5 unit ka video jaldi post kare
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I am trying. Here in our college there is sufficient time for exams

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