As understanding expands questions become more precise its a feedback loop. Cellular memory may be the primary angentic tool (cellbiologist Prof Michael Levin's work)
@@deeplearningpartnership Has to be great, but also fighting for funding and some much competition along with collaboration. Huge ups and downs, great here to focus on the upside. The upside is so powerful.
This channel helped me discover my purpose in life, and effectively ignited a passion and love for science and research within me. In a year I’ll be entering university and working towards a PhD in cognitive neuroscience. I’m intensely excited. Thank you for these videos, they are fantastic.
@@TheBoringInvestorMan Thank you so much! I can't wait to get into the industry! There are so many caring and intelligent people working hard out there; working alongside them is like a dream to me.
@@theAMR1 Thank you for your kind words sir, I really appreciate it. To be honest, all I really want to do is diligently improve myself and expand my realm of understanding in a valuable way which can be of service to others. If this is by deepening the science community's understanding of specific notions, or even paving a path towards new destinations, any endeavor I take will provide me with great fulfilment. With that said, having a profound and instinctive curiosity is another factor which drives me. Thank you for asking :)
Physics walked so Biology could run. A lot of the breakthroughs/developments in biology right now are on the back of breakthroughs made in physics in the 20th century.
Yea definitely. Side effect of insane amounts of compute resources. Litteral biological golden age to rival the physics one we had in the 1940s. Dude we have China just pumping out all sorts of frankenstein shit including as of recent a coronavirus according to the US Government lmfao
@@MrKiach I've often had that thought recently. After the false mania over biotech for a short while in the 90s, it felt like the field had dropped off, when really things just slowly built and waited for AI to get powerful enough. It seems we are now at where physics was in the 1920s, when relativity and quantum physics manifested in technological change. The results were most dramatically shown during the Manhattan Project and the Moon landing, which permanently changed geopolitics and then how we see ourselves. But a lot kept happening after that - it was just the most obvious manifestation. There's also a lot of talk like, "We have been to the Moon but can't..." talk. That talk happens because we cracked physics but not biology.
Not a problem: it's called turmeric. When used in conjunction with black pepper, it has a REMARKABLE ability to regulate the body's inflammatory response. I've been using it for about 14 years now, to prevent my finger joints from developing osteoarthritis, which i am prone to, being someone who does massages for a living: my metacarpal and finger joints often become quite sore, and without a decent dose of turmeric (1 to 2 inches of raw root chewed well, depending upon the roots' thickness, later in a meal where you start out with something you put a goodly dose of black pepper on) they even become stiff after a night's sleep. The turmeric does a FABULOUS job. I also use formulations which contain a concoction of chondroitin, MSN, boron, glucosamine, hyaluric acid and a good anti-inflammatory agent such as boswellia...but oddly enough the turmeric + piperine combo produces better overall results than this jumble of supposed cartiledge-building substances.
@@altareggo Actually a recent study shows that this is not true, but was falsely repeated from somebody who wrote a lot of fraudulent papers about Tumeric. Can only recommend to read up on it!
In the near future, bioengineers can basically be like: “OK, we need to create this kind of protein to perform this type of function to combat emergence of XYZ disease. Let me run this by the computer to get the exact sequence of amino acids needed to construct it. Then we’ll just use CRISPR 3.0 to generate the blue prints to induce these cells into becoming factories for this protein.” Insanely exciting stuff!
@@n10do This is what's so cool about the future implications of this stuff. The possibilities are essentially endless. Obviously there's probably a helluva long way to go before we can do it practically but the implications are mind boggling.
It is totally overhyped. If you train the ai with already solved structures, of course it is going to be 99% correct if you test it with the same sequences! You need to test it with totally new ones.
My vagus nerve is damaged. For my headaches, my neurologist has prescribed 400 mg of vitamin B2 Biboflavin, and we did nerve block. I have been diagnosed with incomplete lupus. I am about to go on an 8-week course of self-hypnosis to calm down my nervous system and hopefully change my brain patterns in how my brain reacts to pain. Thank you for the video it was very interesting.
Well, many people with chronic diseases on the internet and media have stated that cutting UPF consumption in general can improve their symptoms. Did this work for you too?
Can you guys also make one for the field of chemistry? Maybe it's not your expertise, but I am sad to see that there are only math, physics, and biology breakthroughs every year.
Coming from someone who studied biotechnology and thought a lot about the protein folding problem, this is a really insane breakthrough. In the future, I may try and do something about auto-immune disorders such as psoriatic arthritis, and the research results about the vagus nerve may come in handy. Great advances overall!
It’s B cells and Epstein Barr virus that are heavily needing research in for autoimmunity immunexcitotoxicity. Autoimmune neurological issues are very wide and variable. Most issues begin with over activity of certain cells. These cells are triggered by numerous things from infections to chemicals to natural allergens. Antihistamines are sold for such issues but such issues for some need heavier blockers or steroids. Mast cells are very much needing extensive research. It’s like immune systems can end up with ADHD in anyone. Carr T cells therapy’s are emerging as potential permanent solutions for something like arthritis already used for blood cancer treatments. These are so variable but could be custom engineered from patients own cells directed at I’d assume anything. Almost like a vaccine towards unwanted autoimmune cells their damage/ activity. It’s amazing.
@@loveKG26 This sort of approach is called personalized medicine and for some genetic diseases such as spinal muscle atrophy, in this case using Exon Skipping in Antisense-Oligonucleotides, we can actually cure such things. At the basis of almost every disease stand some sort of "overactivity," usually starting with DNA & RNA activity being increased or decreased and certain proteins expressed as a result. The problem with arthritis is that it's real cause is not yet fully understood, and all medication and inventions may temporarily relieve the patients of pain, but are by no means permanent solutions or curing the symptoms completely. Carr T cells for anti-cancer treatment is really amazing though, that's true!! Genetic Engineering may one day treat many, many illnesses, but for now, we need to focus on understanding their exact mechanisms to prevent any future complications. This is also why it takes soooo long for many of the newer inventions to be implemented and widely available (and research being expensive and capitalism ruining things..)
This helped me grasp the significance of these events so much more! It would be so cool to watch a video like this about 2024's biggest breakthroughs in chemistry too!!
One indirect way of observing the link between the Vagus Nerve and the immune system is that some immune cells have acetylcholine receptors on them. When the acetylcholine binds to the receptors, it alters the immune function of the cells, and the acetylcholine is provided by the parasympathetic nervous system, which includes the Vagus Nerve.
Kudos 🎉👏🏼 to the producers of this video, and naturally the microbiologists and scientists involved in 🧬 gene and proteins production. Thanks 👍🏼 for sharing 🙏🏼.
Brain-body connection? It baffles me that we are still conceptually separating the brain (or NS) from the rest of the body this way. Is it an epistemic consequence of platonic dualism, or just an interpretative bias?
Amazing good job! About same time you worked on this, I instead worked on boronic acid sensors. it never got funded through grants. There was a group in Germany that came up with a boronic acid on an insulin receptor agonist. No idea where that went. Beyond that, there were some mimetics a couple decades ago that might get developed. There were some tumor issues with some delivery systems. Insulin is pretty good at developing tumors. The lectin-insulin drug in this video might be good for teenage type 1s who are prone to drift from the discipline needed for optimal glucose management.
I've been waiting for this. Thank you for the upload! It was a delight. Personally I'm speechless about the new possibilities that AI assisted protein design will offer, I could fantasize for days
Most interesting. Brain and inflammation, wonder if things in the gut like IBD can be targeted or helped in this manner. For the protein folding, it isn't just DNA, RNA protein. There are also post-translational modifications. I wonder if the lack of those (or maybe they put some in) will make the proteins less functional. Also wonder if can use some alternative amino acids outside the usual 20. Conotoxins in snails use some unusual ones for instance.
I wonder how many years it will take for Quanta's people to find out about Michael Levin, Josh Bongard, Mark Solms, Karl Friston and other allied researchers. I'll be waiting.
the finding on the vagus nerve seems a little late, considering studies and results of meditation, acupuncture, or dry needling practices, and Buddhist teachings have long been talking about the brain and body connection along the spinal cord/fluid and brainstem, but it does pinpoint exactly where that communication between the varying systems of the brain and body are transferring the information received through our senses and how the disconnect actually is detected by the brain and body systems and how that may result in disorders/disabilities and diseases. Now I wonder if that means the disconnect occurs from what we consume or whether you are born with a disconnected connection between the brain and body. What does that mean for the psychiatric field concerning diagnosis criteria and treatment practices in the medical and therapy fields?
I’m a believer of ‘no pain, no gain!’ But I’m usually no in pain unfortunately. Also, I feel like I can’t self inflict pain in areas of my body where I feel like are aging !
LUCA is cool, the entire process from LUCA to us has always been fascinating but when I read about the inflammation modulator in the brain stem it gives you a good feeling knowing that a good chunk of systemic bodily pathologies have a potential pathway to a (dare I say) potential solution. But the protein folding progress, although definitely has a much higher ceiling (In many fields), feels like a precursor to some nefarious things we cannot even comprehend yet is troubling and can seem like another version of pandoras box (what we can potentially expect when we completely unlock AI).
Well, if the SNP method has the highest accuracy in dating the age of mutations, and does not take into account the variable mutation rate but is accurate to several million years, how can we say that it is correct and that the age of the luca was estimated correctly?
These are the real heroes...The people who push Humanity forward. Probably if the politicians of the world can learn something from this curious brains, the world will turn into heaven.
vagus nerve hypothesis: now Doctors can says that "well, there's nothing apparently wrong with you. you just need to eat healthy, drink lots of water, exercise, get plenty of sleep and go outside" even more confidently
Wouldn’t it be informative if the placebo effect of humans was considered and measured against a Vegas nerve anti/pro stimulation of inflammation? I would even take it further to suggest that the metaphysical neuroplasticity outcomes may very well challenge or supersede expected results. But I’m just an English major.
This video has prompted some interesting thoughts. If we have LUCA and understand its components, along with the ability to create our own proteins, could it be possible that a version of ourselves-or an advanced civilization-made this discovery long ago? They might have been able to replicate these early cells and send them in a sort of 'package' to various potential locations or planets, millions of years away, in the hope that one would resemble 'Earth.' Could it be that this is our ultimate direction? The physical limitations of the human body might prevent us from becoming an intergalactic species. Instead, perhaps our way to ensure the continuation of humanity is to package the prerequisites for life and send them into the distant universe. This could allow life to evolve elsewhere, eventually leading to a form of humanity similar to our own. (Thank you AI for helping me word my idea in a more readable way).
just curious why is there no biggest breakthroughs in chemistry? Don’t get me wrong these breakthroughs in biology, physics, and computer science are amazing but as an undergraduate pursuing a degree in pharmaceutical sciences and having a strong passion in organic chemistry, I was hoping to see some breakthroughs in chemistry 😂
Absolutely mindblown with the predictive capabilities of AI on protein folding. As a Medical doctor i can only fanthom how many monoclonal antibodies we could design to treat so many different untreatable cancer, autoimmune diseases and metabolic diseases in as short as a decade. This could advance the practice of medicine as we know it.
This isn’t true. The vagus nerve was known to influence body functions like heart rate and digestion but no proof that there was a neurocircuit for immune response in the brain
"Great video on protein folding, but how does predicting basic amino acid shapes help with practical applications like brain development or treating diseases? A follow-up on its real-world impact would be amazing!"
Thats not what they said. We still think of the three kingdoms (archaea, eukarya, prokaryota) as individual, monophyletic clades. Going back further you have their common ancestor, LUCA.
@@bluesmanshoes Prokaryota are not a monophyletic clade, but a paraphyletic grouping of archaea and bacteria, and eukaryotes are deeply nested within the archaeal clade, a type of asgard archaeon, rather than a separable third domain. However, eukaryotes are a valid clade themselves, and so are bacteria. This is like the situation w birds, which are a type of maniraptoran dinosaur, but a valid clade within it nonetheless.
Surely you should have said that the two domains of life are Bacteria and Archaea, rather than continuing to use the paraphyletic notion of prokaryotes in 2024? We know now that eukaryotes are deeply embedded within the Asgardarchaeota clade, and so they cannot be a separate domain of life.
Understanding is amazing. People who devote their lives to understanding are heroes.
Best job in the world.
Practically, its more about questioning. Understanding being the byproduct. But yeah, I get your point!
As understanding expands questions become more precise its a feedback loop. Cellular memory may be the primary angentic tool (cellbiologist Prof Michael Levin's work)
Agreed
@@deeplearningpartnership Has to be great, but also fighting for funding and some much competition along with collaboration. Huge ups and downs, great here to focus on the upside. The upside is so powerful.
It's LUCAs fault that we have to pay taxes and do laundry
😂
My name is LUCA. I live on the second floor...
@@musicalneptunian😂
It's LUCA'S fault for your existence
It's my fault I know
This channel helped me discover my purpose in life, and effectively ignited a passion and love for science and research within me. In a year I’ll be entering university and working towards a PhD in cognitive neuroscience. I’m intensely excited. Thank you for these videos, they are fantastic.
Best of luck in your studies! Thanks for all future works and breakthroughs that you'll no doubt be involved in :)
Hey man, hope u find a happy life. I am interested if you can share with us your purpose, it may enlighten someone.
Bravo for you and best of good fortune in your new career!
@@TheBoringInvestorMan Thank you so much! I can't wait to get into the industry! There are so many caring and intelligent people working hard out there; working alongside them is like a dream to me.
@@theAMR1 Thank you for your kind words sir, I really appreciate it. To be honest, all I really want to do is diligently improve myself and expand my realm of understanding in a valuable way which can be of service to others. If this is by deepening the science community's understanding of specific notions, or even paving a path towards new destinations, any endeavor I take will provide me with great fulfilment. With that said, having a profound and instinctive curiosity is another factor which drives me. Thank you for asking :)
It feels like Biology is going through a golden age, the breakthroughs are insane, especially compared to Physics.
Physics walked so Biology could run. A lot of the breakthroughs/developments in biology right now are on the back of breakthroughs made in physics in the 20th century.
Yea definitely. Side effect of insane amounts of compute resources.
Litteral biological golden age to rival the physics one we had in the 1940s.
Dude we have China just pumping out all sorts of frankenstein shit including as of recent a coronavirus according to the US Government lmfao
@@MrKiachExactly! These are not completely separate fields. We are building continuously on top of others.
@@MrKiach I've often had that thought recently. After the false mania over biotech for a short while in the 90s, it felt like the field had dropped off, when really things just slowly built and waited for AI to get powerful enough. It seems we are now at where physics was in the 1920s, when relativity and quantum physics manifested in technological change.
The results were most dramatically shown during the Manhattan Project and the Moon landing, which permanently changed geopolitics and then how we see ourselves. But a lot kept happening after that - it was just the most obvious manifestation.
There's also a lot of talk like, "We have been to the Moon but can't..." talk. That talk happens because we cracked physics but not biology.
how is LUCA a breakthrough? just a weak theory
We got designer proteins before GTA 6
💀💀💀
Inflammatory response control would be wild
Not a problem: it's called turmeric. When used in conjunction with black pepper, it has a REMARKABLE ability to regulate the body's inflammatory response. I've been using it for about 14 years now, to prevent my finger joints from developing osteoarthritis, which i am prone to, being someone who does massages for a living: my metacarpal and finger joints often become quite sore, and without a decent dose of turmeric (1 to 2 inches of raw root chewed well, depending upon the roots' thickness, later in a meal where you start out with something you put a goodly dose of black pepper on) they even become stiff after a night's sleep. The turmeric does a FABULOUS job. I also use formulations which contain a concoction of chondroitin, MSN, boron, glucosamine, hyaluric acid and a good anti-inflammatory agent such as boswellia...but oddly enough the turmeric + piperine combo produces better overall results than this jumble of supposed cartiledge-building substances.
@@altareggoI am from India and we have been using this exact remedy for centuries if not more.
@@altareggo Actually a recent study shows that this is not true, but was falsely repeated from somebody who wrote a lot of fraudulent papers about Tumeric. Can only recommend to read up on it!
@@Fabianvolf Could you provide the name for the study?
Turmeric for inflammation always sounded "hopus focus" to me
Loving these 2024's Biggest Breakthroughs videos. Can't wait for the next one!
The Nobel prize of chemistry is in this video.
@@eSKAone- oops
Can't wait for computer science
They do these every year 🗓️
@@AchwaqKhalid I know but theres multiple each year
I wait for this more than the Nobel Prize.
Protein folding predictions by AI sounds like pure science fiction. What a time to be alive!
In the near future, bioengineers can basically be like:
“OK, we need to create this kind of protein to perform this type of function to combat emergence of XYZ disease. Let me run this by the computer to get the exact sequence of amino acids needed to construct it. Then we’ll just use CRISPR 3.0 to generate the blue prints to induce these cells into becoming factories for this protein.”
Insanely exciting stuff!
@@n10do This is what's so cool about the future implications of this stuff. The possibilities are essentially endless. Obviously there's probably a helluva long way to go before we can do it practically but the implications are mind boggling.
I give it 5 years. You can do it now, with the appropriate access to things
IT'S BEEN THERE FOR 65 YEARS!!!! LINUS POLING MR!!!!!!
It is totally overhyped. If you train the ai with already solved structures, of course it is going to be 99% correct if you test it with the same sequences! You need to test it with totally new ones.
I’m so grateful for all the work people of quanta magazine do! Thank you for all the amazing articles and videos!
My vagus nerve is damaged. For my headaches, my neurologist has prescribed 400 mg of vitamin B2 Biboflavin, and we did nerve block. I have been diagnosed with incomplete lupus. I am about to go on an 8-week course of self-hypnosis to calm down my nervous system and hopefully change my brain patterns in how my brain reacts to pain. Thank you for the video it was very interesting.
Best of luck to you and your medical team.
Well, many people with chronic diseases on the internet and media have stated that cutting UPF consumption in general can improve their symptoms. Did this work for you too?
@erf2324 Yes, it does help as long as I am consistent.
Can you guys also make one for the field of chemistry? Maybe it's not your expertise, but I am sad to see that there are only math, physics, and biology breakthroughs every year.
Chemistry for biology is like math for physics!
Coming from someone who studied biotechnology and thought a lot about the protein folding problem, this is a really insane breakthrough. In the future, I may try and do something about auto-immune disorders such as psoriatic arthritis, and the research results about the vagus nerve may come in handy. Great advances overall!
Thank you Girth Job 😊❤
If there was ever a time to try this, this is the time
precisely
It’s B cells and Epstein Barr virus that are heavily needing research in for autoimmunity immunexcitotoxicity. Autoimmune neurological issues are very wide and variable. Most issues begin with over activity of certain cells. These cells are triggered by numerous things from infections to chemicals to natural allergens. Antihistamines are sold for such issues but such issues for some need heavier blockers or steroids. Mast cells are very much needing extensive research. It’s like immune systems can end up with ADHD in anyone. Carr T cells therapy’s are emerging as potential permanent solutions for something like arthritis already used for blood cancer treatments. These are so variable but could be custom engineered from patients own cells directed at I’d assume anything. Almost like a vaccine towards unwanted autoimmune cells their damage/ activity. It’s amazing.
@@loveKG26 This sort of approach is called personalized medicine and for some genetic diseases such as spinal muscle atrophy, in this case using Exon Skipping in Antisense-Oligonucleotides, we can actually cure such things. At the basis of almost every disease stand some sort of "overactivity," usually starting with DNA & RNA activity being increased or decreased and certain proteins expressed as a result. The problem with arthritis is that it's real cause is not yet fully understood, and all medication and inventions may temporarily relieve the patients of pain, but are by no means permanent solutions or curing the symptoms completely. Carr T cells for anti-cancer treatment is really amazing though, that's true!! Genetic Engineering may one day treat many, many illnesses, but for now, we need to focus on understanding their exact mechanisms to prevent any future complications. This is also why it takes soooo long for many of the newer inventions to be implemented and widely available (and research being expensive and capitalism ruining things..)
We got a universal common ancestor face reveal before GTA VI
Timestamps PLEASE!!!!
Fuck yeah! I took that neuroimmunology stuff as an extra work to my biochem exam in september. It's fantastic to see it here at the end of the year.
It’s really interesting
This helped me grasp the significance of these events so much more! It would be so cool to watch a video like this about 2024's biggest breakthroughs in chemistry too!!
One indirect way of observing the link between the Vagus Nerve and the immune system is that some immune cells have acetylcholine receptors on them. When the acetylcholine binds to the receptors, it alters the immune function of the cells, and the acetylcholine is provided by the parasympathetic nervous system, which includes the Vagus Nerve.
Any idea which programme was used to make these awesome videos?
Brilliantly explained and sincere congratulations to EVERYONE involved in this project
Love these, never stop, look forward to and watch all of them every year. Will show my daughter them as she grows older.
This series is fascinating! Loving it
Is there gonna be chemistry?
Everyone concerned about LUCA, NO ONE wants to talk about big brother FUCA 😭 He's a good boy, I swear.
Absolutely fascinating, especially the idea of inflammatory homeostasis.
The Vegas nerve never transmits what happened last night
YESSSSSS, it's another 2024 biggest breakthroughs... MARRY ME quanta magazine 🥰🥰🥰
What 😂
Kudos 🎉👏🏼 to the producers of this video, and naturally the microbiologists and scientists involved in 🧬 gene and proteins production.
Thanks 👍🏼 for sharing 🙏🏼.
Brain-body connection? It baffles me that we are still conceptually separating the brain (or NS) from the rest of the body this way. Is it an epistemic consequence of platonic dualism, or just an interpretative bias?
The belief that the mind is inside the brain and not in every cell of the body
Breakthroughs for computer science next please
When Dr. Zuker said, “we reasoned that there has to be some sort of homeostatic controls…” Man! Thank God nature is intelligible. This is amazing!
didn't we succesfully map a fruit fly brain for the first time this year?
wish it had been included- great video anyway, keep it up!
It seems like LUCA was just a really chill guy/gal.
I'd definately invite it to my birthday party.
LUCA is responsible for all the wars and hatred 💀
3. Candidate is actually some kind of eastern blotting, holy grail of biology... ❤
Please put timestamps
Amazing good job! About same time you worked on this, I instead worked on boronic acid sensors. it never got funded through grants. There was a group in Germany that came up with a boronic acid on an insulin receptor agonist. No idea where that went. Beyond that, there were some mimetics a couple decades ago that might get developed. There were some tumor issues with some delivery systems. Insulin is pretty good at developing tumors. The lectin-insulin drug in this video might be good for teenage type 1s who are prone to drift from the discipline needed for optimal glucose management.
11:00 Why is the scale dancing in the left?
Superb video
Great show ,thanks!
Can you design a protein to get rid of plastic?
If you mean enzyme then I think some people are trying.
@@milfordgunnie4599 enzymes I know, thought maybe with proteins this works too?
There are already proteins (made by bacteria) that eat plastic
@@garcipat enzymes are protein
@wallahhabibiiii thanks for clarify. i thought something like thatnBut dont have deeper knowledge in that field.
Wow, It’s incredible how AI can predict the randomness of protein folding !
That means protein folding isn't random, just pretty complicated.
Thank you. This video really inspired me
would be nicer to have these reviews as quarterly since by the end of the year its old news
It's not old news 🗞️ to me!
I really love watching these yearly serially look forward to it every time
I can't wait for breakthrough in Computer science
1:47 What is the 4th branch of?
I've been waiting for this. Thank you for the upload! It was a delight.
Personally I'm speechless about the new possibilities that AI assisted protein design will offer, I could fantasize for days
Thank you for this video
I’ve poured so much effort into this video. I’d love for you to watch it and share your thoughts!
U did it bro? Good job 👍👏
@@questmarq7901 yeah, i made it by AI
Most interesting. Brain and inflammation, wonder if things in the gut like IBD can be targeted or helped in this manner. For the protein folding, it isn't just DNA, RNA protein. There are also post-translational modifications. I wonder if the lack of those (or maybe they put some in) will make the proteins less functional. Also wonder if can use some alternative amino acids outside the usual 20. Conotoxins in snails use some unusual ones for instance.
Why no video about breakthroughs in chemistry?
I wonder how many years it will take for Quanta's people to find out about Michael Levin, Josh Bongard, Mark Solms, Karl Friston and other allied researchers. I'll be waiting.
the finding on the vagus nerve seems a little late, considering studies and results of meditation, acupuncture, or dry needling practices, and Buddhist teachings have long been talking about the brain and body connection along the spinal cord/fluid and brainstem, but it does pinpoint exactly where that communication between the varying systems of the brain and body are transferring the information received through our senses and how the disconnect actually is detected by the brain and body systems and how that may result in disorders/disabilities and diseases. Now I wonder if that means the disconnect occurs from what we consume or whether you are born with a disconnected connection between the brain and body. What does that mean for the psychiatric field concerning diagnosis criteria and treatment practices in the medical and therapy fields?
I’m a believer of ‘no pain, no gain!’ But I’m usually no in pain unfortunately. Also, I feel like I can’t self inflict pain in areas of my body where I feel like are aging !
Thank you all for your valuable contributions and to youTube for informing me ~
Peaceful Christmas wishes to all ~ LJ ~
LUCA is cool, the entire process from LUCA to us has always been fascinating but when I read about the inflammation modulator in the brain stem it gives you a good feeling knowing that a good chunk of systemic bodily pathologies have a potential pathway to a (dare I say) potential solution. But the protein folding progress, although definitely has a much higher ceiling (In many fields), feels like a precursor to some nefarious things we cannot even comprehend yet is troubling and can seem like another version of pandoras box (what we can potentially expect when we completely unlock AI).
I love this channel thank you guys for the content its really inspiring
Do these include all genetic mutations over time as a delta?
Well, if the SNP method has the highest accuracy in dating the age of mutations, and does not take into account the variable mutation rate but is accurate to several million years, how can we say that it is correct and that the age of the luca was estimated correctly?
Great channel
Would love to see a Biggest Breakthroughs in medicine
I heard Luka lived on the second floor
needs to keep the music down
These are the real heroes...The people who push Humanity forward. Probably if the politicians of the world can learn something from this curious brains, the world will turn into heaven.
6:42 he says "what other zillion examples" not "what other silly examples" ^^ To whoever makes the subtitles
UW Seattle - Woot!!!
vagus nerve hypothesis: now Doctors can says that "well, there's nothing apparently wrong with you. you just need to eat healthy, drink lots of water, exercise, get plenty of sleep and go outside" even more confidently
can we get a Biggest Breakthrough in Chemistry next year?
14:26 ...and the fourth is national security/defence (war) ?!?!
It would be great to produce food that doesn't cause inflammation instead of altering the vagus nerve to reduce inflammation.
Wouldn’t it be informative if the placebo effect of humans was considered and measured against a Vegas nerve anti/pro stimulation of inflammation? I would even take it further to suggest that the metaphysical neuroplasticity outcomes may very well challenge or supersede expected results. But I’m just an English major.
This video has prompted some interesting thoughts. If we have LUCA and understand its components, along with the ability to create our own proteins, could it be possible that a version of ourselves-or an advanced civilization-made this discovery long ago? They might have been able to replicate these early cells and send them in a sort of 'package' to various potential locations or planets, millions of years away, in the hope that one would resemble 'Earth.' Could it be that this is our ultimate direction? The physical limitations of the human body might prevent us from becoming an intergalactic species. Instead, perhaps our way to ensure the continuation of humanity is to package the prerequisites for life and send them into the distant universe. This could allow life to evolve elsewhere, eventually leading to a form of humanity similar to our own. (Thank you AI for helping me word my idea in a more readable way).
"yet it existed within about two, three, 400 MILLION years of earth forming as a planet"
I read somewhere that the backbone has 4 strands of archaen DNA.
just curious why is there no biggest breakthroughs in chemistry?
Don’t get me wrong these breakthroughs in biology, physics, and computer science are amazing but as an undergraduate pursuing a degree in pharmaceutical sciences and having a strong passion in organic chemistry, I was hoping to see some breakthroughs in chemistry 😂
LOVE THESE VIDEOS💯GOD DESIGNED US SO CRAZY😳🙏🏾🙏🏾🙏🏾
god does not exist
The way things are made is mind bending. Amazing that human beings have figured all this out.
we know luca lived on the second floor
I live upstairs from you...
😂
Absolutely mindblown with the predictive capabilities of AI on protein folding. As a Medical doctor i can only fanthom how many monoclonal antibodies we could design to treat so many different untreatable cancer, autoimmune diseases and metabolic diseases in as short as a decade. This could advance the practice of medicine as we know it.
LUKA situation is crazy
Thank you for sharing with us this video on the modern biology .
Great stuff.
I hardly think vagus nerve stuff is merely 2024 breakthrough tbh, and it being suprising is also weird to say imo...
This isn’t true. The vagus nerve was known to influence body functions like heart rate and digestion but no proof that there was a neurocircuit for immune response in the brain
What if they missed an earlier evolutionary variant? Doesn't it mean they missed a crucial step of a gene development event thus not accurately
What would they miss, exactly?
Everytime they say "it's the beginning"
Why is the guy at 7:06 AI generated tho?
It isnt.
Waiting for computer science
Not much left for computer science, since AI is now physics and chemistry.😅
What was look alike ?
"Great video on protein folding, but how does predicting basic amino acid shapes help with practical applications like brain development or treating diseases? A follow-up on its real-world impact would be amazing!"
"Why are you using quotation marks?" queried beetlejuciefan.
Eukaryotes and bacteria aren’t even a clade??? Mind = blown
Thats not what they said. We still think of the three kingdoms (archaea, eukarya, prokaryota) as individual, monophyletic clades. Going back further you have their common ancestor, LUCA.
@@bluesmanshoes Prokaryota are not a monophyletic clade, but a paraphyletic grouping of archaea and bacteria, and eukaryotes are deeply nested within the archaeal clade, a type of asgard archaeon, rather than a separable third domain. However, eukaryotes are a valid clade themselves, and so are bacteria. This is like the situation w birds, which are a type of maniraptoran dinosaur, but a valid clade within it nonetheless.
so if we tickle vagus-nerve it would help your immune system to work better?
this is so excited! also golden age for biology
Luca was Judith's nephew.
LUCA came from space on a meteor
Surely you should have said that the two domains of life are Bacteria and Archaea, rather than continuing to use the paraphyletic notion of prokaryotes in 2024? We know now that eukaryotes are deeply embedded within the Asgardarchaeota clade, and so they cannot be a separate domain of life.
oh thanks!
You mechs may have copper wiring to reroute your fear of pain, but I've got nerves of steel.
They trying to turn me into a walking bomb? Feels like cold all over shaky veins. Gov put a canister in my heart somehow. Nanotechnology?
Take your meds??
AlphaFolds are really revolutionary 🙂
Absolutely gorgeous.