I'm 54 years old and I just started taurine 3 weeks ago. Dosage 4g per day divided into 2g morning/2g late evening. I am simply amazed by the stuff. I feel fantastic. What amazes me most is how quickly I recover from rigorous exercise. How resilient I feel throughout the day. I really do feel like it's somehow an elixer of youth. I'm also taking Ubiquinol coq10 and I think the combination is working synergistically to improve cellular mitochondria. What a wonderful discovery in my life. Thank you for the video and all the very best
My wife, a diabetic, went to see an HMO nutritionist. She pulled out the food pyramid literature from the 1980's. THAT is the state of conventional medicine.
That food pyramid is likely better than the modern version. Politics infects ALL science and the food pyramid is designed around globalist and big corporate agriculture interests.
Regarding dosing: for now I suggest 2 days of loading dose 12g/day. Any excess WILL be excreted. Then just use the maintenance dose of 5-6g/day, pretty much depending on whether you exercise tthat day or not (exercise = u can lower your dose). U also get some taurine from food so that counts as well. Remember, excess WILL be excreted, so it's FINE to supplement. The typical Western diet includes 40-400 mg of taurine daily. Also, if you supplement with whey protein, there is 66 mg taurine in 100 g of whey powder, so whey-based protein supplements can also be considered a somewhat small source of taurine.
@@ModernHealthspan Common sense and experience with creatine loading. I know this is not creatine but it's kind of similar in how muscles take up creatine from bloodstream. With taurine it looks very similar. 2-days loading phase is there to address any taurine deficiency right away. The rest is just a maintenance dose.
I would not load like that unless you enjoy being on the toilet for a few days. I started out taking 6 grams a day (2 grams 3x day) and had to back down to 4 grams because I was getting urgent bathroom issues. So most people will need to work up to it.
Hi thanks for your kind comments. I have not been doing anything special to for my skin (apart from avoiding excessive sun exposure). Though It might be our upgraded lighting!
Good question re taurine in blood plasma … I’m plant exclusive and got a 40 amino acid plasma test … taurine was 58umol/L range was 26 to 132 which seems to align with the population adult range. I have decided to supplement with 4g. I was surprised that apart from taurine all other amino acids were in the top 75% of range. (Labcorp / lofeestension offer the test).
mmmm... Well, amino acid panels have ranges which I presume are derived from a population of people much like other reference ranges are. But... Prof. Yadav said that excess taurine, such as the increase due to exercise, is excreted, and I assume that transient increases due to supplements would also be excreted. Half life in plasma seems to be short, on the order of an hour. He also said we don't know the healthy range, while also saying that higher levels was "associated" with better health. Higher levels within the known ref. range? Maybe taurine does it's thing, whatever that is, during it's transient increase. Seems reasonable to test my levels and at least try to assure I'm not in the lower part of the range. I started taking 500 mg daily about 10 years ago after seeing research which indicated that it Mg as well) increased circulating endothelial progenitor cells. Taking 500 mg twice a day now. Tesitng soon....
Hi Peter, thanks for sharing your thoughts. It is a good point and Dr Yadav did not directly answer my question which was how good a proxy is the serum levels to levels in the cells. My understanding is that taurine is present in the cells in high concentrations (Dr Yadav mentioned millimolar quantities earlier in the call) so I am not sure that it is like a drug which has impact while it is in the system but then gets cleared. This was the basis for Dr Baur's point about allosteric conversion, I think. Please let us know how it goes!
@@C2C. lol, i personally turn on captioning for almost everyone on youtube. sometimes i have to reduce the playback speed, too. soon i’m going to have to start taking notes……
Hi Richard - very excellent series here on taurine. Thanks for all efforts. will you take taurine? And what dose and when during day? Also looking at your list now take 20 to 30 supplements each day - no issues with this many and as more info comes out could be maybe needing to take 30 to 60 per day. Is there a limit for you? Thanks
Hi Michael, thanks for your question. I am currently taking 1g of taurine in the morning. My over all supplement list is due a refresh and I am thinking about that now. Having a look at some of the clinical trials of taurine they have taken up to 6 g so it does look safe. I need to clean up the list as I take a core set everyday but not all of them.
Very interesting interview Taurine is very important for healthy ageing Is it true that synthetic produced taurine is not properly utilized by the body? I take 500 - 1000 mg but this affects my sleep so using 3-6 gm is not feasible for me 😮
@@eggbenedict-gt7mw my sleep isn't as deep as usual I'm not sure if it is the brand I'm using or what is causing this Not so bad if I take 500mg once a day it's the second dose that affects sleep so I tend to skip second dose every other day to reduce the effects on sleep
Then it's probably the brand I'm using That said I am sensitive to other supplements which also affect my sleep like resveratrol quercetin and b complex Could just be me
Hi thanks for your question and sharing your experience. I don't know the answer to your question, but it does seem quite easy to synthesis and most of the supplements use synthesized taurine. You could try eating a lot of seafood and getting it through your diet.
@@ModernHealthspan thanks Richard I do eat seafood but I don't think you can get enough amounts from this source to get an anti aging therapeutic effect. I guess I will just continue with a lower dose of 500 mg
Dr Vijay is fantastic I like his easy going style while displaying profound knowledge about the subject. Of course Richard's meticulous style is also great. The percentage of life extension in mice looks fantastic, but do those mice exercise? Are they healthy in that sense? Would the Taurine level in wild mice be higher and perhaps decline less with age? So how much of that 10 to 25% increase in lifespan is because of the "life style" of the mice? Same goes for the lab monkeys. and of course, modern humans (which have a life style similar to lab monkeys). The same goes for that other wonder food GlyNac. Glutathione also increases with exercise. pubmed.ncbi.nlm.nih.gov/17925621/ We humans evolved in the wild. We did not evolve in a chair watching tv, or typing on our laptop. So, nature or the universe must be thinking that we have fallen of cliff and can't use our limbs properly. Consequently, it down regulates everything to kill us of quickly so we can make space for healthier individuals. At least that's is my latest armchair theory. 😉
Hi Steven, thanks for your kind comments and thoughts. The confounding factors of lifestyle are important and difficult to tease apart. Do the mice get running wheels in their cages? How engaging is their environment? RCT's have the clearest result but inevitably introduce artificial constraints. Have to take each piece of evidence and weigh its value. I see things in a similar way to you. We evolved to live to 35 or so and after that it is not that our historic environment becomes irrelevant but following what is natural is no longer sufficient. We need to go beyond that, because as you say, nature does not care about us anymore (and may be actively trying to remove us as resource consuming entities!)
Since taurine is cheap and appears to be safe I have started taking it. However, when I started with taking 6 g a day, it gave me flatulence with a sulfuric stench straight out of hell. Did anyone else have that particular problem? I reduced it to 3 g a day and now it is fine. My guess is that my body couldn't absorb so much taurine so that my gut microbes ate the rest producing this very unwelcome side effect.
Hi thanks for your comment. No, it is an association not a causation, so higher levels of taurine were associated with higher LDL. This works both ways of course (something that Dr Yadav made clear). We cannot attribute the cause of the healthy attributes to taurine but neither can we attribute the less healthy. We can only say that they are associated (higher with higher, lower with lower). Also higher levels of hypotaurine were associated with lower LDL - so not clear what this means (which is why I asked the question)
Hi Abu Wahab, thanks for your question. I cannot offer advice but I did find some comments on the internet that say the two should not be taken together as taurine interferes with lithium metabolism, with the effect of leaving the lithium in the system for longer. This may be referring to lithium taken for bi-polar disorder where the dose is in 100's of milligrams rather than supplementing, where the dose is typically 1-5mg. I also found some papers which said that lithium supplementation reduces taurine in the brain.
@@ModernHealthspan But if taken separately, that is not together.....5 Mg Lithium Orotate in the the morning only and 1Gm of Taurine during lunch, one gm of Taurine with Dinner and another one gram before sleep? IS THIS OK
@@abuwahabsufyan679 so many studies on benefits of lithium with trace amounts in water in Texas area and showing good for brain health. As mentioned here amount of lithium is less then 1mg per day. Smokers get o.3 mg from cigarettes and now finding this is why smokers less likely to get Parkinson’s. Taurine too good and only need maybe to 1gram per day. So take lithium in morning and taurine at dinner as mentioned here so no issues.
I concur with Dr. Yadav, here. 500 mg, three times a day (i.e. 1.5 g/day) has been used to lower blood pressure. Higher doses have been studied for antioxidant, lipolytic effects, or to improve the lipid profile. Doses as high as 2 g, three times a day, i.e. 6 g/day, are used for improvements in athletic performance and to treat heart failure. It's probably above my pay grade to decide whether allometric scaling is a good way to convert doses across species. Or indeed, if lab rodents are good models for testing interventions meant for humans. I just want to say that when he arrives at the range of 3 to 6 grams per day for humans, it's a good estimate and it makes sense to me, because these doses are already being researched or in therapeutic use today.
![Taurine: Aging Backwards? [Study 193 Analysis]](http://i.ytimg.com/vi/PNJpM0ac0GU/mqdefault.jpg)
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I'm 54 years old and I just started taurine 3 weeks ago. Dosage 4g per day divided into 2g morning/2g late evening. I am simply amazed by the stuff. I feel fantastic. What amazes me most is how quickly I recover from rigorous exercise. How resilient I feel throughout the day. I really do feel like it's somehow an elixer of youth. I'm also taking Ubiquinol coq10 and I think the combination is working synergistically to improve cellular mitochondria. What a wonderful discovery in my life.
Thank you for the video and all the very best
My wife, a diabetic, went to see an HMO nutritionist. She pulled out the food pyramid literature from the 1980's. THAT is the state of conventional medicine.
I KNOW! It is truly awful. Are the Docs just too lazy or they want to keep everyone sick?
WOW! that is NUTS! so out of date info & just plain dangerous!
That food pyramid is likely better than the modern version. Politics infects ALL science and the food pyramid is designed around globalist and big corporate agriculture interests.
The food pyramid is upside down…it was developed by General Mills.
Regarding dosing: for now I suggest 2 days of loading dose 12g/day. Any excess WILL be excreted. Then just use the maintenance dose of 5-6g/day, pretty much depending on whether you exercise tthat day or not (exercise = u can lower your dose).
U also get some taurine from food so that counts as well. Remember, excess WILL be excreted, so it's FINE to supplement. The typical Western diet includes 40-400 mg of taurine daily. Also, if you supplement with whey protein, there is 66 mg taurine in 100 g of whey powder, so whey-based protein supplements can also be considered a somewhat small source of taurine.
Thanks for sharing. Can you tell me what this protocol is based on? Thanks!
@@ModernHealthspan Common sense and experience with creatine loading. I know this is not creatine but it's kind of similar in how muscles take up creatine from bloodstream. With taurine it looks very similar.
2-days loading phase is there to address any taurine deficiency right away. The rest is just a maintenance dose.
I would not load like that unless you enjoy being on the toilet for a few days. I started out taking 6 grams a day (2 grams 3x day) and had to back down to 4 grams because I was getting urgent bathroom issues. So most people will need to work up to it.
@@catcan221 I guess it depends on metabolism. I might be having issues from 5g, my son is fine since he goes to do #2 every 3-4 days. Very slow.
I had come to the same conclusion … load up with 12 and fall back to 3 to 5.
Richard, Your skin looks very good. What do you do for your skin?
He wanks
Hi thanks for your kind comments. I have not been doing anything special to for my skin (apart from avoiding excessive sun exposure). Though It might be our upgraded lighting!
@@ModernHealthspan Hi Richard, What supplements do you take?
Thank you Richard.
Hey Ron, thanks!
Good question re taurine in blood plasma … I’m plant exclusive and got a 40 amino acid plasma test … taurine was 58umol/L range was 26 to 132 which seems to align with the population adult range. I have decided to supplement with 4g. I was surprised that apart from taurine all other amino acids were in the top 75% of range. (Labcorp / lofeestension offer the test).
So if you have CKD you shouldn’t take taurine?
mmmm... Well, amino acid panels have ranges which I presume are derived from a population of people much like other reference ranges are. But... Prof. Yadav said that excess taurine, such as the increase due to exercise, is excreted, and I assume that transient increases due to supplements would also be excreted. Half life in plasma seems to be short, on the order of an hour. He also said we don't know the healthy range, while also saying that higher levels was "associated" with better health. Higher levels within the known ref. range? Maybe taurine does it's thing, whatever that is, during it's transient increase. Seems reasonable to test my levels and at least try to assure I'm not in the lower part of the range. I started taking 500 mg daily about 10 years ago after seeing research which indicated that it Mg as well) increased circulating endothelial progenitor cells. Taking 500 mg twice a day now. Tesitng soon....
@@eggbenedict-gt7mw That's on you. I understood him fine. And if you aren't smart enough to turn on captions...well, that's on you, too.
Hi Peter, thanks for sharing your thoughts. It is a good point and Dr Yadav did not directly answer my question which was how good a proxy is the serum levels to levels in the cells. My understanding is that taurine is present in the cells in high concentrations (Dr Yadav mentioned millimolar quantities earlier in the call) so I am not sure that it is like a drug which has impact while it is in the system but then gets cleared. This was the basis for Dr Baur's point about allosteric conversion, I think. Please let us know how it goes!
@@C2C. lol, i personally turn on captioning for almost everyone on youtube. sometimes i have to reduce the playback speed, too. soon i’m going to have to start taking notes……
Hi Richard - very excellent series here on taurine. Thanks for all efforts. will you take taurine? And what dose and when during day? Also looking at your list now take 20 to 30 supplements each day - no issues with this many and as more info comes out could be maybe needing to take 30 to 60 per day. Is there a limit for you? Thanks
Hi Michael, thanks for your question. I am currently taking 1g of taurine in the morning. My over all supplement list is due a refresh and I am thinking about that now. Having a look at some of the clinical trials of taurine they have taken up to 6 g so it does look safe.
I need to clean up the list as I take a core set everyday but not all of them.
Red meat doesn’t cause cancer
Very interesting interview
Taurine is very important for healthy ageing
Is it true that synthetic produced taurine is not properly utilized by the body?
I take 500 - 1000 mg but this affects my sleep so using 3-6 gm is not feasible for me 😮
@@eggbenedict-gt7mw my sleep isn't as deep as usual
I'm not sure if it is the brand I'm using or what is causing this
Not so bad if I take 500mg once a day it's the second dose that affects sleep so I tend to skip second dose every other day to reduce the effects on sleep
Then it's probably the brand I'm using
That said I am sensitive to other supplements which also affect my sleep like resveratrol quercetin and b complex
Could just be me
Hi thanks for your question and sharing your experience. I don't know the answer to your question, but it does seem quite easy to synthesis and most of the supplements use synthesized taurine. You could try eating a lot of seafood and getting it through your diet.
@@ModernHealthspan thanks Richard I do eat seafood but I don't think you can get enough amounts from this source to get an anti aging therapeutic effect.
I guess I will just continue with a lower dose of 500 mg
Same here, more than 2-3g will cause restless sleep (or with wild dreams)
Thank both to the channel and the Professor for these very interesting episodes.
Hi thank you!
Fantastic! Thanks Richard and Dr. Yadav.
Hi Thanks!
Dr Vijay is fantastic I like his easy going style while displaying profound knowledge about the subject. Of course Richard's meticulous style is also great.
The percentage of life extension in mice looks fantastic, but do those mice exercise? Are they healthy in that sense? Would the Taurine level in wild mice be higher and perhaps decline less with age? So how much of that 10 to 25% increase in lifespan is because of the "life style" of the mice? Same goes for the lab monkeys. and of course, modern humans (which have a life style similar to lab monkeys). The same goes for that other wonder food GlyNac. Glutathione also increases with exercise. pubmed.ncbi.nlm.nih.gov/17925621/
We humans evolved in the wild. We did not evolve in a chair watching tv, or typing on our laptop. So, nature or the universe must be thinking that we have fallen of cliff and can't use our limbs properly. Consequently, it down regulates everything to kill us of quickly so we can make space for healthier individuals. At least that's is my latest armchair theory. 😉
Hi Steven, thanks for your kind comments and thoughts. The confounding factors of lifestyle are important and difficult to tease apart. Do the mice get running wheels in their cages? How engaging is their environment? RCT's have the clearest result but inevitably introduce artificial constraints. Have to take each piece of evidence and weigh its value.
I see things in a similar way to you. We evolved to live to 35 or so and after that it is not that our historic environment becomes irrelevant but following what is natural is no longer sufficient. We need to go beyond that, because as you say, nature does not care about us anymore (and may be actively trying to remove us as resource consuming entities!)
Can taurine be tested?
Thank you both Dr’s for your information and work in your respective fields, much respect.
Since taurine is cheap and appears to be safe I have started taking it. However, when I started with taking 6 g a day, it gave me flatulence with a sulfuric stench straight out of hell. Did anyone else have that particular problem? I reduced it to 3 g a day and now it is fine. My guess is that my body couldn't absorb so much taurine so that my gut microbes ate the rest producing this very unwelcome side effect.
damn
Taurine increase LDL?
Hi thanks for your comment. No, it is an association not a causation, so higher levels of taurine were associated with higher LDL. This works both ways of course (something that Dr Yadav made clear). We cannot attribute the cause of the healthy attributes to taurine but neither can we attribute the less healthy. We can only say that they are associated (higher with higher, lower with lower). Also higher levels of hypotaurine were associated with lower LDL - so not clear what this means (which is why I asked the question)
Taken with food? On an empty stomach? After waking? Before bed? What?
Highest absorbability on empty stomach. So either 1 hour before, or 2 hours after a meal
@@coffeetalk924 Thanks!
Can Taurine & Lithium Orotate be taken together?
@@eggbenedict-gt7mw please can explain why not together? Both many studies saying good. When best to take each during day?
Hi Abu Wahab, thanks for your question. I cannot offer advice but I did find some comments on the internet that say the two should not be taken together as taurine interferes with lithium metabolism, with the effect of leaving the lithium in the system for longer. This may be referring to lithium taken for bi-polar disorder where the dose is in 100's of milligrams rather than supplementing, where the dose is typically 1-5mg. I also found some papers which said that lithium supplementation reduces taurine in the brain.
@@ModernHealthspan But if taken separately, that is not together.....5 Mg Lithium Orotate in the the morning only and 1Gm of Taurine during lunch, one gm of Taurine with Dinner and another one gram before sleep? IS THIS OK
@@abuwahabsufyan679 so many studies on benefits of lithium with trace amounts in water in Texas area and showing good for brain health. As mentioned here amount of lithium is less then 1mg per day. Smokers get o.3 mg from cigarettes and now finding this is why smokers less likely to get Parkinson’s. Taurine too good and only need maybe to 1gram per day. So take lithium in morning and taurine at dinner as mentioned here so no issues.
I concur with Dr. Yadav, here. 500 mg, three times a day (i.e. 1.5 g/day) has been used to lower blood pressure. Higher doses have been studied for antioxidant, lipolytic effects, or to improve the lipid profile. Doses as high as 2 g, three times a day, i.e. 6 g/day, are used for improvements in athletic performance and to treat heart failure.
It's probably above my pay grade to decide whether allometric scaling is a good way to convert doses across species. Or indeed, if lab rodents are good models for testing interventions meant for humans. I just want to say that when he arrives at the range of 3 to 6 grams per day for humans, it's a good estimate and it makes sense to me, because these doses are already being researched or in therapeutic use today.
One Dr.. who wanted to be in the news ?