*My recommendation for Taurine* * : amzn.to/3JZx08n AMENDMENT: I believe I mention that taurine is an amino acid (true) that can be used in functional proteins - this last part is incorrect; taurine is an amino acid, but it not involved incorporated in proteins through protein synthesis. Also, on a quick search (I haven’t looked into this deeply), taurine seems to reduce or attenuate increases in cholesterol lipoproteins according to a meta-analysis (DOI: 10.1016/j.ejphar.2020.173533). So, as I suspected, it isn’t much of a worry (I’ll need to confirm this) - some people in the comments of my last video on this topic suggested that taurine levels may be elevated in people who consume more meat (saturated fat), which could have an indirect effect on lipoprotein levels. This is a good possibility. *This has been independently lab tested for purity and contaminants; additionally, this is an affiliate link, but I have no relationship with the brand.
At your convenience of course :) Would you mind talking about nutrient synergies and how to do it in a whole foods manner instead of through supplementation? Not that I'm against supplementation, but just that eating common foods seems easier than picking out high quality supplements and keeping track of dosage and price changes between brands and variations.. Also it's a bit easier when eating animals because most nutrients are passed down from the animal's diet into ours, so would be great if you could help with non-animal based combinations for good/ideal nutrient synergies :) Thanks loads in advance :)
Quick question for you if you don't mind In your opinion can Taurine help with reducing inflammation that is caused by psoriatic arthritis and hyperthyroidism?
Thank you for including the correction that taurine is not one of the amino acids used in protein synthesis. I scrolled down to comments as soon as I heard the error. "Sapiens" as our specific epithet is a Latin adjective in nominative singular form, not an English noun in plural form. There is no such thing as "a Homo sapien".
Thank you for NOT shortening your videos. I understand we are all pressed for time in this world with work, family's, and social media. Knowledge should not be sacrificed to accommodate a schedule. I feel we should make the time to properly absorb and digest the material. You teach a lot of topics and the depth you cover is important. More importantly is your clear explanation of the material. Please don't change a thing and continue doing what you do!!🙏
Awesome you are doing this, finally good scientific videos. I have a physics background and really appreciate the time and effort you put in this. We need more people like you!!
My, my, my, how time flies. I remember Pearson and Shaw talking about taurine back in the 80s, saying that someday this would be the new vitamin C. I have been using taurine that long, and what was an inexpensive nutrient will turn into the new darling, become scarce, and go up in price. The dark side to these studies. The GlyNac study did the same thing.
If Durk Pearson looked like he was in 20s ,30s, 40s or 50s, I might say that he is on to something that turns back the clock. Based upon visual appearance (and that counts for a lot in my book), his regimen, if effective at all, would be modest at best. People are quick to discount visual appearance as a marker of aging, but it typically and readily easily allows us to distinguish between young and old (if no cosmetic procedures). There is no doubt about this. A 50 year old looks way different than a 20 year old. If one could truly slow aging, they're likely going to slow the visual markers as well blood and other biomarkers.
@@jackbuaer3828I’m sure a lot of aging folks would certainly want to look like they are in their twenties forever but for people me I just want to be strong and healthy enough that I can still play tag with my grandchildren when the day comes.
@@jackbuaer3828 Ha, ha, I can't argue that about their appearance. However, I think P&S did other things that sabotaged their ability to age slowly. Of course, at the time, science was limited on nutrient intervention, etc. Finally, if you use that as a determining factor to validate the study on taurine, it looks like taurine isn't as good as they are saying, lol.
@@birage9885 I want to clarify that I was in no way meaning to denigrate their appearance. I was only trying to say that they look their age. There is nothing wrong with that. Most people look their age or worse. I was also trying to make the point that it is likel difficult to biohack aging through extreme efforts. So far I am not aware of a miraculous regimen or supplement that reduces the visual impact of aging. We see some Asian people that look much younger than their age, but many of them are not following a single regimen. If at some point we get a miracle pill or miracle regimen, I expect it will cause "across the board" improvements visual appearances among those over 50 presuming that have started the pill or regimen in their late 20s, 30s or 40s. Some people that look much younger than their age in their mid 50s or early 60s claim to do nothing out of the ordinary.
Excellent vlog. I've been taking Taurine for six months and at 64 I'm feeling the benefits. But the best thing I found it useful for is my 8 year old Dog whose epilepsy has returned after 2 years on a medication called Epiphen. The seizures started back in August and as I keep a seizure journal I could see how these seizures have come back gradually until December from the 1st up until the 14th she suffered 16 seizures. After hearing it helps with brain dysfunction and is ok for dogs I gave my dog a dose and since the 15th December she hasn't had 1 single seizure. I have documented this and done a RUclips vlog confirming how it has helped her and I'm doing weekly updates. Unlike the Epiphen the Taurine may even extend her life and it's beneficial for her overall health which is more than I can say for the Epiphen. Anyone wishing to hear the progress on my findings can see it for themselves on my RUclips channel (Just Kidding) yes that's the name of it.
The algorithm is lagging i love this type of content and have never heard of you until now. I started dabbling with taurine 20 years ago when i was an idiot that took clen to get summer lean and heard Taurine prevents clen muscle cramps. The cramps were for real. Taurine seemed to help. I forgot about Taurine until a few years ago when i heard it helped with bile so i took it when i noticed digestive issues. Cut to a year later i read that taurine helps with anxiety by converting glutamate to GABA and potentially by reducing blood pressure which is part of the anxiety cycle ; feeling physiologically excited (heart rate hot face) thinking others notice this which is furthering nervousness. Anyways i had always been someone who lived with anxiety like literally sweating if someone i didnt know well was close to me talking to me for long enough to elicit this response. But i noticed as i read about this plausible taurine mechanism that i had not gotten that anxiousness since regularly taking taurine. So theres that. It also helped my sleep onset which used to take hours sometimes likely from anxiety over thinking when trying to sleep and taurine seems to just calm the mind it's amazing for so many things.
3 месяца назад
I’m so glad you didn’t shorten the video. Every second was time well spent. When I saw the length of it I thought I should just watch the intro and then listen to the rest during my daily walk. Once I started watching, I couldn’t stop. The visual information you provided was essential in helping me understand everything you said. Thank you for the time you spent creating this video.
I'm just so into these lectures of yours, Verhoeven. As a neurologist, all this is so fascinating to me. Immeasurably more fun than allopathic medicine.
Please never stop making videos!! I just found you today & took my 1st Taurine!! (60)....Love how you take your time and break it down !!the longer the video the better!!!♥️
A gastrointestinal transit test is a diagnostic procedure used to assess the movement of food and waste through the digestive system. It is often employed to diagnose conditions such as constipation or gastrointestinal motility disorders. The test involves tracking the passage of a substance (such as a radioactive marker or a capsule containing markers) through the digestive tract. The transit time is then measured to evaluate the function of the digestive system. To detect an improvement in a gastrointestinal transit test, you would typically look for a decrease in transit time. A faster Transit Time: If the transit time of the substance through the digestive tract decreases, it suggests that the motility of the gastrointestinal system has improved. This can be an indication of improved muscle contractions and coordination in the digestive organs. Good guess Nicolas!
I knew an old guy, thin as a rake and he was always chugging Monster energy drinks. I have to admit to being worried for the guy. Little did I know that he was immortal.
@@garyssimo Not really. Compared to what? What is his TDI for sugar? How active is he? 33g is basically jack shit for moderately active people that work out and do cardio during the week. It's a lot for S.A.D. metabolic disorder having American couch potatoes that are the problem. A person with a healthy metabolism really needs 60-90g per hour of zone two work out alone, a can of this will do nothing to them, American couch potato will need to shoot themselves with insulin just looking at it.
Taurine is used greatly by the brain> GABA, the heart and the thyroid. I have been rx taurine for dysfunctional thyroid and elevated LDLs, anxiety…ETC for years. Scientific publications have documented all the above-- years ago. When it makes it to MSM/textbooks etc, it is 5-10 yrs old info if not older.
I supplement with Taurine, about 6G a day for longevity reasons. Are age of 68, I would like to be 67 next year thank you. I work out heavy 5 times a week, I also do creative and glycine.
By far one of the most interesting channels! Thank you! The research is amazing! The only thing I would add is your personal recommendation in regards to dosage, etc.
I am 51 and take Taurin 2 grams daily for 6 months. My sleep got better, my mood is like more balanced and i have more energy keeping low heard pace. I don‘ t know the reason, but my doktor seing my blood work, regading my LDL cholesterol asked me if i take any medicine. After my negative answer he said, that he has never seen so low cholesterol lebels on individual with my age without taking any pills. Regards
I'm wondering what the taurine contents is in the lab food for the mice, fish and worms are. I know they use some form of standardized food pellets. But if these are deficient in taurine compared to the *natural* foods of the animals out in wild nature, then no wonder that supplementation has big effects. It's like: Give 100 mice food pellets with no vitamin C, and give other 100 mice food pellets + vit. C supplementation. Now watch how all mice in the first group die young, and conclude that "vitamin C supplementation doubles life span". But taurine is found in meat, so maybe baseline intake is already optimal in human?
You raise a valid point, but note that there was an added benefit to a higher dose of taurine, which would be impossible to get from food alone. Also, I'm not a mouse expert, but I don't think mice have much taurine in their natural diet.
I have taken 7 grams of taurine for over 7 years to renew my lungs from smoking. I can now run without any issues, wheezing is gone, no more trouble feeling like I'm not getting enough air. I still smoke when I'm having cocktails. No apparent side effects.i suppose I should add that it has been 7 grams (7000mg) a day
I quit smoking after 42 yrs of smoking. I didnt take anything, but I run regularly and only had wheezing and out of breath issues when I started running. I have no obvious ill effects from smoking. All we can offer is our own anecdotal evidence, and both ours have the same outcome with or without taurine.
@@tullyapx500You don't say how long ago you quit. Give it some time and a different result could appear. Make sure you test your lungs frequently for abnormal growths!
Interesting comments guys. Nick should do a video on respiratory issues. So much going on from alcohol effects on lungs, evali, covid, supplements like NAC, nmn, vitamins/minerals, omega3, ginseng, and now taurine.
Good for you! but anecdotes can be misleading and throw you of the fast of truth seeking fast. You could share where you based your assumption that it would renew your lungs on.
I don't currently supplement with taurine, although I am considering it. I found the section on WBC quite interesting because my recent lab results showed a low WBC which was initially concerning to me. However, I did some research and discovered that a slightly reduced WBC count is an indication that your immune system is likely optimized, i.e. your white blood cells aren't being called upon as much to fight infection and therefore are naturally lower. Lower WBC is indeed an indication of reduced inflammation. I should mention that I am very healthy... I do IF, exercise daily and take high quality immune boosting supplements, so a low WBC makes sense for me.
@@theantiqueactionfigureI’m a man and started getting tested in my 40’s. You have to ask. You are your own health advocate. Nobody else really cares about your health .
Excellent presentation! A question..I normally always have a low white blood count , do you think taurine supplementation would be a problem? Thank you for all the time and work you invest in these podcasts!
Re. the elevated cholesterol etc: Dr Aseem Malhotra (cardiologist) and others don't seem to worried about them. I think he and others have speculated the statin reductions in mortality may be due to a decrease in inflammation? With all the positive effects of Taurine ...I dunno?
@@MajesticArtimus It's complicated I don't have a sense of certainty about the issue, but that doc I mentioned is a respected guy. He's worth a listen. Genetic differences may account for you/hubbies cholesterol differences, different diets can benefit people with differerent genetics.
Dr. Verhoeven, thank you for your work here. I've been supplementing taurine for about 10 years now, buying it in bulk packages of 1 kg and mixing it in drinking water in gallon jugs, with large quantities of MSM. My daily dosage is about 2.5 g of taurine. I started doing this only for this one reason: I had read that in places like Japan, where people are famous for their longevity, one of the isolated factors for this was that their diet was high in taurine. I didn't really learn much of the details until I saw your work. But there is one thing that troubles me. I also powerlift regularly, so building and retaining muscle mass is a priority for me. And apparently, taurine supplementation short-circuits the end of the mTOR pathway. I know there are several paths to activate mTOR, but apparently taurine suppresses the very end stage, of this special protein that is responsible for stimulating muscle protein synthesis, so it appears that regardless which way you approach mTOR, taurine suppresses muscle protein synthesis. There are several known compounds that do this, that are all associated with longevity and anti-aging: rapamycin (whence comes the name "mechanistic target of rapamycin" or "mTOR"), resveratrol, epi-gallo catechin gallate, etc. All are known for improving longevity, but suppressing mTOR. Apparently taurine supplementation has the same exact effect: it improves your longevity generally, by delaying cell senescence and the subsequent buildup of "zombie" cells, but it also suppresses the buildup of muscle mass. If this is right, it's very disappointing: if I want to retain muscle mass, I have to live with the normal aging pathways. If I want to delay aging, I have to live with my powerlifting not yielding one of the most desirable rewards of that work. Do you know of any way to get around this?
If someone has a workaround, I'd like to see it myself. Until then the best path may be one of lowered expectations. It seems like living longer has more benefit. I suspect you have a lot of muscle allready, more than enough to take you comfortably into older age. I'm 72 and weak as a kitten, which I am fighting (with myself) to change. I've lost 80 pounds and time to work on some muscles. I need some but not really that much. I think Taurine will help me in general and not interfer with normal body building or shaping. If your one of the powerbuilding elite then your needs are specialized, I'd ask a professional somebody for advice.
Is it a significant amount of suppression? Meaning, would it keep a person from gaining bulk or would it keep the muscle from growing at all? As a woman I’m only interested in maintaining firm muscles that are also strong
In regard to the dose you are supplementing with for taurine you may need to pull back. There's something called a hormetic effect. That means that something is more effective taken in a smaller amount and can actually harmful taken in a larger amount. I would investigate that as a pertains to taurine. (Dietitian since 1982)
Is there any indication as to where Taurine is _used_ in the cells? What _organelle?_ I suspect the mitochondria, but I took cell biology back in 1974. If it is know where Taurine is used, how was this determined?
When I was in college, molecular biology was a NEW major! That was a lifetime ago, and though I eventually wound up in computer science as a career, I still love to hear "trash" talk from biology people. I'm also interested in it because I'm getting old and looking for the Fountain of Youth. I've been taking Taurine for about 3 months now, but haven't yet noticed any significant changes. I'm thinking about increasing my dosage. Thanks for this and good luck with your studies.
Started taking taurine and creatine because of you in depth reporting. Looking at glynac. I see you are somewhat ambivalent about glynac. Back ground, 74 yr old, went from sissy squats to 280/300 pound 3 set/20 rep squats. Thanks for all your help in understanding supplements.
Fascinating research! If I understand this correctly, Taurine has so many benefits except for muscle development where it can be a negative side affect if trying to build muscle. If that is correct, then no elders should take this. I'm 71, petite, female and have been supplementing a 1000 MG. I feel like I have lost muscle not gained, even though I lift heavy weights. A clarification would be appreciated. Thank you, Nick, I love your videos and learn so much from you. PS: and you sure are easy on the eyes. 😊
I don't feel so bad about those sugar free energy drinks now. :) Not to mention they have Niacin in them. Both Taurine and Niacin have been suggested for longevity. Wouldn't that be funny if all these energy drinkers lived to 100. At least those drinking the zero sugar ones.
Def not the sugar-free ones. Can't wait until these poisons are banned. So many healthy sweeteners that could be allowed instead not allowed, like glycine.
@@larsnystrom6698 You might want to watch this channel and other science based channels plus look at websites like Science Based Medicine. They all say there is no cause and effect evidence that artificial sweeteners are bad. Those are generally giant studies where a bunch of unhealthy people who turned to diet drinks at the end of there lives get shuffled into the data. Reverse causation.
@@midnightsnack1306 "Might be" is the key phrase here. You might want to watch this channel and other science based channels plus look at websites like Science Based Medicine. They all say there is no cause and effect evidence that artificial sweeteners are bad. Those are generally giant studies where a bunch of unhealthy people who turned to diet drinks at the end of there lives get shuffled into the data. Reverse causation. David Sinclair one of the leading experts on aging, rated Sugar as a 10 bad for you and diet drinks as possibly a 1. ruclips.net/video/kUGZqQlU7BA/видео.html
I'd love to see a video on Thiamine- there are a lot of claims of it's health benefits in high doses and the different forms of it. Specifically TTFD and benfotamine.
It helped my young son improve his stutter significantly. The effects would wear out but I would just supplement again while also trying other methods. He’s now a teen and no longer stutters.
Benfotamine helped tremendously for my essential tremor for about a month. For some unknown reason, it stopped working. Frustrating. Finding that sweet spot of dosing has been difficult.
Would diet provide enough taurine as we age? If so, what food will give us enough taurine? Sadly, studies, nowadays, mostly always revolve around supplementation instead of real food.
No, you want to avoid foods that have taurine. As the best predictor of longevity is legume consumption ,meaning plant proteins. In the study, they used massive quantities that are nothing you can get even close from food. 250mg per kg of bodyweight, so around 20g daily!
@@Nobody-Nowhere where in the study that says legume consumption is best? As far as i can tell, there is currently no study on taurine in human. Hence, that automatically negates any idea on food containing taurine.
I'm watching this particular video for the third time to glean the maximum amount of information contained herein. I am a classically trained epidemiologist and tend to dismiss...or outright laugh at...most medical channels here on RubeTube. You have a winner and a subscriber.
Interesting that the yeasts are not affected by the taurine. Good to know that these critters in our bodies wouldn't be growing with human supplimentation
@susymay7831 I guessed that had something to do with that yeast is single celluar, and Taurine works on multicelluar organisms. Something to do this, perhaps: "Since taurine is a key organic osmolyte in most cells, the possibility that the effects of taurine on ion transport could be related to its osmoregulatory activity."
Adding my two pennies here: that particular strain of yeast did not show a measureable change, that does not speak for all yeast strains. Secondly, yeast are "weird birds", neither animal or plant in nature. And for sure they are not animal. They are single cell, but most do have multi-cellular properties.
Very well explained, thank you very much. Concerning the table with the colors at 1:10, it seems that overall hypotaurine has more blue than taurine, so I wonder, how is taurine converted to hypotaurine? Is is via an enzyme? Could the conversion be increased?
Harry Serpanos has finally been vindicated with his taurine shilling. If you don't know this guy, he is a carnivore political crank on youtube, who proclaims the gospel according to taurine. Ignore his political tirades, but his nutritional recommendation on taurine is well supported by research. There's a bit of older research on taurine especially from asia which had inspired me to supplement well before the hype.
Awesome presentation! You answered many of the questions I had as I've been taking Taurine for awhile now. Can you do a presentation on vitamins D3and K2 with respect to the circulatory system?
There should be a lot against sacrificing animal models And if there were humans wouldn’t think so little of animals because I can tell you right now animals have never done anything to humans of this caliber, and wouldn’t dream of doing it even though their DNA has memory of every transgression against their kind. I don’t like that you said that and I don’t believe that behavior and thought process should be widely acceptable. I think that has a lot to do with my humans cannot measure to the benevolence of an animal. We consider ourselves to be intellectual? I think it’s quite simple if you want to experiment experiment on yourself and if you want do it yourself and don’t do it I hope I’ve made myself, There are commandments, even if you’re not religious they’re basically guidelines to live by one of them is thou shall not kill there is no exemption clause, And for those who choose to do wrong and participate in doing wrong whether they’re actually the one that yields the acts, there will be a price to pay
The more information I hear on this nutrient, the more it sounds like its deficiency could be the cause of a bunch of symptoms that have been lingering,sometime before, and more so after having thyroid surgery, thats mess up my metabolism thoroughly. One thing that seems to be linked is a lingering problem with low body 1:05:56 temperature, which I guess taurine helps to regulate. But U've been all around the block, looking for a way to balance my metabolism, and so far ,taurine seems promising. 🤔👍🏻😌🙏⚡🔥
L Taurine is the compliment of glutamine. If you are sensitive to MSG taking L Taurine can balance out MSG when you feel you have ingested too much of it. MSG is slathered into so many processed foods, even under different names. Truth in labeling is an org that is educational on how much MSG people are actually eating under different labeling.
Very interesting study. Nice work on presenting. I think the bone mass of the samples including humans would be further increased with k2 supplementation. I am certain this was not in the animal feeds.
And cutting out meat, as meat consumption decreases bone mass and increases osteoporosis. "Several studies indicated that frequency of meat consumption was associated with bone mass and fracture rates in humans" As meat comes with antinutrities like purines, that are acidic and to combat this body leaches out calcium from the bones to neutralize the acidic environment.
I haven't watched the video yet, just read the title, but what I can tell you is, that I used to drink a lot of red bull (which contains Taurine) for most of my teens and 20s... im 27 now, and not drinking it as much anymore.. but as a 27 year old, I still get mistaken for a 16 year old sometimes, literally the other day I couldn't buy cigarettes for my mother because they were not sure if I was 18 or not. Maybe I should add that I'm vegan and also very careful about being in the sun and using spf.. so that probably adds to it too
Yeahhhh I’m pretty sure it wasn’t the Red Bull that kept you looking young lol. A combination of good genetics and good skin care/sun protection will do the job.
This was a great breakdown of this study and you covered it well, and you put it into layman terms that we can all understand. You provide good evidence and as a 64 year old with a deteriorating spinal condition I found it encouraging and have now included Taurine into my diet. I have in the past 5 years made many changes in how I look after myself and the first thing I did was to stop smoking, then I worked on my weight and completely changed my diet and have been a pestcaterian for 2 years, I have gone from 18.4 stone down to 13 stone and I have a daily exercise routine. I include kefir in my diet as I understand the importance of gut health. I have managed to come off all my medications which there were many including Statins and blood pressure medication, and this vlog has convinced me that this is really an essential supplement that all over 50s should consider. Thank you for this breakdown on Taurine I found it encouraging. Great channel you're a good man. Thank you, Thank you.
Besides a long, long life the other factor is particularly relevant. One must know the goal of such a long existence. There is no point to live so long if there is nothing you would like to die for.🎉🇵🇱🕎
16:35. Over time we shrink. Hay, I was a tad taller than 6 feet in high school now that I’m 45 in a tad taller than 5’ 11”. I have back issues now. So, that degenerative joint disease is real. All you younger people take care of yourself. Your older version of yourself will thank you for it
Taurine declines with age (what doesn't?). Did this study look at blood levels of taurine before supplementation? Meaning, was the supplementation simply bringing the blood level back to normal or was this a dose in excess of normal levels (mega dosing). I'm about to do an amino acid profile test. If my taurine comes back in the normal range do I still supplement?
I took a test done by cellular nutrition assays . A blood test , a natural path had me do it . My taurine was very low . But my B1 was ok . But I question this cause I don't swett perspire. That's a sign of low B1 . The test really help . I started to take taurine but not high doses now I will . I am going to go on ketoe diet geared more to carnivore. A regular blood test will probably not help .need a more indepth one .
Man, I'm binging on your stuff. If you get a chance to take a look at the omega 6/omega 3 ratio claims, I'd be very grateful. My intuition is that it's nonsense, but I would love to see a thorough break down by someone like you. Cheers!
It is nonsense, there are no real studies about it. Both, omega 6 & omega 3 are essential fatty acids, and both are anti inflammatory even in large quantities. If you are interested in quality content, check out channel named "nutritionmadesimple".
I'm not convinced yet, but I have seen the video from NutritionMadeSimple. I would like to see more research. I have no problem with corn oil and inflammation in moderation. But if I eat a ton of it, it does cause me inflammatory issues. But I am more inclined to credit that inflammation to the caloric surplus that comes with eating a whole large pizza drenched in corn oil. Eating at caloric maintenance and exercise can work wonders for all this chronic inflammation, even if you're eating like crap.
@@limitisillusion7 Buddy, the majority of the fat in pizza comes from cheese, the majority of which is saturated. Sounds like you really want to blame corn oil.
@@phillustrator No, I used to eat pizza without cheese and the same effect occurred when I ate a whole pizza. I also get inflammation from eating too much fried potatoes or lean fried chicken. I don't want to blame corn oil. In fact, I love the stuff. I'm not convinced is all. I think inflammation is a phenomenon that we haven't quite narrowed down yet. My inflammation also decreased when my omega 6:3 ratio dropped to ~5.
Great video! Can you go next level breakdown on oxalates? And then the link - bad link - between it and curcumin, which was a bummer to hear from a great oxalates doc video on YT. That's me asking. Who the hell am I to ask? I don't know, I'm just asking, you don't have to get pissy about it. A nod to your humor, which is awesome!
A critical take regarding supplementation in humans from Peter Attia: "A critical variable largely ignored by the study authors is precisely why taurine levels decrease with age. Given that endogenous taurine synthesis is so low in humans, circulating taurine is determined by a balance of absorption from diet and excretion (primarily in urine). This leaves us with three (non-mutually exclusive) possible reasons for the apparent decline with age: 1) a reduction in dietary intake; 2) a reduction in rates of intestinal absorption of taurine from food; or 3) an increase in the rate of taurine excretion. No nutritional data have ever indicated that people consume less meat and seafood at age 60 than they do as kids, so we can exclude possibility #1. Possibility #2 would suggest that we need to consume more taurine as adults than we do as children in order to absorb the same amount, which in turn might mean that supplementation would boost circulating levels and help mitigate their age-related decline. Possibility #3, on the other hand, would mean that supplementation would have very little effect on circulating taurine. So which is it? We don’t currently know and have no direct data to address this question, but the pieces of evidence we have make the best case for possibility #3. Taurine reabsorption in the kidneys - a process that returns taurine to circulation and prevents its excretion - requires co-transport with sodium ions moving down their chemical gradient (i.e., from high extracellular concentration to low intracellular concentration), an energetically favorable process which helps to drive taurine transport forward. But with age, renal ability to maintain electrolyte gradients gradually deteriorates, contributing to the well-documented age-related decline in kidney function. Thus, it seems likely that the capacity to reabsorb taurine from urine also falls over time, resulting in increased excretion. This possibility is further supported by the observation that, regardless of age, taurine levels are typically low in the presence of chronic kidney disease. Why is supplementation unlikely to help most individuals? In general, amino acids can filter into urine, but most are reabsorbed by the kidneys at rates of ~98-99%, meaning that very little is actually excreted. Taurine is different in that it is only reabsorbed at a high level when circulating levels are low. When dietary intake and circulating levels are high, taurine reabsorption rates can be as low as 20%, resulting in a high level of excretion. On the other side of the equation, rates of taurine absorption from the gut decrease with increasing circulating taurine levels due to reduced transporter expression. Some have reported that dietary availability thus has relatively little impact on circulating taurine. Combined, these observations suggest that supplementation would be useless in increasing circulating taurine levels in those already within typical physiological ranges. (Data in humans with unusually low taurine levels, as is often seen with obesity, kidney disease, or strict vegan diets, suggest that supplementation does indeed raise serum levels in these individuals.) Any excess either wouldn’t be absorbed or would be excreted. And if taurine levels decline with age due to an increase in excretion, the threshold that defines “excess” taurine is effectively reduced. For instance, a taurine concentration of 50 µmol/L in a 20-year-old could be raised with supplements, but the same level in a 60-year-old might represent an upper limit. In this way, we can liken the body’s taurine levels to water collecting in a bucket. As long as the bucket isn’t full, the water level will continue to rise as more is added. But once it reaches the top, any additional water will simply spill over the edge and the amount of water in the bucket can increase no further. Now imagine that over time, the bucket rim slowly erodes, resulting in a shorter and shorter bucket that can hold less and less water. No matter how much water you add, the bucket will never contain as much as it did before. So why did supplementation “work” in mice? Again, it may relate to a difference in their taurine biology relative to humans. In addition to the three possible explanations described above for the decrease in taurine with age, mice may have another contributing factor that would be largely irrelevant in humans: a decline in endogenous synthesis. Like reduced absorption, this explanation would also suggest that supplementation could have a meaningful impact in elevating circulating levels. To use the bucket analogy again, a loss of taurine due to reduced absorption or synthesis would be comparable to slowing the rate of water flow into the bucket to a point at which the rate of evaporation outpaces the rate of water collection, and the water level gradually drops despite the fact that the bucket remains the same size. In this case, supplementation with another water source would be helpful in refilling the bucket."
@kurtniznik8116 I think we need to know more about this. But my guess is that we get most taurine from the bodys own production of it. And much less, perhaps half, from animal food. Taurine is produced from cysteine, which we don't get enough of, and needed for many other things. (Glutathion, Creatine) It's my guess that absorbtion isn't a problem. It's likely the bodys production which is reduced with age.
Can you explain the glucose portion and specifically in regards to low blood sugar? I have hypoglycemia but all studies reference seem to lokk at hyperglycemia leaving my specific issues out of the conversation.
Taurine is different from most amino acids in that it is not incorporated within proteins. The reason being that the acid group is not a carboxylic acid, but a sulfonic acid. I found that part of the video quite misleading. Edit. I see the author added a note afterwards to clarify this point. Well done.
I need some of that. I'm 76 and think I could use it because my muscle mass has decreased and my stamina isn't like it used to be. Oh wait! The Government wants to get rid of old fools like me. Geezzzzz forget it, I'm doomed.
So, should we be using taurine daily or do that "hit-and-run" thing? If the latter, how long does it take to trick your body to think it's taurine deficient? Is the latter the same for CoQ10 or GlyNac?
If taurine incessed lipoproteins, one has to ask "so what"? As the link between elevated LDL cholesterol and and heart disease, is not concluvsive. Also some of the health benefits may actually come from elevated LDL. As there are correlation studies that suggest this.
Never, as its pointless. They consumed massive amounts of taurine in the study. You would need to take around 20g per day to reach the amounts they used in the study. Dont believe hype nonsense like this. No one is going to be taking 20g of taurine daily for the rest of your life. Form a healthy diet you can sustain in a long run.
There is a missing point: how much a 14 months old mice weight ? I found that is around 15 grams. If that is true, numbers are complicated. They were feeding 1 g /day to a mouse of 15 G ? A mice is supposed to eat max 5 gr /day. Humans eat 1 kg /day so we will need 200g /day ? Well, the protein part in my low carb diet will be taken then
One weird side effect from it was I felt stronger after taking it, but not in drink form, they must put very little in energy drinks. It's getting rid of my skin condition so I have to take it daily.
Great work, thanks. I’m on board but going in with extreme caution. We have been manipulated for decades and the research always points to supplementation vice some small dietary adjustment; i.e eat broccoli sprouts, etc. We all run out and spend hundreds of dollars, whilst telling ourselves “this is the one”. NMN, resveratrol, pterostilbene, quercetin, NR, spirulina, magnesium… and Taurine will have it’s day.
You're wrong on NMN. I have physical proof of its benefits (on myself). Not self-deception, but curing of a physical condition I had for 10 years until I made one and only one change - taking NMN.
@@thisisreallife5086 I don't disagree with you, I was speaking general terms, I actually use NR myself, NMN is further up the pathway and would seem to be more effective than NR but far less studies on NMN led me to NR, still effective but safer IMO. Best to you and your journey.
Accessibility request: Please leave some clear space at the bottom of a slide, to reduce overlap of the figure with captions. Fig.Q is particularly bad. On that one, I had to pause & turn off captions in order to read the graph.
Tried taurine for first time a week ago. Dissolved about 300mg in water and drank. Five minutes later felt warm tingles all over my body and felt kinda high, lasted about an hour, totally weird. Next morning took another 500mg. Same effect. Evening another dose, only a slight effect. Repeated over the next few days. No more tingling, but gone was my 67 yr old brain fog. Memory and energy levels noticeably better. Now using about 2 grams a day. What is optimal for a healthy, athletic 67 yr old 200lb man who walks or runs 5-6 miles a day?
44:45 they switched it because it is a similarity tree, dendrogram, ordered by similarity, look on top of each stack image. Taurine works better on muscle and brain than liver (taurine aged liver is more similar to aged, than young).
Very informative channel i learn a lot quick question are the different forms of taurine have a certain effect on humans do we know what is best to consume afaik there is 2 forms L and D Taurine.
Isn't it bad to both have no telomerase and no senescent cells? I would expect an increased risk of cancer in the tert-/- sample with taurine supplementation...
Ok, hear me out. I'm 41yo, a reasonably healthy male. I've just started supplementing taurine and noticed some magical things started happening! Energy levels are up, very noticeably - I used to love working out but over the last few years I've somewhat deflated, lost my edge and will to work out - straight after supplementing taurine I started to feel the urge, the tingle to hit the gym and my muscles hard again! The quality of sleep dramatically improved, especially the falling asleep aspect, which in turn seems to have started to normalise my circadian rhythm. Borderline insomnia has been my struggle as long as I can remember. I've always dreamt of becoming an early bird - maybe now I have a chance to achieve it. But wait, there's more! Most importantly of all I noticed a dramatic improvement in my RSI (forearms) and radial nerve damage in my right arm. The pain has gone from severe to barely noticeable just after a couple of days of supplementing taurine. Before, I've tried everything, all supplements (apart from the taurine) and exercises, including the "nerve flossing" exercises, with very little impact. Looking forward to seeing what comes next. Best regards to all!
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*My recommendation for Taurine* * : amzn.to/3JZx08n
AMENDMENT:
I believe I mention that taurine is an amino acid (true) that can be used in functional proteins - this last part is incorrect; taurine is an amino acid, but it not involved incorporated in proteins through protein synthesis.
Also, on a quick search (I haven’t looked into this deeply), taurine seems to reduce or attenuate increases in cholesterol lipoproteins according to a meta-analysis (DOI: 10.1016/j.ejphar.2020.173533). So, as I suspected, it isn’t much of a worry (I’ll need to confirm this) - some people in the comments of my last video on this topic suggested that taurine levels may be elevated in people who consume more meat (saturated fat), which could have an indirect effect on lipoprotein levels. This is a good possibility.
*This has been independently lab tested for purity and contaminants; additionally, this is an affiliate link, but I have no relationship with the brand.
At your convenience of course :) Would you mind talking about nutrient synergies and how to do it in a whole foods manner instead of through supplementation? Not that I'm against supplementation, but just that eating common foods seems easier than picking out high quality supplements and keeping track of dosage and price changes between brands and variations.. Also it's a bit easier when eating animals because most nutrients are passed down from the animal's diet into ours, so would be great if you could help with non-animal based combinations for good/ideal nutrient synergies :) Thanks loads in advance :)
ah yeah! this is what i was looking for!!!
Quick question for you if
you don't mind
In your opinion can Taurine help with reducing inflammation that is caused by psoriatic arthritis and hyperthyroidism?
Thank you for including the correction that taurine is not one of the amino acids used in protein synthesis. I scrolled down to comments as soon as I heard the error.
"Sapiens" as our specific epithet is a Latin adjective in nominative singular form, not an English noun in plural form. There is no such thing as "a Homo sapien".
Are you taking taurine yourself?
My great, great, great, great grandkids will ask me if I’m on taurine 😊
Hahaha! And you'll jump out of bed with your newly acquired bionic legs and say, "Kids, let's go dunk a basketball."
Great attitude. Hope it happens. ✌️
@@jmc8076 🙂
🙏🌸😂
By then that will be old news.
Thank you for NOT shortening your videos. I understand we are all pressed for time in this world with work, family's, and social media. Knowledge should not be sacrificed to accommodate a schedule. I feel we should make the time to properly absorb and digest the material. You teach a lot of topics and the depth you cover is important. More importantly is your clear explanation of the material. Please don't change a thing and continue doing what you do!!🙏
Absolutely I've learnt so much from this man with great data supports the theory. Last 5 months my energy level went thru the roof with his advice.
Awesome you are doing this, finally good scientific videos. I have a physics background and really appreciate the time and effort you put in this. We need more people like you!!
Thanks, Michael!
Thank you for not adding stupid background "music". Please let your channel clean. It is the important message I want to hear. ❤ your education.
First time on your channel. You explained everything methodically and clearly for the average person to understand. Great job!
That's kind of you to say - thank you.
My, my, my, how time flies. I remember Pearson and Shaw talking about taurine back in the 80s, saying that someday this would be the new vitamin C. I have been using taurine that long, and what was an inexpensive nutrient will turn into the new darling, become scarce, and go up in price. The dark side to these studies. The GlyNac study did the same thing.
If Durk Pearson looked like he was in 20s ,30s, 40s or 50s, I might say that he is on to something that turns back the clock. Based upon visual appearance (and that counts for a lot in my book), his regimen, if effective at all, would be modest at best.
People are quick to discount visual appearance as a marker of aging, but it typically and readily easily allows us to distinguish between young and old (if no cosmetic procedures). There is no doubt about this. A 50 year old looks way different than a 20 year old. If one could truly slow aging, they're likely going to slow the visual markers as well blood and other biomarkers.
@@jackbuaer3828I’m sure a lot of aging folks would certainly want to look like they are in their twenties forever but for people me I just want to be strong and healthy enough that I can still play tag with my grandchildren when the day comes.
@@jackbuaer3828 Ha, ha, I can't argue that about their appearance. However, I think P&S did other things that sabotaged their ability to age slowly. Of course, at the time, science was limited on nutrient intervention, etc. Finally, if you use that as a determining factor to validate the study on taurine, it looks like taurine isn't as good as they are saying, lol.
@@birage9885 I want to clarify that I was in no way meaning to denigrate their appearance. I was only trying to say that they look their age. There is nothing wrong with that. Most people look their age or worse. I was also trying to make the point that it is likel difficult to biohack aging through extreme efforts.
So far I am not aware of a miraculous regimen or supplement that reduces the visual impact of aging. We see some Asian people that look much younger than their age, but many of them are not following a single regimen.
If at some point we get a miracle pill or miracle regimen, I expect it will cause "across the board" improvements visual appearances among those over 50 presuming that have started the pill or regimen in their late 20s, 30s or 40s. Some people that look much younger than their age in their mid 50s or early 60s claim to do nothing out of the ordinary.
@@jackbuaer3828 " I was only trying to say that they look their age" They were looking awful for their age
I’ve been taking taurine the last month
I’m 60 and I feel as fit now as I did when I was younger
It’s amazing 🥊
How much are you taking?
Excellent vlog. I've been taking Taurine for six months and at 64 I'm feeling the benefits. But the best thing I found it useful for is my 8 year old Dog whose epilepsy has returned after 2 years on a medication called Epiphen. The seizures started back in August and as I keep a seizure journal I could see how these seizures have come back gradually until December from the 1st up until the 14th she suffered 16 seizures. After hearing it helps with brain dysfunction and is ok for dogs I gave my dog a dose and since the 15th December she hasn't had 1 single seizure. I have documented this and done a RUclips vlog confirming how it has helped her and I'm doing weekly updates. Unlike the Epiphen the Taurine may even extend her life and it's beneficial for her overall health which is more than I can say for the Epiphen. Anyone wishing to hear the progress on my findings can see it for themselves on my RUclips channel (Just Kidding) yes that's the name of it.
Only few min in and gave thumbs up just on quality of research and effort to organize data and facts for viewers. Brilliant. Thx Nic.
Thanks, jmc!
The algorithm is lagging i love this type of content and have never heard of you until now.
I started dabbling with taurine 20 years ago when i was an idiot that took clen to get summer lean and heard Taurine prevents clen muscle cramps. The cramps were for real. Taurine seemed to help. I forgot about Taurine until a few years ago when i heard it helped with bile so i took it when i noticed digestive issues.
Cut to a year later i read that taurine helps with anxiety by converting glutamate to GABA and potentially by reducing blood pressure which is part of the anxiety cycle ; feeling physiologically excited (heart rate hot face) thinking others notice this which is furthering nervousness. Anyways i had always been someone who lived with anxiety like literally sweating if someone i didnt know well was close to me talking to me for long enough to elicit this response. But i noticed as i read about this plausible taurine mechanism that i had not gotten that anxiousness since regularly taking taurine. So theres that.
It also helped my sleep onset which used to take hours sometimes likely from anxiety over thinking when trying to sleep and taurine seems to just calm the mind it's amazing for so many things.
I’m so glad you didn’t shorten the video. Every second was time well spent. When I saw the length of it I thought I should just watch the intro and then listen to the rest during my daily walk. Once I started watching, I couldn’t stop. The visual information you provided was essential in helping me understand everything you said. Thank you for the time you spent creating this video.
I'm just so into these lectures of yours, Verhoeven.
As a neurologist, all this is so fascinating to me. Immeasurably more fun than allopathic medicine.
Please never stop making videos!! I just found you today & took my 1st Taurine!! (60)....Love how you take your time and break it down !!the longer the video the better!!!♥️
A gastrointestinal transit test is a diagnostic procedure used to assess the movement of food and waste through the digestive system. It is often employed to diagnose conditions such as constipation or gastrointestinal motility disorders. The test involves tracking the passage of a substance (such as a radioactive marker or a capsule containing markers) through the digestive tract. The transit time is then measured to evaluate the function of the digestive system.
To detect an improvement in a gastrointestinal transit test, you would typically look for a decrease in transit time. A faster Transit Time: If the transit time of the substance through the digestive tract decreases, it suggests that the motility of the gastrointestinal system has improved. This can be an indication of improved muscle contractions and coordination in the digestive organs.
Good guess Nicolas!
I knew an old guy, thin as a rake and he was always chugging Monster energy drinks. I have to admit to being worried for the guy. Little did I know that he was immortal.
33 grams sjger per 8 ounces will ruin his health.
@@garyssimo sjger is that the new street drug from Prague? or is that cake?
@@garyssimo Not really. Compared to what? What is his TDI for sugar? How active is he? 33g is basically jack shit for moderately active people that work out and do cardio during the week. It's a lot for S.A.D. metabolic disorder having American couch potatoes that are the problem. A person with a healthy metabolism really needs 60-90g per hour of zone two work out alone, a can of this will do nothing to them, American couch potato will need to shoot themselves with insulin just looking at it.
recommended dosing for a 65 year old active female
can this supplement help someone w/ cancer?
Taurine is used greatly by the brain> GABA, the heart and the thyroid. I have been rx taurine for dysfunctional thyroid and elevated LDLs, anxiety…ETC for years. Scientific publications have documented all the above-- years ago. When it makes it to MSM/textbooks etc, it is 5-10 yrs old info if not older.
So did you manage to significantly reduce anxiety and is your thyroid ok now? May I ask what is your dosage? Thx!
@@lostinthoughts5645 I am a doctor that prescribes it for these issues. Yes it works along with much other support. Dose is dependent…
I supplement with Taurine, about 6G a day for longevity reasons. Are age of 68, I would like to be 67 next year thank you. I work out heavy 5 times a week, I also do creative and glycine.
Optimal dosing information should offered in the public segment.
Left out purposely
Thanks to Physionic I'll be an amateur molecular medicine scientist soon. Mom will be so proud of me 😃
Have you started your RUclips channel yet? ❤ 😂
@@theantiqueactionfigure lol. No I'm not as charming as Physionic. Maybe in another life😅
A new skill
That’s how I started 30 years ago - I now include all this in my regular teaching - they love it
And it keeps me interested
By far one of the most interesting channels! Thank you!
The research is amazing!
The only thing I would add is your personal recommendation in regards to dosage, etc.
I am 51 and take Taurin 2 grams daily for 6 months. My sleep got better, my mood is like more balanced and i have more energy keeping low heard pace.
I don‘ t know the reason, but my doktor seing my blood work, regading my LDL cholesterol asked me if i take any medicine. After my negative answer he said, that he has never seen so low cholesterol lebels on individual with my age without taking any pills.
Regards
Low TC And low LDL, contraindicated for longevity, despite what centralized doctors tell you
Not so, can be the sign of efficient hormone activity. As high cholesterol is one of the signs of low thyroid function
I'm wondering what the taurine contents is in the lab food for the mice, fish and worms are. I know they use some form of standardized food pellets. But if these are deficient in taurine compared to the *natural* foods of the animals out in wild nature, then no wonder that supplementation has big effects. It's like: Give 100 mice food pellets with no vitamin C, and give other 100 mice food pellets + vit. C supplementation. Now watch how all mice in the first group die young, and conclude that "vitamin C supplementation doubles life span". But taurine is found in meat, so maybe baseline intake is already optimal in human?
You raise a valid point, but note that there was an added benefit to a higher dose of taurine, which would be impossible to get from food alone.
Also, I'm not a mouse expert, but I don't think mice have much taurine in their natural diet.
I have taken 7 grams of taurine for over 7 years to renew my lungs from smoking. I can now run without any issues, wheezing is gone, no more trouble feeling like I'm not getting enough air. I still smoke when I'm having cocktails. No apparent side effects.i suppose I should add that it has been 7 grams (7000mg) a day
I quit smoking after 42 yrs of smoking. I didnt take anything, but I run regularly and only had wheezing and out of breath issues when I started running. I have no obvious ill effects from smoking. All we can offer is our own anecdotal evidence, and both ours have the same outcome with or without taurine.
you should just quit smoking- it's disgusting
@@tullyapx500You don't say how long ago you quit. Give it some time and a different result could appear. Make sure you test your lungs frequently for abnormal growths!
Interesting comments guys. Nick should do a video on respiratory issues. So much going on from alcohol effects on lungs, evali, covid, supplements like NAC, nmn, vitamins/minerals, omega3, ginseng, and now taurine.
Good for you! but anecdotes can be misleading and throw you of the fast of truth seeking fast. You could share where you based your assumption that it would renew your lungs on.
Taurine commonly exist in dairy, fish and meat ya? No wonder those vegan looks old. No taurine on their food😂
By far the best channel I've found for indepth explanation of studies. Thank you so much for taking the time.
Thanks, Jenna!
"We can't sacrifice humans to get the data that we need."
Big Pharma has entered the chat.
CDC says hold our beer & take your Modelo-19 booster.
I don't currently supplement with taurine, although I am considering it. I found the section on WBC quite interesting because my recent lab results showed a low WBC which was initially concerning to me. However, I did some research and discovered that a slightly reduced WBC count is an indication that your immune system is likely optimized, i.e. your white blood cells aren't being called upon as much to fight infection and therefore are naturally lower. Lower WBC is indeed an indication of reduced inflammation. I should mention that I am very healthy... I do IF, exercise daily and take high quality immune boosting supplements, so a low WBC makes sense for me.
Yes, Taurine levels go down as we age, but isn't this true for almost everything?
Just playing devil's advocate here.
The only thing I knew about taurine was that it is important in cat food.
Excellent info, thanks! Btw, bone mass matters way before 80 yo. Women start losing bone density in their 50's or even earlier.
They don't test men for bone density until it's too late. Don't ask me how I know!
@@theantiqueactionfigureI’m a man and started getting tested in my 40’s. You have to ask. You are your own health advocate. Nobody else really cares about your health .
Bone density peaks in your 20s, starts declining in your 30s and plummets from your 40s onwards
yes, true
Excellent presentation! A question..I normally always have a low white blood count , do you think taurine supplementation would be a problem? Thank you for all the time and work you invest in these podcasts!
Excellent work! Appreciate the time stamps for future reference.
Incredible work you put in - thank you!!
Re. the elevated cholesterol etc: Dr Aseem Malhotra (cardiologist) and others don't seem to worried about them. I think he and others have speculated the statin reductions in mortality may be due to a decrease in inflammation? With all the positive effects of Taurine ...I dunno?
@@MajesticArtimus It's complicated I don't have a sense of certainty about the issue, but that doc I mentioned is a respected guy. He's worth a listen.
Genetic differences may account for you/hubbies cholesterol differences, different diets can benefit people with differerent genetics.
Dr. Verhoeven, thank you for your work here. I've been supplementing taurine for about 10 years now, buying it in bulk packages of 1 kg and mixing it in drinking water in gallon jugs, with large quantities of MSM. My daily dosage is about 2.5 g of taurine. I started doing this only for this one reason: I had read that in places like Japan, where people are famous for their longevity, one of the isolated factors for this was that their diet was high in taurine. I didn't really learn much of the details until I saw your work.
But there is one thing that troubles me. I also powerlift regularly, so building and retaining muscle mass is a priority for me. And apparently, taurine supplementation short-circuits the end of the mTOR pathway. I know there are several paths to activate mTOR, but apparently taurine suppresses the very end stage, of this special protein that is responsible for stimulating muscle protein synthesis, so it appears that regardless which way you approach mTOR, taurine suppresses muscle protein synthesis.
There are several known compounds that do this, that are all associated with longevity and anti-aging: rapamycin (whence comes the name "mechanistic target of rapamycin" or "mTOR"), resveratrol, epi-gallo catechin gallate, etc. All are known for improving longevity, but suppressing mTOR. Apparently taurine supplementation has the same exact effect: it improves your longevity generally, by delaying cell senescence and the subsequent buildup of "zombie" cells, but it also suppresses the buildup of muscle mass. If this is right, it's very disappointing: if I want to retain muscle mass, I have to live with the normal aging pathways. If I want to delay aging, I have to live with my powerlifting not yielding one of the most desirable rewards of that work.
Do you know of any way to get around this?
Thanks for sharing 😅
I’m very interested in the answers to this.
If someone has a workaround, I'd like to see it myself. Until then the best path may be one of lowered expectations. It seems like living longer has more benefit. I suspect you have a lot of muscle allready, more than enough to take you comfortably into older age. I'm 72 and weak as a kitten, which I am fighting (with myself) to change. I've lost 80 pounds and time to work on some muscles. I need some but not really that much. I think Taurine will help me in general and not interfer with normal body building or shaping. If your one of the powerbuilding elite then your needs are specialized, I'd ask a professional somebody for advice.
Is it a significant amount of suppression? Meaning, would it keep a person from gaining bulk or would it keep the muscle from growing at all? As a woman I’m only interested in maintaining firm muscles that are also strong
In regard to the dose you are supplementing with for taurine you may need to pull back. There's something called a hormetic effect. That means that something is more effective taken in a smaller amount and can actually harmful taken in a larger amount. I would investigate that as a pertains to taurine.
(Dietitian since 1982)
Is there any indication as to where Taurine is _used_ in the cells? What _organelle?_ I suspect the mitochondria, but I took cell biology back in 1974. If it is know where Taurine is used, how was this determined?
When I was in college, molecular biology was a NEW major! That was a lifetime ago, and though I eventually wound up in computer science as a career, I still love to hear "trash" talk from biology people. I'm also interested in it because I'm getting old and looking for the Fountain of Youth. I've been taking Taurine for about 3 months now, but haven't yet noticed any significant changes. I'm thinking about increasing my dosage. Thanks for this and good luck with your studies.
How much do you take?
With food? Or before food?
Thank you for not making your videos shorter 🎉
Thank you for this video. You a a brilliant man. Very interesting video
Started taking taurine and creatine because of you in depth reporting. Looking at glynac. I see you are somewhat ambivalent about glynac. Back ground, 74 yr old, went from sissy squats to 280/300 pound 3 set/20 rep squats. Thanks for all your help in understanding supplements.
Fascinating research! If I understand this correctly, Taurine has so many benefits except for muscle development where it can be a negative side affect if trying to build muscle. If that is correct, then no elders should take this. I'm 71, petite, female and have been supplementing a 1000 MG. I feel like I have lost muscle not gained, even though I lift heavy weights. A clarification would be appreciated. Thank you, Nick, I love your videos and learn so much from you. PS: and you sure are easy on the eyes. 😊
Oh noooo😢. I just ordered a bottle from Amazon. 1000mg is that what I should take?
@@lovemissle Oops so did I… the powder. Also 71 like Kathy and enjoying muscle hypertrophy.
Powder is cheaper to buy than capsules.
Taurine is fine for muscle development.
@@lighthealerastrid1465dhea is your answer among a range of vitamins. In females a tiny amount of dhea is highly anabolic in older females
Historical I’ve been skeptical of taurine supplementation, but this new research has my interest. Excellent review of this research 👏🏾
Don't forget exercise & eating greens ,,,
I don't feel so bad about those sugar free energy drinks now. :) Not to mention they have Niacin in them. Both Taurine and Niacin have been suggested for longevity. Wouldn't that be funny if all these energy drinkers lived to 100. At least those drinking the zero sugar ones.
@Quixote1818
But the energy drinks without sugars has artificial sweeteners, so the avid consumer probably won't get a day over 90.
Def not the sugar-free ones. Can't wait until these poisons are banned. So many healthy sweeteners that could be allowed instead not allowed, like glycine.
The flavoring and artificial sweeteners of these no sugar drinks might be negatively offset the benefits from its niacin and taurine content.
@@larsnystrom6698 You might want to watch this channel and other science based channels plus look at websites like Science Based Medicine. They all say there is no cause and effect evidence that artificial sweeteners are bad. Those are generally giant studies where a bunch of unhealthy people who turned to diet drinks at the end of there lives get shuffled into the data. Reverse causation.
@@midnightsnack1306
"Might be" is the key phrase here. You might want to watch this channel and other science based channels plus look at websites like Science Based Medicine. They all say there is no cause and effect evidence that artificial sweeteners are bad. Those are generally giant studies where a bunch of unhealthy people who turned to diet drinks at the end of there lives get shuffled into the data. Reverse causation. David Sinclair one of the leading experts on aging, rated Sugar as a 10 bad for you and diet drinks as possibly a 1. ruclips.net/video/kUGZqQlU7BA/видео.html
I want a taurine+glycine supplementation experiment!! PLZ!
I'd love to see a video on Thiamine- there are a lot of claims of it's health benefits in high doses and the different forms of it. Specifically TTFD and benfotamine.
It helped my young son improve his stutter significantly. The effects would wear out but I would just supplement again while also trying other methods. He’s now a teen and no longer stutters.
I hear a lot of people talking about that stuff, but don't know much about it. I am desperate to heal my gut health.
@@Bazza5000 check out Elliot Overton
@@amylee9 wow that's great!
Benfotamine helped tremendously for my essential tremor for about a month. For some unknown reason, it stopped working. Frustrating. Finding that sweet spot of dosing has been difficult.
Would diet provide enough taurine as we age? If so, what food will give us enough taurine? Sadly, studies, nowadays, mostly always revolve around supplementation instead of real food.
No, you want to avoid foods that have taurine. As the best predictor of longevity is legume consumption ,meaning plant proteins.
In the study, they used massive quantities that are nothing you can get even close from food. 250mg per kg of bodyweight, so around 20g daily!
@@Nobody-Nowhere where in the study that says legume consumption is best? As far as i can tell, there is currently no study on taurine in human. Hence, that automatically negates any idea on food containing taurine.
This is brilliant. Thank you
Thank you!
Yes, it's VERY important to follow LDL/HDL results using Taurine in further videos.
Ok
I'm watching this particular video for the third time to glean the maximum amount of information contained herein. I am a classically trained epidemiologist and tend to dismiss...or outright laugh at...most medical channels here on RubeTube. You have a winner and a subscriber.
Thank you!
I love love love you as my RUclips professor!!!
Interesting that the yeasts are not affected by the taurine. Good to know that these critters in our bodies wouldn't be growing with human supplimentation
@susymay7831
I guessed that had something to do with that yeast is single celluar, and Taurine works on multicelluar organisms.
Something to do this, perhaps:
"Since taurine is a key organic osmolyte in most cells, the possibility that the effects of taurine on ion transport could be related to its osmoregulatory activity."
Adding my two pennies here: that particular strain of yeast did not show a measureable change, that does not speak for all yeast strains. Secondly, yeast are "weird birds", neither animal or plant in nature. And for sure they are not animal. They are single cell, but most do have multi-cellular properties.
Nick so happy to hear you say “to be FRANK with you” instead of ‘to be honest’…!
Very well explained, thank you very much.
Concerning the table with the colors at 1:10, it seems that overall hypotaurine has more blue than taurine, so I wonder, how is taurine converted to hypotaurine? Is is via an enzyme? Could the conversion be increased?
Harry Serpanos has finally been vindicated with his taurine shilling. If you don't know this guy, he is a carnivore political crank on youtube, who proclaims the gospel according to taurine. Ignore his political tirades, but his nutritional recommendation on taurine is well supported by research. There's a bit of older research on taurine especially from asia which had inspired me to supplement well before the hype.
Awesome presentation! You answered many of the questions I had as I've been taking Taurine for awhile now. Can you do a presentation on vitamins D3and K2 with respect to the circulatory system?
Btw I’m a 78 yr old woman who has osteoporosis which makes me interested in this as a supplement
I started taking taurine, glycine and NAC in the morning and glycine and NAC at night. Hoping to see a difference.
There should be a lot against sacrificing animal models
And if there were humans wouldn’t think so little of animals because I can tell you right now animals have never done anything to humans of this caliber, and wouldn’t dream of doing it even though their DNA has memory of every transgression against their kind.
I don’t like that you said that and I don’t believe that behavior and thought process should be widely acceptable. I think that has a lot to do with my humans cannot measure to the benevolence of an animal.
We consider ourselves to be intellectual? I think it’s quite simple if you want to experiment experiment on yourself and if you want do it yourself and don’t do it
I hope I’ve made myself,
There are commandments, even if you’re not religious they’re basically guidelines to live by one of them is thou shall not kill there is no exemption clause,
And for those who choose to do wrong and participate in doing wrong whether they’re actually the one that yields the acts, there will be a price to pay
The more information I hear on this nutrient, the more it sounds like its deficiency could be the cause of a bunch of symptoms that have been lingering,sometime before, and more so after having thyroid surgery, thats mess up my metabolism thoroughly.
One thing that seems to be linked is a lingering problem with low body 1:05:56 temperature, which I guess taurine helps to regulate.
But U've been all around the block, looking for a way to balance my metabolism, and so far ,taurine seems promising. 🤔👍🏻😌🙏⚡🔥
I am age 81, never smoked or used alcohol and exercise regularly but I am feeling weaker so I will seek source and dose of Taurine immediately.😅
Try Super B Complex and Magnesium
You might look into Creatine and Berberine too...
How did it go?
he has beautiful, flawless skin. how!?
L Taurine is the compliment of glutamine.
If you are sensitive to MSG taking L Taurine can balance out MSG when you feel you have ingested too much of it. MSG is slathered into so many processed foods, even under different names.
Truth in labeling is an org that is educational on how much MSG people are actually eating under different labeling.
Very interesting study. Nice work on presenting. I think the bone mass of the samples including humans would be further increased with k2 supplementation. I am certain this was not in the animal feeds.
And cutting out meat, as meat consumption decreases bone mass and increases osteoporosis.
"Several studies indicated that frequency of meat consumption was associated with bone mass and fracture rates in humans"
As meat comes with antinutrities like purines, that are acidic and to combat this body leaches out calcium from the bones to neutralize the acidic environment.
@@Nobody-Nowhereoh please😂
@@theantiqueactionfigurego read it’s true. Same with milk.
Animals such as mice are able to produce their own vitamin k2 in sufficient quantities from the vitamin k1 in their feed.
I haven't watched the video yet, just read the title, but what I can tell you is, that I used to drink a lot of red bull (which contains Taurine) for most of my teens and 20s... im 27 now, and not drinking it as much anymore.. but as a 27 year old, I still get mistaken for a 16 year old sometimes, literally the other day I couldn't buy cigarettes for my mother because they were not sure if I was 18 or not. Maybe I should add that I'm vegan and also very careful about being in the sun and using spf.. so that probably adds to it too
Yeahhhh I’m pretty sure it wasn’t the Red Bull that kept you looking young lol. A combination of good genetics and good skin care/sun protection will do the job.
if you avoid the sun and eating animals, make sure you're getting enough Vitamin D.
This was a great breakdown of this study and you covered it well, and you put it into layman terms that we can all understand. You provide good evidence and as a 64 year old with a deteriorating spinal condition I found it encouraging and have now included Taurine into my diet. I have in the past 5 years made many changes in how I look after myself and the first thing I did was to stop smoking, then I worked on my weight and completely changed my diet and have been a pestcaterian for 2 years, I have gone from 18.4 stone down to 13 stone and I have a daily exercise routine. I include kefir in my diet as I understand the importance of gut health. I have managed to come off all my medications which there were many including Statins and blood pressure medication, and this vlog has convinced me that this is really an essential supplement that all over 50s should consider. Thank you for this breakdown on Taurine I found it encouraging. Great channel you're a good man. Thank you, Thank you.
Besides a long, long life the other factor is particularly relevant. One must know the goal of such a long existence. There is no point to live so long if there is nothing you would like to die for.🎉🇵🇱🕎
16:35. Over time we shrink. Hay, I was a tad taller than 6 feet in high school now that I’m 45 in a tad taller than 5’ 11”. I have back issues now. So, that degenerative joint disease is real. All you younger people take care of yourself. Your older version of yourself will thank you for it
Are you taking taurine yourself?
@physionic
I can't have taurine, it makes me charge at anything red. I don't feel that this is a normal side effect.
How come
If the charge is reasonable, I don’t see a problem.
Elaborate please
@@stevemarshall_uk it's a joke about turning into a bull
Taurine declines with age (what doesn't?). Did this study look at blood levels of taurine before supplementation? Meaning, was the supplementation simply bringing the blood level back to normal or was this a dose in excess of normal levels (mega dosing). I'm about to do an amino acid profile test. If my taurine comes back in the normal range do I still supplement?
Back aches increase with age. :)
If taurine is in normal range (for young men), then no, I wouldn’t supplement.
Deuterium
I took a test done by cellular nutrition assays . A blood test , a natural path had me do it .
My taurine was very low .
But my B1 was ok . But I question this cause I don't swett perspire. That's a sign of low B1 .
The test really help . I started to take taurine but not high doses now I will .
I am going to go on ketoe diet geared more to carnivore.
A regular blood test will probably not help .need a more indepth one .
Another video speculating on the optimum human dose would be great!
Man, I'm binging on your stuff.
If you get a chance to take a look at the omega 6/omega 3 ratio claims, I'd be very grateful.
My intuition is that it's nonsense, but I would love to see a thorough break down by someone like you.
Cheers!
It is nonsense, there are no real studies about it.
Both, omega 6 & omega 3 are essential fatty acids, and both are anti inflammatory even in large quantities.
If you are interested in quality content, check out channel named "nutritionmadesimple".
I'm not convinced yet, but I have seen the video from NutritionMadeSimple. I would like to see more research. I have no problem with corn oil and inflammation in moderation. But if I eat a ton of it, it does cause me inflammatory issues. But I am more inclined to credit that inflammation to the caloric surplus that comes with eating a whole large pizza drenched in corn oil. Eating at caloric maintenance and exercise can work wonders for all this chronic inflammation, even if you're eating like crap.
@@limitisillusion7
Buddy, the majority of the fat in pizza comes from cheese, the majority of which is saturated.
Sounds like you really want to blame corn oil.
@@phillustrator No, I used to eat pizza without cheese and the same effect occurred when I ate a whole pizza. I also get inflammation from eating too much fried potatoes or lean fried chicken. I don't want to blame corn oil. In fact, I love the stuff. I'm not convinced is all. I think inflammation is a phenomenon that we haven't quite narrowed down yet. My inflammation also decreased when my omega 6:3 ratio dropped to ~5.
Love this hardcore science. Excellent job explaining, and so patient with us! Thank you!
Great video! Can you go next level breakdown on oxalates? And then the link - bad link - between it and curcumin, which was a bummer to hear from a great oxalates doc video on YT. That's me asking. Who the hell am I to ask? I don't know, I'm just asking, you don't have to get pissy about it. A nod to your humor, which is awesome!
A critical take regarding supplementation in humans from Peter Attia:
"A critical variable largely ignored by the study authors is precisely why taurine levels decrease with age. Given that endogenous taurine synthesis is so low in humans, circulating taurine is determined by a balance of absorption from diet and excretion (primarily in urine). This leaves us with three (non-mutually exclusive) possible reasons for the apparent decline with age: 1) a reduction in dietary intake; 2) a reduction in rates of intestinal absorption of taurine from food; or 3) an increase in the rate of taurine excretion. No nutritional data have ever indicated that people consume less meat and seafood at age 60 than they do as kids, so we can exclude possibility #1. Possibility #2 would suggest that we need to consume more taurine as adults than we do as children in order to absorb the same amount, which in turn might mean that supplementation would boost circulating levels and help mitigate their age-related decline. Possibility #3, on the other hand, would mean that supplementation would have very little effect on circulating taurine.
So which is it? We don’t currently know and have no direct data to address this question, but the pieces of evidence we have make the best case for possibility #3. Taurine reabsorption in the kidneys - a process that returns taurine to circulation and prevents its excretion - requires co-transport with sodium ions moving down their chemical gradient (i.e., from high extracellular concentration to low intracellular concentration), an energetically favorable process which helps to drive taurine transport forward. But with age, renal ability to maintain electrolyte gradients gradually deteriorates, contributing to the well-documented age-related decline in kidney function. Thus, it seems likely that the capacity to reabsorb taurine from urine also falls over time, resulting in increased excretion. This possibility is further supported by the observation that, regardless of age, taurine levels are typically low in the presence of chronic kidney disease.
Why is supplementation unlikely to help most individuals?
In general, amino acids can filter into urine, but most are reabsorbed by the kidneys at rates of ~98-99%, meaning that very little is actually excreted. Taurine is different in that it is only reabsorbed at a high level when circulating levels are low. When dietary intake and circulating levels are high, taurine reabsorption rates can be as low as 20%, resulting in a high level of excretion.
On the other side of the equation, rates of taurine absorption from the gut decrease with increasing circulating taurine levels due to reduced transporter expression. Some have reported that dietary availability thus has relatively little impact on circulating taurine.
Combined, these observations suggest that supplementation would be useless in increasing circulating taurine levels in those already within typical physiological ranges. (Data in humans with unusually low taurine levels, as is often seen with obesity, kidney disease, or strict vegan diets, suggest that supplementation does indeed raise serum levels in these individuals.) Any excess either wouldn’t be absorbed or would be excreted. And if taurine levels decline with age due to an increase in excretion, the threshold that defines “excess” taurine is effectively reduced. For instance, a taurine concentration of 50 µmol/L in a 20-year-old could be raised with supplements, but the same level in a 60-year-old might represent an upper limit.
In this way, we can liken the body’s taurine levels to water collecting in a bucket. As long as the bucket isn’t full, the water level will continue to rise as more is added. But once it reaches the top, any additional water will simply spill over the edge and the amount of water in the bucket can increase no further. Now imagine that over time, the bucket rim slowly erodes, resulting in a shorter and shorter bucket that can hold less and less water. No matter how much water you add, the bucket will never contain as much as it did before.
So why did supplementation “work” in mice? Again, it may relate to a difference in their taurine biology relative to humans. In addition to the three possible explanations described above for the decrease in taurine with age, mice may have another contributing factor that would be largely irrelevant in humans: a decline in endogenous synthesis. Like reduced absorption, this explanation would also suggest that supplementation could have a meaningful impact in elevating circulating levels. To use the bucket analogy again, a loss of taurine due to reduced absorption or synthesis would be comparable to slowing the rate of water flow into the bucket to a point at which the rate of evaporation outpaces the rate of water collection, and the water level gradually drops despite the fact that the bucket remains the same size. In this case, supplementation with another water source would be helpful in refilling the bucket."
@kurtniznik8116
I think we need to know more about this.
But my guess is that we get most taurine from the bodys own production of it. And much less, perhaps half, from animal food.
Taurine is produced from cysteine, which we don't get enough of, and needed for many other things. (Glutathion, Creatine)
It's my guess that absorbtion isn't a problem. It's likely the bodys production which is reduced with age.
Interesting. I’d like to see a retort to this. But so far, silence.
Don't shorten your videos. Wonderful lecture.
You should look at the Korean Cholesterol Mortality Study published in 2019.
Can you explain the glucose portion and specifically in regards to low blood sugar? I have hypoglycemia but all studies reference seem to lokk at hyperglycemia leaving my specific issues out of the conversation.
Taurine is different from most amino acids in that it is not incorporated within proteins. The reason being that the acid group is not a carboxylic acid, but a sulfonic acid.
I found that part of the video quite misleading.
Edit. I see the author added a note afterwards to clarify this point. Well done.
I need some of that. I'm 76 and think I could use it because my muscle mass has decreased and my stamina isn't like it used to be. Oh wait! The Government wants to get rid of old fools like me. Geezzzzz forget it, I'm doomed.
You are 76! You are blessed, plus from how you write, you still have it together upstairs. Hope to see you around for another 10 years! Cheers
So, should we be using taurine daily or do that "hit-and-run" thing? If the latter, how long does it take to trick your body to think it's taurine deficient? Is the latter the same for CoQ10 or GlyNac?
If taurine incessed lipoproteins, one has to ask "so what"? As the link between elevated LDL cholesterol and and heart disease, is not concluvsive. Also some of the health benefits may actually come from elevated LDL. As there are correlation studies that suggest this.
When is the best time to take taurine? Morning, afternoon or before bed? Does it help with sleep?
Never, as its pointless. They consumed massive amounts of taurine in the study. You would need to take around 20g per day to reach the amounts they used in the study.
Dont believe hype nonsense like this. No one is going to be taking 20g of taurine daily for the rest of your life.
Form a healthy diet you can sustain in a long run.
There is a missing point: how much a 14 months old mice weight ?
I found that is around 15 grams. If that is true, numbers are complicated. They were feeding 1 g /day to a mouse of 15 G ? A mice is supposed to eat max 5 gr /day. Humans eat 1 kg /day so we will need 200g /day ? Well, the protein part in my low carb diet will be taken then
You have the most unusual talent to explain things very clearly, I am so glad I found you , I hope you expand your repertoire! 😍😍😍😍😍
off topic but you are very handsome.
Taurine: Second energy of the Astrology. They ALL have their places.
One weird side effect from it was I felt stronger after taking it, but not in drink form, they must put very little in energy drinks. It's getting rid of my skin condition so I have to take it daily.
What skin condition do you have?
What's the skin condition?
Feel stronger since taking as well.
Great work, thanks. I’m on board but going in with extreme caution. We have been manipulated for decades and the research always points to supplementation vice some small dietary adjustment; i.e eat broccoli sprouts, etc. We all run out and spend hundreds of dollars, whilst telling ourselves “this is the one”. NMN, resveratrol, pterostilbene, quercetin, NR, spirulina, magnesium… and Taurine will have it’s day.
nr and magnesium good, topping up aminos is probably a good idea. those other things you list are good for the bin
Agree, I’ve fallen prey to this. I’m much more discerning now. Diet and lifestyle continue to be my focus and I’ve paired down supplementation
You're wrong on NMN. I have physical proof of its benefits (on myself). Not self-deception, but curing of a physical condition I had for 10 years until I made one and only one change - taking NMN.
@@thisisreallife5086 I don't disagree with you, I was speaking general terms, I actually use NR myself, NMN is further up the pathway and would seem to be more effective than NR but far less studies on NMN led me to NR, still effective but safer IMO. Best to you and your journey.
Collagen peptides.
Please do not shorten the vids. I want ALL the data. Thx Nic.
So, is 1g a day a good start? Haha I think I'll give this a go
Accessibility request: Please leave some clear space at the bottom of a slide, to reduce overlap of the figure with captions. Fig.Q is particularly bad. On that one, I had to pause & turn off captions in order to read the graph.
Nope no shortenings, much much too important what we can learn and whst you've to say..thanx and greetings from Switzerland - Isa 🤩
Eating meat so no need to supplement with taurine
Tried taurine for first time a week ago. Dissolved about 300mg in water and drank. Five minutes later felt warm tingles all over my body and felt kinda high, lasted about an hour, totally weird. Next morning took another 500mg. Same effect. Evening another dose, only a slight effect. Repeated over the next few days. No more tingling, but gone was my 67 yr old brain fog. Memory and energy levels noticeably better. Now using about 2 grams a day. What is optimal for a healthy, athletic 67 yr old 200lb man who walks or runs 5-6 miles a day?
44:45 they switched it because it is a similarity tree, dendrogram, ordered by similarity, look on top of each stack image. Taurine works better on muscle and brain than liver (taurine aged liver is more similar to aged, than young).
Very informative channel i learn a lot quick question are the different forms of taurine have a certain effect on humans do we know what is best to consume afaik there is 2 forms L and D Taurine.
.
Isn't it bad to both have no telomerase and no senescent cells? I would expect an increased risk of cancer in the tert-/- sample with taurine supplementation...
Ok, hear me out. I'm 41yo, a reasonably healthy male. I've just started supplementing taurine and noticed some magical things started happening! Energy levels are up, very noticeably - I used to love working out but over the last few years I've somewhat deflated, lost my edge and will to work out - straight after supplementing taurine I started to feel the urge, the tingle to hit the gym and my muscles hard again! The quality of sleep dramatically improved, especially the falling asleep aspect, which in turn seems to have started to normalise my circadian rhythm. Borderline insomnia has been my struggle as long as I can remember. I've always dreamt of becoming an early bird - maybe now I have a chance to achieve it. But wait, there's more! Most importantly of all I noticed a dramatic improvement in my RSI (forearms) and radial nerve damage in my right arm. The pain has gone from severe to barely noticeable just after a couple of days of supplementing taurine. Before, I've tried everything, all supplements (apart from the taurine) and exercises, including the "nerve flossing" exercises, with very little impact. Looking forward to seeing what comes next. Best regards to all!
I’m very much like you and libido’s gone lol since my youth and I hope this tablespoon a day helps my issues
What's the recommended dosage? I supplement with 2000mg per day
3-6 grams a day for 70kg body weight if I remember correctly, might be 80kg. Take with NAC and Glycine (powder is cheaper). Plus search GlyNac.