mTOR Pathway and its Regulation

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AKT/PKB Signalling Pathway :
• PI3k/AKT/mTOR Pathway
In this video we will be discussing about the mTOR Pathway.
mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription.As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors.[12] mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.
mTOR Complex 1 (mTORC1) is composed of mTOR, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (mLST8) and the non-core components PRAS40 and DEPTOR.This complex functions as a nutrient/energy/redox sensor and controls protein synthesis.The activity, insulin, growth factors, phosphatidic acid, certain amino acids and their derivatives (e.g., l-leucine and β-hydroxy β-methylbutyric acid), mechanical stimuli, and oxidative stress....

[@gem1632]

It takes massive amount of research to firstly understand this concept..
Then simplify it,is another challenge
Then making such brilliant drawings is yet another big challenge
And finally completing the video...
Wow wow wow...this is huge amount of work u put in ..i guess to make this single video,atleast 7 to 10 days have to be spent...
U R GREAT. ....

[@hussainbiology]

Yes, buddy..It takes lot of efforts and a time to put in this kind of concentrated video...
( this took me 7 days )
thanks for appreciation ...

[@CharitysClarity]

I can not believe how simple you made this considering it’s so complex to understand let along explain!! Bravo 👏thank you !! I wish you much success in your career

[@hussainbiology]

thanks dear for appreciation.... Glad my stuff is helpful...

[@suckerpunchofficial1758]

Hey thank you so much man! I am a Business major who is procrastinating and I don't take any biology classes but this really helped me understand it!

[@hussainbiology]

Glad it helps

[@michaeleisenberg7867]

Hi Shabir! Another amazing and fascinating animation!!! I love it 😊💖💗. More lock and keys 🔓 🔑. Of course it just adds to my confusion 🤔 of how on earth 🌎🌏 did this happen? From elements to thousands of complicated and uniquely functioning polypeptides. But today I'd like to focus on my appreciation 💗 to you for reporting on these byzantine cellular processes and to the research scientists 🔬 in all the labs across the world who brilliantly decode and decipher these complex processes. It is beyond amazing that people like you and your peers can go in a lab, invent an experiment, and trace these polypeptide pathways down to which amino acid is phosphorylated and which part of the protein is then bent or twisted to achieve its purpose--allowing all of us to live--including my 2 English golden retrievers 🐕🐶 (Chuck & Bert). Bravo 👍👏👏🙌🙌!!

[@hussainbiology]

Thanks Dr. Mike. for appreciation...♥️♥️♥️

[@RehanKhanNISER]

Please keep making such video, never ever stop.

[@hussainbiology]

thanks for appreciation

[@medicalbiochemistry_]

Keep up the great work

[@hussainbiology]

thanks for appreciation ✌️✌️

[@ImtiazAli-vm3gk]

Great sir

[@nishatfatima2091]

Sukriya sukriya.....

[@hussainbiology]

thanks for appreciation..
Glad to know that it helps ✌️

[@deepakthakur7129]

You are awesome sir. Like always. And yu know what if people start watching yur video for 5-10 mints ..they can save their hours.and crack their PhD interviews whether it's iits in India or other colleges in abroad

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@a45sankhadiptoghosh64]

Very hard concept , amazing

[@hussainbiology]

Yes... tried to make it easy....✌️✌️✌️

[@nathan-498]

How does IGF-1 effect myostatin?

[@kaushikk4425]

Thanks sir. Superb

[@hussainbiology]

thanks for appreciation

[@akashpathak7182]

Very good work

[@hussainbiology]

Thank you! Cheers!

[@masharab2695]

Would you plz make a video on (counter current exchange mechanism), one of the sub topic of regulatory function of kidney.
I HOPE you will make a video for us.
We will very thankful to you by heart and soul.

[@hussainbiology]

InshaAllah will consider making

[@measententia2154]

Sir are you a single person behind your videos?? Is there anywone to help? Appreciate your hardwork..❤️

[@hussainbiology]

Yes.. i am the only one behind Hussain Biology.... If there had been anyone to help me , the videos would have been uploaded frequently....

[@hussainbiology]

thanks for appreciation

[@priyakamboj5850]

Sir atni achii drawing kha sa sikhi h its really amazing style to show whole process thanks so. Much.

[@hussainbiology]

thanks Priya for appreciation..Glad u like my stuff.. Ab diagrams ban rahe hai ache(✌️☺️

[@priyakamboj5850]

@@hussainbiology sir apka sare lecture mind blowing h really I passed my bsc just because of you and now I am doing Msc it's very helpful thank so. Much for giving such a valuable information in free of cost thank u so much

[@hussainbiology]

Arey ye toa kafi acha hai...Keep sharing and supporting ✌️

[@hussainbiology]

All the best ahead.. aur kis mai M.Sc kar rahe ho

[@priyakamboj5850]

@@hussainbiology biotechnology

[@krishnendukundu6446]

Complex concepts..mess my brain...but kudos your efforts 🙏

[@hussainbiology]

thanks for appreciation...

[@karakraft9190]

wHAT'S YOUR CHESS RATING?

[@sbb230]

Sir this video remain available latter???

[@iftekarhossain1669]

Yes

[@hussainbiology]

Yes.... it will

[@useranonymous9274]

Hussain are you a scientist? I feel like you make groundbreaking research in a lab somewhere.

[@hussainbiology]

thanks John for such an amazing words..It really boost's my confidence......
Nah i am still a student John

[@useranonymous9274]

Hussain Biology If you’re still a student after all these videos and knowledge then I have such a long ways to go to become a scientist 🤯

[@hussainbiology]

@@useranonymous9274😊.... No way we learn everyday and i believe u too will be a great scientist one day.... Rise and shine...

[@michaeleisenberg7867]

@@hussainbiology There is no doubt that Shabir will succeed at anything he puts his mind to. 🧠🎓

[@anjalidevadas6934]

Sir how about now...did you crack JRF NET?DID YOU BECAME A SCIENTIST@@hussainbiology

[@beautyblossoms1879]

Are you from Kashmir?

[@hussainbiology]

Yes sir... I am from Kashmir

[@beautyblossoms1879]

@@hussainbiology okay Mashallahh
May Allah bless your efforts and help you excel Aameen!