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Nice Video but i miss SIRT1 and the NFkB signal, SIRT1 has a direct influence on FoxP3. As long as SIRT1 is not stable, FoxP3 cannot work properly, and the trigger for the autoimmune reaction may lie before FoxP3. In addition, FoxP3 does not have to detect mutations but only has instability, so that there is an imbalance in the Treg and T cells. But the video is more Basedow on the T cells, and it is perfect...big thx
Please share my channel link with your friends. Also you can pay us money ( only 10$) to cistomize your presentation. Feel free to connect via email any time.
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
CD4+ T cells become Helper T cells because CD8+ co-receptor is down regulated (1:55). Those with CD8+ co-receptor are found on cytotoxic T cells or natural killer T cells.
Thank you, Video helped me in clearing confusion, it means that CD25 which is Receptor of IL2, so this CD25 is present over both Treg and CD4 T cell, and so Treg CD25 competes with CD25 of CD4 cell so that IL2 doesn't act on CD4, so CD4 doesn't get activated, Is my thought process right?
Very interesting! Do you know if there are ways/research to increase Treg cells? Would be great if you could try to boost these to reduce inflammation / improve autoimmune response.
@@animatedbiologywitharpan amazing thank you for the link and your reply! :) Definitely a fascinating topic - personally was diagnosed with MS 3 weeks ago and am looking for ways to biohack my body a little / stop it attacking itself besides the treatment I will likely start soon
Thank you for excellent lecture. I have one question The question appears on test in Korea. What is the biomarker of Treg cell and is related to IL-2 receptor? 1.CD4 2.CD19 3.CD25 4.FoxP3 5.GATA3 I think there are two answers(both 3&4) Can you choose one?
Foxp3 is a good marker of Tregs especially if panels of markers were used for their identification. T REG Cells will be CD4(+)CD25(high) Foxp3(+) . CD25 alone is not a very specific marker.
Sir, what happens when Tregs supress APC Or Macrophages inflammatory response? Does the Macrophage become unable to signal Th2 cells and that way allergies stop happening?
bro if its ok...can i get ur ppt file or pdf file...i need this for my thesis...and ofcourse i will credit you and also label your name under reference...
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Wonderful explanation. You have a gift of explaining hard to understand concepts nicely! Thank you!
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Don't forget to check out my entire immunology playlist
Again a clear cut explanation saved my time
Please share my channel link with your friends and help me to reach big audience.
@@animatedbiologywitharpan sure
This is so helpful. Thank you for this video. This helped me a lot today. I like your teaching skills.
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This totally came from, Dr Cepika MD articule on Tregophaties, thank you very much for the explanation very helpfull for the inmunologist community
Thanks, glad to see that you liked it
Nice Video but i miss SIRT1 and the NFkB signal, SIRT1 has a direct influence on FoxP3. As long as SIRT1 is not stable, FoxP3 cannot work properly, and the trigger for the autoimmune reaction may lie before FoxP3. In addition, FoxP3 does not have to detect mutations but only has instability, so that there is an imbalance in the Treg and T cells. But the video is more Basedow on the T cells, and it is perfect...big thx
saved my presentation today, thank you so much
Please share my channel link with your friends. Also you can pay us money ( only 10$) to cistomize your presentation. Feel free to connect via email any time.
Bravo ,kratko ,jasno i efikasno !
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
Just what I needed right now! Thank you so much!
Please share my channel link with your friends and help me to reach big audience.
Dont forget to check out my immunology playlist for all the concepts in immunology
CD4+ T cells become Helper T cells because CD8+ co-receptor is down regulated (1:55). Those with CD8+ co-receptor are found on cytotoxic T cells or natural killer T cells.
Yes cd8+ coreceptor is characteristic to cytotoxic t cells
Thank you, Video helped me in clearing confusion, it means that CD25 which is Receptor of IL2, so this CD25 is present over both Treg and CD4 T cell, and so Treg CD25 competes with CD25 of CD4 cell so that IL2 doesn't act on CD4, so CD4 doesn't get activated, Is my thought process right?
Very interesting! Do you know if there are ways/research to increase Treg cells? Would be great if you could try to boost these to reduce inflammation / improve autoimmune response.
Yes there are ways , may be i should make a video on that
Read this article to know more www.nature.com/articles/s41577-019-0232-6
@@animatedbiologywitharpan amazing thank you for the link and your reply! :) Definitely a fascinating topic - personally was diagnosed with MS 3 weeks ago and am looking for ways to biohack my body a little / stop it attacking itself besides the treatment I will likely start soon
sir super explanation do more videos of immunology at molecular and genetical level. than you vey much sir
Check out my immunology playlist .....I think it covers quote a lot of topics
@@animatedbiologywitharpan 🙏🙏🙏
Thank you for excellent lecture.
I have one question
The question appears on test in Korea.
What is the biomarker of Treg cell and is related to IL-2 receptor?
1.CD4 2.CD19 3.CD25 4.FoxP3 5.GATA3
I think there are two answers(both 3&4)
Can you choose one?
Foxp3 is a good marker of Tregs especially if panels of markers were used for their identification. T REG Cells will be CD4(+)CD25(high) Foxp3(+) . CD25 alone is not a very specific marker.
Wow, thank you very much😊
Can I ask your career?
Cd8 population also inhibited by same tregs or any other different mechanism .? Please upload Bregs too.thankyou
Sir, what happens when Tregs supress APC Or Macrophages inflammatory response? Does the Macrophage become unable to signal Th2 cells and that way allergies stop happening?
1:53 "CD4 positive T cells" not "CD8"
Yes noted.... small mispronunciation.... thanks for pointing out
thank you lerony
Brother, which software u use to get these figures and animations....
Microsoft PowerPoint only
@@animatedbiologywitharpan bdw gentleman u r a lier...
@@yasirquershi3070 why?
Very helpful, thank you
Please share my channel link with your friends and help me to reach big audience
Nice explanation. Thanks.
Andrew Foers don’t forget to check out other videos in the playlist .....please share among friends and help me to reach big audience
Very helpful, thanks!
Glad to know that it helped....share among friends and help them as well
Do video on regulations of t-cell and bcell response
Check out the immunology playlist and you would find it....
i think regulatory t cells can have either CD8 or CD4 receptors.
As far as I know treg cells are subclass of cd4 t cells......I would check the current literature and let you know......thanks for raising the point
@@animatedbiologywitharpan yeah I have seen it in some articles. I will also try do further research. great video though!!
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It's really helpful....can you please make a video on foxp3 role in immunological pathways of recurrent pregnancy loss.
aynal saba please share my playlists with friends and help me to reach my audience
Ya sure.
bro if its ok...can i get ur ppt file or pdf file...i need this for my thesis...and ofcourse i will credit you and also label your name under reference...
What is ur topic for ur thesis
Thank you sir
Please share my channel link with your friends. Stay tuned
IL-2 compete IL-10autoimmune disorder delayed anti-inflammatory response
what about TGF-β
thnx a lot...😌
Tanushree sarkar glad it helped ......share among friends and help them as well