Why sex really matters | David Page | TEDxBeaconStreet
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- Опубликовано: 27 авг 2024
- David Page, Director of the Whitehead Institute and professor of biology at MIT, has shaped modern genomics and mapped the Y chromosome. And he's here to say, "Human genome, we have a problem." Page contends that medical research is overlooking a fundamental fact with the assumption that male and female cells are equal and interchangeable in the lab, most notably because conventional wisdom holds that the X and Y chromosomes are relevant only within the reproductive tract. But if the sexes are equal, why are women more likely than men to develop certain diseases, and vice versa? This compelling talk from TEDxBeaconStreet foretells how changing the way we understand the sexes could transform health care.
The Director of Whitehead Institute and MacArthur genius grant winner David Page is a pioneer in genetics, and his renowned studies of the sex chromosomes have shaped modern understandings of reproductive health, fertility and sex disorders.
In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations) 
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It's about time people started studying this. I think a lot of us out there have suspected this type of thing for a long time.
Biology mode on XDDDDDDDDDDDDDDDDDDDDDDDDDDDDD
Could anyone make this same speech today without getting cancelled?
No. Men and women are not the same and life starts at conception. Thanks for coming to my TED talk
He is a very good orator, every word is delivered, important thing especially for non native English speakers.
Xxxxxxxxxxxx
I’m sure his wife thinks he’s a great orator too
@@AlmostaFlipinSkater are you absolutely sure or just a little bit?
Came here to learn about why the act of sex matters, but thankfully found this to be a fairly interesting talk.
yes I thought the topic was about sex and sexuality being healthy for humans. But the talk was a topic I'd find interesting though I thought the title was purposely deceptive.
9. Les hommes qui ont écrit la Bible étaient-ils honnêtes ? Qu’est-ce que cela montre ?Jean B
Still taking notes and texting in class
this is a great presentation. i can only imagine how great a teacher this guy is. the genetic test i bought actually verified a few things that i was previously told by a doctor and counselor
Excellent, superb presentation!
Mr. Page had my rapt attention throughout. His clear diction, and the pace of his phrasing, allowed my layman's mind to easily fully comprehend every point that he was putting forth.
Now, almost ten years after this talk took place, I'm first hearing of this concept.
That makes me wonder how much progress has been made in the field.
It makes 100% absolute sense.
I will be talking about this subject with others and researching it further.
Thank you very much, Mr. Page.
Not sure why but after watching (mostly listening) i feel so much calmer...
But i love it how this person asks certain questions and is not laughed at. like most people that try to better the life or the knowledge about the universe.
Hi 🙋
Men and women are fundamentally different.
Shocking and controversial.
Hi there I can still
testosterone, and estrogen logic , and emotions
Excellent talk. I am grateful that at least one scientist is still a thinking man who has the moral fortitude to finally state the obvious.
It's recently been determined that autism spectrum disorder is more widely recognized in men because it presents differently in women and girls than it does in men and boys. It isn't necessarily that it's more common in men, but it's often been overlooked in girls and women because doctors didn't know what they were looking for.
Thank you! I think their are some other things wrong with this video. Not saying he is incorrect throughout whole the video.
Was looking for this comment. This was a good Ted talk but it makes me also want to hear a Ted talk about how things like diagnoses and seatbelts are designed for the male subject
@@fiekelief He also claimed that chimps males share 98% of their DNA with Human males. This is misleading. In reality, if you include indels the number drops to 95% with some conservatives dropping the number down to around 90% when talking about MtDNA comparison. On top of that, while 18 pairs of chromosomes are ‘virtually identical’, chromosomes 4, 9, and 12 show evidence of being ‘remodeled.’ In other words, the genes and markers on these chromosomes are not in the same order in the human and chimpanzee. Chimp's DNA structure is different from human DNA. So I'm not sure why he tried to mislead the audience so badly there.
I would say that if it presents differently in women and girls than it does in men and boys, it actually reinforces the concept that Dr. Page is trying to get across, that the XX vs XY combination makes a big difference in all aspects of human health.
A little correction: chromosomes don’t carry all the hereditary information. There are mitochondria in the cells also contain DNA, which are only from the oocyte. So in term of hereditary material, offsprings get more from their mothers.
I dont know.. I am exactly like my dad in looks and calibre and personality.
@@RAIRADIO bruh
The mitochondrial DNA accounts for much less than 1% of the total DNA.
But yeah, you get very slightly more genetic material your mother. Also some certain 'mitochondrial diseases' can only be passed on from a mother to the child.
Thank you very much for expressing in a simple and direct way what many laymen know without being able to qualify. Now the important is to convince doctors of the advances and new challenges. It has been very gratifying to listen to an expert and great communicator. Really necessary. Thanks again!
So much humility in the comment section.... Get over yourselves people. How many ted talks have you been invited to give? I'm not saying giving a ted talk means you're infallible but most of you have ZERO credibility, other than a PhD in criticism and arrogance. Let go of your egos and try to gain some insight from someone who has devoted decades of their life to developing extensive domain expertise.
I doubt you know the credentials of these commentors, they could be professors or they could be fishermen. You don't know, you are in no position to judge the validity of these peoples points. If you want to do that you should at least look into their backgrounds and fact check what they are saying, of course including references and a bibliography. If not, then I'm afraid you're the one with zero credibility, playaasaaaa!
tell em, lopez!
way2tehdawn Hi, I did some research and I found out who this guy is. and he really is an authority in the matter, he is the director of an institute, a professor at MIT, has won several awards in his field and The New York Times and other big magazines give him credit. I hope he makes great breakthroughs in medical biology. So, I appreciate his efforts and those of the TEDx Talks community.
Vanessa Voxx l'm amazed that you haven't gotten a + until now . way2tehdawn seems to think they let any bozo with no cred talk . Yeh right .
+Argentarii Homini , amour, , 6
I really enjoyed this presentation. The presentation is clearly pesented and intelligent. This talk is about why scientists should take into account the genetic differences in the treatment of diseases. Dr. Page is right that the scientists should not turn a blind eye to this fundamental gender differences when trying to find the treatments for various types of diseases. Some commenters said that the feminists would not like his talk. I said that he is on the contrary trying to debunk the bias held by the male-dominated science community that has tendency to treat diseases from the unisex standpoint (totally ignoring the fundamental differences between xx and xy chromosomes). The outcome of such false medical practices is flawed medical research and practice on the treatment and control of diseases.
I consider myself a feminist, well a "traditional" feminist if you will, and I totally agree with you. This talk was very interesting and underlines very well the sex blindness that is rigging a lot of medical studies, and why it matters that we get rid of it.
Robert Henstein Thats very crass its the 21st century.
Oh Robert, you've taken the religious approach rather than the scientific one.
Beautifully put. His entire point is that our approach to science, specifically the treatment of disease in regard to genetic differences relating to gender, should not be biased based on our social constructs, hence his use of the quote by Bill Clinton. Anyone who is attempting to bring up feminism,or any other cultural philosophies from a place of personal bias in regards to the subject of this ted talk is completely misguided.
Agreed. Differences may be small but they are important for treatment. I do think that his attempt at humor using the Clintons should have been left out. I also think that saying that men and women are not equal is done provocatively, just as the title was. Men and women are not the same is actually a more accurate statement and scientists should strive for accuracy. Ask yourself if a hammer or a screw driver are equal or the same and you will see how this works.
I keep forgetting this is about what gender you are, not about how important sex and intimacy are.
I should take this into consideration in my PhD next year, amazing how I or my supervisor never take these things into consideration.Thank you
mpoi makhetha 9The
Would be great! Now being a year later, do you? 😊
All the best
They are notidenticl. That is not to say they are not equal.
Being equal is not the same as being identical - we can acknowledge differences between the genders without ranking them
Well, maybe he could have phrased it better, but he is correct. He is not saying that people should not consider men and women socially equal, he is basically saying that diseases don't treat them equally.
R5reee! 56zà
Men and women are equal when it comes to who they are. They both are spiritual beings , They been programmed to perform different task in life.
Equality is a human creation(which doesn't exist anywhere in the universe) , it is synonymous with identical.
Being equal means having equivalent value, not being identical. Equal respect in respect of our differences.
Most of the people criticising don't even know what the speech was about.
But they do know that they wasted about ten minutes of their time.
David Page is making a case for using the male/female filter appropriately in our research because it could be impeding our progress.
Didn't think it was boring at all. I wish more people on this level of intelligence would also think outside the box. We might get a lot more accomplished.
He is a perfect example of an inside the box thinker. In the statistics interpretation he ignores completely sociocultural effects of the culture of dividing people in genders, wich is the most logic explanation for the data he presented since the different genders have different behaviours wich will lead in the statistics to different responses in health to certain diseases, or even a general difference. This difference is observable and may be tested since not everyone of the same gender has the same biological sex, thefore the hipothesis 0 should be that the correlation is socially caused, meaning that he should first prove it is not socially caused and just later sugest that is is caused by some factor that is different between biologic sexes, wich might or not be the X Y chromossomes. He said that the answer he hears the most when asking people the reason of the statistical difference he presented is "i don't know", so he obviously must be ignoring all te explanations or even not looking for answers from people who understand what he is showing, probably both. He is just intellectually disonest and obcessed with proving right his sexism.
Joaquim Pedro I'd have to disagree, why? I'd like to think that in the process of trying to determine why women and men suffer from disease A or B differently, that the researchers have examined the lifestyles and habits of the individuals they are studying as well as the environment they find themselves in and as such, would have taken into account the differences presented by gender divisions either knowingly or unknowingly. It wouldn't make sense to try and determine why there are differences otherwise. So, your argument that socio-cultural effects of dividing people up into genders is the root cause should already be off the table, unless you are saying that merely associating yourself with a gender will make you more susceptible to one disease.
So, yes, what he's doing would be considered outside the box thinking. He's considering a possibility that people are overlooking in a situation where all possibilities should be looked at.
He actually was not being sexist, he clearly knew the impact of saying men and women are not equal and did that for dramatic effect. I'd argue that YOU were being sexist by inferring that he was being sexist merely by stating that there might be a genetic reason behind women and men having different affinities for certain diseases.
It'd be stupid not to look into something simply because it points out one of our few differences, after all, a difference does not make one thing or the other better.
klick08 He showed a correlation between gender and response in life expectancy given a disease, nothing else. Using a method for eliminating the sociocultural effects of gender is really important, since those effects obviously exist, after all everybody knows that different genders have different healths, and the biological sex is ALWAYS attached to gender or to many gender related values. With this in mind what becomes really important in his research, what gives it validity is the quality of this specific methodology (and you seem to agree with me, since you said you’d like to believe he used it). He has to present it, otherwise it is the same as no research at all since the difference in health he presented is already wkown by everyone, everybody knows men and women’s health are different.
He didn’t even bother to suggest having considered those factors. And even if he had considered, the efficiency of this methodology would rely on knowing EXACTLY what are the sociocultural factors that are influent, and that is almost impossible. He could never guarantee to have covered everything. He could only try to suggest some correlation after intensely refining this methodology, observing changes in results according to changes in it. And, obviously, the methodology must always be presented.
You would be very much surprised to know how much, willingly or not, this kind of bad or absent methodology convinces loads of people of invalid conclusions based on utterly meaningless data just because they “would like to believe” something; because as there are people who would like to believe something there are researchers who would like to convince people of something. And some would like to convince people, and/or themselves, of the supposed results either for notoriety or to rationalize a personal belief. Scientist are people too.
Wich takes me to this: You said, “...he clearly knew the impact of saying men and women are not equal and did that for dramatic effect”. You take this as an evidence that he is NOT sexist? You think he wanted to be dramatic to alert people of the social dangers of saying things in a stupid way like he is doing, or what?
Other thing: “...unless you are saying that merely associating yourself with a gender will make you more susceptible to one disease.” Men and women have different behaviours, wich will lead to different healths, be it as a response to a given disease or as susceptibility to a disease. So, yeas, associating a person with a gender will dictate the behaviours wich will change health. That’s the whole point of sorting out the socioculturally caused difference.
And i believe by now you have understood that i’m not “inferring that he was being sexist merely by stating that there might be a genetic reason behind women and men having different affinities for certain diseases”. I do believe those differences must be considered when proven to exist, and there must be research about this matter. The only thing i’m saying is that he didn’t show anything that should convince anyone of what he is willing to convince. Actually the fact that he couldn’t find any evidence of it only makes me think that there are actually less difference than people think. Research in this subject is not sexist, but the sexism suggested by his attitude was just the most probable reason to have led him to make this research.
Hard to think if you're snoozing
@@joaquimpedro3267 OMG... So if I were to have been dressed up in girls clothes from an early age, played with dolls, stayed home with the kids, washed the dishes & floors and had the occasional “girls night out” I’d be more likely to contract RA or Lupus than “men”? Right... 🙄🤦🏻♂️🤦🏻♂️🤦🏻♂️ (btw. I’m XY if that matters... 😏)
If you are not in the arena with David Page or anyone else, you have no right to criticize. If you are in the "arena", give him feedback that's useful.
Wow, this is very intresting. I was really grabbed by the fact that students studying human cells dont even know if they are male or female. Very intresting. Has there been any progress on this comprehension in the science community since of the bilogical diffrence?
I decided to stay up all night and study different ted talks. its onderflly interesting, and more peaceful to study at night.
I am surprised to know that medical research has left unnoticed this important difference between human beings. I hope that in recent years that has already been corrected. Great talk Mr Page. thanks a lot for the enlightenment !!
That's what I found shocking. How such intelligent people can miss something so essential and I would have thought, obvious.
One fundamental notion also never addressed by earthlings is the absence of rut from their own dna/genome (Mammals; Anthropoids; Cro-Magnon, mating season). Which will certainly require a definitive remede, eventually.
Hi Hugo have you come across the book Cupid's poisoned arrow?
@@CarolinHauser Hi Carolin ! no ..I guess I should look for it and read it uh thanks for your recomendation ! best regards !!
@@hsierra50 yes I highly recommend it
Lol at all the people complaining because they don't realize that the word sex can have more than one meaning.
Loppy2345 y
This comment has changed my life
You are absolutely right !!! :>)
Loppy2345
get off this damb line.
Lou Leone hey what's up.
I loved the close-up of the X and Y chromosomes. Will be interesting to hear what XY/XX researchers come up with.
Drug trials on humans are done with mainly male volunteers aged 18-35. This is to avoid potential harm to female reproductive organs.
No, it is not. It is because women reacts differently to the same dosis/kg bodyweight. If I, weighing at present 64 kg, takes 3 6cl-schnappses, I will be more than tipsy, I will be drunk. If a man weighing the same, takes the same amount of alcohol, he may not be tipsy, but he will be much less drunk.
There are at least two reasons for that:
1) Men have a larger percentage of water in their bodies.
2) Men's livers work faster breaking down alcohol than women's.
Many medicines behave similarly. So, to make thing easier (and cheaper!) for those who do drug trials, they have used men. Which does NOT make things easier for the women who later on uses the medicine. That is why women have a higher rate of unwanted side-effects from drugs. Those who do their research says: - But they work just fine with men!
Maybe that's true Birthe - I can't say. I worked at a drug lab; the doctors told me that protecting women's reproductive organs was the reason they mainly use men instead.
That's just silly. Don't the men's reproductive organs need protection too?
Hi Birthe
I worked at the drug unit about 10 years ago so I'm not sure of their current policies. While I was there women did participate in trials but most were conducted on men. I remember I was given reasons along these lines (pasted from article):
"There are also historical reasons for excluding women, particularly those in their child-bearing years. In the 1950s, the sedative thalidomide caused pregnant women to give birth to babies with missing limbs, and DES, an estrogenlike drug prescribed to prevent miscarriages, increased the risk that female babies would develop rare vaginal cancers later in life. When these findings came to light, clinicians and drug companies became cautious. "There was this worry: What about women who might get pregnant?" says Ruth Faden, executive director of the Johns Hopkins Berman Institute of Bioethics."
I've included the full article (see link below). It discusses reasons for excluding women and why that might be harmful. Very interesting.
Drug Problem: Women aren't properly represented in scientific studies
www.slate.com/articles/health_and_science/medical_examiner/2010/07/drug_problem.html
I am amazed that scientist study cells without knowing whether the cells are male or female. That should be the first thing in the label when the cells are collected.
Probably done to eliminate scientific bias.
Amazing how 10 years ago it was understood that men and women are different. “Men and women are not the same, life begins at conception. Thanks for coming to my TED talk “
I think that's precisely why he used such a wording, to provoke people and keep them interested in the important things he's said. It's really just a matter of capturing interest.
I think so too and in my opinion, it's important to notice that this is a very specific subject.
that wasn't what I expected. thanks for sharing
this seems like common sense. The Y chromosome is not dormant in nonsex organ cells. The proteins produced by the Y chromosome are not just male hormones. Males and females present different symptoms for some of the same medical conditions. They respond differently to some medicines that are not know to interact with sex hormones. It is also known that children and adolescents do not always have the same symptoms of some disease or do not react to medicines the same as adults. Different genes are active to different degrees at different ages. Surely those genes are not only the genes for sex hormones? Could some of the differences also be from our wanting to simplify our understanding of the human genome?
Yes. It comes from human ability to be lazy and take shortcuts that turn out to be a stumbling blocks to good science and good practices. It seems researchers, for whatever insane reason, decided to dismiss the XX/XY variable in their work. That cannot be said for all research, but it seems to be the case in genetics if this speaker is correct in his conclusions. The real question is: Was it politics that caused the ignorance or just simple human error?
Why are we so uptight about this? This isn't about feminism. That was a poetic license, phrases used for a rhetorical effect that'll pique your interest. This TEDx talk is thought provoking as it should be. Just like how we address vulnerability of a race towards some diseases. Judging racist or sexist wouldn't help you with breakthroughs of how we view health and/or treat diseases. Let's be pragmatic for once.
I don't understand how this only has 2M views after 8 years. It seems like no one has listened to this man. Men and women are still suffering from these diseases without much progress.
I wonder about 1000 people who disliked this. Great speech and thinking!
Yes I agree!
Misleading title but a tedx talk that actually brought some important knowledge to general public for once.
My intuition is that autoimmune disease is a lot more prevalent in women because pregnancy is a weird process for the immune system.
Sara Anderson
Interesting. It's certainly a valid consideration.
Wow. How smart. This should be pursued.
Whoa. That made me stop and think. Awesome comment!
Very informative and well thought out talk. You definitely raised the bar!
Disease is not merely reflection of genetics. For a professor at MIT, I'm surprised he does not acknowledge the obvious counter-argument to his presentation : that disease, just like any trait for that matter, is mixture of what is ACQUIRED and what is INNATE. Life experience, societal upbringing, gender roles, behavior, have probably as much impact on us and our health - as do our chromosomes. Granted, it's true "we don't know" to a full extent what causes disease, but the fact that we have men with rheumatoid arthritis, or females with autism kind of makes me wonder just how the X versus Y "theory" of disease has any relevance... Just my thoughts. Still a fun to watch, nice presentation.
With eight minutes, he could hardly have given much time to counter arguments.
How can you not mention diet as a factor for health when we know that the consumption of animal products promotes cancers?
Frederik Dortmund
Because he has eight minutes and his topic was not "Why you should be a vegetarian"
and rheumatoid arthritis can be contributed due to the lack of exercises especially in the form of resistance training ie. body weight training; weight lifting; career related as no woman would carry no heavy shit ever at their job. (giving their bfs the grace of carrying their shopping bags). How can we say this is gender related due to nature and not NURTURE? he should at least address this. Women are susceptible to osteoporosis(weakening of bone density) than men due to calcium absorption at older age however, it is not significant to show the disparity between the statistic.
However his talk about why diseases should be treated with women and men, getting more informations about cancers and diseases would be a very good resource for understanding illnesses and the field of epidemiology. However his presentation was not that related. However i enjoyed the pictures of the chromosomes
Constantin Filip Woah.. Preach on brother!
God finally I hope this man is going to save so many lives if people will only listen
It seems kind of obvious that the XY chromosomes would make a difference to the entire person, especially when you consider the things that go wrong in people with XXX and XXY and other mutations of the XY set. I'm amazed they haven't thought about this before now.
this man is amazing..you rock sir
when genius + creativity = this man.
Genius+creativity= Einstein
It would be interesting to examine people who have had organ transplants from one gender to another in this regard.
1lightdweller h
What about blood transfusions ? xx or/and xy cells
@@ya472 Red blood cells don't have a nucleus in human beings or in other mammals. So it wouldn't have any nuclear DNA. It also loses is mitochondria so it doesn't have that DNA either.
@@englishgalmd How do they get DNA from a blood sample?
This is about healthcare. Why does feminism or *insert ideology here* need to be brought up?
In line with this idea, it's kind of surprising it's taken this long to think of. I don't know biology, but would assume that chromosomes would have a lot to do with everything, considering it determines your sex, a pretty big distinction
Vince Lowe It´s not about what he says, it´s about how he presents it.
And btw. that sex makes a medical difference is long known - I at least know that they 1993 finally included women in drug studies, after they had twice the chance of side effects in AIDS medication.
Vince Lowe UFO sightings
Vince Lowe UFO
Vince Lowe p
Vince Lowe m
gender and sex are NOT the same thing, actually. Sex is the biological aspect of the differences between chromosomes, gender is a socially constructed concept attached to XX/XY differences, which considers the social and psychological aspects of this.
Anatomically higher levels of testosterone can help prevent arthritis. In fact most of his questions I would say the persons hormones and imbalance in those hormones over a lifetime often can cause disease. Beyond that for the same gender at the same time, a different lifestyle changing the results greatly
Men and women are equal
Men and women are not the same.
?
Well that title got this ted talk a lot more attention than normal
Haven't seen this one in a while. Figured it would have been banned by now.
I am discovering more and more that most medical research was only ever done on MEN.
Women were considered just "too complicated" - they bear children, have periods, go through menopause - all health-related issuses never experienced by men. This was considered "too complicated", and as a result the symptoms of the same disease are not recognised in women, though they are in men.
It is very high time this issue was addressed - and it beggars belief that it still isn't, all these years later!
It is way past high time this issue is addressed, and way past time this research gets funded.
This presentation answer alot of questions I have in mind . Great presentation thanks Ted x
Super interesting specially now that we see the difference of the severity of covid between men and women 👍
Staggering really, that medicine - a field based in biology - should have a blind spot regarding two obvious biological facts. People mostly come in two types, and every cell in the body reflects that division.
As a physician I agree, receptors and its reaction to stimuli is gender dependent, take pain as example
@Nikki Pettway The threshold of pain is not the same (valid paper science) which concurs with the data on the video
Great talk. Very interesting. I hope that this discovery will usher in new answers to the myriad of diseases found in man & woman and towards its cure, God willing.
Non binary people watching this:
👁️👄👁️
No hate, it's just gonna be a pain to find out xy or xx without y'all getting upset
This is very interesting research, but I think the phrasing is something that he should be very careful about. As comments here already show, many people are bound to misunderstand the phrase 'men and women are not equal'. I doubt people will realise that he is talking about disease and will instead use this as an excuse to justify socially and politically, etc. inequal treatment of men and women.
Eh, there are always people who have opinions. It's really not researchers wrinkle to work those out for them. Each researcher is spending their lives trying to figure out life and the universe for themselves and are really only willing to express the principle in the language that was created to discover these things. While people will assume that the reasoning is an "ism", it is because the language for biology has been under creation and strict restrictions to avoid the irrationalities of religion. While psychology and social sciences have allowed the cultures they are studying to depict the language. Using biology terms such as asexual in one science but meaning something else in a differing science creates convolution and so on and so forth. So people can complain and ridicule as they like. But if they aren't putting in the reading and the thinking that these subjects do deserve then that's on them. Sciences will move on without them and keep them fed if a bit unhappy.
some notes from the talk...
* genetic difference between men vs women (98.5%) compared to men vs men (99.9%) is 15x greater, due to Y chromosome (we wrongly believe that Y chromosome only affects reproductive tissue, now know it's present and affects every cell in your body)
* relates to disease incidence, e.g., autism is 5x more prevalent in men, rheumatoid arthritis 3x more prevalent in women
* have tools to understand why one woman (or man) is at higher risk of a disease than another, but not cross-gender
Really worht watching I have known this all the time since I was growing up I think that it is commendable the research world starts their focus with these insights. Dr Page good work.
This is fascinating. It makes me curious about the effects of hormone treatments in people that are transitioning in relation to their biological xx or xy chromosomes.
Already happened before, mid 80 - late 90, lots of athletes were using anabolic steroids (dope). This thing causes all kind of problems, changes people hormones - have different effects between men and women.
This has been truly fascinating, to know what research is currently being conducted, and on what basis. Without your very valuable input, we would never have known - So thank you very much for educating us! The Indian Ayurvedic system of medicine treats people according to the 4 elements, in terms of our body types, what we prefer to eat, and have even mapped out very accurate personality profiles according to each element - air, fire, water and earth. It's also so inspiring when Eastern and Western health experts share their expertise, and knowledge that's often 1000's of years in the making!
have you come across the book Cupid's poisoned arrow?
This is such interesting research that results in profound questions. More people, and doctors especially, need to hear about the differences between X & Y.
His microphone is shaped funny lol
I'm curious. What is the genetic make up of intersex individuals? Do they have an imbalance in their system? Are some of their cells XX and others XY?
I am in biomedical research and I have never been taught that the Y chromosome is only affecting the reproductive system. The differences in diseases have always been accounted to the chromosomes in my circles.
Good to hear. I don't know how long you've been in the field but this talk was 8 years ago and maybe why you do it differently now.
I think this talk was incredibly well presented, and here`s why. Beginning with the quote from Bill Clinton, he illustrates the ways in which our cultural environment can influence, perpetuate, and also benefit from social constructs. Such as, equality across gender and race. The negative aspect of this is that it has biased our scientific approach. However, the benefits of our social ideologies are becoming apparent *as well* because it indicates that while our social environment is promoting equality of life and experiences regardless of gender, we are now seeing despite this environment of equality there remain unexplained differences between genders which we can now approach from a scientific perspective.
This is brilliant and this man is a genius .
I thought everyone already knew this.
How does this affect blood cells?
Particularly receiving and donating blood.
from further up the comments 'Red blood cells don't have a nucleus in human beings or in other mammals. So it wouldn't have any nuclear DNA. It also loses is mitochondria so it doesn't have that DNA either.'
Usually nothing but men should not get blood from a woman who has been pregnant because there is a protein that can me deadly to men in the blood of women who have gestated.
To half-answer the question, according to genetics, all intersex individuals are male. They have an X and a Y chromosome. However, there may have been either a mutation or a damaged copy of either the X or Y has been obtained and somehow continued to multiply (There is a mechanism that's supposed to kill an 'incorrect' cell.)
There are usually some other genetic complications on top of the genetic complications of having an XY. Its really an interesting topic, and 'intersexuality' is various.
On the Y-chromosome is one geme (sry gene) that codes for other genes to work out as ether male or female. So intersex is probably a disfunction of 'switching of the female genes and switching on the male genes'
I don't know if these researchers have tried to determine if environments/culture of these sexes have any effect? Would Lupus statistics be the same in the US as opposed to UK, India, or China? The food we eat, the amount of activity we do, how clean our environment is, can effect the likely hood of these genetic diseases being switched on (epi-genetics) as well as the socialization of the sexes (Men drink more, work in hard labour, etc..)
Also noted from some comments here where the process of diagnoses of diseases is flawed because they often look for traits that are shown in one (Autism) but the other sex is neglected because they lack this checklist of traits. Is this due to biological difference, or is there a sociological difference at play?
I understand the idea that this video is going for, but there are so many other factors one has to cross out before we can look at it directly from the sex/hormones (with the exception of reproductive diseases of course)
+Shannon LeClerc Don't know about Autism but for Dilated Cardio. there is nothing cultural about it. If it's in your DNA, you get it. There might be environmental factors at play, but researchers are usually smart enough to not select one group from china and other from ireland.
There are undoubtedly some sociocultural reasons for the differences between male and female disorder rates. But at this point in time, it's pretty clear that the main reason for the differences is the genes.
Look into what the implications of X-linked diseases. This means that men with a mutant allele on the X chromosome will not have a healthy copy to compensate, therefore has a far higher chance to get the X-linked disease. It's a matter of statistics, women are astronomically less likely to get it. If carrier probability is p=0.1, then men would have a 10% chance to get it, women would have a 1% chance to get it, though the real probability is closer to 0.001
+Raymond Piatt Two X chromosomes is like having a backup hard drive so if a part of one drive is corrupt, the backup has the information to perform the task. Therefore, the women will only get a mild or no deficiency experience from the corrupt gene. Men have no backup X so if the X they get is flawed, they get the full force of the genetic deficiency. That's life.
That's not really the full story. The XY chromosome pair is number 23 out if 23. The other 22 are all "XX" chromosomes for both genders. The vast majority of genetic diseases and deficiencies result from the non-sex chromosomes or are partly influenced by non-sex chromosomes. Yet, gender still affects many of those conditions too. This can only mean the Y-chromosome is very promiscous in the parts of the body that are altered. And not always for the worse. Many times the Y-chromosome makes males less likely to get certain ailments. It's not that women have an extra copy of their hard drive, it's that men and women run on fundamentally differenent operating systems.
Key point - they're genetic diseases, not environmental.
I have posted this comment before and it has mysteriously disappeared, like some of my answers to other comments, so here it is again:
In the statistics interpretation he ignores completely sociocultural effects of dividing people in genders according to the biological sex, wich is the most logic explanation for the data he presented since the different genders have different behaviours wich will lead in the statistics to general differece in health, like life expectancy or even responses in health to certain diseases. This difference is observable and may be tested since not everyone of the same gender has the same biological sex, thefore the hipothesis 0 should be that the correlation is socially caused, meaning that he should first prove it is not socially caused and just later sugest that it is caused by some factor that is different between biologic sexes, wich might or not be the X Y chromossomes. He said that the answer he hears the most when asking people the reason of the statistical difference he presented is "i don't know", so he obviously must be ignoring all te explanations or even not looking for answers from people who understand what he is showing, probably both. Using a method for eliminating the sociocultural effects of gender is really important, since those effects obviously exist, Everybody knows that different genders have different healths, and the biological sex is ALWAYS attached to gender or to many gender related behaviours. He is just intellectually disonest and obcessed with proving right his sexism.
Dont get me wrong, research in this subject is not sexist, the sexism suggested by his attitude was just the most probable reason to have led him to make this research. I do believe those differences must be considered when proven to exist, and there must be research about this matter. The only thing i’m saying is that he didn’t show anything that should convince anyone of what he is willing to convince. Actually the fact that he couldn’t find any evidence of it only makes me think that there are actually less difference than people think.
Most people would be very much surprised to know how much, willingly or not, this kind of bad or absent methodology convinces loads of people of invalid conclusions based on utterly meaningless data just because they would like to believe something, because as there are people who would like to believe something there are researchers who would like to convince people of something. And some would like to convince people, and/or themselves, of their supposed results either for notoriety or to rationalize a personal belief. Scientist are people too.
So you are denying that there might be medical differences based on sex alone? Is that your premise?
Joe Dokes What? Read the comment..
Great comment!
Joaquim Pedro Different cultures and subcultures all have their own role distinctions or lack thereof. The data he mentions and specific illnesses he highlighted are the most consistent across controls. In fact even with the increase of rate from vaccine injury autism is still most commonly something a child was born with. The treatment of that individual has no chance to influence the occurrence of that injury. For anyone who doesn't have the bare basics of autism, it is caused by brain damage.
Indeed just because his research shown a certain diffrence it doesn't mean it's genetical. Yes we are diffrent in our bodies in many way, but on a CULTURAL level women are exposed to less stress thanks to their less significant roles in making desions and far less hard manual labor (being exposed to chemicals, anything with heavy lifting etc.) which are all danger factors in diseases. Women have their own role related danger factors. Also you can tell from his use of language that he wants to spark controvery for views or promote his own agenda. Using different instead of not equal would have helped us take him more seriously, but he choose hype lust over professionalism. Men would have the same or even higher lifespan if the would have the same lifestyle as women...given if they don't die from boredom thanks to their thirst for action.
A clear and fascinating discourse. Thank you.
have you come across the book Cupid's poisoned arrow?
Organ transplants also get rejected. It would be interesting to look at the rates between cross v.s. same gender organ rejection, but sadly I don't think such studies exist at this point. That is part of the point of this talk, that we should be studying such things.
Incidentally current studies are indicating that it is not unreasonable for people to get organ transplants from pigs with possibly only a few tweeks. So there is no difference between people and pigs?
Guys if you watch this on 2.5x speed he talks like a normal human.
thank you! hahah i only went up to 1.5 but it made a huge difference hahah
You must have a better youtube than I do. I can only crank mine up to 2x.
I find that most of the ADHD videos are easier to watch at > 1x.
2x is only the beginning. In the perfect world, we'd be able to crank it up to "11".
WTF THANK YOU!!! Ya boy was talking in grandma miles per hour.
Hahaha I thought I was the only one who did this!!
Omg! Thank u!!!
Aren't the statistics on Autism Spectrum Disorder difficult to quote because research has been primarily and in HUGE part centered around the common symptoms and tells for boys and very little has been done to see how ASD is expressed in girls? There are so many girls who have ASD and can't be diagnosed because some hide the signs of their place on the spectrum and because so little is known about how to distinguish its features in girls.
Ry Ting ASD you think girls can hide ASD? But boys can't? You think ASD hasn't had enough research to find basic consistencies??? Are you aware that ASD is an umbrella term and has many illnesses that fall under that general term? ASD has been well studied plenty, just like many other ailments that disproportionately affect males. Scientists are scant to study females because our systems are believed to be more complex. But don't get that conflated with the actual data on who is affected by it. Especially since the general belief is that most illness associated with ASD is caused by testosterone.
Perceptial bias in full force there are difference s in disease among men and women and many other traits which is why I stated men and women separate but equal
Wow, superb talk. Thank you.
My personal opinion: the big difference in diseases exist because of beauty and hygiene products. Skin is the largest organ - what we put on it influences hormones, organ toxicity, cancer risks.
Men use less, modern marketing tells women to use more. Tampon chemicals are enough to give any woman a hefty dose of PMS or auto-immune disease.
Why are the brightest in these respective fields so myopic toward these simple changes that could make a HUGE shift toward WELLNESS???!!!!
It's honestly terrifying for me to trust any "specialist" or GP.
Am I going nuts? I can't exact the time, but around 13.59, he actually does a time glitch! Nope, I can't be serious! Hey? Somebody please tell me that this glitch is not only for my eyes! Wow!
This is a very informative video! I learned a lot!
this title tricked me :/
hehe. It tricked me too, but I am into genetics and relationship stuff both. So, I'm glad I clicked.
@@smallheelcatcher guess I can safely skip this bs lol thanks!
@@ShaferHart And that is the why you are an uneducated moron. END OF!
In ancient Egypt it was known that the Earth is not flat.
How could anyone dislike this video? Very eye opening...
Probably pissed off those pushing their woke BS like lots of multiple genders rather than XX and XY...
@@HJC1950 there are cases of xxy and xyy. What gender are these people.
@@jasonwiley798 Who cares? What percentage of people fall into those categories?
@@HJC1950 my point is there are more than 2 biological sexes. It isn't as simple As you would love me it to be
Wonder why it's taken so long to recognize this
have you come across the book Cupid's poisoned arrow?
How amazing that 10 trillion cells communicate wireless. What he said makes sense.
Spent 20 mins telling us that men are women are more different than previously thought and we should do something about that >_>
Scientist questions groupthink .... now that is news!! Real respect Mr Page.
Hormones play a difference in many diseases, Nutritional deficits, estrogen dominant diseases and the malfunctions caused by this malnutrition have shown them selves to be correctable. Since there can be no pill to fix this medical science sill not tackle these problems. Vaccinations also play a role in this due to the different vaccines being spaced so close together along with the aluminum in the vaccines to get a reaction from the body.
Men and women are completely different creatures. But I thought he was going to talk about how sex is important to prevent disease.
+mspixiedust100 Well, he _is_ saying that which sex you are is important information in the treatment and prevention of disease. But I suppose you were hoping to be told that engaging in sexual intercourse would prevent disease?
The title says "Why Sex Really Matters". Not why Gender really matters.
+mspixiedust100 You're confusing the everyday use of "sex" (meaning the physical activity) with the scientific meaning. Your sex is hard-wired into every cell in your body (male/female chromosomes), whereas your gender is only really about your mind (masculine/feminine attitudes, traits, preferences etc.). This talk is about how the sex of cells is fundamentally important to understanding why they behave differently in men and women, leading to sex-specific patterns of ill health.
+mattlb2 I understand the difference in meanings for the word sex. And I understand what this talk is about. But any normal person would go into this video thinking he's going to talk about why sex really matters. Not why sex matters. Maybe an asexual man might not understand that.
+cathie romero The title is very much correct. It's a bit misleading i know, but nothing can be done about it.
We use the word 'sex' while refering to male or female individual when it's about anatomy or biology. We use 'gender' in social and anthropological terms.
An additional explanations for gender related differences is the following. Females have 2 X chromosomes and genes are mainly expressed from one active X. Besides some pseudoautosomal genes, the other X is mainly silenced. Nevertheless, in many women, some genes escape X chromosome inactivation as a consequence of epigenetic instability. Sine X-linked genes are involved in most of our body functions, these escapees will affect cell properties which may influence chances to develop diseases.
When you have health problems and you go to an hospital, you learn what being a patient means.
Thanks everybody, I'm out.
Has anyone thought about this in reference to the functions of binary algebra?
Could it be that certain aspects of men, on a cellular level could be viewed as 0s and those same aspects in women as 1s. This could have a dramatic effect on how each body's cells respond to external stimuli.
Just a thought.
T3MPL3GU4RD14N, Boolean Algebra. I always think about this. Genes, however, are more like the digit spot in, say, a byte where a 1 or 0 exists. The environment is always turning on and turning off different genes, especially the younger you are. So, just like you can have "the psychopath gene" that is supressed by training, you can have genes that lead to a "positive" trait if invoked by the environment or training. Trivially, I believe that people with the psychopath gene -- which leads to lack of capacity for empathy -- hold an advantage for empathy over people without the gene; as long as they're environment 'nurtured' the quality. Another example, males dominate in tests of mental visiospatial rotation problems (flipping cubes). But provide a female more training than her male counterpart during adolescence and she completely overcomes the deficit.
You could have a micro genome such as
[a][b][c][d]
Where: a=good, b=bad, c=good, d=bad
Each can be activated (1) or deactivated (0). This may determine if psychopathy, b, is active -- unless, the environment determined that b should be used for empathy. So an activated b genotype could lead to a psychopath OR an empath.
Think of it this way. The lack of the placeholder could mean no risk for a disorder, but the host might not achieve high fitness. Whereas, the presence of it may lead to a disorder, but it may also lead to much higher fitness. Absence is safe but limiting, presence is high risk / high reward.
(Mind you, good & bad are social constructs but also determine fitness, socially or not, for reproduction and genetical advantages for the self and offspring)
I believe this is the case with other genes as well.
There are many other factors that culminate disease that are caused by excess hormonal saturation and steroidal glucocorticoids. Environmental and genetic predisposition derived by cellular mutation expedite disease within the human genome.
Even pharma companies have not looked at drugs from this angle. It is taken for granted that 98.5 % similarity between men & women response equally to all drugs. Dr David pointed out, Men & women are different as it is evidenced decades ago through genome research - XX & XY - it is time that drug efficacy be evaluated separately though separate clinical trails for men & women. Examining drugs in this way may have terrible impact on prescriptions of drugs for complex diseases. In my opinion there are no drugs yet developed for mental health problems which are very complex diseases. I have not come across any person (even through connections) who is known to be taking drugs and living life close to normalcy. Now there seems to have one more reason (in part) for failure of drug development/ research. And that is, they (pharma cos) are having clinical trials on men (say for checking/ controlling dopamine in brain) and prescribing to women. What can be expected?..
+Sunny Acrobat1 It has been studied before but no one wants to give any credit or publicity to the results because it 'offends' some people who continue to try to argue that men and women are exactly the same. Here's a study from 2005 that said, "A meta-analysis of more than 95,000 patients has shown that aspirin can significantly reduce the risk of stroke in women, but it appears to have no protective effect in men, according to a new analysis by Duke University Medical Center cardiologists." Source : corporate.dukemedicine.org/news_and_publications/news_office/news/9388
+q5sys Yep that's the main reason why no one is looking into this. A research assistant friend of mine wanted to do his PhD on the development of intellect on male and female children under the age of 5.
He spent a year working in his thesis, after that his research was shut down by the faculty because it was deemed "unethical". And he was asked to research something less "provocative"
Coincidentally that was exactly one week after he submitted his first trial's report to his supervisor.
It's sad that today's liberals are more conservative about some subjects then conservatives.
His presentation makes common sense. As a female, that is why I prefer a female primary care provider. Female Drs. have a much better idea/experience dealing with female patients. They are one.😊
Im not a specialist, so couldn’t know. But the ‘reproductive tract’ is responsible for hormones, so it can just be the case that these diseases come from these hormonal differences. However, seems best to study all possibilities.
If he gets some answers I'd love to know! I have been curious for years about how hormones play a role in my disease. I have Hashimoto's thyroiditis which is much more common in women than in men.
have you come across the book Cupid's poisoned arrow?
Macrophone hooked around an ear may problematically dis eases balance, the homeostasis of corporeal, fundamental functioning. . . Any fidgeting or flirtation exerted externally favors flaws or flowers or "FEEL LIKE MAKING LOVE" - Bad Company
Makes gender dysphoria kindof a mental thing without much physical justification.
Interesting.
No disrespect, but I feel like that’s a logical jump b/c it’s assuming those individuals do not (tend to) have chromosomal differences (XXY, for example). I am not claiming that they do, I’m just saying his talk doesn’t rule that out. As such, I don’t feel like it can be said to do quite what you claimed.
Sex and gender are two different terms.
Sex - n. either the male or female division of a species, especially as differentiated with reference to the reproductive functions.
Gender - n. a set of classes that together include all nouns, membership in a particular class being shown by the form of the noun itself or by the form or choice of words that modify, replace, or otherwise refer to the noun. The most familiar sets of genders are of three classes or of two.
Ty loved this presentation though it was done 9 years ago. Ty!❤