Plague Inc: Official Scenarios - Mad Cow Disease (Mega Brutal)

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  • Опубликовано: 12 фев 2018
  • FINALLY. With a tight strategy and a lot of luck, it CAN be beaten on Mega Brutal.
    If you enjoyed this video, consider hitting the Like button! It helps the channel grow by affecting search results on RUclips.
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    No copyright infringement intended. Plague Inc. Evolved copyright is owned by their respective owners which includes but is not limited to Ndemic Creations. I did not make the game (or assets) and do not claim to. I do claim recording the video and audio associated with this playthrough.
    Music credit:
    "Shake Down"
    by Gavin Luke
    Provided by Epidemic Sound (www.epidemicsound.com)
  • ИгрыИгры

Комментарии • 1 тыс.

  • @uqqr3464
    @uqqr3464 5 лет назад +2546

    *when he start and Saudi Arabia and instantly gets pork*
    *us Arabs: are we a joke to you?*

    • @dmichand5191
      @dmichand5191 4 года назад +41

      Maybe...

    • @MostafaAhmed-bp7ce
      @MostafaAhmed-bp7ce 4 года назад +41

      I dont think it really affects the game

    • @baimm5390
      @baimm5390 4 года назад +143

      Mostafa Ahmed it’ll be cool if it did

    • @LazoGT
      @LazoGT 4 года назад +14

      @@baimm5390 it does im pretty sure

    • @whitejester
      @whitejester 4 года назад +83

      As a Muslim this is hilarious

  • @r4r1ty69
    @r4r1ty69 6 лет назад +1089

    9:42 I just want to see a boat get into Greenland (uninfected boat goes into Greenland)

    • @Anna-kj3np
      @Anna-kj3np 4 года назад +72

      Punked by the universe. You see it all the time.

    • @hempellsravens
      @hempellsravens 4 года назад +1

      No there was a boat going

    • @birdmonster115
      @birdmonster115 4 года назад +1

      @@hempellsravens what?

    • @chudsoyjak
      @chudsoyjak 4 года назад +1

      @Bobska is epic lol yes

    • @DiamondYoshi101
      @DiamondYoshi101 4 года назад +20

      Pravus: Listen here you little S**t

  • @kyloluma1212
    @kyloluma1212 3 года назад +839

    It is interesting because this isn’t really accurate to the real mad cow disease. It took about 5 years for people to begin to display symptoms and then it was 100% lethal

    • @user-rm6mx7np4l
      @user-rm6mx7np4l 2 года назад +1

      its a mutation of the mad cow disease, its not the real thing

    • @krisspychissp
      @krisspychissp Год назад +15

      If it was like that …
      I wish

    • @kichiroumitsurugi4363
      @kichiroumitsurugi4363 Год назад +137

      Another fun fact. Lethality in this game essentially calculates how long it takes for an infected person to die, as infected cannot recover without the cure in Plague Inc (unless you're doing Cure Mode, in which case Prion is given an automatic 100% Fatality Rate

    • @georgeuferov1497
      @georgeuferov1497 Год назад

      Creators of a Plague Inc. had to do a lot of simplifications and compromises when it comes to prions. In real life they are literally uncurable and can manifest spontaneously, but can be transmitted only by ingested. Moreover, some people are just blatantly resistant or immune to it. Although there are rumors about the possibility of prions transmitting through air, in which case we're screwed

    • @aeriona626
      @aeriona626 Год назад +84

      Prion diseases are also incurable (at least at the time of me writing this). Genuinely now idea how you’d cure widespread protein misfolding in the brain on a massive scale. Tracking infection sources would also suuuuck given it’s ridiculous incubation rate.

  • @pendalfus123
    @pendalfus123 6 лет назад +3477

    so your saying you had 22 times talking to yourself every time you try to record?

    • @Platonis-The-Warlock
      @Platonis-The-Warlock 6 лет назад +736

      Oh yeah, if he don't deleted it all - we need "Salty Pravus Rage and Cursing compilations"

    • @glowbomb1223
      @glowbomb1223 6 лет назад +247

      Yes please he needs some compilations.

    • @KlaweKlapki
      @KlaweKlapki 6 лет назад +333

      Mad pravus disease

    • @glowbomb1223
      @glowbomb1223 6 лет назад +78

      Dont even try to bakeract him, as Lord Pravus will smite thee with lightning from his rending gale, flood your spirit with seeking arrows, and fire faulty fireballs at your everything; before making your people worship him as your corpse is forgotten.

    • @rhythmicluke4555
      @rhythmicluke4555 6 лет назад +5

      Andrej Nedorezov “

  • @overratedpancake9034
    @overratedpancake9034 6 лет назад +1779

    Let's try get 3 stars! I mean, how difficult could it be? :D
    *cries internally*

    • @shmegalodonschmuckington786
      @shmegalodonschmuckington786 5 лет назад +1

      Seba #Relatable

    • @tommyspringer3693
      @tommyspringer3693 5 лет назад +4

      I would like to see a stream where he must get 3 stars

    • @arthursantana2973
      @arthursantana2973 4 года назад +3

      I tried it more than 20 times (mega brutal) and didn't get 3 stars ;-;
      It's almost impossble haushaauaha

    • @predrop
      @predrop 3 года назад +8

      Finally
      3 stars
      After 182 tries

    • @iJeffersonNguyen
      @iJeffersonNguyen 3 года назад +2

      @@predrop damn. Was it worth it?

  • @heronb.4965
    @heronb.4965 6 лет назад +795

    this is the most intense plague inc video i have ever seen

    • @slendergaming8171
      @slendergaming8171 6 лет назад +27

      When Pravus plays the Mad Cow Disease Scenario
      *Intense Gameplay*

    • @heronb.4965
      @heronb.4965 6 лет назад +24

      *intensity intensifies*

    • @arandomperson86
      @arandomperson86 6 лет назад +22

      *intensified intensity intensifies*

    • @roshotsutsujimorienjoyer
      @roshotsutsujimorienjoyer 5 лет назад

      NiRe me either and i’ve been binging theses all day

    • @Deadchannel547
      @Deadchannel547 4 года назад +7

      wins on casual: aaaaaaaaaaa yes!
      wins on normal: YUS! LETS GO! OMG!
      wins on brutal: *BOW DOWN ####**#S**! I'M THE KING OF PLAGUE INC!*
      wins on mega brutal:
      I'm done, i'm done, i'm honestly done. I'm done with this game.

  • @tdoyr2119
    @tdoyr2119 5 лет назад +791

    There is one problem with this game. IT DOESN’T COUNT THE RESEARCHERS IN ANTARCTICA!

    • @derpysheep5872
      @derpysheep5872 5 лет назад +9

      Michael kinney oof

    • @Alvah37
      @Alvah37 4 года назад +130

      Yeah but they dont have any resources and there's a small amount of them

    • @graceliu8839
      @graceliu8839 4 года назад +102

      Michael kinney The Thing got them

    • @zakosist
      @zakosist 4 года назад +77

      I'm pretty sure researchers in antarctica are exclusively animal or environmental researchers, plus no people actually live there. But maybe I'm wrong

    • @-Kc1937-
      @-Kc1937- 4 года назад +59

      @@zakosist apparently research shows that around 50 scientific researchers Live in Antarctica full time I'm also sure that between 100-200 researchers work in Antarctica daily so technically humanity wouldn't be wiped out.

  • @stardra
    @stardra Год назад +194

    did anyone else notice at 11:10 how Greenland just got absolutely WIPED with the prion in less than a second? Like jeez-

    • @aaiiuiiuua2407
      @aaiiuiiuua2407 Год назад +27

      DESERVED. GREENLAND IS A MENACE IN THIS GAME 💀💀

    • @thatbachus
      @thatbachus Год назад +5

      ​@@aaiiuiiuua2407 On GOD!!!🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️

    • @cinnamon_board
      @cinnamon_board 7 месяцев назад

      No one
      People in Greenland
      🤒🤧🤒🤧🤒🤒🤧🤒🤧🤒🤧🤒🤧🤒🤒🤒🤧🤧🤒🤒🤧🤧🤧🤒🤒🤒🤧🤧🤧🤧🤒🤒🤒🤒🤒🤒🤧🤧🤧🤧🤧🤧🤧🤒🤒🤒🤧🤧🤒🤒🤧🤧🤧🤒🤧🤧🤧🤒🤒🤧🤧🤧🤧🤧🤧🤧🤧🤧🤧🤒🤒🤧🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤧🤒🤒🤒🤒🤒🤒🤒🤒🤒🤧🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤒🤧🤧🤧🤧🤧🤒🤒🤒🤧🤒🤒🤒

    • @IsaiahRowland-jg7sg
      @IsaiahRowland-jg7sg 7 месяцев назад +4

      ​@@aaiiuiiuua2407BLUD WOKE UP AND DECIDED TO SPIT FACTS 🔥🔥🔥🔊🔊🔊

    • @CrimsonXYR
      @CrimsonXYR 5 месяцев назад +1

      @@aaiiuiiuua2407STOP SPEAKING FACTS 🗣️🗣️🗣️

  • @Fun001
    @Fun001 6 лет назад +173

    14:12 RIP Japan got nuked again.

    • @elsymartinez4522
      @elsymartinez4522 6 лет назад +12

      Japan when it happened:
      FUUUUUUKKK U AMERICA

    • @dlcshadowheartlordofdomina7504
      @dlcshadowheartlordofdomina7504 6 лет назад +12

      You thought it was America, but it was I, *DIO BRANDO*

    • @senorhace4746
      @senorhace4746 6 лет назад +8

      Logan is the 3rd atomic bomb drop on Japan

    • @tommyspringer3693
      @tommyspringer3693 5 лет назад +3

      I just realized the again part...

    • @Niiue
      @Niiue 4 года назад +8

      DLCShadowHeart Lord of Domination You thought it was Dio, but it was me, NUCLEAR REACTOR!

  • @AM-gv9db
    @AM-gv9db 6 лет назад +119

    I was saved by the fish once too. I got detected super early and Caribbean shut its port before I could infect it. I wanted to give up, but decided to keep going as if nothing happened. When I only had around 100 000 people left alive someone in Caribbean ate infected fish and I immediately devolved some lethality so I could infect the country, and managed to complete the scenario. It felt really really good. This was on normal and I can't even finish the scenario on brutal becuase it's so darn hard.

  • @asclepihex
    @asclepihex 6 лет назад +398

    Rosalia bruises are black
    This wasn't done with ease
    But Pravus finally completed Mad Cow Disease!

    • @LolitaCraft
      @LolitaCraft 6 лет назад +8

      Nice Trauma Team reference :D

    • @realuity3075
      @realuity3075 6 лет назад +6

      Heck, Hexpresso, tis me, Real!
      Also why aren't there any Rosalias on Plague Inc it would be perfect

    • @peepeepooopooo7889
      @peepeepooopooo7889 5 лет назад +1

      Hexpresso nice free verse poem

    • @user-yg8sr4wv4x
      @user-yg8sr4wv4x 8 дней назад

      You should be a poet

  • @KeenoDaddy
    @KeenoDaddy 4 года назад +59

    Out of so many Plague Inc games, it's great to see the other side of him where he finally breaks down and swears at the game's difficulty.

  • @krishkapoor1833
    @krishkapoor1833 6 лет назад +265

    11:05 points at the Caribbean and calls it the Philippines

  • @kpopcan_slap_me5557
    @kpopcan_slap_me5557 4 года назад +1380

    Mad Cow Disease: exists
    Vegans: laugh in corner
    *Mad Cow Disease evolves to infect plants*
    Vegans: Wait no, that's illegal-

    • @MAGNITUDE16
      @MAGNITUDE16 3 года назад +16

      What is meat cow disease

    • @fionnaclarissamuharlie168
      @fionnaclarissamuharlie168 3 года назад +55

      Prions indeed can get into plants though, through corpse, for example.

    • @andrewaftontheandroidhedge2780
      @andrewaftontheandroidhedge2780 2 года назад +7

      @@MAGNITUDE16 i think it makes zombie like cows becuse ppl get zombie like wen they eat human meat at least i think thats how it gos take this with a grain of salt

    • @user-rm6mx7np4l
      @user-rm6mx7np4l 2 года назад +41

      @@andrewaftontheandroidhedge2780 no it doesnt

    • @Artizap_
      @Artizap_ 2 года назад +5

      @@andrewaftontheandroidhedge2780
      No

  • @theunitedstatesofamerica3556
    @theunitedstatesofamerica3556 4 года назад +108

    Judge: anything else?
    6ix9ine: I know how to infect Greenland in Plague Inc.

    • @ElPastalero
      @ElPastalero 4 года назад +10

      instantly forgiven

    • @emicharr
      @emicharr 3 года назад +2

      Is pretty easy honestly i always play in brutal or mega brutal and it’s pretty easy a bit more than other countries but easy

    • @adibalabharat8247
      @adibalabharat8247 2 года назад +4

      @@emicharr shut up

    • @nataneryyyyy
      @nataneryyyyy 2 года назад +2

      @@emicharr you just got ratiod for being better

    • @nataneryyyyy
      @nataneryyyyy 2 года назад +1

      @@emicharr good for you

  • @kjlnbh9943
    @kjlnbh9943 6 лет назад +62

    On the first attempt when he said "get a boat into greenland," a non-infected boat entered. R.I.P.

  • @horner385
    @horner385 6 лет назад +187

    After this Pravus was like
    "HEY! HONEY! I FINALLY DID MAD COW DISEASE ON MEGA BRUTAL!"

    • @ainyaly_
      @ainyaly_ 6 лет назад +19

      But literally tho. Just had to check to see if Pravus recorded himself saying this to me because this is basically an exact quote.

    • @tommyspringer3693
      @tommyspringer3693 5 лет назад

      Finally, peace

    • @thedarkoverlordofall
      @thedarkoverlordofall 5 лет назад +2

      Ainyaly lmao you his wife?

  • @Pluvita
    @Pluvita 6 лет назад +131

    FINALLY I KNEW THE LORD COULD DO IT

  • @MourningButterflies
    @MourningButterflies 3 года назад +41

    "Help you spread through many kinds of meat-"
    Oh cool, like what-
    "Starting with insects-"
    HOLD ON WHAT

    • @-Mr.O
      @-Mr.O 2 года назад +7

      Yeah some people eat insects, kinda weird but apparently that’s actually somewhat healthy

    • @-Mr.O
      @-Mr.O Год назад

      @@rinustechtips yeah, people do
      Problem?

    • @-Mr.O
      @-Mr.O Год назад +1

      @@rinustechtips some bugs are healthy

  • @rndomclipz2431
    @rndomclipz2431 3 года назад +104

    I love how Pravus explains his strategies. Many of his plays have also carried me to winning a lot of different scenarios (as well as just the normal disease types)

  • @KingCheckOut
    @KingCheckOut 3 года назад +21

    Image if he forgot to press record

  • @memeboi5504
    @memeboi5504 4 года назад +27

    Scientist 1: I have a headache, blood from every hole, I forgot my name, I feel that my leg is paralysed, and I hear the Death whispers in my ears.
    Scientist 2: It's just flu
    Scientist 1: *lol okay, lets go do a vaccine*

    • @outtathepantry
      @outtathepantry 4 года назад +2

      Poor anti vaxxers... They are screwed.

    • @Perseagatuna
      @Perseagatuna Год назад +12

      fr how do scientists in this game do even 1% of cure progress while confused, with dementia, paralyzed, with no sleep, while insane, while in a coma, etc.

  • @irinahuerta1895
    @irinahuerta1895 6 лет назад +68

    I gave up after 4 attempts in normal and 2 in casual. I realized that if I could not beat it in casual there was no way in hell I was ready for normal. I'm actually still trying to beat it in freaking casual.... *Sobs forever*

    • @sadamiamani
      @sadamiamani 4 года назад +1

      You probably gave up didnt you?

    • @ElPastalero
      @ElPastalero 4 года назад +6

      It triggers me when people use (REDACTED) instead of [REDACTED]

    • @boilledwater_3306
      @boilledwater_3306 4 года назад +2

      I fucken beat it on casual on first try, cure was like at 90%, not doing it on normal D:

    • @blueleviathan15
      @blueleviathan15 4 года назад +1

      I beat it on casual first time, struggled on normal, then I used Pravus' strategy and beat it on normal and brutal

  • @horner385
    @horner385 6 лет назад +275

    If Dark Souls had a baby with Plague Inc, then it'll be Mad Cow Disease

    • @ck7993
      @ck7993 4 года назад +7

      on mega brutal

    • @ElPastalero
      @ElPastalero 4 года назад +6

      at 3 am

    • @fireinthehole_727
      @fireinthehole_727 4 года назад +4

      And acute encephalitis is also a preloaded trait

    • @ElPastalero
      @ElPastalero 4 года назад +3

      @@fireinthehole_727 at 3 am

    • @fireinthehole_727
      @fireinthehole_727 4 года назад +4

      @@ElPastalero but like I said acute encephalitis is also a preloaded trait

  • @goodva3027
    @goodva3027 6 лет назад +182

    >*God* left
    >*Pravus Gaiming* changed his name to *God*

    • @fireinthehole_727
      @fireinthehole_727 4 года назад

      >Cyan has joined the chat
      Cyan: >Don't worry guys I have a plan
      >Cyan has left the *game*

  • @MORDArts
    @MORDArts 6 лет назад +135

    It's finally here! Praise Pravus!

  • @dragonfire101g
    @dragonfire101g 6 лет назад +169

    I remember doing a scenario and waiting for Genetic Reshuffle 3 and saving up. They finished the cure just as I had saved enough. I did it anyway. It worked.
    Beautifully

    • @user-jc1kq1qb5j
      @user-jc1kq1qb5j 5 лет назад +39

      Well,even if they make 100% cure and start curing people,you still can reshuffle or take a symptom like coma and they will have to make it to 100% before they are able to start curing people again. And those who were cured can still be infected again if cure is not 100%.

    • @modothegreat108
      @modothegreat108 5 лет назад +39

      "The cure is complete! Oh wait, the virus evolved again and now our cure doesn't work anymore."

  • @armageddon3315
    @armageddon3315 6 лет назад +62

    The madman finally beat it!

    • @slendergaming8171
      @slendergaming8171 6 лет назад +2

      Looks like the madman defeated the madcow (Disease)

  • @WebmistressL
    @WebmistressL 6 лет назад +29

    No joke, I was thinking to myself "I hope Pravus gets this scenario done" sometime last night.
    TIMING!
    This scenario looks brutal - I'm already dreading doing it myself.

  • @solarapacifica991
    @solarapacifica991 4 года назад +19

    Select infection through avocado
    Californians: hehe I'm in danger

  • @dorukayhanwastaken
    @dorukayhanwastaken 6 лет назад +130

    4:52 "then we're gonna pick up a pork" Hold on a second, does this transmission work in Saudi Arabia and other Islamic countries?

    • @voxmustshutdown9665
      @voxmustshutdown9665 5 лет назад +6

      Nope,in real life pork is banned in Islamic countries I think

    • @zekedia2223
      @zekedia2223 4 года назад +4

      In the game.

    • @neyoid
      @neyoid 4 года назад +3

      @@voxmustshutdown9665 I think pork is allowed, just that most people in the country can't eat it.

    • @delta6378
      @delta6378 4 года назад +2

      @@neyoid pork is illegall in saudi arabia

    • @jamison1477
      @jamison1477 4 года назад +3

      perhaps the pork boost only starts working when it gets to other countries

  • @rivia_jr1
    @rivia_jr1 6 лет назад +26

    13:41 Pravus got turned on

  • @TheIndigoExperiment
    @TheIndigoExperiment 6 лет назад +14

    "Avocado's always been kind of a difficult one for me to swallow..."
    *groans intensely*

  • @johnbailey5835
    @johnbailey5835 3 года назад +15

    It can spread through consumption of fish.
    Me, a british person: well shit.

    • @NottsAiry
      @NottsAiry 5 дней назад

      NOOOO OUR FISH AND CHIPS 😭😭😭😭😭

  • @Kozlowskijennifer
    @Kozlowskijennifer 5 лет назад +27

    When he says’ I’m not going for any Lethality’ 80.1 K people dead😹😹

  • @thedarkoverlordofall
    @thedarkoverlordofall 5 лет назад +24

    Praise Pravus! He sacrificed his sanity for a RUclips video for us.

  • @greywhizzadventurer8535
    @greywhizzadventurer8535 6 лет назад +9

    Flipping well done my man. You really are the best at Plague Inc.

  • @kimjongun7569
    @kimjongun7569 6 лет назад +16

    Ohh,you're my best friend in a world we must defend!

    • @fridaykittens2287
      @fridaykittens2287 5 лет назад +1

      Kim Jong Un hello person from the other side of the world 🌍

    • @outtathepantry
      @outtathepantry 4 года назад +1

      Pokémon, gotta catch em all...
      .
      .
      .
      All the diseases.... Just catch them, I need to beat the game.

  • @glowbomb1223
    @glowbomb1223 6 лет назад +49

    Nothing can stand in the way of Lord Pravus. Praise be!

  • @hydekido7506
    @hydekido7506 6 лет назад +4

    Finally!!I've been waiting for you to play this official scenario!

  • @thephantom604
    @thephantom604 6 лет назад +21

    Gg Lord Pravus and of course... PRAISE PRAVUS

  • @adryanus9
    @adryanus9 6 лет назад +33

    good job! Praise Pravus!

  • @meatystalactite531
    @meatystalactite531 4 года назад

    I watched this video and ever since I've been watching your videos constantly. There's just something so alluring about them

  • @drvir
    @drvir 6 лет назад +1

    I knew you would eventually be able to do it!
    You're king of plague Inc after all!
    Praise Pravus!

  • @kezzerz
    @kezzerz 6 лет назад +3

    You don't know how I've been waiting for this its insane!
    Just like ur videos 💞

  • @markuhlman3767
    @markuhlman3767 5 лет назад +3

    Omg...your videos are so fun to watch. Your reaction to your victory here is memorable to say the least. I found this game probably a year or two ago. Played for a while and gave it up. After stumbling upon some of your other videos I have reinstalled the game. You seem to have a different version. Looks different. Anyway, had to leave a comment and say hello after watching this one.

  • @zakhinithezucchini4598
    @zakhinithezucchini4598 6 лет назад +1

    It only took me 3 attempts on mega brutal, I just bought a lot of transmission and traits with mutation chances, therefore, I can focus on ability traits, which really helped me so yea, but good one, Pravus, you really did well

  • @kevindavid8879
    @kevindavid8879 6 лет назад

    damn! gg, I haven't played mad cow yet, but I've herd that it's pretty crazy, been trying to look for some strategies before I dive head first, cause I know Ill just end up playing it over and over till I got it, and I'd end up driving myself crazy, thanks man, didn't actually know severity worked like that.. It explains A LOT! 🤔

  • @ashimochi
    @ashimochi Год назад +3

    Mad cow's disease is the "common" name for Bovine Spongiform Encelopathy (or BSE). This condition on humans is called *variant* Creutzfeldt-Jakob's disease or CJD-v (the variant refers specifically to the one that is acquired by consuming infected tissue)
    The BSE outbreak that happened in England started due to, as a meaning of cutting costs, cows were fed with sheep remains, and sheep were already commonly enough affected by Scrapie (their version of the prion infection), so cattle meant for human consumption developed BSE, which passed consequently to human hosts. Prion diseases have a very slow onset and are hard to detect for the very same reason (nowadays can be detected by clinical exams such as the Western Blot, but coming up to even suspect a prion infection is the tough part)
    Prions are misfolded, anomalous proteins that cause other nearby proteins to misfold as well, and its onset in the brain results in a sponge like texture in the brain, giving it its name of *spongiform* encelopathy (sponge-like brain pathology).
    Unlike what the name "mad cow" might make you expect, no one goes in some sort of rage, the affected person or animal suffers brain deteroriation and starts losing mobility and physical control, in its last stage the host will be unable to move and will die when it reaches the point it can't even function properly. Prion diseases are a death sentence basically, and due to the nature of the pathogen (a protein) medical advances haven't gone too far into the matter, tried measures aren't able to cross the hemato-encephalic barrier (the barrier that works as some sort of firewall for your brain) while the prion has no issues. Most places have to get rid of cow brains and neurological tissue just in case, English veal has been unbanned in most countries relatively recently (I believe the last to lift said ban was France) and blood banks mostly rejected blood from people that spent time in England or Europe when the outbreak happened (this ban is also starting to get lifted as the pandemic left us short of blood donors in general). Some other interesting facts about prions is that soil that was used by infected sheep or cattle is deemed risky for further animal raising, as proteins are VERY HARD to actually destroy. They tried sterilizing procedures for medical equipment in contact with prions, but heat will only briefly inactivate the protein and said equipment is rendered unusable and has to be destroyed. Prions are also behind that moose disease that also had some sort of sensationalistic name (something in the like of zombie moose? Thrashing syndrome? Something like that, honestly I forgot) and has suspected links with Alzheimer's, though nothing can be confirmed as of yet, there's also suspicion that there might be multiple types of prions.

    • @ashimochi
      @ashimochi Год назад

      Yes I wrote this heck of a Bible under another comment but it took me a while so I'm here to show it thanks

    • @jamesdinius7769
      @jamesdinius7769 Год назад +1

      It's not even a case of basically. All known Prion diseases in both humans and animals are 100% lethal so far as we know, and are completely incurable. We know of a few others besides vCJD such as Familial Fatal Insomnia and Kuru. They also are usually only transmissible through the injection or consumption of contaminated fluids or tissues, most often brain matter, but it can also spread through blood and muscle tissue (though cases from consumption of muscle tissue are usually believed to be due to that meat being contaminated with brain matter). Some evidence suggests that prion-infected matter can be aerosolized and spread through inhalation, but this basically cannot occur naturally (though there are regulations regarding using pressure washers in slaughterhouses for this very reason).

    • @ashimochi
      @ashimochi Год назад

      @@jamesdinius7769 Yeah yeah, went mainly on vCJD because that's the one emulated in the scenario, and naturally making prions in game 100% lethal would bring balance issues. Prion diseases have long latencies and even if caught early by protein exams such as Western Blot... Uh, it doesn't help your case much, you are just getting more palliatives lol, I guess a realistic prion gameplay would be kind of boring as it's rather slow and silent, and the in-game prion's "prion features" are low infectivity, and evolutions taking longer to present themselves, supposedly they are harder to cure as well if I'm not mistaken, but I have a hard time buying that when some random country just goes and whips out a prion disease cure in like two minutes 🙄 are prions amazing in science? Yes. In-game? They are kinda one of the most boring pathogens to play as for me at least lol

  • @LuckyBird551
    @LuckyBird551 5 лет назад +12

    Try doing a custom scenario of Cholera, there are quite a few and it is often the "forgotten" plague because it usually happens in poor nations and does not usually spread out from them (like the outbreak in 2010 in Haiti)

  • @Muddragon104
    @Muddragon104 3 месяца назад

    Thank you for making these videos. Yes I have only been able to get two bio hazard symbols on casual. So I can only imagine how hard it is on mega brutal.

  • @Kainoverlord75
    @Kainoverlord75 6 лет назад

    well done and good luck in the future also PRAISE PRAVUS!!!!!

  • @lavender2453
    @lavender2453 5 лет назад +3

    I find your videos very long but I subscribed because of how much effort you put into them

    • @lavender2453
      @lavender2453 5 лет назад

      And I also appreciate how you actually read the pop ups!

  • @Derpixied
    @Derpixied 3 года назад +8

    I know I'm really late but JEEZ I didn't know it was possible to beat this disease ON MEGA FRICKIN' BRUTAL!

  • @thatgrumpychick4928
    @thatgrumpychick4928 Год назад +1

    13:40
    The squeal in your voice is hilarious. I'm glad you won

  • @epsilon-1125
    @epsilon-1125 4 года назад

    Thanks I was really struggling with this scenario.

  • @funnyfunnyfunnyxd
    @funnyfunnyfunnyxd 4 года назад +4

    i love how this popped up first in my recommended after loosing for the 10th time doing that damn mad cow disease scenario

  • @DN0103
    @DN0103 4 года назад +6

    You know what would be a funny name for the Mad Cow Disease? *"BURGERS"*

  • @user-ws9be6qi8z
    @user-ws9be6qi8z 6 лет назад +9

    You did it! *_Praise Pravus!_*

  • @friedwater6519
    @friedwater6519 6 лет назад +10

    11:10 look at greenland

    • @classicsquidward4869
      @classicsquidward4869 3 года назад +1

      Its been so long no one is talking about it how it explodes for the 3rd fricking time 🤣🤣

  • @cecilleferrer2077
    @cecilleferrer2077 6 лет назад +1532

    Holy cow you did it! (Cheesy pun intended.) sorry I just I had to milk it. Ok now I'm bovinally done.
    Edit: oh wow 25 likes I am very grateful of this.
    Edit 2: 100 likes wooo I am dairy thankful.
    Edit 3: I think it's udderly awesome how so many people like my puns.

    • @dakotamew
      @dakotamew 6 лет назад +26

      N O terrible puns only black and white puns :>

    • @cecilleferrer2077
      @cecilleferrer2077 6 лет назад +3

      dakota mew give me an example of a black and white pun no cheating

    • @dakotamew
      @dakotamew 6 лет назад +3

      It was a terrible pun :C

    • @cecilleferrer2077
      @cecilleferrer2077 6 лет назад +4

      dakota mew so?

    • @galaxel1494
      @galaxel1494 6 лет назад +6

      i did not even laugh at the cow part the milk part made me laugh

  • @MoondustManwise
    @MoondustManwise 6 лет назад +6

    Happy pravus makes me happy

  • @gachadragon7525
    @gachadragon7525 5 лет назад +8

    Wow, great job! I love plauge inc, but suck at it, so to watch this makes me feel good ^^. Also P.S. I have never seen anyone get so exited over fish 😂

  • @OrchidAlloy
    @OrchidAlloy 5 лет назад +9

    To think there are a few people on this planet that have gotten 3 stars on mega brutal

    • @fss1704
      @fss1704 4 года назад

      OrchidAlloy the World Health Organization is one of them

    • @nhnavs7933
      @nhnavs7933 4 года назад

      @@fss1704 that's not a person lol

  • @tectamk.thorne7837
    @tectamk.thorne7837 3 года назад +8

    I think why Plague.Inc is less realistic is because once someone gets infected, they will be infected with it forever until some cure comes round or they die, as well as more.
    I’d like a game where rather than win or loss, the game will rate you out of 10. Yeah where wiping humanity is a challenge even on minimal difficulty. And the score scales on how much damage you do

  • @dyingisahobby9190
    @dyingisahobby9190 4 года назад +5

    You have some beef with this scenario.

  • @flyingkoifish1011
    @flyingkoifish1011 6 лет назад

    Congratulations! You've finally done it!

  • @NylaTheWolf
    @NylaTheWolf 6 лет назад +2

    Ah, I can't seem to get this right! Imma keep trying because this seems like a very solid strategy and you sound like you know what you're doing.
    Mainly my problem is not getting to kill off the world before the cure is finished, or them working on it too early or quickly. Or I'm not spreading quickly enough in Greenland and in two recent playthroughs in other countries that aren't islands.
    Watch, I'm going to beat it as soon as I post this comment XD

    • @MayPastel
      @MayPastel 5 лет назад +1

      YOU CAN DO IT NYLA!! I BELIEVE IN YOU!!!
      But seriously, congrats on winning one of the hardest scenarios!!

  • @anglegaming6
    @anglegaming6 6 лет назад +5

    Pravus be praised!

  • @ascendedcat260
    @ascendedcat260 4 года назад +3

    11:11 *looks at greenland* Well that escalated quickly

  • @lunarchy1075
    @lunarchy1075 4 года назад +2

    "that's why you go for fish guys"
    -Pravus, 2018

  • @saltychipps9936
    @saltychipps9936 3 года назад +2

    Pravus: SCREW YOU MAD COW DISEASE
    Game: *crashes*
    Me: *smirks*

  • @Decrupt
    @Decrupt 6 лет назад +6

    Praise Pravus

  • @ethanbailey5773
    @ethanbailey5773 6 лет назад +6

    PRAISE PRAVUS

  • @1kizwell
    @1kizwell 6 лет назад

    Classic Pravus Gaming video!!!

  • @steelvenom8479
    @steelvenom8479 6 лет назад

    FINALLY! THANK YOU SO MUCH!

  • @killianmontgomery2777
    @killianmontgomery2777 6 лет назад +4

    And they had the balls to put this as the second scenario for people who didnt buy the next one

  • @leoncrazyman07
    @leoncrazyman07 6 лет назад +3

    Why the hell are these so addictive to watch? I don't even own Plague Inc!

    • @classicsquidward4869
      @classicsquidward4869 3 года назад +3

      So true i basiclly watch pravus play plague inc EVERY SINGLE DAY
      (Not saying pravus is a bad youtuber i love his vids)

  • @Fraglers
    @Fraglers 6 лет назад

    Just found out you channel. Subscribed!

  • @evanjones9602
    @evanjones9602 Год назад +2

    From what I've seen, as of March 2023 a grand total of 12 people have gotten 3 stars on mega brutal on this scenario, and they had to use save scumming.

    • @sammy_sand_utubeyt6901
      @sammy_sand_utubeyt6901 11 месяцев назад

      Wow! That's terrifying. Thanks for letting us in the comments know!!

    • @agustinbarquero8898
      @agustinbarquero8898 5 месяцев назад

      Wow! That's terrifying. Thanks for letting us in the comments know!!

  • @airmanon7213
    @airmanon7213 6 лет назад +6

    This link here shows a strategy for handling it with 3 stars: steamcommunity.com/sharedfiles/filedetails/?id=1258854729
    I had tried it myself on casual and did get the 3 stars, but I don't know if it works on higher difficulties

  • @justtheletterV274
    @justtheletterV274 5 лет назад +9

    Every other game: Starts in India!
    This game:Start in Ind- never mind, beef doesn’t exist.
    China it is!

    • @purtlethetenguin
      @purtlethetenguin 3 года назад

      gotta evolve it into cats & dogs then

    • @sovietsky5039
      @sovietsky5039 2 года назад

      U mean saudi arabia

    • @legitimate8463
      @legitimate8463 2 года назад

      @@sovietsky5039 but india has rural hot and humid while arabia only has hot and arid. Plus there is more population

  • @scar445
    @scar445 6 лет назад +1

    "come on. come on. GET A BOAT IN THERE DANG YOU!!" im dead xD

  • @igorsiuda8108
    @igorsiuda8108 Год назад +1

    This disease has two variants: Bovine Spongiform Encephalopathy (BSE) in bovine (especially cattle) and vCJD (Variant Creutzfeld-Jakob Disease) in human (also known, to differ form former, as human mad cow disease).

  • @AGKaiju
    @AGKaiju 5 лет назад +5

    You almost crossed the cursing line.... I could tell right at the end.
    It was that bad, eh?

  • @Conor_ish
    @Conor_ish 4 года назад +3

    there is 30 minute ad about people saying chemicals

    • @ElPastalero
      @ElPastalero 4 года назад

      Oh yeah, this is big brain time.

  • @Raymondstyles
    @Raymondstyles 5 лет назад

    I couldn't beat it with your strategy. I found a very different strategy where you don't devolve anything worked a lot better and was finally able to beat ut.

  • @radiriz1396
    @radiriz1396 6 лет назад

    OH HE DID IT
    HE DID IT
    PRAISE BE TO THE LORD AND SAVIOR PRAVUS

  • @KingofFray
    @KingofFray 6 лет назад +6

    moral of this video : don't eat fish

  • @piggehthepig5973
    @piggehthepig5973 5 лет назад +3

    at 7:32 We just won 2500$ on the pennsylvania Lottery

  • @jasonmcgill8984
    @jasonmcgill8984 6 лет назад

    Praise Pravus and good job

  • @johnluikart
    @johnluikart 2 года назад +1

    Praise Pravus!

  • @Assassin-bk8lb
    @Assassin-bk8lb 6 лет назад +9

    22 attempts?
    I'm on attempt 46 and still failing.

  • @smallpupper
    @smallpupper 5 лет назад +6

    how to win this:
    infinite dna cheat

  • @euginarex5649
    @euginarex5649 3 года назад +1

    Potatoes: Infected
    TechnoBlade: *Confused Scream*

  • @joshmaggard6
    @joshmaggard6 6 лет назад

    Love this game. Have you ever heard of Nurgle from the Warhammer 40K universe? That's what I picture happening while you play.

  • @chronicwakner9994
    @chronicwakner9994 6 лет назад +4

    you do realise that the Norwegian port goes to greenland to?

  • @eduardoalves2685
    @eduardoalves2685 6 лет назад +8

    Agaybe

  • @cassww
    @cassww Год назад +2

    They should have made a joke with apple transmission saying “an apple a day gets the doctor aray”

  • @dolan3623
    @dolan3623 6 лет назад +1

    I have a feeling that spontaneous infections in greenland will be a common thing. I got one when i played this scenario