How The Modern World Tricks Our Bodies Into Hurting Themselves
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- Опубликовано: 9 окт 2019
- Thanks to the University of Minnesota for sponsoring this video! twin-cities.umn.edu/
The same enzyme that used to save us is now killing us because the body reactions it catalyzes now cause more harm than good.
Thanks also to our Patreon patrons / minuteearth and our RUclips members.
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To learn more, start your googling with these keywords:
Cyclooxygenase: An enzyme responsible for the production of thromboxane and prostaglandins.
Thromboxane: A lipid that acts as a platelet aggregator.
Platelets: Special non-nucleic blood cells that clump together to cause blood clots.
Prostaglandins: A lipid that causes vasodilation and inflammation.
Aspirin: A form of acetylsalicylic acid that acts as an NSAID.
NSAIDs: Non-steroidal Anti-Inflammatory Drugs that inhibit COX, and thus inflammation and clotting.
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Credits:
Script Writer and Narrator: David Goldenberg
Video Illustrators: Ever Salazar and Sarah Berman
Video Directors: David Goldenberg and Ever Salazar
With Contributions From: Henry Reich, Alex Reich, Kate Yoshida, Ever Salazar, Peter Reich and Julián Gómez
Music by: Nathaniel Schroeder: / drschroeder
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References:
Fitzpatrick, F. (2004). Cyclooxygenase Enzymes: Regulation and Function.Current Pharmaceutical Design. 10:577-588. Retrieved from: www.ncbi.nlm.nih.gov/pubmed/1....
Dubois, R., Abramson, S., Crofford, L., Gupta, R., Simon, L., Van De Putte, L., Lipsky, P. (1998). Cyclooxygenase in biology and disease. The FASEB Journal 212(12):1063-73. Retrieved from: www.ncbi.nlm.nih.gov/pubmed/9....
Havird, J., Kocot, K., Brannock, P., Cannon, J., Waits, D., Weese, D., Santos, S., Halanych, K. (2015). Reconstruction of cyclooxygenase evolution in animals suggests variable, lineage-specific duplications, and homologs with low sequence identity. 80(3-4):193-208. Retrieved from: www.ncbi.nlm.nih.gov/pubmed/2....
Ricciotti, E. and FitzGerald, G. (2011).Prostaglandins and Inflammation. ATVB In Focs. 31(5): 986-1000. Retrieved from: www.ncbi.nlm.nih.gov/pmc/arti....
Rao, P., and Knaus, E. (2008). Evolution of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Cyclooxygenase (COX) Inhibition and Beyond. Journal of Pharmaceutical Science. 11 (2): 81-110. Retrieved from: www.ncbi.nlm.nih.gov/pubmed/1....
Van't Hof, J., Duval, S., Misialek, J., Oldenburg, N., Jones, C., Eder, M., Luepker, R. (2019). Aspirin Use for Cardiovascular Disease Prevention in an African American Population: Prevalence and Associations with Health Behavior Beliefs. Journal of Community Health. 44(3):561-568. Retrieved from: www.ncbi.nlm.nih.gov/pubmed/3....
Leupker, R. (2019). Personal Communication. Minnesota Heart Health Program. University of Minnesota.
Chipman, J. (2019). Personal Communication. Department of Surgery. University of Minnesota. 
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cool
i like it
Mintute Earth love your videos helps me at school because we're learning about this stuff in science 😁😁😁😁😁
Thank you!!!
Interesting video, but shouldn't you guys add something like "Don't use medication without informing with your physician first"?
*C O C C Z*
Sorry I don't have money
"In the modern world, Cox is often tiggered into action unnecessarily"
So true.
"and the ensuing response can have disastrous results"
even more true
@@Jeddostotle7 that went from funny to a dark place very quickly
And the only way to stop it is eating ASSpirin.
Help me to help you
Help me to help you
Blondie
Even in school :D
*cries*
Could he say “cox” a few more times
Archimedes Joseph Calnan yes please lol 😂
He just loves cox so much
I think he said it enough
Cox
Cox Cox Cox cox
2:16 "blocking cox"... lol
I get a sneaking suspicion his whole video was conceived of just for the puns
Hehehe, "conceived"
( ͡° ͜ʖ ͡°)
"Blocking" is a legit term in scientific literature.
But in this case, pun intended.
As opposed to any other video?
I don’t get it
Scientist: What should we call a thing that saves you life when you get an infection?
Scientist 2: * under breath * Cocks.
Scientist: Ah yes! COX!
It's short for Cyclooxygenase
@@monicag.k.tambajong well they could make another nickname for it but i guess that's the name that they got stuck with lol 😂
PS: please don't hurt me, just a random stranger making a random joke
@@oddpotato4038 be warned, they are coming
Thanks now i finally understand why everyone is like this ....
@@LL-pl2ek I also didn't get it. Why everyone is do immature?
"Stop hurting yourself! Stop hurting yourself!"
"But I can't"
"Why?"
"Because my COX is hurting me!"
TOXIC MASCULINITY I TELL YOU
IT'S ALL TOXIC MASCULINITY
In a nushell
Take Aspirin;)
Yah, I'm sure your COX is causing trouble. 😏
@@justinruiz5054 Definitely saw that coming.
@1:19 "... If this happens near the heart, you get a heart attack. And when this happens in the brain..."
Me: You can get a brain attack.
Actual: the clot can cause a stroke
oh
so cox and strokes are related
@@bigteo90 but cox cause strokes, strokes don't cause cox
@@doommaker4000 so what you're saying is it takes cox to stroke??
@@handshoesandhorsegrenades1848 No, Im saying if you stroke your cox you get unexpected results. And it's not a heart attck
@@doommaker4000 yeah most people cox really get going with some agitation
I'm too childish to suppress my laughter
COX STICKY PLATELETS
I JUST REALIZEDD AAHAHAHAHAAHAH
"Ow!"
"What?"
"My Cox!"
We need to do alot more cox blocking
@@lonestars1158 tampons
So, will we just ignore the Raikou at the beginning?
How many references are in this vid
@@minolcaruiz8288 several
That's a saber tooth, dumbass
@@MsSiobhanmurphy dont be mean
@@MsSiobhanmurphy No, that's a Raikou. Last I checked, Sabertooths don't have purple neck hairs, a Raikou does though.
2:17 My heart just broke for that COX
Too much potential for dirty jokes
Sorry everyone took them
"Sticky platelets"
*By stopping the cox*
no offense, but your username explains it all
edit: i love it
Peoples Cox are hurting my ass
"our chance of dying from cox related problems has actually increased."
Don't kink shame.
Another unfortunate thing caused by the Cox, are a few select types of epilepsy.
Well it doesnt cause them persay, however, it triggers the epileptic events.
I suffer from a neuro-type epilepsy, that is to say, the area effected by my epilepsy is the brain, rather than the body.
When having an episode, i get sudden severe migraines, that are so intense, i am completely paralyzed by pain, unable to do much more than cry and squeeze my eyes shut, waiting for it to end.
My first seizure was when i was 2. I was 5 when they determined the migraines were caused by epileptic reactions in my brain. I was 24 when they determined that the seizures were being triggered by the Cox randomly increasing blood flow in some areas of my brain, trigger a seizure in the special part of the brain that regulates, of all things, pain reception, and the area that sends signals to increase or decrease flood flow...in my brain...
the resulting chaos causes the blood vessel in my brain to constrict, while the Cox actively tells them to relax, while my brain continuously receives pain signals with no origin, causing the pain to simply 'stay' in my head...
Medication has helped, i used to have 3-10 seizures a week....now i have them...maybe 2-6 times a year.
This is the first time I’ve actually understood how terrifying a clogged artery is
I've had many cox inside of me; still do.
Love it. Thanks biology!
So is everybody else, including ur mom hehe
But you actually have less cox inside of you these days, compared with when you were younger.
FBI OPEN UP
Apparently my body is working way harder than I do. I am just lying on my bed, watching videos on my phone, while my body wanna fight, and don't care who will be the opponent.
...yes
no its more like, the immune system wanna find the bacteria and fight it, but cant, and decide to fight your self because maybe thats the bacteria?
Immune system will throw hands at anything. Bacteria? FUCK EM UP! Fungi? FUCK EM UP! Pollen? FUCK EM UP! Any prosthetic not made of gold or specially treated titanium? FUCK IT UP! Your own tissues? YOU GODDAMN GUESSED IT!
"By blocking cox..." Sorry, I missed everything after that.
Coxblocker
Neat little easter egg of the Cox having a Deku Shield!
Protection
"cox" lol
Yeah... *insert lenny face*
@David Jameson Thank you!
cocks!! I have achieved comedy
@@TheUltimateNoobHDhey... Don't say the word let the imagination do the job 😉😆😉😆😉
Came here to say this.
0:19 Oh cool my cox makes extra sticky stuff
:)
;)
:)
):
XD
Fun fact: In Chile aspirin is no longer given for prevention on high risk patients due to the huge chance of gastric ulcers and cancer that exists (mainly due to Helicobacter pylori), instead it is prescribed to people who already have had a vascular episode (like a heart attack or a stroke) to prevent from it happening again.
humans: *stop diseases*
body: fine ill do it myself
Sponsored by Aspirin ™
Aspirin isn't a trademark, it comes from contracting a form of the chemical name, but then it would be funny if the university of minnesota had research connections to Bayer or something.
@@micahphilson it was
@@tonish727wrong objection. Aspirin IS a trademark, like jello and band-aid
Oh hey, cool! Thanks for making this video. It's a really easy resource for me to share with people who have autoimmune and other challenges for whom I try to help learn how to reduce external exposure.
I always found that when I was younger and got more scrapes and cuts, I got sick a lot less than when I wouldn't get hurt for a while...
When you get scrapes or cuts infectious germs enter the body and you get sick, but however you immune system in your body remembers germs that have entered the body before so you don't get sick anymore because your immune system have learned how to deal with the germs
Somehow I am certain there is more to this topic than what was covered in this video.
Great video, keep up the good work.
Didn't they recently rescind the recommendation for aspirin regimens?
Did they?
But then... cox
Cox is like Dobby. Almost kills us trying to save us from something we can kill ourselves
So Aspirin is a COX BLOCKER!?
Yes
The Nearby Cox That Sound Weird
Thank you for the vids... it helps us in developing countries to learn new things in much enjoyable way
Oh the dirty jokes I could make.
Also, 1:57 Stomach: :3
Thank you Dr. Chipman for finding more forms of COX
I love how the smilodon image has raikou's cape things
1:51 If the nurse isn't giving way, then eliminate her as well!
Sounds like eating genuinely better more wholesome food is the key to fixing this problem
Huh, cool. I thought this was going to be about how we are working too much / too hard. Learned something new. Great vid.
Do a video on How to prevent this chlorestoral build up and stuff relate to health. Alot of us will like it. I know it will include exercise but I want a video cover it anyways
When ur cox has a deku shield, it means you're using protection :)
I dare you to not laugh when he says "blocking Cox".... 😂😂😂🤣🤣🤣
Imagine cells bullying you that you become depressed.
The best Aspirin ad I've ever seen
What has been heard cannot be unheard....
Good to hear that cox blocking can be useful
Wow, thank you so much for explaining! I know low dose aspirin could help in heart diseases because it alters the COX mechanism but never fully understood why, your vid is so simply and really helpful xD!
sooooooo in other words, aspirin COX blocks you?
omg the animation is so endearingly cute!
0:08 the animal's fang , tail and cloud like hair on its back is similar to the Pokemon named raikou the legendary Pokemon released in gen 2
I can’t stop watching minute earth
"If no one's going to attack me, im gonna attack myself" - WBC
You made me cry over the the little poor Cox guy. Didnt know also people have multiple cox. ;)
I have been waiting for this :3
Please do you have any studies on link between cholesterol deposits (blood clots) and dietary cholesterol intake?
I can totally imagine the writer putting this episode together, all starry-eyed and innocent. They’re so proud when the upload completes.
Then the horror slowly dawns on them as the internet responds and they realize what they’ve done.
Don’t play with cox, children.
The innocent one was me. David was aware of this the whole time
love the raikou easter egg!!
BEST. EPISODE. EVER. =D
Wouldn't it be more effective to lower the colesterol with a healthy diet (no side effects) than taking aspirin regularly (some side effects)?
Short answer? Yes.
@@EcceJack It wasn't really a question, but thanks :D
@@Blackhuf Haha, sorry :D
that's why I'm not looking that much at protecting myself myself because I've seen how much more efficient the nature is at doing it
That chair at the end is giving me Blue's Clues vibes :D
One thing that bugs me is that we are at the same time told that we are having stronger immune system than ever before because we get in contact with so many (well it is 2020 now :P). So which is it? I think it is both, we are prone to more airborne diseases than ever before and also more variety of them than ever before since many of them will come from the other side of the world. However we are much less prone to other types of infections such as food poisoning and open wound infections. Not sure how our bodies adapt to that.
Cox is basically dobby. Trying to help Harry, but ends up hurting him.
Lol
*Reads title**
Wait wtf
Did they make that sabertooth look like Raikou? LOL
"You either die a hero or live long enough to be the villain"
No one:
Me, an immature high schooler: "hehe, cox."
Hi Mr Dong how is your cox doing
Not funny
isn't that the point?
I mean opening a meme up with Nobody: isn't funny
Me, an immature adult: "Hehe same."
curious
several years ago my doc prescribed the wee aspirin daily....never knew why
Why didnt you just ask the doctor? you should know why you are taking something
Such a positive video..
Nice Bayer ad.
Good channel
0:11 i like the pokémon reference of Raikou right there
Bork(entei came bois)
Though it was a little odd that it was never called acetylsalicylic acid (ASA); seeing as how Aspirin is Beyer's name for it I was half expecting "this episode brought to you by Beyer."
Thanks youtube demonetization, now I keep expecting ads shoehorned into everything.
I loved the animation😃
In summary, safe yourself by not trying to safe yourself
Yes, I love Cox. It protects me.
Pain makes us stronger and wiser.
Pff hahaha bullshit
😂
And deader
Cox is basically Dobby trying to save Harry Potters life and injuring him in the process 😆
no pun at the end? nice
2:27 That has a whole different meaning without context.
1:35 Best Flat Face Drawing I've Ever Seen
that saber tooth tiger looks like raikou
Spencer MacDougall 😉
I was waiting for this video is sponsored by Aspirin
Love One Another God Bless Everyone
me: hurts myself
mom after watching this video: because of that phone
0:04 is that Raikou
tnx
“...Fatty diets”
So are you telling us we all fat
.....yes.....
Technically we all eat something that contains fat
But not fat as obese
And not everyone who has plaques are fat! People who look otherwise healthy can already have plaques in their arteries!
The process cannot be reversed, unfortunately, and there are things that can make it worse (e.g. high blood pressure associated with high sodium diet or high stress) or less worse (e.g. exercise). The high-fat diets we have nowadays certainly does not help the situation.
Replace "fatty" with "carby" for accuracy
Some fats are healthy and are needed
Does this have anything to do with why asprin seems to help prevent my sinuses from going crazy?
0:01
Where is Kate?
I prefer her voice for bedtime stories
Uh there is more than one writer
@@imsyed5 so it doesn't have to be her all the time
@@scottcrabtree4498
She can
It's not compulsory that only writer will voice it's project
She can voice projects written by others too
[And stop liking your own comments]
The mindless defenders are already here!
Coronavirus be like dang it
i love the little angry guys in these videos
Believe me, COX are the last thing that's hurting me.
Lol
Good 1 thx
Nice video. I am not sure it is proven that the deposits come from fatty diets however. I know the whole diet question is pretty komplex but there is enough evidence, as far as I know, that especially plant based fatty diets can help to dissolve the deposits.
2:00 VIBE CHECK
Cox:NANI
Others:AHHHH
I feel hurt now
Aspirin also reduces risk of colorectal carcinoma
its either a saber-toothed tiger or raikou
Best video ever.
Awesome, I go to the UofM.