Hippo Signalling Pathway | Organ Size Control Mechanism

The Hippo signaling pathway, also known as the Salvador/Warts/Hippo (SWH) pathway, controls organ size in animals through the regulation of cell proliferation and apoptosis. The pathway takes its name from one of its key signaling components-the protein kinase Hippo (Hpo). Mutations in this gene lead to tissue overgrowth, or a "hippopotamus"-like phenotype.
A fundamental question in developmental biology is how an organ knows to stop growing after reaching a particular size. Organ growth relies on several processes occurring at the cellular level, including cell division and programmed cell death (or apoptosis). The Hippo signaling pathway is involved in restraining cell proliferation and promoting apoptosis. As many cancers are marked by unchecked cell division, this signaling pathway has become increasingly significant in the study of human cancer.[1]
The Hippo signaling pathway appears to be highly conserved. While most of the Hippo pathway components were identified in the fruit fly (Drosophila melanogaster) using mosaic genetic screens, orthologs to these components (genes that function analogously in different species) have subsequently been found in mammals. Thus, the delineation of the pathway in Drosophila has helped to identify many genes that function as oncogenes or tumor suppressors in mammals.
en.wikipedia.org/wiki/Hippo_s...
Thumbnail Hippo Icon Credit : www.awf.org/

[@markmcdonald1371]

Wonderfully detailed explanation! :)

[@hussainbiology]

thanks for appreciation...

[@johnmandrake8829]

Nice

[@data790]

Ah yap. My PhD thesis in a nutshell and still a very mysterious co-transcription factor

[@bismayouseuf2018]

Sir plzz complete mamalian development pay lecture banaye..aap ache se explain karte hai..and without wasting time...

[@hussainbiology]

thanks Bisma for appreciation... InshaAllah i will soon start a series on Development Biology ✌️

[@MikeMrASR]

But it has also been demonstrated that Rho A inhibits hippo pathway, one way through actin polimerization (stress fibers formation) and the other way is that Rho prevents amot phosphorylation in ser 176 enhancing amot binding with actin and prevents it's association with Merlin (activator of the hippo pathway) the other way is that Rhoa directly interacts with the coiled coil domain of amot preventing Merlin binding with amot

[@human2951]

Sir, I am a huge fan of yours. Please respond my query. i want to control(inactivate) the MOB1A protein in my research. will inactivation through designing leads to cell proliferation , mitosis and ultimately cancer formation? One word , does this protein is good for alleviating cancer cells or causes cancer?

[@SouravGhosh-pn7bl]

Excuse me sir but a lot of research paper has stated that YAP is present in the cytosol and when phosphorylated cannot enter nucleus but when in dephosphorylated form enters the nucleus....can you please check that and verify my information ?

[@hussainbiology]

I would love to research on that......... I will give u response soon

[@SouravGhosh-pn7bl]

thank you

[@hussainbiology]

That is true ,
The dephosphorylated form of YAP is present in the Nucleus and when it gets Phosphorylated by LATS it is translocated into the cytoplasm,,,,,,So this is how it controls the Cell Proliferation.
Source : www.ncbi.nlm.nih.gov/pmc/articles/PMC2045129/

[@SouravGhosh-pn7bl]

Thanx

[@hussainbiology]

Welcome brother.....Always here to help....

[@gokularora965]

Still not clear