Making Diphenylmethanol: Part 2 To Meeting The Hat Man
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- Опубликовано: 20 мар 2024
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Im no chemist but from what i can tell. Home chemistry seems to be about following the literature til u get bored then ramping up the reagents to speed things up or just 'for science'.
I am a chemist, and that's actually what real chemistry is like, too.
LOL
I swear, the only reason I take metric tons of Benadryl is because I have severe allergies!!!
I swear, the only reason I take metric tons of Benadryl is because I have severe insomnia!!1
Ahh ur allergic to reality, or theres nothing on the telly.
Shits real bad on the liver and kidneies. I wouldn't recommend prolonged usage 😂
@@RoboArcand leads to dementia
dude, just eat some local honey
I fucking love that Squarespace sponsored this video! 😂
Respect.
You know when the compound has as a side effect on the psychnonaut wiki noted "unspeakable horrors" that it is the shit
bro didn't take his chance to do carrot/hair catalyzed reduction of ketones 😆
The hatman looks suspiciously like my imaginary childhood friend .
Wait a minute ....
He used to come to me when i was about 5 and narrate my nightmares / dreams.
used to see a fugure like that in the dark as a kid but he was shorter@@greatestytcommentator
saw him when i had sleep paralysis
@@unlockeduk I CAST VISCOUS MOCKERY; NAT20 LET'S GOOO
I live in kansas, can confirm tornados do destroy our houses like that
I actually did this reaction in my ochem lab today! But we used fluorenone instead of benzophenone. I was monitoring with tlc and like you mentioned if you used tlc you could have determined if the excess yield was starting material. Awesome video!
I think that a simple TLC could have told you if the first reaction was finished or not, the two products should have a pretty significant difference in Rf. I've seen reductions use 0.5-0.75 equivalents of NaBH4 (although it's usually used as 2-4 eq. because it's so cheap), so the stoichiometry should not be the issue here.
I have TLC done. I got my lamp and will post the results soon!
best way to use Diphenylmethanol is to make M*dafinil
drop the procedure
Synthesis of benadryl is a more good way,becose modafinil dont make high
Why’d you censor Modafinil? Isn’t it a prescription
man, i didn't meet no damn hat man on diphenhydramine. i took 750mg, which was enough for many people to have fully realistic and interactive hallucinations of alien entities, and all i got was a dry mouth, short term memory loss, and the hallucination of what looked like blurry ants crawling on the wall. i did feel like i was hallucinating the sound of someone speaking outside my room, but this might've just been placebo, because (for a while at least) there actually was someone outside my room who i couldn't hear clearly, and i didn't want to leave to check in case i was more messed up than i realised
Yesss so excited to see you run up your run time more with tlc it’s therapeutic to watch u do chemistry
Reminds of a time with my high school associates. They heard about this i volunteered as the babysitter. Yea watch 5 guys drool for 6hrs.
Time that some of the chemistry RUclipsrs meet up and try to do a fckinh complex synthesis like in a phd
Microbiological-free syntesys of cyanocobalamin its a good idea?
Props for the tight animations.
Finally the next Vid
Good luck with the Hat Man i think sometimes i will try this too ( for legal reasons no) but who knows
thanks for the tutorial
Those blizzards and swizzards and swiggidy-swap grayscale phase shiftings back and forth were honestly among the coolest chem clips I've seen. Nice, now eat it! Thanks
check out chemical force
W video as always coming from chemdelic
hey we did the reduction of benzophenone in my OChem Lab for uni last week! Super cool!
The mechanism in alcohols goes via the tetraalkoxy borane, which is more reducing as far as I know but you also lose potential reducing moles through the production of hydrogen. For sure having some hydroxide around stabilises the borohydride and I think there's a list somewhere of cations to add if you want to do something more exotic with borohydride (underrated reducing agent)
With the mechanism for reduction, in theory it should procede 4 times until a borate salt is formed. The borate is then hydrolysed in mild acid to yield boric acid, borates and your alcohol. In neutral conditions, you expect to see the borates. However what I will say from experience, LiAlH4 reductions often use 1:1 mols with the species to be reduced and the mechanism of reduction is similar, so maybe that's why you need to add more NaBH4. Perhaps adding things in one portion generates enough heat to allow the reaction to fully proceed? Who knows.
That was a good yield Sir.
That rizz drop meme was fkn HILARIOUS 😂😂😂 BROOOO
hell yeah! we can´t wait to finally see you meet the hat man :3
I owe him money so kinda nervous lol
@@chemdelicI’ll go with u as ur backup brother 😉👊🍻
@@chemdeliche may wear your ass as a hat as punishment 😂
I will download this for archival purposes only
Is benadryl illegal to make?
@@70othl3ss4 you’ll have to check your local legislations, don’t do it without legal backing or a license to do so
@70othl3ss4 Nope
@@70othl3ss4not at all!
Reutov describes the mechanism of action of NaBH4, or rather BH3, on page 438.
Hello. Can you help with choosing a solvent-catalyst system for the transamidation reaction? In the literature I read about a method using CuOAc in tert-amyl alcohol at 140°C, can it be replaced with some high boiling solvent? For example, glycerin. True, then the question arises of how to separate the product. The boric acid catalyst also requires high temperatures and shows high yields with liquid amines with no solvent at all (my reagents have a high melting point), and using, for example, xylene, shows low yields, according to the paper. Perhaps you have heard of other acceptable systems? I don't have such a wide selection of available catalysts and solvents
Huh... somehow I missed this video! ❤
The hat man is no joke. Well, at least he wasn't when i accidentally took way too much as a kid. It's a long story, but i kept seeing something in the corner of my eye and in the shadows.
Hat man here we come!!!
Chemdelic bout to be the subject of a ChubbyEmu video.
There's already a CE vid about diphenhydramine od.
@@abraxasjinx5207 there's more than one.
I do love your video’s. I personally can’t say iv experienced the black hat man - although I have experienced the phantom cigarette from doing Datura seeds. Gave that a capital letter because it demands respect - all delerents do really because up that dose just a tiny bit and it is a poison. Mind you, I guess you could say that about any molecule with an LD50 - which most do!
The squarespace ad is way too funny to me.
I’ve seen stuff like this when I used to take ambien.
The Great Scott of Chemistry
Caleb lives again.
From Blood 1997 PC
God bless the hat man
Do a homemade preworkout with DMAA and DMHA Next
I’m doing DNP and DMAA!
@chemdelic Did you use minoxidil or something else while you were growing your beard?
No just have crazy good beard genetics. My head hair not so much💀
Bro actually did it I can't believe lmao
Could an ozoneolysis work on this too? Or would it attack the double bonds in the benzene ring too bro?
The benzene rings are what's known as aromatic and don't actually have double bonds. They are just often drawn like that (the relevant search term is resonance). So, no they won't participate in an ozonolysis reaction. Ozonolysis usually referes to the oxidative cleavage of alkenes, alkynes and rarely azo compounds. I am not aware of any kind of ozonolysis reaction that could occure here. Ozone is a strong oxidizing agent and for sure won't reduce the carbonyl to an alkohol like sodium borohydride, but there might be some reaction with ozone cleaving the molecule at the carbonyl group and forming e.g. benzoic acid, but I'm not aware of that and I would assume that, if it does exist, such a reaction would have poor yields and many side-products. Under different conditions you might be able to use ozone to do the reverse reaction (oxidation of diphenylmethanol to benzophenone). Hope this helps
You should get the chemical analysed to be sure you have what you say you have.
As someone whose deepest experience with chemistry is high school, I think it would be cool if you did a Chemdelic’s Chemistry Crash Course
Please hire me, I’m so poor 😩😩
Best advice I can give anyone if doing so regardless drink plenty of water please or you'll end up in the hospital I know from experience it's been 5 years I don't do otcs anymore it's not worth brain damage or liver failure
this is a cool looking reaction
Please make delta 8 so I know how those gas station carts are made
It's just regular THC with a bond missing so it would barely be different than a delta-9 total synthesis.
I don’t wanna meet the hat man again, I owe him money
So I was thinking about you. Dimethylamine is required for lysergic chemistry. Also hydrazine the anhydrous hydrazine mandates nitrogen gas as O2 likely causes explosion. The hard part is obtaining ergot to begin isolating ergotamine. What Id suggest is look for organic farms the plant rye or less likely wheat. Then if you find ergot you will want to learn about mycelium and fungus groth. Using mycological grade molasses for 48 hours then isolate using chromatography. You want the glow in the dark blueish substance however use some of the fungal spores to inoculate the following year rye you plant. This can give you a very interesting life. Dont forget the red and yellow safety lights.
In Russia and other post-soviet countries you can buy "kofetamin",tablets from caffeine and ergotamine.But "making LSD at your kitchen" is a delirios
Please get it tested so we can see what it is exactly and any impurities)(the first batch)
This is the type of chemical that goes hard with an N-,N-Dimethyl ethyl moiety 🔥😳
Осталось сделать реакцию Вильмсона с дифенилметилатом натрия и хлорэтилдиметиламином
Has anyone else heard of hyoscine? Its sold as travel calm .. in high doses apparently it changes over to scopolamine or something like that and can cause hallucinations
The motion sickness medication is hyoscine hydrobromide, it is scopolamine, there's no conversation as they are the same. Also remember plants containing scopolamine will likely have other tropane alkaloids such as atropine (which is also used for medical purposes) and others. Some plants have an active dose very close to the lethal dose. Based on your comment I'd suggest more research and don't try it
3.56... methanol reacts with NaBH4 faster than with water, not an issue
LESSSS GOOOO 🤠🤠🤠🤠🤠🗣️🗣️🗣️🗣️🗣️🗣️🔥🔥🔥🔥🔥🔥🔥
Dude, I LOVE YOUR CHANNEL TO DEATH!!!
Do you think you can make 5-Meo-DMT?
Didn't find anyone on youtube that can do it.
Your salvia video is a blast.
I hope your channel skyrockets!
HUGS BRO
Can someone make me coke whiout lefs let's make a drug empire togather 😅😂
One night I couldnt sleep so I took 8 Bemadryl, it was the worst night ever.
Everything OK?
pls can you make an Homunculus ?
To generate borane as the active reducing agent, protonolysis of BH4(-) with MeOH evolves H2, so one hydride is lost. I just made a post about the mechanism based on a paper published 5 months ago after an email chain with the author. I showed the reduction of benzoin to hydrobenzoin in a recent video and spent a lot of time looking into the mechanism because it's still not fully understood. I could be wrong, but it seems like borohydride has 2-3 active hydrides in alcoholic solutions- I'm not sure if the intermediate MeOBH2 has to undergo another protonolysis with MeOH to generate the active reducing agent. If it does, then borohydride has 2 active hydrides in alcoholic solutions, if not, it has 3. My point is that it's highly likely that sodium borohydride doesn't have 4 active hydrides for reductions in alcoholic solutions.
That’s really interesting! What’s the paper called?
@@chemdelic I thought so too :) it's called "Protonolysis of BH4- Leads to Intermediacy of BH3-σ(H2) That Evolves H2 and Furnishes Borane as the Key Reducing Agent"
In the post on my channel there's info about some of what was covered in the paper including applying the revised mechanism to the reduction I did. The paper is heavy on computational chemistry, so it took me several reads to begin to understand. It's not on sci hub and idk if you have institutional access to it so I can send you the pdf on discord if you want
@@ChemDungeonplease send on discord and I’ll take a look at your channel too
Question, why would you use methanol as the solvent? Wouldn't a hydride ion just deprotonate methanol? Or is hydride a stronger nucleophile than it is a base or something like that?
From what I understand, the reaction first forms sodium methoxide, which in turn forms the more stable sodium monomethoxyborohydride.
@@maxjoechl5663 couldn't such a reaction consume all the hydride ions and end up with something like trimethyl borate?
@@rodrigomack13 I think the methoxide affects the polarity of the remaining B-H bonds.
As in, the hydrogens might become significantly less "hydride-like", and therefore less reactive towards the protic solvent.
Borane/Borohydride reductions can be somewhat unintuitive from a mechanistic standpoint since boron likes to act as an electrophile/Lewis acid due to its lack of valence electrons, while also creating hydride nucleophiles due to its low electronegativity.
So why is sodium borohydride so demanding for the reaction if you could just add hydrogen from the get go, hydrochloric acid/aluminum to get hydrogen?
We need hydride to reduce the ketone. Hydrogen by itself wouldn’t reduce it unless it had a catalyst like Pd/C
is that 2nd part of the disclaimer a twitter reply by benadryl?
A chatGPT disclaimer lol
@@chemdelic big lol
Hmm yes thank you
im sorry did i miss some chemdelic lore why are you trying to meet the hat man?
He's trying to see what's under the hat
I owe him money
Ehhh.... if i had infinite resources, i would have gone with lithium aluminium hydride as the reducing agent. It's slightly better at reducing sterically hindered molecules like benzophenone.
As it stands, I'm don't have infinite resources, so i'd probably have tried a direct electrochemical reduction on a copper catalyst in the menthol.... so mixed results at best.
yeah anti-histamine high is one of the worse that can be
SNiffing toulene glue must be the worst.. It was a big thing in scotland in the late sventies then cheap bad quality acetylated semi heroin from the turkish mafia was a big hit but all using the same needle and injecting temazepam gel pill became all the rage. Tragic I think they would lick cats arses to get high there.
benzophenone moment
benzophenone smells like bibles or old encyclopedias diphenol methanol can be used to make the methadone family if opiates.
Diphenylmethanol isn't diphenhydramine?¿?
I'm gonna tell Papa Chemdelic you're doing sus shit in the shed.
Please no💀💀
I thought the hat man was the FBI
No way the FBI is that cool or dependable .
Even if i made it, im not gonna take it 😂 jesus, get some rats 😂
The Hat man is my last chance to have game,
Beware of dry mouth, if you cant pee take a warm shower. Be safe!
Okay but why has Benadryl been around for so long but the hat man hasn't been referenced before 2000? Why were there not reports of common delusions and hallucinations with large amounts of Benadryl before? Did no one just take too much Benadryl until the year 2000?
The answer is the mass adoption of the internet.
There will be many reports prior to 2000, but since not a great deal of people were on the internet prior to this, those reports would not have been digital (existing in cyberspace)
Desoxypipradrol
I remember reading about that one. Basically, scientists at CIBA were like:
_"What if methylphenidate, but instead of having a properly medicated ADHD kid, you have an ADHD kid whose meds keep them up for >24 hours?"_
d-... did you say "expecially"?
BTW for anyone reading this, DPH gives you early onset dementia (don't take my word for it, look it up). Pretty weak for this video not to mention that.
Methanol react with NaBH4 at room temperature, that's why all MeOH/NaBH4 reaction should be be performed in an ice bath below 10C.
Also NaBH4 react really slowly with water and many reduction are performed in alcohol/water or just water (even at high temperatures), so water is not the problem
Weirdly enough, the procedure I followed did it at rt
@@chemdelic try adding NaBH4 in methanol (1g in 5/10ml), you should see some bubbles and as reaction proceed it warms up, getting more and more vigorous until il boils out. Or at least that's my experience with it:)
Please report back!
Man, as someone who tried DPH (and saw hatman), do NOT do it ... please, you'll regret it.
If you want to test some dr*gs, try classical psychedelics, it is way funier and better for you.
didnt you just talk mad NaBH4 gibberish? how is multiplying by 1 reducing it, instead of 4???
youre just using less nabh4, because you thought it didnt reduce?
the product is likely fine, you just need to was out the residual borates, either add some acid to destroy any remaining nabh4, or wash thouroughly with water.
also for the next reaction, add a tiny amount of koh to stabalize the nabh4
In theory that molar amount works. In practice people generally use 1:1. Of course it likely worked with the amount in the procedure, I just used more to calm my mind about using that specific amount. And yes using KOH would have helped, I just wanted to follow the procedures best as I could :)
i just find it strange that you ended with more product than you started with, i highly doubt it had much water left since your drying seemed to be reasonable.
NaBH4 is pretty alright in MeOH, with water you usually stabalize.
just for NaBH4 it doesnt really degrade that fast, so neutralization by acidifying would be a good choice, or when poured down your drain, youre kinda at risk of causing a hydrogen poof somewhere in the sewers
i also would like to point out that scaling a reaction by 35 pretty far from following a procedure as best as you can
The hatman touched my no no square 😭
I like that unlike nilered, you don't charge money to see you do sus shit. lol I'd rather have a massive disclaimer wall then a paywall.