I personally think using animal models without trying to evaluate those against the human studies we do have, however limited, is irresponsible. Those of us with ADHD who need and rely on stimulants to keep our lives together, need both laypeople and professionals to understand just how life giving they have been and require more nuance when discussing potential reasons to refuse treatment with stimulants. My main concern is raising concern without sufficient evidence or research for it to impact clinical care in any meaningful way. At least I hope it wouldn't, if we made decisions based on every mouse study we'd be in trouble. Misdiagnosis is more of a concern, with research already available as to the strong corollation between early stimulant treatment for those not needing it, and later development of severe/multiple mental health disorders.
Sadly we don't have any alternative solution for this problems that involves dopamine, but living with anhedonia and apathy absolutely terrible thing and also indirect leeds to death of neurons due to lack of physical and mental activity, i think here we just need to seek balance while using this medication
@@sanelprtenjaca9147 Unfortunately there is no Modafinil Wellbutrin in my country 😢 I hate this attitude towards these drugs 😡 Pramipexole is quite an interesting option. thanks!
Guanfacine? I've been on Vyvanse for like 10 years but considering other routes due to my own concerns about aging + transient blood pressure increases or whatever even when it doesn't show up clinically
Thx for this video. You mentioned the problematic responses to huge spikes in dopamine. I coach guys in porn recovery and prolonged and extended porn use rivals (and exceeds some) dopamine levels of these street drugs. It’s no wonder so much of society is in a fog bc their drug is porn and readily available in their front pocket.
quiting porn was the best thing i ever did for myself! it really is silently wrecking lives and so many people are completely unaware of how it is negatively impacting their life.
Very interesting. I have always opted to prescribe methylphenidate over Amphetamine based products due to abuse potentials and from my cursory studies/research, lower risk of neurotoxic/cardiotoxic effects. Do you know what the dose of MPH in the rat studies was in dose/kg for the rats and if any of your literature review hinted at level MPH toxicity compared to amphetamine toxicity? Thanks for posting. Love the vids!
Would supplementing with TUDCA help the liver repair or maybe prevent some further injury while people work to lower their doses or stop taking the medications?
7,8 dhf Polygala Uridine N acetyl L Cysteine ALCAR Micro-dosing (shrooms would recommend) Lions mane mushroom EXERCISE Good Diet SLEEP Build relationships and socializing (this is inportant for the your brain) Maybe like read or meditate and don’t hyper stimulate
Is it known what serotonin receptors adderall acts on? I understand amphetamine’s action on serotonin is minimal compared to dopamine. Are there any other medications that act on those same serotonin receptors?
The doses are very high. Antipsychotics were discovered due to their use as tranquilizers to people who overdosed to amphetamine. It was OTC back then and people would take down bottles.
Just discovered the channel, loving the videos. Any thoughts on a video on evidence for lithium/lamotrigine/other mood stabilizers for unipolar depression, gad, comorbid gad/depression?
I want to see a study that analyzes the addiction risk associated with long-term stimulant therapy by examining outcomes for recipients of longstanding stimulant administration upon involuntary discontinuation of the medication. Otherwise, it's always seemed a little like saying, "Look! Continuous morphine administration does not contribute to the risk of heroin addiction during ongoing administration!" It's like, yeah... no shit. Why should they climb that tree when you've bent the branches down? They can just reach up and grab the fruit. If the findings of that study agree with the current consensus and demonstrate that stimulant therapy doesn't contribute to one's risk of addiction, then I think I could accept the results.
I used to drink alcohol and I can say that it is definitely dose dependent. As for the stimulants, what about the behavioral changes they produce in the short term as well as in the long term use of them by humans, keeping in mind the dose dependency issue?
Doesn't the methyl group simply allow amphetamine to cross the blood brain barrier more easily? The studies are what they are, but it's just such a small chemical difference.
Dr. ROSSI My son was eating deodorant speedstick. Anti perspirant to get high could that cause Neurotaxicity, he is currently in a mental hospital and they think that he has schizophrenia and he doesn't.
I feel low dose stimulants don't cause much neuronal death. High dose over years has to cause neuronal death and more likely to cause habtuation. Just my observation. I'm not diagnosed adhd.
I am not a doctor but know some people with parkinson deseaze so I began reading about it En about there medicine leverdopa and about dopamine and there working I have some expirience with stimulants also read a lot about that and there working and I found the same in one docters review Wat you tel here so I thought then the same that maybe the prescription drugs like dexamfetamine also could have side affects (dangerous) now I just saw your video intresting topics you have👍
Does this apply for all stimulants, such as caffeine? I'm sure most of your viewers would like to know if their daily cup of coffee is safe or not (though we'll all probably still have it even if it isn't lol)
I personally think using animal models without trying to evaluate those against the human studies we do have, however limited, is irresponsible.
Those of us with ADHD who need and rely on stimulants to keep our lives together, need both laypeople and professionals to understand just how life giving they have been and require more nuance when discussing potential reasons to refuse treatment with stimulants.
My main concern is raising concern without sufficient evidence or research for it to impact clinical care in any meaningful way. At least I hope it wouldn't, if we made decisions based on every mouse study we'd be in trouble.
Misdiagnosis is more of a concern, with research already available as to the strong corollation between early stimulant treatment for those not needing it, and later development of severe/multiple mental health disorders.
Sadly we don't have any alternative solution for this problems that involves dopamine, but living with anhedonia and apathy absolutely terrible thing and also indirect leeds to death of neurons due to lack of physical and mental activity, i think here we just need to seek balance while using this medication
Pramipexole, Modafinil and Wellbutrin might help.
Agreed.
@@sanelprtenjaca9147 Unfortunately there is no Modafinil Wellbutrin in my country 😢 I hate this attitude towards these drugs 😡
Pramipexole is quite an interesting option.
thanks!
@@minepolz320 No problem! :)
Guanfacine? I've been on Vyvanse for like 10 years but considering other routes due to my own concerns about aging + transient blood pressure increases or whatever even when it doesn't show up clinically
you mention the neuronal changes on methylphenidate, but do these significant changes and risk for parkinson’s translate to the risks of adderall?
I wonder if that also applies to dopamine enhancing meds, like bupropion.
Yep i am also
Can you post your references for the studies on stimulant use and substance abuse disorders? I would be interested in reading more into it!
Just Google it. They are easy to find.
Thx for this video. You mentioned the problematic responses to huge spikes in dopamine.
I coach guys in porn recovery and prolonged and extended porn use rivals (and exceeds some) dopamine levels of these street drugs. It’s no wonder so much of society is in a fog bc their drug is porn and readily available in their front pocket.
quiting porn was the best thing i ever did for myself! it really is silently wrecking lives and so many people are completely unaware of how it is negatively impacting their life.
Very interesting. I have always opted to prescribe methylphenidate over Amphetamine based products due to abuse potentials and from my cursory studies/research, lower risk of neurotoxic/cardiotoxic effects. Do you know what the dose of MPH in the rat studies was in dose/kg for the rats and if any of your literature review hinted at level MPH toxicity compared to amphetamine toxicity? Thanks for posting. Love the vids!
Would supplementing with TUDCA help the liver repair or maybe prevent some further injury while people work to lower their doses or stop taking the medications?
How do I recover from neurotoxity
7,8 dhf
Polygala
Uridine
N acetyl L Cysteine
ALCAR
Micro-dosing (shrooms would recommend)
Lions mane mushroom
EXERCISE
Good Diet
SLEEP
Build relationships and socializing (this is inportant for the your brain)
Maybe like read or meditate and don’t hyper stimulate
What about using caffeine for adhd ..
Is it known what serotonin receptors adderall acts on? I understand amphetamine’s action on serotonin is minimal compared to dopamine. Are there any other medications that act on those same serotonin receptors?
Dr. Rossi, is it true that amphetamine carries a greater risk of psychosis than methylphenidate?
The doses are very high. Antipsychotics were discovered due to their use as tranquilizers to people who overdosed to amphetamine. It was OTC back then and people would take down bottles.
@@benzapp1 Interesting! Thanks.
Sigh I wish I realized what I was doing to myself years ago.
Just discovered the channel, loving the videos. Any thoughts on a video on evidence for lithium/lamotrigine/other mood stabilizers for unipolar depression, gad, comorbid gad/depression?
Yaaay new vid!
I want to see a study that analyzes the addiction risk associated with long-term stimulant therapy by examining outcomes for recipients of longstanding stimulant administration upon involuntary discontinuation of the medication. Otherwise, it's always seemed a little like saying, "Look! Continuous morphine administration does not contribute to the risk of heroin addiction during ongoing administration!"
It's like, yeah... no shit.
Why should they climb that tree when you've bent the branches down?
They can just reach up and grab the fruit.
If the findings of that study agree with the current consensus and demonstrate that stimulant therapy doesn't contribute to one's risk of addiction, then I think I could accept the results.
I used to drink alcohol and I can say that it is definitely dose dependent. As for the stimulants, what about the behavioral changes they produce in the short term as well as in the long term use of them by humans, keeping in mind the dose dependency issue?
Are you using a microphone?
Doesn't the methyl group simply allow amphetamine to cross the blood brain barrier more easily? The studies are what they are, but it's just such a small chemical difference.
Dr. ROSSI My son was eating deodorant speedstick. Anti perspirant to get high could that cause Neurotaxicity, he is currently in a mental hospital and they think that he has schizophrenia and he doesn't.
Can you do a video about rTMS that is NOT about depression? Everything on youtube about rTMS is regarding depression since it’s FDA approved for that.
I feel low dose stimulants don't cause much neuronal death. High dose over years has to cause neuronal death and more likely to cause habtuation. Just my observation. I'm not diagnosed adhd.
I am not a doctor but know some people with parkinson deseaze so I began reading about it En about there medicine leverdopa and about dopamine and there working I have some expirience with stimulants also read a lot about that and there working and I found the same in one docters review Wat you tel here so I thought then the same that maybe the prescription drugs like dexamfetamine also could have side affects (dangerous) now I just saw your video intresting topics you have👍
I appreciate you watching the video, please consider subscribing and spreading the word
Does this apply for all stimulants, such as caffeine? I'm sure most of your viewers would like to know if their daily cup of coffee is safe or not (though we'll all probably still have it even if it isn't lol)