MOV10 - Ceman Lab, Department of Cell & Developmental Biology

Video credit: Aatiqu Nawaz, Stephanie Ceman. Department of Cell & Developmental Biology, School of Molecular & Cellular Biology, University of Illinois Urbana-Champaign
MOV10 is an RNA helicase that is highly expressed in developing brain and is required for viability. Researchers have now identified an important regulatory event (phosphorylation of serine 970) that blocks the ability of MOV10 to unfold and facilitates mRNA degradation through Argonaute 2. This finding gives insight into how MOV10 regulates protein expression in the developing brain. The predicted structure of MOV10 in this video is from Alphafold2, an artificial intelligence system for protein structure prediction, and visualized using PyMOL.
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The motifs for the structure of RNA helicase MOV10 are as follows:
Orange: N-terminus
Blue: Helicase core containing C-terminus
Red: ATP binding and hydrolysis
Cyan: Nucleic Acid binding
Green: Coordinated Nucleic Acid and NTP binding
White: S970
P: Phosphorylation at S970.