Acute Myeloid Leukemia | Clinical Presentation
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- Опубликовано: 6 фев 2025
- What is acute leukemia? It is a condition in which the hematopoietic stem cells in the body become abnormal and accumulate in the bone marrow and blood serum. Acute leukemia can be split into two types: myeloid or lymphoblastic. This depends on the lineage of the hematopoietic stem cell. This video discusses the pathophysiology and major clinical signs and symptoms.
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My son was diagnosed with AML three years ago when he was 19. He had acute monocytic leukemia. Interestingly, while he had probably had it for a little while, it was diagnosed after he had his wisdom teeth removed, and it didn't seem to be healing and his gums were extremely swollen. That, along with his WBC count of 108,000 led his oncologist to diagnose him even before he had any testing done. He also had it in his cerebral spinal fluid. He went through 5 rounds of intense chemotherapy. He has been in remission for 3 years, and is engaged to get married this summer.
That’s what happened with me and a nose surgery
@@briansnoopy You have to be joking I'm 19 and got diagnosed after a septoplasty. I finished my transplant a month ago and I just got my line out😌
@@cjzelaitis So, you had AML and got a stem cell transplant? I hope you are feeling better now. Fortunately, my son did not require a transplant. He went into remission after his first round of chemo, and then completed the remaining 4.
@@AS-yz2iz I'm doing a lot better now, thank you! I still have a long way to go, but I'm so happy about your son and congrats on the wedding! I technically went into remission after my first round, but I still had two more rounds plus the transplant. I'm just happy that both of us were lucky enough to catch it early🧡
@@cjzelaitis I'm glad you're doing so well. I pray you have a long, happy, healthy life.
I'm a medical student. I've never seen any lecture better than this. Thank you very much.
I found this while researching my cancer A.L.L. Don't worry, I'm in remission, have been for... I think five or six years now. This is very helpful in learning about it. Sadly, I have either O+ or O-, whichever one is the rarest blood type. The sad thing is, because I had a blood cancer, I can't donate any bodily fluids. I don't know if I can donate organs though.
I got acute lymphoblastic leukemia when I was five, almost six years old. We found out after I almost slept through a fire drill. I had to be woken up by two classmates. When I woke up, I was surprised because I heard a fire alarm. I think you would be alarmed too (that pun was just too easy to pass up). Oh yeah, I forgot to say, I was in kindergarten and naptime used to be part of kindergarten and naptime just happened to be before the drill that day.
that's because you don't know Dr Luna from Fernández Hospital
I got diagnosed with acute myeloid leukaemia aged 14, after 3 months of symptoms and been told by doctors it was a water infection, pulled muscles and puberty. Finally one doctor listened and ordered blood tests. 18 months later from remission aged 16 I relapsed and had a stem cell transplant. Now I'm 31 and although not in the best of health from side effects of the chemo and radiotherapy (had a bad reaction to it all) I'm thankfully still here.
Hello is it completely curaable my 28 year old only son died due to lukemia aml Chemotherepy 2 nd cycle we lost our son he had after chemo lot of infection . After diognose immediately we take treatment all of suddenly happens before that he was very healthy no any bad habits how he got this discese. We lot our son lost year till today we are suffring what happed to our son?
Amazing...no one can explain such a highly complicated topic in such a simple way like its done here....Great work... Keep it up
2 years ago I was diagnosed with AML. Doctors called me dramatic and was saying since I was 18-19 years old that blood counts can fluctuate. It was until my hemoglobin dropped to 4.5 and a hospital stay that they finally saw it in my blood and sent me to Emory in Atlanta. I‘ve learned SOOO much about the disease and want to be able to help others like me through. After losing 4 friends from AML I’ve been pursuing a nursing degree for oncology and hopes to further this into a doctor of Hematology oncology. Thank you for your post and for helping me to further understand! To anyone watching this vid or reading this post that has been or is currently going through treatment for any type of leukemia, I’m praying for YOU!!💜
You’ve got your mission. Go to it.
I lost my father due to Acute Monoblastic Leukaemia this week. It's been 5 days and i am trying to accept the fact that he isn't with me anymore. He was only diagnosed 4 months ago and he was completely okay whilst his treatment was going on until he caught a fever and then a lung infection which took him away from me.
As a person from the medicine and health sciences field and my sister is a doctor herself we closely monitored our dad daily and made sure he lived the best life he could in his last days. I wish he was here because I wanted to do SO much for him. I will always regret it.
my condolences. if you don't mind, me asking my uncle has been diagnosis with AML and Im trying to get a feel of the medicine affect. how old was your father and was he in good health before this happened?
@@pamcraftsandtreats My father was just 60. Yes he was perfectly fine, he had no symptoms whatsoever until one day he bled a lot through a small cut and then we got his blood reports which showed reduced platelets and finally through the bone marrow test we got to know he had AML. The only medications are to suppress the symptoms if the patient has any underlying disease (which my dad didn't have any nor did we have any familial history w cases of cancer) and the conventional treatment is ofc Chemotherapy to reduce the WBCs.
My dad got diagnosed in the month of July and he passed away in October. It was all so quick, I just couldn't believe all of it.
My condolences
(from Tina Bigham) My husband passed away at tbe age of 59 from AML after a 2-year battle. I never really understood it competely, but I understand it a little better now. Thanks for this help.
im so sorry for your loss.
Is there any possible for someone if he/she can survive this kind of sickness? Thank yoi
This is the best tutorial I've ever received on Acute leukemias. I've studied this 2x in class and no professor has simplified it like osmosis did in this video.
If you're here because you know what happen to Kyedae, Let's all pray for her
Prayers up, Get well soon Kyedae
I had AML when i was 12. I´m forever grateful to science, doctors and my friends and family for the fact i always had a positive surrounding and beat it after 8 months of intensive chemo. today i am 26 and so happy to be alive. if any person could say that he loves everyone and anything, it would be me. i just love everything, there's no other way to explain my feeling towards the world. The feeling of "i get to live and experience life after being so close to death" is unexplainable. however i did not always have this thought process after my treatment. I felt a lot of pain for a long time... Why me ? Why cant i do the same things as other kids? Why cant i have a normal childhood ? why cant i think the same way as other kids? why cant i focus on my dreams? why do i feel like little things don´t matter? why do i have no sense of direction? why am i feeling depressed? and loads of other thoughts that followed. I was never a victim but my thoughts for long time between the age of 16-24 were negative and for again, for a long time i felt like i was this victim that i told myself so often i wasn´t. If you are reading this and have a family member, friend or if you are going through this yourself, please speak out, to anyone! whether it be me, your dad, uncle, friend...Life after cancer can be hard, but we all need to make a choice to speak about it and seek the help that we may need.
Hi happy to hear you survive this aml. My 28 year old only son died due to lukemia aml after diognose only two months alive my son second cycle Chemotherepy he had lot of infection suddenly he passed last year without our son till today suffering lot he was very healthy no any bad habits how he got this discese we dontno parents we are lot dippression
you are awesome, im happy you beat it and having so inspiring outlook on life :)
Are you Swedish? I’m trying to teach myself Swedish and so far I’ve only seen “kj” used to form a single consonant in the Swedish language.
Other than that, glad you survived all your troubling emotions. This is the inner battle we must all fight no matter what adversity we have to face.
@@unclesam5655 Thank you, hopefully i can inspire others to feel the same. Love.
@@DaRyteJuan Thank you my friend! I am from Iceland. Life carries on and the earth will not stop turning no matter what we feel. Which is why whatever happens, happens. We just gotta keep turning like our beautiful planet.
Thank you so much for helping me learn about my cancer. Btw, I'm about five or six years into remission so don't worry. I had acute lymphoblastic leukemia.
So glad you've gotten better ❤️💜
Thank God you better
for anyone that is watching this because kyedae got diagnosed with myleoid lukemia, Please Pray or Send Guidance to her because she needs us right now.
That's what made me click on the video, I was surprised she told us which cancer she got diagnosed with since a lot of people choose to keep it to themselves so people don't look it up. A lot of people are just spreading misinformation and negativity but we don't even know which specific type of cancer she has, I hope she will be ok.
AML in 2007 with a stem cell transplant. All is well thanks to God and all the amazing Dr's and nurses in Calgary.
A classmate of mine passed away from AML just last week at age 23. Thank you for a great video.
Thank you for terrific presentation. We lost our daughter in July with AML, it having progressed from MDS. She first had symptoms at age 15 and passed away at 42. No one explained this to us.
I feel your heartbreak. She is still there with you, she’s only a thin veil away.
My love to you both.
I'm very sorry for your loss, I wish that God gives strength to you and your family. May God keep her in His arms but always close to your hearts.
This past Father's Day my dad was diagnosed with leukemia, and it ended up being a mixed phenotype, so he had both lymphoid and myeloid leukemia combined. It took him in about two weeks. I'm going into medicine, and normally this sort of thing is super fascinating to learn about, especially something so rare as mixed phenotype acute leukemia. But it just hits different when the patient in question is your dad. I'm glad to see stories of survivors here, and I hope everyone who sees this video holds their loved ones close.
I too lost my father a few months ago to acute myeloid leukaemia, I’m sorry for your loss. I never had the heart to research it because I was too afraid of the information as it concerned my own father. May you have a bright career in medicine!
My aunt just got this 5 hours ago today
Im praying everything’s okay:(
Hows she now
Thank you so much for this
-Clear visual presentation
-Smooth logical, concise flow
It was So helpful!
It’d help me, my colleagues and patients too!
My Brother is suffering from it. Currently undergoing chemotherapy. Lets all pray for his speedy recovery. InshaAllah
Osmosis is just the best. Teaching the hardest concepts in the simplest manner. Thank you so much
Very good teacher. Explained everything so simply and clearly.
Medical lab science student who absolutely loves your videos!
im in remission from acute myeloii leukemia. three years now...still cautious though as its a five year mark an im only three years in...i wish you all who are suffering or in remission like myself for healing
Don't worry u will be ok
@@milibhattacharjee1587 ty
How are you now?
There is no one in world who can give concept like this video👌🥳✌️🤩
bless this channel! it's the only reason I'm passing my classes; Lord knows my professor is useless. 🙏
Soo thankyou to the entire osmosis team!. You guys work soo hard to make any topic soo much informative and concise. God bless you all!
I'm watching this video because I had a tumor removed from my intestines (9cm) that according to test is myeloid leukemia in a mass. Two weeks later I got my bloodwork and bone marrow results back. Wbc count is dropping and bone marrow came back clean. It appears I'm cancer free at the moment without any treatment except removal of the tumor. They said I am a rare case and require alot more study and monitoring.
Bro everything's gonna be alright okay,, you hear me bro,, the good doctors will find a way to cure you so never give up bro everything's going to work out for you bro
@@asdafaafsaffa2871 Thank you. Even though everything was clean they still want me to go next week for chemo, then a bone marrow transplant. Complications from a transplant are very scary. My poor wife is so afraid and so am I. My son is hurting but trying to be strong. Once again thank you. You words made me feel a little better
@@masterrick2759 I hope everything went well with you bro
@@AY-ct8yj thank you. I spent the last 3 weeks in the hospital where I had the 7+3 chemo plus a spinal tap and chemo injected there also. I go back for a bone marrow transplant soon as they can find a donor. I have another channel called Mangus music on RUclips where I put up some guitar videos and a couple of hospital videos incase I don't make it. The chemo was really rough . Thank you ,any words of encouragement help at this point .
Best of luck, everything will be fine❤️ im here to study and hopefully can help people in my future🤗
The video is so beautifully made! Definitely managed to teach me a lot more than my lecturers! Thankyou for making this video
Thank you very much for this fabulous video ... Even it is 10 min it equals at least 1 hour lecture. I am very satisfied with it.
Wow RUclips recommendations are super specific. My husband is in remission from AML.
i am an internal medicine resident. and whenever i need to revise something i still come here
No one can explain this topic better than you🙏🙏🙏🙏🙏🙏🙏🙏
i dont think that it could be understood more easier than this..to explain this topic in such easy manner is quite e difficult job.....kudos to team osmosis....
i hope kyedae has a speedy recovery
My wife and I lost our just turned 2 year old son 7 months ago to Aml. He had MLL gene rearrangement or subtype KMT2A or 11q23. He had a translocation between chromosomes 6 and 11, t(6;11). He received cytarabine, daunorubicin, etoposide, gemtuzumab ozagamicin then mitoxNtrone and cytarabine. He relapsed after the second chemo which signified refractory Aml which had a poor prognosis. Decitabine with mylotarg was then used. He died shortly after from within 4 months of treatment. Some side effects he had were bloody nausea and diahrea. Horrible bloody mouth sores. He was in pain all over. His right eye was covered by a leukemia pool that ended up bleeding.He had a lot of liquid in his lungs which they thought was pnemonia. He ultimately died from a brain bleed within 24 hours caused we think by the chemo.
Iam also lost my 28 years old only son one month before he had aml Taking 2 nd chemo bloodcounts are down infections are more I lost my son with in two months of diognosis even today with out my son I amsodeprresion what to do why God doing all this in my life my son was very inteligent no bad habits no family histry of cancer why he funish this diceice
My son hast been also Diagnose with aml report Came in yesterday and i am also afraid to losse Him coz his heart is sick n lungs full of water
@@annettesteck6683 how is your son now I am usha I lost my son before four months
@@ushas5546 😰😰
So sorry, my daughter has this type of AML too. Wishing you peace to your family.
One of my best friends (we’re both 12) has aml leukaemia and it started off with her staying home a lot because they thought she had the flu but she didn’t obviously. She was away for atleast 3 months and was in and out of the hospital the whole time but none of her friends got to visit her or see her but she came back to school yesterday and found out she isn’t loosing her hair and she’ll be done chemo in January. She’s had over 5 bone marrows done and has a centre line I think it’s called which goes underneath her shirt. She’s the same person and you wouldn’t even know she has leukaemia/cancer if she didn’t tell you. A nurse from the hospital she was at told us all about it and said they are certain she’ll survive.
Good to hear. Hope she never sees or hears from it again.
Bless your friend ❤️ glad she has a positive future
I have AML and I'm getting treated. We found about it on December and started the chemo treatment on January and had 3 bone marrows till now. I have lost my hair but I still have little bit of it. I feel well now just finished the second dose of chemo last week and I feel normal but the first month was horrible. 2-3 months are remaining to finish my treatment. Non of my friend know about it and basically no one expect my family because I don't want anyone to know. Actually I'm much happier now even though I'm stuck in the hospital 24/7 because before I was diagnosed with AML I was sad all the time and overthinking. I feel better now cuz I toke a break from the world and had time to my self.
good for him. my brother just died this april because of this cancer. he was only 25. missing him daily. started maybe february. he never got the chance to have chemo because his blood never became normal.
I am so suprised that how a 10 min video is much instructiv than 1.5 hour lecture
Monday got exam for these.... very detailed video thanks
Great primer on leukemia. 👍🏻
Jesus Christ healed me of 28 years of drinking and doing drugs then in 2001 Jesus Christ healed me of AML at Maricopa county hospital in Phoenix az 2001. I only had AML for a month. I have been healed ever since. Doctor fine told me I had 70 percent chance of dying from leukemia. I told Dr fine, Jesus Christ will heal me. I have been healed 20 years now amen!
Amen, I think I'm pre lukemia? You think that is possible my legs always hurt when I used to drink
@Ela Lamblin I will pray for her but she must ask God to forgive her of her sins. Then she must go to a Christian church and ask Jesus Christ for the pastor to pray for her, after the pastor prays for her then know she is healed. Wait on the Lord Jesus Christ to heal even when death is at your door. Pray and pray that Jesus Christ will heal never give up. Please believe Jesus Christ will heal. Also remember to confess your sins and ask for forgiveness.
I got diagnosed this year and will die in the next few months. Why won’t Jesus Christ or god help me?
@@dr.chickenfingers5696 you must have faith Jesus Christ will heal you. You must not doubt, you must act as if you are already healed. Repent of your sins with your heart and hold unto God's word forever.
I have AML, I have been in remission for 10 years. Chemo and a stem cell transplant healed me, but I am not cured. I think you're a charlatan who is peddling religion as a cure to desperate people, you disgust me. I don't believe you had AML for one minute. And no, don't pray for me, just pray that I don't come looking for you. 😡
Thank you very much man! You saved my exam xD
Thanks for helping me in my presentation tomorrow.
Really Appreciate it
Awesome video!!!!
The title should be Acute Leukaemia though, not Acute Myeloid Leukaemia
Again, many many thanks. This was extremely helpful 🙏🏽
Hey thanks man with this. I was always unsure about the family of leukemias
My father entered the hospital three days ago after a fall and injuring his knee the next day a home nurse came to check on him and said he needed to go to the hospital right then by ambulance. He had a severe infection. When the specialist came in after he received his labs he asked if any doctor mentioned that he had ASL. We were shocked, so obviously no. And looking at his blood work in the last 8 years it was right there. Why did no Dr see this? As well my brother has a daughter who was born with Downs and was diagnosed with leukemia??????
Me an oral surgeon and expert on oral pathology ..watching this whole video for the hypertrophic gingiva due to blast infiltration
My blast count was 70% when they found my AML. Luckily I had a genetic mutation called inversion 16, and now I'm 4 years in remission.
Thanks for the cool illustrations.❤
Beautifully explained, thank you very much for uploading!
Recently my wife passed away at 52 years from Acute Myeloid leukemia. I am so sad.
Amazing explanation 🙏🏻
My son had that
7 years old
Doing treatment right now
Big hugs to those suffering with AML. ❤ patients and loved ones.
Absolutely stunning explanation i am a med stud
Great lecture
Thanks for uploading 📚💓🙆🏻♀️
okay is this osmosis or pathoma or maybe best of both worlds and I am just so happy!
Thank you Medscape
Im here because of kyedae tweeted that she got AML. Now im broken
Same
Aww nice information. My step daughter passed away with this a few days ago
There’s nothing like “AWW” in this specific video
I’m sorry for your family’s loss :( hopefully, they make more advancements in treatments. No one should suffer from this horrible disease.
My condolences
@@rosiegarza953 thanks
these videos are legit so good, thank you
I have to really appreciate this lecture ,whataaa explanation it was!!!!
You did not comment on the prognosis for myeloid.
Please what did you mean by t(12:21)being a good prognosis and the later being a poor prognosis. i.e in this context?
Does it mean the condition was caught late? 5:15
My Mom passed away from a short diagnosis of AML after years with APA and MLS.
Am medical student thank you at last i understood
My cousin died from AML and he was just 18 years old. Very rare to get AML before you are 60 years old.
My 28 year only son died from aml four months before he was very healthy before when diagnosed within two months we lost him during chemotherepy your cousine after diognise how many days he alive
@@vinays4757 I think he lived about 1 year but I could be wrong it might have been less. It was 10 years ago so I don't remember the exact time. Sorry for your loss.
My mother passed away at 51 from AML. She's been gone 10 years this year.
@@vinays4757 sad to hear that. my younger brother also died just this april. he was diagnosed late feb. never got the chance to have chemo because his blood never went normal like the hemoglobin and platelets never went up. he also have an infection that damaged his kidneys. missing him daily. he was only 25
Please discuss about CML
you have a mistake in the video. t(9,22) is not all but cml, please get it fixed
That can occur in ALL and CML both, but the difference lies in the molecular weight of the protein the fusion codes for. It's 190 Kda in the former and 210 in the latter. Additionally , the prognosis is inversely proportional to the molecular weight. Less the weight poorer the prognosis and vice versa. That's why AML has a poor prognosis
you are really the best, and you literally saved me!!!
My son died from this a week after being diagnosed, the chemo caused the lining of his bowel to rupture
nice presentaion..im not totally familiar interms of medical aspect but its a very good presentation
I hoped that you would explain more about acute erytroblast leukemia, maybe you can include this later. I find it so hard to fint information about the AML M6 (Erytroblast)
Beautifully presented.
Excellent
Kindly tell me that biopsy is safe for 80+ person who is on oxygen and some of the infection in lungs..plz guide me
Can acute myeloid leukaemia M2 autologous stem cell transplantation be completely recovered?
Very great explanation ! Cheers 👍🏼
l am medical student. l like it very much
very nice and clear vedio
Amazing explanation thanks you sir .
Thank you so much for this video. 😀
Very helpful. Thank you for sharing!
This topic is about whole leukemia
Those who are confused acute myeloid leukemia is telled later after clearing the basics 😇😇
Thank you. It was an awesome explanation.
I have myelocytes in my blood but the thing is my WBC isn’t up. So I’m not sure if i have it or not.
Best lecture
My mother is 68 and she has had this disease for 3 years. Is it really curable? I read online that it’s difficult to cure but her doctor seems to think it can be… I think age is also a factor.. she’s been on treatment for it and it did seem to go away, but they are keeping track of things and continuing to test her marrow.
Then recently she got sick with a cold or flu and ended up very poorly and had to be hospitalized. Her body seems vulnerable when she catches a cold..
Necesito traduccion de éste video🙏
My dad just passed away because of this dreadful disease :(
Thank you so much.appreciate it.
Thankyou so much😢
Can we get this video in urdu translation?
Thank you
Can someone tell me what is the normal range of abl copies in aml?
Can someone please explain to me why Multiple Myeloma is a "Myeloma" yet it arises from Lymphoids not myeloids?
Paraproteinemia
Masterpiece ❤️😊
This was great! Thanks
Great work,Thank you :-)!
pl make vedio on cml
Ummmmm idk if im being delulu but this lecture is literally what is there in pathoma. Like exactly the same things were told in pathoma lectures. Crct me if im wrong though.
Thank you❤❤❤
Is it like myeloid stem cell give rise to myeloblast but fails further development into granulocytes ?