I'm thankful that you could read & respond to my attempt to understand the mechanics of the voltage gate operation, and I wonder if you could explain how the hydrophobic alanine (residue? Is residue the right word for it?) and the IFM moiety are mutually attracted (in inactivation of the open gate)? I'm guessing that when they're close enough intermolecular forces 'bind' them temporarily, but what attracts them together initially when the alanine is exposed?
This diagram and explanation is extremely helpful! Thank you for making it! At 6:10 , is it correct to say that sufficient depolarization pushes the voltage sensor outward toward the extracellular environment, and because the voltage sensor is CONNECTED to the activation gate, it PULLS the attached activation gate open, which gate component was blocking the pore which was created by & is between S5 & S6? And that there are FOUR gates or gate sections, one in each of the 4 domains ? And at 6:49, is it correct that as the activation gate swings open, it exposes hydrophobic (residues?) which attract a 'ball' (IFM moiety) on its molecular 'chain' toward it, such that the 'ball' swings into the pore and blocks the bottom of it and inactivates the channel? Could you say in what way the hydrophobic alanine and the IFM moiety are mutually attracted? And presumably when the voltage sensor returns downward when the membrane at that location re-polarizes, it pushes the gate part back into both closure of the pore, and also interferes with the IFM moiety/alanine connection and breaks it, taking the channel out of inactivation?
Yes, your understanding is correct! But, these are theoretical models based on experiments done so far. In future, these models could be updated/revised to incorporate additional findings.
@@ThePhysiologyChannel Thank you, not only for this wonderful animated 'cartoon' which helps me understand the mechanical actions of the gating better than any I've seen before, and for verifying my attempt to understand, but perhaps most importantly for reminding me that these are theoretical models based upon painstaking experiments, which models may need to be improved as time goes by.
@@ThePhysiologyChannel Thank you for your reply! Follow up question: is the IFM similar to the N-terminal (N-ball) based deactivation, or is that a completely different thing? If so, how?
@@ThePhysiologyChannel Morever, given that potassium-gated channels activate upon depolarization, would their sensor be less reactive, in the sense that there has to be a higher positive charge inside the cell in order to cause them to open?
Can you explain how the new drug pregablin works that is prescribed to people with epilepsy and who may suffer from anxiety. Those who supply this drug cannot explain the mechanism of this drug - but they suspect that it binds calcium to the alpha 1 gated receptor. Pregabalin is an anticonvulsant drug used for neuropathic pain, epilepsy and generalized anxiety disorder.[4] It presents antihyperalgesic actions by binding to the α2δ subunit of the voltage-dependent calcium channels without presenting antinociceptive actions.[5] Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release).[13] It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S.[4]
I am proud to be one of your students♥♥' ,, keep making videos please!
Best regards🌸'
Literally I'm feeling lucky to came across this video. You explained very well! Thank you sir!
Thanks for the comment!
you helped me to understand 3h lecture in 9 mins. thank you so much
Excellent video. Perfect pictographic representation of Na Channel action. Thank you.
You're welcome. Thanks for the comment
Thank you very much for your effort to clarify a difficult subject like this in an informative and easy way.
+Gökçe Gürler you're welcome. Thanks a lot for the feedback
Thanks a lot sir. This lecture cleared my confusion 🙂
You are welcome
Thanku sooo much for making such a perfectly explained mechanism.hats off to simplicity yet understandable
Thanks for the feedback! You are welcome!
i am absolutely love this, idk if that make me a nerd or what but i just love this
Beautifully explained. Really cleared all my doubts..
Thanks
Very clear video, thank you very much for explaining such a complicated diagram so well!
Great explanation. The movement and animation really helped.
Thanks!
Wow!
What a video!😍😍
Thank you very much for this clear and precise explanation! The animation is great as well
it helped me too. your video presentation is very informative and easy to understand sir. thank you.
You're Welcome. Thanks a lot for the feedback
Thank you very much for a superb video! I really liked your animation of the Sodium channel's mechanism.
+zezafa I made this for a seminar long time back. I'm glad you liked it.
Life saver ! Thanks for the video sir.
Welcome!
Amazing . Please make more videos sir. Request- Hyperkalemia and ecg changes
Thanks Nawin. Will work on that
Your amazing you explained it so clearly can you work at stony brook university please!
Excellent explaination sir
Thanks 🙏
Well done Mate!
Keep up the good work- You are a real help
Thanks for the feedback Stefan
I'm thankful that you could read & respond to my attempt to understand the mechanics of the voltage gate operation, and I wonder if you could explain how the hydrophobic alanine (residue? Is residue the right word for it?) and the IFM moiety are mutually attracted (in inactivation of the open gate)? I'm guessing that when they're close enough intermolecular forces 'bind' them temporarily, but what attracts them together initially when the alanine is exposed?
Thanx a lot,, I really like ur video and it helps me
Taro198827 2711998 thanks for the feedback
thankyou very easy to undersand....
You are welcome
ur the boss, beautiful explanation .
Very good description. Thanks for sharing.
Thanks for leaving feedback B Kumar
Superb
Thanks
This diagram and explanation is extremely helpful! Thank you for making it!
At 6:10 , is it correct to say that sufficient depolarization pushes the voltage sensor outward toward the extracellular environment, and because the voltage sensor is CONNECTED to the activation gate, it PULLS the attached activation gate open, which gate component was blocking the pore which was created by & is between S5 & S6? And that there are FOUR gates or gate sections, one in each of the 4 domains ?
And at 6:49, is it correct that as the activation gate swings open, it exposes hydrophobic (residues?) which attract a 'ball' (IFM moiety) on its molecular 'chain' toward it, such that the 'ball' swings into the pore and blocks the bottom of it and inactivates the channel?
Could you say in what way the hydrophobic alanine and the IFM moiety are mutually attracted?
And presumably when the voltage sensor returns downward when the membrane at that location re-polarizes, it pushes the gate part back into both closure of the pore, and also interferes with the IFM moiety/alanine connection and breaks it, taking the channel out of inactivation?
Yes, your understanding is correct! But, these are theoretical models based on experiments done so far. In future, these models could be updated/revised to incorporate additional findings.
@@ThePhysiologyChannel Thank you, not only for this wonderful animated 'cartoon' which helps me understand the mechanical actions of the gating better than any I've seen before, and for verifying my attempt to understand, but perhaps most importantly for reminding me that these are theoretical models based upon painstaking experiments, which models may need to be improved as time goes by.
superbb
thank you very much
This video is wonderful! Just wondering, does this same process follow for potassium channels as well?
Voltage sensing mechanism is common for most voltage gated channels. Though subunits in each channel modify the opening/ closing dynamics.
@@ThePhysiologyChannel
Thank you for your reply! Follow up question: is the IFM similar to the N-terminal (N-ball) based deactivation, or is that a completely different thing? If so, how?
@@ThePhysiologyChannel
Morever, given that potassium-gated channels activate upon depolarization, would their sensor be less reactive, in the sense that there has to be a higher positive charge inside the cell in order to cause them to open?
tnku so much sir....it's very easily described to understand thx alot
+Neha Mittal you're welcome!! I'm glad to hear the feedback
Hi, can you tell me is there 1 voltage sensor which is made of four S4 segments? Or there are 4 voltage sensors?
very very nice video :)
Thanks 😊
Great video! Really helpful and easy to follow :)
+D thanks for the feedback
Can you explain how the new drug pregablin works that is prescribed to people with epilepsy and who may suffer from anxiety. Those who supply this drug cannot explain the mechanism of this drug - but they suspect that it binds calcium to the alpha 1 gated receptor.
Pregabalin is an anticonvulsant drug used for neuropathic pain, epilepsy and generalized anxiety disorder.[4] It presents antihyperalgesic actions by binding to the α2δ subunit of the voltage-dependent calcium channels without presenting antinociceptive actions.[5] Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release).[13] It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S.[4]
Thank you so much 🤩
😃 Glad to have been of help!
Kindly make video on potassium as well as calcium channels
thank you , great explanation
thank you very much for your video
+n harshi You're welcome
It helped me alot .. thank you
You're Welcome. I'm glad it helped.
Thank you Doctor :D Great video
oDivaaH ll you are welcome
What physiology text contain this info?
perfect!
what is it? I show down there, what is it, cause the youtube, does not let to preview, it used to show, but it is crazy
What is the mechanism behind the selectivity pore.
i mean how it only allow Sodium to pass through?
watch ben1994 chnnel vidios for that . it is to do wit hydration energy of some sort
ruclips.net/video/hfXGsJCOC9A/видео.html
HELLO SIR! MAY I CORRESPOND WITH YOU BECAUSE I NEED YOUR SUGESTIONS FOR PREPARATION OF CSIR
Hi Prashant, I'm sorry. I am not familiar with CSIR exams.
This alpha subunit has 4 --------??
Plz can u write it in replay
Domains
quite difficult
Thank you so much for this video. Everything has been explained so clearly.
Thanks for the feedback!