Vitamin D (calciferol): Sources, Synthesis, Metabolism, Functions, Deficiency ||
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- Опубликовано: 10 сен 2024
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Vitamin D (calciferol): Sources, Synthesis, Metabolism, Functions, RDA, Regulation and Deficiency
Vitamin D (calciferol)
Characteristics
-------------------------
Active form: 1,25-dihydroxyvitamin D (1,25-(OH)2 D3, calcitriol)
Sources:
--------------
Ergocalciferol (vitamin D2): mushrooms, fortified foods (e.g., milk, breakfast cereals, formula), yeast (from ergosterol)
Cholecalciferol (vitamin D3)
Synthesized in the skin (stratum basale) when exposed to UV light
Fortified foods (e.g., milk, breakfast cereals, formula), fatty fish (liver), egg yolks
Vitamin D synthesis
--------------------------------
Liver: cholesterol → 7-dehydrocholesterol (provitamin D3)
Enzyme: cholesterol dehydrogenase
Skin
Storage of 7-dehydrocholesterol
Cleavage of 7-dehydrocholesterol via irradiation with UV light → cholecalciferol (in the stratum basale of the skin)
Liver: hydroxylation of cholecalciferol to 25-hydroxyvitamin D (25-OH D3, calcidiol; activated vitamin D2)
Kidneys: 1α-hydroxylase hydroxylates 25-hydroxyvitamin D → 1,25-dihydroxyvitamin D
Transport to target cells: vitamin D-binding protein (DBP)
Storage: mainly in adipose tissue as 25-hydroxycholecalciferol
Regulation of vitamin D synthesis: via regulation of 1α-hydroxylase activity in proximal convoluted tubule
↓ Calcium, ↓ phosphate, and ↑ PTH → ↑ 1α-hydroxylase activity → ↑ 1,25-dihydroxyvitamin D biosynthesis
↑ Calcium, ↑ phosphate, and ↑ 1,25-dihydroxyvitamin D → ↓ 1α-hydroxylase activity → ↓ 1,25-dihydroxyvitamin D biosynthesis
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Unthwoods
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Keep making short and sweet videos like this. Thank you. All the best
Thank you, I will
Great lecture .. very short still covers all aspects .. excellent job it was time saving
Tysm 😊
Your vídeos are the BEST guys!
Thank u so much
This information is lucrative for us thanks you
100IU and 400IU is literally nothing.
You need atleast 1000-5000IU
what's the difference between "literally nothing" and "nothing"? Why add the word "literally" is it scientific or just stupid talk. Mr. Akash. Looking forward to your explanation.
Stupid question.@@ryanm.5381
U need 60 k in a week or a month and10000 iu in a day or a week
Thank you Indian or Pakistani man!!
Your videos are very helpful
My pleasure, iam indian
Loved ❤️ from Pakistan 🇵🇰
Great video very informative
Thanks Sir ji for your information about it 👌🏼💐🎉💕🙏🏼
Ur most welcome
good English👍👍
How are Vitamin D supplement made? Are they vegan? Are they mostky defived from ovine sources? Is the Vitamin D made by our body through sunlight exoosure really sufficient? Halibut and cod liver oils contain both Vitamin A and Vitamin D - won’t we overdose on the Vitamin D? Which part of the sheep are Vitamin D supplemebts detived? The liver? What about halal issues? I have more questiojs but please kindly answer thress pressing questions first. Thank you
Thank you so much Sir 😌
Thanku so much sir!
This was very helpful. 💓👍
Thank you so much for videos😇👍
Glad you like them!
Thank you Sir for this video.....
Sir U r the best
Excellent summary. Thank you
Glad you enjoyed it!
Thank you Doctor Bhanu
Awesome 👌
Thanks
Welcome 😊
Thanks sir for that valuable video
Doc I have low levels at 25 then I started vit d3 at 4000iu with k2 and my body doesn’t respond well at all I get more anxiety cold sweats etc what should I do ?
Абалдееееть😍класс. Спасибо
Some people take 10000 IU everyday is that right?
Kindly explain.
If you have a vitamin D deficiency and start taking supplements what is the prognosis for improvement in bone density? Can you increase your bone density even if you are an adult? I have a vitamin D deficiency + osteopenia 😢
GOD bless you aour teacher
Tysm
Nice info. Dr.tqs for sharing such useful info.
Swaad aa gaya 👌
Great sir💖
Sir I'm surching for your Vitamin b 12 vedio
Very soon
Super video ☺
Thank you so much sir🙏
So nice of you
thank you. it helped a lot
Very good job
Thank you so much 😀
Thank u Sir ❤️
At what time is best for sunbathing for vitamin D production in our body..? What's the duration time for sunbathing..? Is it harmful at mid day sunlight exposure to skin..?
excellent vedio full of pure knowledge
well 100/100
sir.this deffiency is coursed for buring sensation to lower back
Very informative, thank you for sharing.⚕️🌞
Thank u sir..Keep it up
Keep watching
❤sir
Can we get (synthesise) vit D if we stand in sunlight with shirt/T-shirt? Or is direct sunlight on skin required? Also guide for morning sunlight or anytime?
better without shirt/t-shirt. Time frame is before 11:00 am and after 18:00 pm to ensure safe UV exposure.
Does vitamin d3 deficiency cause any ear broblem or feet burning?????
Thank you sir
Welcome
Very informative video..Thanks sir
❤
gud
Plz handi ya urdu ma b batya kary.....sab ko english ni ati sir..
A pro
Which cells of kidney release 1-hydroxylase enzyme???
Is it normal a fatty liver can synthesize vit d
هههههههههههه ألف شكر
Hmm
So maybe a leep but let's say you radiate someone with EMPs over time say 20 years. You'd leach their body and the kids would develop bone deformities like rickets. Also sudden increase in radiation would increase permeability of the intestinal lining causing nausea and vomiting with excess Vit D absorption. Then loss of Vit D due to hemorrhagic vasculitis of the radiation. If you wanted to do WW3. That's one way to do it.
Some sweet sweet disinformation.... where are your credible references sir ? writing in the description what you said in your video is not a source
really ?
I mean… he’s saying whitamin D… so how ever its defined he may yet be correct 😭
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Sar hindi me video banaiv
Sir I didn't you to be so Meaningless
Bhag makarpada difardi bgfghv
Hindi nahi aati lagta teko
haan nai aatha hai
How are Vitamin D3 supplement made? Are they vegan? Are they mostky defived from ovine sources? Is the Vitamin D made by our body through sunlight exoosure really sufficient? Halibut and cod liver oils contain both Vitamin A and Vitamin D - won’t we overdose on the Vitamin D? Which part of the sheep are Vitamin D supplemebts detived? The liver? What about halal issues? I have more questiojs but please kindly answer thress pressing questions first. Thank you