HASHIMOTO'S THYROIDITIS: Etiopathogenesis, Morphology & Complications

Hashimoto’s thyroididtis
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Most common cause of hypothyroidism in areas where iodine levels are sufficient.
Gradual thyroid failure due to autoimmune destruction of thyroid gland
Definition:
It is Characterized by
1. Diffuse goitrous enlargement of the thyroid
2. Lymphocytic infiltration of the thyroid gland
3. Presence of thyroid autoantibodies.
Age incidence: 45 - 65yrs.
Male: Female: 1:10 to 1:20
It can occur in children and is a major cause of nonendemic goiter in children.
1. Genetic predisposition.
2. Immune causes: Autoantibody production
3. Environmental factors: In a genetically susceptible individual environmental factors, such as infection, dietary factors (iodine), stress and pregnancy, may initiate autoimmunity in the thyroid.
Genetic predisposition:HLA-DR3 & DR5
Immune causes
Immune Regulatory Genes
[CTLA4, PTPN22]
cytotoxic T lymphocyte-associated antigen-4 (CTLA4)
protein tyrosine phosphatase-22
Thyroid specific genes
(thyroglobulin and thyroid-stimulating hormone [TSH] receptor )
GROSS
-Diffuse enlargement , may be Nodular
- Gland well demarcated
Cut section; Pale, yellow tan, rubbery to firm/nodular
MICRO
Atrophy of the follicles
Diffuse infiltration by mononuclear cells
Formation of lymphoid follicles
Hurthle cell metaplasia
Interstitial connective tissue may be increased
Clinical features : Middle aged women
Painless enlargement
Variable degree of
hypothyroidism
Laboratory findings: T3 & T4 decreased
TSH increased
Antithyroid antibodies
Diagnostic tests: FNAC
HPE of Biopsy
COMPLICATIONS
Hashitoxicosis
B-cell Non Hodgkin Lymphoma
Increased risk for other autoimmune diseases
Diabetes type 1, Adrenalitis, SLE, Myasthenia Gravis..
Increased risk(variable) thyroid epithelial neoplasms.. Papillary Carcinoma
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Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"
• NEOPLASIA 6: WARBURG E...
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[@biancaojovan2085]

Very useful, especially for the part where you described the actual attack on the tyroid tissue. Thank you

[@radosawwujec959]

I very much like your explanation :) Its sad really that you posted so little - you are a great teacher please share it with with the world :)

[@innocentamaeruchi4845]

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[@navaneeth_us]

Top-notch conceptual correlation and beautifully crafted and articulated session on Hashimotos thyroiditis.
Thank you so much, Sir.
Lots of love ❤️.
18/DEC/2021.

[@meghanacr2176]

Thank you sir, very helpful to understand the concept

[@sarakhan3151]

Sir please make more videos on CNS pathology

[@tutidoye3233]

👍👍👍 very efficient for exam point of view👌

[@hitz7854]

Thanks... Very helpful

[@ayashwanthreddy1405]

Very much helpful thank you bhai

[@manishchoudhary5522]

Thank you sir ❤️

[@adiscovers4290]

Very good explanation indeed.

[@richasingh1020]

It's from prashant Patel book

[@dibrahim3447]

what are the treatment of hashimoto,s disease

[@azmaalifia9445]

Awesome sir 👌🏻 did u made on follicular carcinoma of thyroid

[@mitehater]

autoimmune hashimotos -( low thyroid) is most often caused by (Blastocystis hominis was isolated through a stool microbiologic examination, implicating that this parasite can cause the development of Hashimoto's thyroiditis and chronic urticaria ) and can be cured with ivermectin high dose

[@gayathrisake370]

Tysm 😊

[@navaneeth_us]

Sir, Please do make videos on FEMALE REPRODUCTIVE SYSTEM PATHOLOGY. Thank you. 🙏🏻

[@ilovepathologyVijayPatho]

Have uploaded few..shall be completing in sometime 😊

[@navaneeth_us]

@@ilovepathologyVijayPatho Sir, Please do it asap before our finals on 19th January 21.

[@starrysky1588]

Thanks a lott!

[@manindra2182]

Please upload tutorial on graves disease

[@r.krishnamandal8535]

thnks frm Nepal..very helpful

[@RubiscoTalks]

Subscribed!!!

[@itzme5120]

excellent sir

[@bddybdz]

I’ve had a thyroid punction test and they found ; Lymfocytaire Thyreoditis. They found a lot of lymfoid cells / macrofagen/ histiocytes. I am feeling very bad and still have to wait to see a specialist in 3 months... Could you tell me what my results mean? And what can be done? Or do I need more blood tests? Thank you in advance 🙏🏻

[@jennyvarshavski3138]

I hope u r fine now

[@suryam7075]

Nice video thx

[@viniviwotsa6060]

Please post more !

[@afifarahman4377]

Best 👍 best 👍 Best

[@swetapadmamohanty72]

Sir ur videos are really helpful...why dont u make more sich videos??

[@acetheplabs9667]

U r awesome 👍👍👍

[@pld455]

too good

[@KidsandKitchen7]

How to cure this naturally permanently

[@innocentamaeruchi4845]

I have Hashimotos and I remembered how I felt when the doctor told me it will be very hard for me to conceive but, all to the glory of GOD that after using DR RORPOPOR HERBAL on RUclips natural infective herbal medication am a mother of four kids......

[@KidsandKitchen7]

@@innocentamaeruchi4845 wow.. thanks sis.. could u pls share the link of the video

[@innocentamaeruchi4845]

@@KidsandKitchen7 ruclips.net/channel/UCkZwKW6qES4dXDWzb0YQErA

[@innocentamaeruchi4845]

@@KidsandKitchen7 contact DR RORPOPOR HERBAL with this link 👆

[@aaddyasinghchauhan1111]

❤❤❤❤

[@AnkitaDas-ol4sm]

Very useful.

[@rupamhansdah604]

Your videos are good but can you please try to speak little clearly...

[@shubhakadkol3155]

Hashimotos thyriditis and left adenoma 32*22mm thyroid gland enlarged. Its major or what

[@sahotasonia1102]

You are ok sir g

[@immadisarojini2775]

Super

[@aayushasthaa]

👍👍👍👍

[@joanne4850]

Is it safe to take the covid vaccines if you have Hashimotos?

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[@itsokaytobeclownpilled5937]

No. That injection isnt safe.

[@neetuyadav2316]

Is this curable or not?