Good info, I like how you just get into the discussion without all the meaningless jabber. We look at a lot videos and most are long with unnecessary stuff, whereas you are short, direct and to the point. Thanks
thank you so much ! from Denmark :) Your approach, voice and explanation methods are pleasant to listen to as well as fun. You are good at simplifying the subject.
You are so sweet and smart I am out of words, WOW bravo !! So blessed by the Almighty God Jesus Christ to have found your video and channel. Thank you for a straight forwad, with pictures I might add video easy to follow and understand. Looking forward to the next👏
Great Video clip! Sorry for butting in, I am interested in your opinion. Have you ever tried - Marnaavid Unexplainable Intervention (google it)? It is a great exclusive product for learning how to hack your flow state without the normal expense. Ive heard some great things about it and my old buddy Taylor finally got excellent results with it.
Excellent Video clip! Apologies for chiming in, I would love your opinion. Have you ever tried - Ienyott Breathtaking Idea (google it)? It is a good exclusive product for getting a reliable erection minus the normal expense. Ive heard some interesting things about it and my coo-worker at very last got great success with it.
more details on reactions are definitely needed ( as a uni student thats whee the top marks come from) then again description does say basic overview so thank you for clearing up a lot of factors that confused me!!
Hey, if youre still checking the comments- I do worry about the processes you skipped (eNOS and cGMP effect) and would very much enjoy an additional video! Thanks for the overview :)
So interestingly, the shear stress sensors are cilia using polycystin 1, which as the name suggests is heavy in sulfur. So if sulfur was deficient, you'd expect problems here, especially as ciliary turnover is quite high I recall
Hello I like your presentation, I was chasing the subject of Nitric Oxide and how it works after reading Dr Esselstyn,s book on reversing heart disease. In the book i got the impression the Nitric Oxide is on the surface of the endothelium this then stops the blood sticking to the surface of the endothelium. You mentioned also about the oxide being released relaxing the muscle to expand the artery and reduce blood pressure. Dr Esselstyn is also in favour of a whole food plant based eating plan to aid this process and mentions it can ease angina, have you read any of his books? I am not promoting his work more i am very interested in this topic, many thanks
Great video, looking forward to more. But I wish you went into a little more detail about the reaction at 5:00. Just a suggestion for future videos :) Thanks!!
thank you for your presentatiot. it's wonderful. i just want to make sure. so, NO has a bad effect for vessel right? meanwhile it can make vasodilate vessel, but it is also make stickiness
Very nice explanation! My question is: do the endothelial cells change their shape during the vasodilation? i.e. does the allignment of the ECs change from along-the-blood-flow to perpendicular to the blood flow during vasodilation? I would imagine having a constant number of deformable cells on the endothelium, that is the case.
Can someone please tell me why chronic weight lifting doesn't damage endothelial cell function due to shear stress? Obviously the paracrine function of NOS in the cell would help, but if you lift weights 4 -5 days a week for 30 years of your life, and go intensely, you'd think that it would damage the cell lining? Any evidence based research on this?
I'll bet endotheleum can also stimulate smooth muscle above it to contract that vessel, not just dilate it. During contraction, stickiness or "hold until help arrives" can happen when an underlying toxin is detected by endothelium.
Hi there.I took proargi 9+ and that pm bp was105/65 shrtly after.But next am bp was 193/101.I think I have a problem with the grape seed extract.Got any thoughts.
Hi you mention another video which follows on from this one (covering glycocalyx) - I can't seem to find it on your channel. Is the video still live? thanks :)
+haughem Hi! I haven't actually found the time to make the glycocalyx video yet. This was a great nudge, though. I'll try to get to it this week or next :).
I hear That penis pump indeced in the beganning alote of NO so it give some good sensation in the beganning. But due to over negative presure it increase tgf beta indecate inflammation response. In this point is it make the peins numb with lower erection quality. In this point What happen to endothelial linning in the cavensal carpora?
Nitric oxide should not be confused with nitrogen dioxide (NO2), a brown gas and major air pollutant, nor with nitrous oxide (N2O), an anesthetic.[7] Lol, NOS.... your funny. Nitrous oxide (N.O.S) is not nitric oxide (N.O) Nitric oxide and nitrous oxide are such two compounds. The main difference between nitric oxide and nitrous oxide is that the nitrogen of nitric oxide has the oxidation state +2 whereas the oxidation state of nitrogen in nitrous oxide is +1
Hi, Evan. Congratulations! You have won an award for being a jerk on the internet. I absolutely love to hear comments on my videos - which I make on my own time for the sole purpose of helping people - that serve no purpose other than to make me feel bad and/or to make the commenter feel superior. Have a great day, and enjoy your award!
you are the ADHDers dream professor. Thank you for starting by explaining the bigger picture.
Good info, I like how you just get into the discussion without all the meaningless jabber. We look at a lot videos and most are long with unnecessary stuff, whereas you are short, direct and to the point.
Thanks
Such a fantastic presentation ...I could listen all day. Plus the way you teach the material, it stays in my memory. Thanks a million.
Corla.
+Comhairle O Donnchadha Thank you!
You are welcome!
So helpful!!! you made it so easy to understand and I have to say English isn't my mother language!!! Thank you
thank you so much ! from Denmark :) Your approach, voice and explanation methods are pleasant to listen to as well as fun. You are good at simplifying the subject.
You are so sweet and smart I am out of words, WOW bravo !! So blessed by the Almighty God Jesus Christ to have found your video and channel. Thank you for a straight forwad, with pictures I might add video easy to follow and understand. Looking forward to the next👏
She is fabulous!!
+Eating For Acne Thanks :)
Aw. Thank you :)
Great Video clip! Sorry for butting in, I am interested in your opinion. Have you ever tried - Marnaavid Unexplainable Intervention (google it)? It is a great exclusive product for learning how to hack your flow state without the normal expense. Ive heard some great things about it and my old buddy Taylor finally got excellent results with it.
very simple but nevertheless very informative
you are a fantastic teacher
keep up the good work
Thank you!
Amazing presentation! You are the teacher I want to be someday! :)
P.S> Cool interior! ;)
Excellent Video clip! Apologies for chiming in, I would love your opinion. Have you ever tried - Ienyott Breathtaking Idea (google it)? It is a good exclusive product for getting a reliable erection minus the normal expense. Ive heard some interesting things about it and my coo-worker at very last got great success with it.
Thanks for this video!! I really love your presentation and found it very helpful in understanding my lecture!
You are very welcome.
Interesting video. Interesting channel. Definitely subscribing. Thanks for posting this.
This is a great video. -super cool explainer - thank you so much!!
Great video, my daughter has pulmonary hypertension from Pactus Ductus Arteriosis. Thanks for the video. Informative.
you explained everything very clear !!
wish you can upload more videos on the biochemical pathway :)
more details on reactions are definitely needed ( as a uni student thats whee the top marks come from) then again description does say basic overview so thank you for clearing up a lot of factors that confused me!!
+RyanF0800 Will try to get to a more detailed description later. Agreed - those details are important.
I loved the explanation, thank you very much. Could you make some content about exercise and nitric oxide?
how you teach makes it fun and exciting to learn
Hey, if youre still checking the comments- I do worry about the processes you skipped (eNOS and cGMP effect) and would very much enjoy an additional video! Thanks for the overview :)
So interestingly, the shear stress sensors are cilia using polycystin 1, which as the name suggests is heavy in sulfur. So if sulfur was deficient, you'd expect problems here, especially as ciliary turnover is quite high I recall
Love you 💯
But still very much interested in the I-NOS & N-NOS effect
thank you! this was super easy to understand although I think it would be worth it to go through the biochemical pathway
Hello I like your presentation, I was chasing the subject of Nitric Oxide and how it works after reading Dr Esselstyn,s book on reversing heart disease. In the book i got the impression the Nitric Oxide is on the surface of the endothelium this then stops the blood sticking to the surface of the endothelium. You mentioned also about the oxide being released relaxing the muscle to expand the artery and reduce blood pressure. Dr Esselstyn is also in favour of a whole food plant based eating plan to aid this process and mentions it can ease angina, have you read any of his books? I am not promoting his work more i am very interested in this topic, many thanks
Hey ROger. -how did the interest go with Dr Esselstyn research & reading?
His work is excellent ;-)
Fantastic!
Glad you enjoyed it.
This was very helpful! Thank you! Keep up the good work :)
Great video, looking forward to more. But I wish you went into a little more detail about the reaction at 5:00. Just a suggestion for future videos :) Thanks!!
Thanks for the feedback! I was worried that it was getting too long - perhaps in another video :).
thank you for your presentatiot. it's wonderful. i just want to make sure. so, NO has a bad effect for vessel right? meanwhile it can make vasodilate vessel, but it is also make stickiness
Excellent work!
The Hippie thing got me. Content was fine also.
awesome video, thanks so much.
whatabout the vascular endothelial glycocalyx?
A shield from direct contact.
hi, i love the way you explane! can you give me more info on eNOS?
Very nice explanation! My question is: do the endothelial cells change their shape during the vasodilation? i.e. does the allignment of the ECs change from along-the-blood-flow to perpendicular to the blood flow during vasodilation? I would imagine having a constant number of deformable cells on the endothelium, that is the case.
cGMP causes the dephosphorylation of myosin which decreases binding to actin = smooth muscle relaxation
Thank u so much this was very helpful! 🙏🙏🙏
Fab! Love it! Thanks so much for this. :-)
Any update? Can Nitrostat help?
Very clear
Can someone please tell me why chronic weight lifting doesn't damage endothelial cell function due to shear stress?
Obviously the paracrine function of NOS in the cell would help, but if you lift weights 4 -5 days a week for 30 years of your life, and go intensely, you'd think that it would damage the cell lining?
Any evidence based research on this?
I'll bet endotheleum can also stimulate smooth muscle above it to contract that vessel, not just dilate it. During contraction, stickiness or "hold until help arrives" can happen when an underlying toxin is detected by endothelium.
❤️❤️
Excellent beautiful, India
outstanding thank you
is it good for pad disease in legs and calcification in the artery such as arteriosclerosis
Tx, good job ... 70 Going On 100
It helped alot thankyou!!
Hi there.I took proargi 9+ and that pm bp was105/65 shrtly after.But next am bp was 193/101.I think I have a problem with the grape seed extract.Got any thoughts.
thank you
Hi you mention another video which follows on from this one (covering glycocalyx) - I can't seem to find it on your channel. Is the video still live? thanks :)
+haughem Hi! I haven't actually found the time to make the glycocalyx video yet. This was a great nudge, though. I'll try to get to it this week or next :).
@@kcamillefreeman looking for your glycocalyx video
I hear That penis pump indeced in the beganning alote of NO so it give some good sensation in the beganning. But due to over negative presure it increase tgf beta indecate inflammation response. In this point is it make the peins numb with lower erection quality. In this point
What happen to endothelial linning in the cavensal carpora?
Plz tell the source maam
Source name plzz maan
Thanks
where is next video? T_T
Nitric oxide should not be confused with nitrogen dioxide (NO2), a brown gas and major air pollutant, nor with nitrous oxide (N2O), an anesthetic.[7]
Lol, NOS.... your funny. Nitrous oxide (N.O.S) is not nitric oxide (N.O)
Nitric oxide and nitrous oxide are such two compounds. The main difference between nitric oxide and nitrous oxide is that the nitrogen of nitric oxide has the oxidation state +2 whereas the oxidation state of nitrogen in nitrous oxide is +1
Rats, I'm not a hippie
Good information but her arms waving around during her presentation reminded me of an unattended fire hose.
Hi, Evan. Congratulations! You have won an award for being a jerk on the internet. I absolutely love to hear comments on my videos - which I make on my own time for the sole purpose of helping people - that serve no purpose other than to make me feel bad and/or to make the commenter feel superior. Have a great day, and enjoy your award!
Cut the crap, please
I love ice cream