Hypocomplementemia (Low Plasma Complement Level)

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►👨‍🏫💊Antibiotics Lectures: www.medicosisp... ... Check out my brand new "Electrolytes" course at www.medicosisp... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Hypocompolementemia (aka low plasma complement level) is seen in many diseases due to underproduction or over-destruction (decreased supply, or increased demand).
In systemic lupus erythematosus (SLE), you might find low plasma levels of C3 and C4 complement proteins.
In this video, I have discussed the classical complement pathway. I have previously talked about the alternative complement pathway in my video "Paroxysmal nocturnal hemoglobinuria" • Paroxysmal Nocturnal H...
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[@MedicosisPerfectionalis]

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[@aakankshapatel2192]

Wonderful 🌈❣️ precise and to the point, it takes very strong concepts to simplify rheumatology, very clearly visible ✌🏻✌🏻✌🏻✌🏻✔️✔️✔️✔️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@dsun_blue183]

far better than my professor....you are the best !!

[@MedicosisPerfectionalis]

I am honored...Thank you dear for your kind words 😊

[@MedicosisPerfectionalis]

So, what are you studying?

[@dsun_blue183]

Preparing for step 1 ..

[@MedicosisPerfectionalis]

Awesome 👏...Let me know if you have any questions.

[@mackette54]

HOW MANY BOYFRIENDS??? LOL
I Came across this video because i have a low compliment value
Thanks!! More information than an office visit to MD!!

[@MedicosisPerfectionalis]

Thank you so much!

[@AzraelPercussionNEO]

The Aries speaks...thank you

[@OnlyJalenPhd]

So interesting. I’m not an MD, but since I have “rhupus,” I am interested.

[@okaystaab]

Can you speak to low c3, low ch50 but normal autoimmune workup?

[@annebailey6261]

Thanks!

[@MedicosisPerfectionalis]

Wow! Thank you so much for supporting my channel!

[@ahmedfalah8611]

Awesome

[@MedicosisPerfectionalis]

Thank you!

[@CordManJoonYah]

at 5:07.....sir you are by no means an idiot. With deepest thanks from the bottom of my heart, thank you for what you do here on RUclips

[@MedicosisPerfectionalis]

Thank you!

[@shahwarzaman6784]

Your explanations are absolutely drop dead gorgeous. Also what is the role of AH50 in testing?

[@rittenbrake1613]

Good job again bro 👍🏻

[@MedicosisPerfectionalis]

Thanks again, dear :)

[@AMCTKate]

What about C4 overconsumption in the lectin pathway, or is overconsumption in that pathway not a thing?

[@ABC-fv7ow]

Superb presentation .Woak Prof. can't do...🤓

[@MedicosisPerfectionalis]

😃😃

[@dfwgal68bailbailey68]

Thank you 🙏🏻

[@MedicosisPerfectionalis]

My pleasure 😇

[@samuelfiergeonpicardi1378]

How about decreased c3 and normal c4, its caused by infection only ? Or may be another caused ?

[@LinneaSanchez]

Following

[@anastasiasmith3097]

Question! What is C3 is 82, C 4 is normal, CH50 is more than 60! dsDNA, ANA is negative

[@MedicosisPerfectionalis]

What was the reference range (normal values) of C3 and CH50 in your lab?
Also, what are the symptoms?

[@ZZ-ux7dx]

Hi plz can you talk about complement inhibitors plz

[@albertkevin3125]

Thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@hamidehhamzehpoor514]

Wonderful ❤

[@MedicosisPerfectionalis]

Thank you 😊

[@Anon.G]

I have undetectable c4 :(

[@bushraliaqat9522]

U r best

[@MedicosisPerfectionalis]

Thanks 🙏

[@khoinguyenhuynh1871]

In SLE, which complement should be low before another? C3 or C4? Thank you

[@ahmedabdelmomen172]

c3

[@user-ti8pw9mt1o]

Nice

[@MedicosisPerfectionalis]

Thanks a lot!

[@MuhammadAli-ml9bt]

thanks alot

[@MedicosisPerfectionalis]

My pleasure 😇

[@eisvogel.1481]

13:18 What is meant with positive "Bradjinski"? (Sorry, English isn't my first language)

[@mamashiraz]

What does it mean when someone has normal C3 and C4 but has a high CH50? 🤷🏻‍♀️ Same person has positive “Early Sjogrens Panel” (anti salivary, anti carbonic anhydrase) and positive ANA.

[@Jiggy77XD]

They probably have early onset sjogrens syndrome if they have the symptoms.

[@mamashiraz]

Jiggy77XD But what does a high CH50 mean?

[@Jiggy77XD]

@@mamashiraz a high ch50 means that there is increased activity of the classical and combined complement pathways compared to normal. This is often found in conditions that cause inflammation, normally in the acute setting but also some chronic inflammatory conditions. The differentials would include infections, acute/chronic inflammatory conditions and malignancies. But given the findings of positive ro/la/rf it is likely sjogrens syndrome.

[@mamashiraz]

Jiggy77XD Ro and La are negative as well as RF. But has an inflammatory arthritis: psoriatic arthritis.

[@Jiggy77XD]

@@mamashiraz a seronegative spondyloarthritis in the acute setting would also cause that change in complement levels. Over time there would be a decrease in complement levels through overconsumption. I presume the patient has signs and symptoms consistent with psoriatic arthritis (enthesitis, dactylitis, sacroilitis, possibly some extra articular manifestations including possible psoriasis) and has been tested for HLA B27 before coming to that diagnosis. Does the patient have ulcerative colitis? Some patients with UC induced enteric arthropathy often have raised ch50 that is chronic in nature.

[@user-ru3pw3bk2k]

Have u explained Systemic lupus erythematosus

[@MedicosisPerfectionalis]

On my website:
www.medicosisperfectionalis.com/

[@shuxian89]

Can C3 C4 be low in acute blood loss?

[@ahmedtzaki4476]

‏‪12:44‬‏
why not also C3?

[@osaniss]

I have hightened C3d levels. What does that mean?

[@MedicosisPerfectionalis]

I don’t know 🤷‍♂️

[@genuine_meteen9169]

So, in SLE is it just Decreased c4 or Decreased C3 & C4 ?

[@Anon.G]

I have both and I have lupus

[@tashaalvarez777]

Do you have any videos about high complement total ch50. Mine is high

[@MedicosisPerfectionalis]

Unfortunately, I don't!

[@tashaalvarez777]

Its ok. You do have a lot of useful info

[@calvinhobbs7399]

What does it mean if you have slightly low c3 and extremely low c4, signs of kidney issues, ANA positive, low beta 1 globulin?

[@jordanashley4708]

Thank you for this! What do you think of me having normal c3, low c4, high ch50, positive ANA, negative DSDNA? I have fatigue, brain fog, sore lymph nodes in neck, low grade temps, muscle aches, joint pain, involuntary muscle jerking. Labs came back but still haven’t heard from the rheumatologist 🥲