Another way to remember the effects of anticholinergics is "can't see, can't spit, can't pee, can't shit" (if you don't swear, switch it out for poop, which follows the 1st letter pattern "s-s-p-p")
Awesome mnemonic! Let me add something to that :D : Can't see, can't spit, can't sweat Can't pee, can't shit nor do anything in bed. (lower sweat secretion and erectile dysfunction are also effects of anticholinergics)
Thank you I have been reading the slides of my lecturer almost 2 hours and I don't understand, what you have taught me just 14 minutes Thank you Keep posting pharmacology videos🎉❤
First of allas a Med Student, I'll definitely say that you've summed up 2 hours long work into a video of around 14 minutes. It's really helpful. But, I would like mention one thing that Cisatracurium has an elimination half life of around 22 minutes (Intermediate Acting), not ~90 minutes as you've mentioned... And thanks a lot for your great work... 👍🏽
Nondepolarizing agents doesnt "allow for lower doses of general anesthesia" as you indicate around 9:00!!!!!!! These aren't painkillers or sleep medications!!! They make patients cannot move!!!! That doesnt mean that they are well asleep or don't have pain.
"paralysis may permit use of lower doses of general anesthetic agents, which may speed recovery and avoid side effects of these agents" Reference: anesthesiology.pubs.asahq.org/article.aspx?articleid=1945289
Good lectures. You said cisatracurium was superior to atracurium as it is metabolised free from the liver, atracurium is also metabolised by Hoffman degradation
This video is really good! Once I calmed down and got back it emwas way easier ❤️, but How is nicotine used to help ppl quit smoking if it's part of the sigrates smok? And how can it be used as antagonist and agonist in the same time? I don't get it!
Leaving smoking at once can show withdrawl symptoms due to nicotine tolerance. Which makes it difficult to leave smoking. Also, smoking is dangerous primarily because of its effects on lungs due to inhalation. Nicotine patches completes the need for nicotine while smokers work towards quitting. And the dose in patches can also be reduced, gradually. It's very effective during the quitting process.
At lower doses, nicotine stimulates the receptors bcz ofc they are sensitive to nicotine and thus cause release of other neurotransmitters like epinephrine, dopamine etc resulting in increased cholinergic effects but at higher doses, it paralysis the receptors and stimulatory effects cease.
I thought midriasis occured when the pupillary muscles contracted... which is what happens if sympathetic NS is favored over the parasympathetic NS. Isn't the Ciliary muscle for accomodation?
When doctors don't see the issue is anticholinergic syndrome, you can accidently get diagnosed with lupus and labeled a problem patient because you're not getting better. Hard to get better when you're being drugged to death. It was literal torture.
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YOU have just turned 2 lectures (4 hours) in faculty of pharmacy into 14 min ,GREAT WORK thx
U r right
mechenism of action is not included in thi video..
Explaining an entire medical school pharmacology lecture in less time and so much more clearly! Can't thank you enough!
Bro i just wached a full 2 minute advertisement for you😄😄
Keep doing what you are doing bro,you are fantastic in this!👍
Dude you just let me understand a lecture of 5 hours in 14 mins.. thank u so muchhhhhh !
Another way to remember the effects of anticholinergics is "can't see, can't spit, can't pee, can't shit" (if you don't swear, switch it out for poop, which follows the 1st letter pattern "s-s-p-p")
liltenshi39 i love u
liltenshi39 I'm sorry but this is a Christian comment section. Your comment can not contain swear words like 'frick', 'heck' or 'shit'.
Awesome mnemonic! Let me add something to that :D :
Can't see, can't spit, can't sweat
Can't pee, can't shit nor do anything in bed.
(lower sweat secretion and erectile dysfunction are also effects of anticholinergics)
Bullpoop
Thanks.
You're making such light work of what I have to learn in my Clinical Pharmacology course, Great job! Thank you for doing what you do.
Thank you
I have been reading the slides of my lecturer almost 2 hours and I don't understand, what you have taught me just 14 minutes
Thank you
Keep posting pharmacology videos🎉❤
loved the Neuromuscular blocker section, so clear, and images very reinforcing! thanks!
Your videos are amazing, short, clear and easy to remember. Thank you for helping us everytime we need a quick reminder to a pharmacology topic.
Fantastic!! you really made it very simple!!
keep posting your videos, please!
thanks
agree!
I hv been reading this subject for 2 hrs and i got nth while ur 14 mins video explains everyth.
Thank you so much 😁😁
Pharmacology the back bone of medication. What a wonderful lecture
First of allas a Med Student, I'll definitely say that you've summed up 2 hours long work into a video of around 14 minutes. It's really helpful.
But, I would like mention one thing that Cisatracurium has an elimination half life of around 22 minutes (Intermediate Acting), not ~90 minutes as you've mentioned...
And thanks a lot for your great work... 👍🏽
Very good video! Love the animations!
Out standing pharma lectures in entire RUclips channels.....Completely following pharma Tara book
Thank yewwww sooooo much .....finally I've searched bestttttt video on this topic after searching for 20 mins on u tube😢😢😢
BEST CHANNEL FOR ALL THE MEDICOS
Thank you for all of your wonderful videos. They help put everything together
Your video is light for CNS pharmacology, thanks master
Every video is a jewel.
Thankyou for making pharmacology this easy. ❤️
It’s a great work sir❣️
Keep it up to make pharmacology more easier.
Thank you 😊
Just confirming that I'm a beneficiary of your videos
Thank you for this wonderfully crafted video
You're a life savior ! thank you
An amazing job done here ⭐
I have a way better understanding anticholinergic drugs, thanks to you!
You the best lecture , you make things simpler that seems difficult
Great efforts at these vids , thank you very much
deserves immediate subscription...
Can't wait for more video from you. It's so clear and its help! :)
Really helpful..provide more videos please
One word: Thankyou
Nondepolarizing agents doesnt "allow for lower doses of general anesthesia" as you indicate around 9:00!!!!!!! These aren't painkillers or sleep medications!!! They make patients cannot move!!!! That doesnt mean that they are well asleep or don't have pain.
"paralysis may permit use of lower doses of general anesthetic agents, which may speed recovery and avoid side effects of these agents" Reference: anesthesiology.pubs.asahq.org/article.aspx?articleid=1945289
Well done your videos are short and sharp thank you very much
I salute u sir u made every topic so easy to learn 😊😊 appreciating 👏👏
Great speed
One of the best videos of pharmacology which is very simple, easy to understand. Cheers
Ur all lecture are really very helpful
Loved the Video 🤩🤩😍
Thank you for this 😊
Holy crap that was awesome thank you!
Your videos are really helpful,please consider making more of these with a bit of detailing 🥺
Thank you very much, very composed and beautifully
summarised, good for revision.
Good lectures. You said cisatracurium was superior to atracurium as it is metabolised free from the liver, atracurium is also metabolised by Hoffman degradation
Your videos are simply AWESOME 😀👍THANKS
Your videos have always helped for clear concepts
Thankful to you
Keep uploading your updates
It literally helped me out seriously you made it so simple and especially I loved the abbreviation like always keep up the excellent work ♥️
Great work 💯
you make it easy for me, great
presentation long live is my wish .
Best channel ever!!!
Can Nn antagonists used against Nm receptors coz both are nicotinic receptors ???????
nicely presented n all topics covered in short😃 Thanks a lott😊
keep making such videos....grtt work👍
Very grateful for all your videos🙏.. they r simple to understand n very helpful :)
thanks for the very clear and high yield content
thnaky You!
please make more videos they are very helpful :)
thanks please post a video on anticancer drugs
you nailed it , fantastic.
very helpful video
Looks like these lectures are going to be necessary revision material after month-long versions!
12:10 i dont quite understand this part here, if the channels are open and there's a deplorization, wont that make the calcium get released?
Excellent presentation
I used to be on Amitriptyline, I hated the anticholinergic effects from it, which gave me Restless Leg Syndrome, often.
best video out there for anti colinergics!
Amazing simple explanation
Thank you for what you are doing and god bless you brother
best pharmacology videos! thank you veryyyy veryy muuchhh
Great job man!..Keep it coming!
Amazing ❤️ This made pharma easy for me
every thing is perfect in your videos.i thanks you a lot the only thing i miss is some words difficult to catch with your accent
Simple and to the point 👍✅
Thanks a lot for teaching us
This video is really good! Once I calmed down and got back it emwas way easier ❤️, but How is nicotine used to help ppl quit smoking if it's part of the sigrates smok? And how can it be used as antagonist and agonist in the same time? I don't get it!
Leaving smoking at once can show withdrawl symptoms due to nicotine tolerance. Which makes it difficult to leave smoking. Also, smoking is dangerous primarily because of its effects on lungs due to inhalation. Nicotine patches completes the need for nicotine while smokers work towards quitting. And the dose in patches can also be reduced, gradually. It's very effective during the quitting process.
And I don't know the answer of your other question. Maybe someone else can answer that for me as well.
At lower doses, nicotine stimulates the receptors bcz ofc they are sensitive to nicotine and thus cause release of other neurotransmitters like epinephrine, dopamine etc resulting in increased cholinergic effects but at higher doses, it paralysis the receptors and stimulatory effects cease.
@@ahmadmunir2215 Gorgeous clarity in your explanation. 🙏
Thank you so much sir your videos are very helpful and informative, thank you so much once again!
Amazing explanation
why would you give someone scopolamine after they've been sedated with propofol before surgery? It would make urination almost impossible
After watching These series I feel like I can discuss without research a book
thank you so much, thank you so much, THANK YOU SO MUCH
Thank you for posting this presentation
Excellent 👌 tnq for this ...
it's a very good video. thank you
Good job 👍🏻
Great work thanks
thank you so much for your efforts i love this
Anticholinergics
- atropine
- scopolamine
- iprateopium
- tiotropium
- tolterodine
- darifenacin
- solifenacin
- oxybutynin
- trospium
- fesoterodine
- benztropine
Trihexyphenidyl
Ganglionic blockers:
- Nicotine
Neuromuscular blockers:
Non depolarising: bind AchR but don't induce channel opening
- Curariform drugs (cis-atracurium, pancuronium, rocuronium, vecuronium)
Depolarising: Ach receptor agonists that are résistent to Ach-ase => prolonged depolarisation -> phase 2 block
- succinylcholine
I find it really hard to understand but good video overall
Thank you so much 💜💜
Thank you sir you made my life easy
I thought midriasis occured when the pupillary muscles contracted... which is what happens if sympathetic NS is favored over the parasympathetic NS.
Isn't the Ciliary muscle for accomodation?
Very Nice Presentation
congratulations for these explanations. Could you tell me what program you use for your videos?
Thxs alot...Awesome lecture👏🏻
Where are the cholinesterase regenerators? :(
Very impressive 👍🏽
Thank you very much best video ever thank you again to help in self study you are awesome sir 🙏🙏🙏
Thank you. Great Job.
Nice videos, and motivate me towards study
Do muscarinic antagonists increase dopamine levels?
The lecture is very amazing but i dont get why the persistent depolarizing agents cause flaccid paralysis instead of spastic paralysis.Thank you
When doctors don't see the issue is anticholinergic syndrome, you can accidently get diagnosed with lupus and labeled a problem patient because you're not getting better. Hard to get better when you're being drugged to death. It was literal torture.
thank you so much sir ❤️❤️❤️