💉 📜 50 hematology cases are waiting, LIMITED availability, go to www.patreon.com/medicosis/ 😅 If you like mnemonics, try Picmonic: www.picmonic.com/referrals/JK55NQXQQB9JLC119 👩💻Sign up for Dropbox here: db.tt/IIlB8ejxWe 📕📗 Books that I recommend, www.amazon.com/shop/medicosisperfectionalis
This was great, I have been researching "how do you test for angioedema?" for a while now, and I think this has helped. You ever tried - Miyhloe Wordless Magic - (should be on google have a look )? It is an awesome one of a kind product for discovering how to eliminate hives and angioedema minus the normal expense. Ive heard some unbelievable things about it and my co-worker got great success with it.
regarding questions, 1. C1 esterase INH activity and concentration (less than 50% of normal levels) and C4 concentration. One single test of the above three is not sufficient for screening. 2. Urticara is absent in HAE, so does elevation of IgE levels. 3. FFP has kallikrein-kinin system proteins, meaning that more bradykinin may be produced by these, potentially leading to a worsening of acute attacks. Furthermore, potential presence of viruses in FFP is not deactivated. Thus, FFP shouldn't be used in this regard unless i.v. C1 INH and s.c. Bradykinin receptor B2 blocker are both not available.
Best explanation I've found yet. Using Kalbitor for acute attacks and about to start takhyzyro for preventative meds. It took a decade and a good doctor in an ER to figure out what was was wrong with me
@@MedicosisPerfectionalis After the Kalbitor much better. I had issues since I was a kid with my hands and lips. The attacks disappeared from ages 10-21 but came back worse than ever in adulthood. I'm 31 now so I've been dealing with this for 10 years now, and thanks to that ER doctor I have gotten a good idea what's wrong with me. Now I'm getting the treatment I need and am having my serpin1 gene tested although I believe I need my f12 gene tested since my complement levels are normal. Either way I should be starting takhyzro soon for preventative medication with Kalbitor to treat the acute
Thank you so much for your amazing presentation..🙏 I have been following your channel from quite some time and I feel blessed to find It . Such a great teaching with added humour in all ur videos. Keep going...👍 Love from India ❤️
I do really appreciate your effort in this series and the others, but I have get so much confused now, exactly in video #25 of Blood&Coagulation series talking about Hereditary Angioedema Treatment between minute 4:30 and minute 4:47. You pointed to that the mechanism of Renin inhibitor-induced Angioedema is that "all of the ACE is busy converting HMWK into ugly Bradikinin […] since renin is history". But being said, and known, that ACE inhibits the conversion of HMWK into Bradikinin and takes the already convertd Bradikinin to the cleaner, so how come that FREE OF OTHER DUTY (angitensin 1 coversion into angiotensin 2, since NO MORE angiotensin 1 is available due to inhibition of renin)-ACE converts HMWK into Bradikinin?!! Please kindly clarify this point with full respect!
I am an HAE patient in South Africa with no Icatibant or Ecallantide available here.. We were told FFP is not recommended in acute attacks because it takes too long (here it takes a minimum of 4 hours to cross match for plasma compatibility and so on), by the time you can receive the FFP the attack is already too far along and may be nearing life threatening.. In acute cases treatment is needed extremely fast
Hi am am a HAE patient too. I'm interested to know what you did to minimize your attacks because, mine have been more frequent lately and I don't know what to do
Hi Hana, how did you get the diagnóstico and how did they research further how you responded if from hereditary of from an adquired Ang ed.? And what did they give you to be prepared and to prevent ? And did they test if you had the C1 INH?
Without HAE we have C1 esterase inhibitor in our body which inhibits C1 enzyme... that means C1 is not converted into active C1...so what happens when a bacteria enters ? Does C1 inhibitory enzyme concentration decreases in body? But that may lead to HAE..... what's the go through?
Why is C3 normal in HAE? If there is overactivation of C1 (due to C1Inh deficiency), and there is consumption of C4, should not C4 also be consumed downstream in cascade?
Good morning, I have HAE. I found out by accident when I swelled after heparin. During my lifetime I had very small seizures, my family had swelling, but no one took care of it because we almost always cut deep submucosa. Perhaps you can tell why heprayna caused such a large seizure. Whole body seizure. Now I know we are not allowed fibrinolytics, people with hae. I'm just wondering technically how it happens in the cells of the body that I had such a big seizure after heparin.
Dear sir I am from Bangladesh. My wife has been suffering from HAE for long time. Her leg, hand, lips are swelling several times with abdominal pain and vomiting. I have appointed many doctors in our country but no one can cure it. I am in great problem with my wife. So please help me how I can get treatment for this disease. Please please help me 😭😭😭
Let me give you a classical way of helping regular people that is not trying to be a doctor or practice medication all that code talk don't mean a Dan thing to a person that's suffering from angioedema for many years people with with swelling was diagnosed with allergies or sinus and basically it wasn't coming from any of that it was a disease they were born with so getting to the point when a person is hungry for a phix they basically want to know what does help the situation and then you can get into all the political parts of the body and different things that trigger these type of symptoms which you don't have to do anything to trigger this this problem I have had swelling all my life when I didn't eat anything drink anything or take anything for month detox my body the swelling does not go away it's a disease and all that political talk is not necessary let's get into what you can take to prevent this headache of a problem that deprives you from life and stop talkin doctor language that people are not interested in other than the people that practice what you practice we just need help in knowing what we can take all that code talk is not necessary because it doesn't tell me how brilliant you are because if you were brilliant you wouldn't have to be on RUclips you be a master in teaching everybody so let's get into what can help individuals believe in that you cannot diagnose everyone's situation with this swelling be a real doctor in own up that you can only teach what you are taught but if you experience it then you are bad mamajama when you can find out the truth about it thank you and have a pleasant doctor day
Being said, and also known, that ACE inhibits HMWKs into Bradykinin, then how come you have said that in Renin inhibitor-induced angioedema, the mechanism is that since renin is history, there would be no angiotensin 1 to be converted into angiotensin 2, and as a result all ACE would be busy converting HMEKs into ugly Bradykinin..!!! (This was between 4:30 and 4: 47 in this video). Please feedback because I am confused now.
My lip swells up about ones a year or so. Sometimes upper lip sometimes under lip. It starts with a rice sized little thing deep in the lip and it grows fast and worse every day for three - five days. Eventually it gets so big I look like extreme restylane experiment gone wrong. It always end with the lip open and a crust that is very little solid and easily is pealed off, yellow puss and almost black crust, a bit blood. Last time it went beyond my lip and my face swolled up a bit up til under the eyes. This isn't herpes, I sometimes have on the mouth corners, and the doctor sent me to the dentist twise, I knew it wasn't because of teeth and the dentist said so too. I searched and I have no allergies except nikkel a bit, but I hadn't done anything unusual or eaten or been out. Clean home, clean bed sheets, I saw many with lips like mine who said they had angio edema. But when I asked the doctor he gave strong antibiotics and thought it was streptococcus or staphylococcus because of the sore and yellow black crust. I just think it's strange since it happens so regularly. Have had anti immune hepatitis before that probably burned out over years of getting better with steroids and imurelle. I struggle very much with fetigue and out of breath, but lungs are fine, liver function is fine now, I just wonder if a doctor like you could say if I can have angio edema or is it something else? I don't dare to mention it to my doctor, if I may be wrong. I just wish I knew why I m so exhausted all the time and this lip thing happens about 7 times now, maby when very stressed and exhausted. Single mom to an autistic youth, so I need my energy and can't spend money on myself, so if a doctor have any suspicions, I would be greatful. I only know if I get a like, but can unlike and I still get notification, I think. Don't expect answers, but hope ;-) :-)
Though yours seems a bit more severe than mine, I was misdiagnosed with this and told to take histamine blockers forever. Unrelated, I started eating clean. Before I ate alot of processed food, I would eat a whole box of salty snacks. I believe it was the amount of sodium in my diet. I eat fairly healthily now, and since doing this it has not happened since. This was 5 or more years ago. Clean up your lifestyle (if you haven't already) and see what happens. Doctors are alot less necessary than we have eaten ourselves into believing.
@@ThisHandleIsntTook ! Mine also while I was sleeping. Started with a tiny little seed sized mini mini lump deep inside the lip ,and it just starts filling up with blood or something until I look like a duck .a crust comes when it's so big it leaks...ugly .Hate to go out ,but usually have to. My dad is a surgeon, he doesn't know what it is . Gives two types of antibiotics incase of streptococcus or staph infections. I don't think it is that ,but I want to find out and stop it. I do eat salty liqurish, if that's why I m a bit surprised, but I know unhealthy foods gives unhealthy consequences. I thought it had to do with stress because it often comes in those times where it feels too much and that on top of everything 🙊🙈..Thank you for your reply and tip.I'll reduce my salt intake and see .🙂
Today's questions? A. What type of hypersensitivity reaction is "serum sickness"? 1. What's the most reliable and cost-effective screening test for hereditary angioedema (HAE) 2. What distinguishes hereditary angioedema from allergic angioedema? 3. Why is fresh frozen plasma (FFP) NOT recommended in the acute treatment of hereditary angioedema? Let me know the answers down below. The answers to 1,2&3 are available NOW on www.patreon.com/medicosis/
You mentioned renin inhibitors will cause angioedema by directing more ACE from angiotensin system towards bradykinin system. But more ACE at that arm will lead to less bradykinin and no angioedema. Am I right?
A. serun sickness is type3 HSVR. 1: most cost effective test is C4 level in blood. 2: skin prick test differentiates HAE from Allergic AE 3: because FFP also contains coagulation factors and XIIa is gonna cause increase in kallikerin
I do really appreciate your effort in this series and the others, but I have get so much confused now, exactly in video #25 of Blood&Coagulation series talking about Hereditary Angioedema Treatment between minute 4:30 and minute 4:47. You pointed to that the mechanism of Renin inhibitor-induced Angioedema is that "all of the ACE is busy converting HMWK into ugly Bradikinin […] since renin is history". But being said, and known, that ACE inhibits the conversion of HMWK into Bradikinin and takes the already convertd Bradikinin to the cleaner, so how come that FREE OF OTHER DUTY (angitensin 1 coversion into angiotensin 2, since NO MORE angiotensin 1 is available due to inhibition of renin)-ACE converts HMWK into Bradikinin?!! Please kindly clarify this point with full respect! This is a repost of a previous comment because i too have the same doubt.
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💉 📜 50 hematology cases are waiting, LIMITED availability, go to www.patreon.com/medicosis/
😅 If you like mnemonics, try Picmonic: www.picmonic.com/referrals/JK55NQXQQB9JLC119
👩💻Sign up for Dropbox here: db.tt/IIlB8ejxWe
📕📗 Books that I recommend, www.amazon.com/shop/medicosisperfectionalis
This was great, I have been researching "how do you test for angioedema?" for a while now, and I think this has helped. You ever tried - Miyhloe Wordless Magic - (should be on google have a look )?
It is an awesome one of a kind product for discovering how to eliminate hives and angioedema minus the normal expense. Ive heard some unbelievable things about it and my co-worker got great success with it.
regarding questions,
1. C1 esterase INH activity and concentration (less than 50% of normal levels) and C4 concentration.
One single test of the above three is not sufficient for screening.
2. Urticara is absent in HAE, so does elevation of IgE levels.
3. FFP has kallikrein-kinin system proteins, meaning that more bradykinin may be produced by these, potentially leading to a worsening of acute attacks. Furthermore, potential presence of viruses in FFP is not deactivated. Thus, FFP shouldn't be used in this regard unless i.v. C1 INH and s.c. Bradykinin receptor B2 blocker are both not available.
Best explanation I've found yet. Using Kalbitor for acute attacks and about to start takhyzyro for preventative meds. It took a decade and a good doctor in an ER to figure out what was was wrong with me
And how are you doing now?
@@MedicosisPerfectionalis After the Kalbitor much better. I had issues since I was a kid with my hands and lips. The attacks disappeared from ages 10-21 but came back worse than ever in adulthood. I'm 31 now so I've been dealing with this for 10 years now, and thanks to that ER doctor I have gotten a good idea what's wrong with me. Now I'm getting the treatment I need and am having my serpin1 gene tested although I believe I need my f12 gene tested since my complement levels are normal. Either way I should be starting takhyzro soon for preventative medication with Kalbitor to treat the acute
@robert that's relieving to hear, hope you never suffer from it again.
May i know -out of curiosity- in which country do you live?
Thank you so much for your amazing presentation..🙏 I have been following your channel from quite some time and I feel blessed to find It . Such a great teaching with added humour in all ur videos. Keep going...👍 Love from India ❤️
Thank you so much ☺️
Thank you for explaining this in best possible way ! Bravo
Thank you 🙏
Man your students are gonna be awesome doctors
Thank you 😊
I certainly hope so!
Super man, sorry etra ordinary man, you made it very simple which text books made very complicated
Thank you 🙏
Thank you for this video, it covers so much and is so well explained. Much appreciated
My pleasure 😇
Super🎉❤
Thank you!
Serum semickness is type ||| hypersensitivity
it occurs one to two weeks after exposure
I do really appreciate your effort in this series and the others, but I have get so much confused now, exactly in video #25 of Blood&Coagulation series talking about Hereditary Angioedema Treatment between minute 4:30 and minute 4:47. You pointed to that the mechanism of Renin inhibitor-induced Angioedema is that "all of the ACE is busy converting HMWK into ugly Bradikinin […] since renin is history". But being said, and known, that ACE inhibits the conversion of HMWK into Bradikinin and takes the already convertd Bradikinin to the cleaner, so how come that FREE OF OTHER DUTY (angitensin 1 coversion into angiotensin 2, since NO MORE angiotensin 1 is available due to inhibition of renin)-ACE converts HMWK into Bradikinin?!!
Please kindly clarify this point with full respect!
Did you ever find the answer to this question?
omg ... what an explanation !!! lots of love
Thank you so much 😊
I respect & love you very much Dr Medicosis
Thank you ☺️
I am an HAE patient in South Africa with no Icatibant or Ecallantide available here.. We were told FFP is not recommended in acute attacks because it takes too long (here it takes a minimum of 4 hours to cross match for plasma compatibility and so on), by the time you can receive the FFP the attack is already too far along and may be nearing life threatening.. In acute cases treatment is needed extremely fast
I am so sorry to hear that
Hi am am a HAE patient too.
I'm interested to know what you did to minimize your attacks because, mine have been more frequent lately and I don't know what to do
@@londiwemyeni7816 Are you in South Africa and are you part of our member organisation?
@@hanafaulds5323 Yes I am South African but I am not a member,
Hi Hana, how did you get the diagnóstico and how did they research further how you responded if from hereditary of from an adquired Ang ed.? And what did they give you to be prepared and to prevent ? And did they test if you had the C1 INH?
Great struggle.
Well done 👏
:)
HAE is type 1 hypersensitivity reaction which is rash & hypotension
You wouldn't give plasma when accutte due to a possible cytachine storm Produced by autoiimnue response against the donors plasma?
Without HAE we have C1 esterase inhibitor in our body which inhibits C1 enzyme... that means C1 is not converted into active C1...so what happens when a bacteria enters ? Does C1 inhibitory enzyme concentration decreases in body? But that may lead to HAE..... what's the go through?
did you ever find the answer to this question?
Thanks
My pleasure 😇
Alkaline-phosphatase & C1 esterase enzyme ? Is there any connection regarding HAE?
Why is C3 normal in HAE? If there is overactivation of C1 (due to C1Inh deficiency), and there is consumption of C4, should not C4 also be consumed downstream in cascade?
How can I make venule phlebotomy and arteriole phlebotomy to get rid of those nasty Bradykinin ? "in case of HAE"
Good morning, I have HAE. I found out by accident when I swelled after heparin. During my lifetime I had very small seizures, my family had swelling, but no one took care of it because we almost always cut deep submucosa.
Perhaps you can tell why heprayna caused such a large seizure. Whole body seizure. Now I know we are not allowed fibrinolytics, people with hae. I'm just wondering technically how it happens in the cells of the body that I had such a big seizure after heparin.
Thank you so much for explaining this Angioedema. Now my question is Can I vaccinate with COVID 19 ? If I vaccinate Wht will happen.
16:13 can we use the orotracheal intubation?
serum skins type III hypersensitivity reaction >>
Dear sir
I am from Bangladesh. My wife has been suffering from HAE for long time. Her leg, hand, lips are swelling several times with abdominal pain and vomiting. I have appointed many doctors in our country but no one can cure it. I am in great problem with my wife.
So please help me how I can get treatment for this disease. Please please help me 😭😭😭
Thanks!!
My pleasure 😇
Is it the same as quincke’s disease
How danazol helps for prevention of attacks dear Medicosis
Let me give you a classical way of helping regular people that is not trying to be a doctor or practice medication all that code talk don't mean a Dan thing to a person that's suffering from angioedema for many years people with with swelling was diagnosed with allergies or sinus and basically it wasn't coming from any of that it was a disease they were born with so getting to the point when a person is hungry for a phix they basically want to know what does help the situation and then you can get into all the political parts of the body and different things that trigger these type of symptoms which you don't have to do anything to trigger this this problem I have had swelling all my life when I didn't eat anything drink anything or take anything for month detox my body the swelling does not go away it's a disease and all that political talk is not necessary let's get into what you can take to prevent this headache of a problem that deprives you from life and stop talkin doctor language that people are not interested in other than the people that practice what you practice we just need help in knowing what we can take all that code talk is not necessary because it doesn't tell me how brilliant you are because if you were brilliant you wouldn't have to be on RUclips you be a master in teaching everybody so let's get into what can help individuals believe in that you cannot diagnose everyone's situation with this swelling be a real doctor in own up that you can only teach what you are taught but if you experience it then you are bad mamajama when you can find out the truth about it thank you and have a pleasant doctor day
Does ACE creates bradykinin in renin inhibition?
I am afraid I didn’t understand!
@@MedicosisPerfectionalis In the video on diagnosis and treatment of angioedema I pointed out to segment between 4:30 to 4:46 min.
type 3 for ss
Respect
Thank you so much for supporting my channel by clicking on the “join” button!
I appreciate you, Doctor!
Kalikerin or kalikrein? I'm so confused now 😂
What is the age of presentation of hereditary angioedema?
Adolescent
I’m 23 and just got diagnosed 2 months ago
I am sorry to hear that!
How is your health?
Being said, and also known, that ACE inhibits HMWKs into Bradykinin, then how come you have said that in Renin inhibitor-induced angioedema, the mechanism is that since renin is history, there would be no angiotensin 1 to be converted into angiotensin 2, and as a result all ACE would be busy converting HMEKs into ugly Bradykinin..!!! (This was between 4:30 and 4: 47 in this video). Please feedback because I am confused now.
Age varies, most people display when they're teenagers, however, some display symptoms in infancy.
Ur so cute❤
Thank you so much 😊
Its really hard understandinv anything u was saying
My lip swells up about ones a year or so. Sometimes upper lip sometimes under lip. It starts with a rice sized little thing deep in the lip and it grows fast and worse every day for three - five days. Eventually it gets so big I look like extreme restylane experiment gone wrong. It always end with the lip open and a crust that is very little solid and easily is pealed off, yellow puss and almost black crust, a bit blood. Last time it went beyond my lip and my face swolled up a bit up til under the eyes.
This isn't herpes, I sometimes have on the mouth corners, and the doctor sent me to the dentist twise, I knew it wasn't because of teeth and the dentist said so too. I searched and I have no allergies except nikkel a bit, but I hadn't done anything unusual or eaten or been out. Clean home, clean bed sheets, I saw many with lips like mine who said they had angio edema. But when I asked the doctor he gave strong antibiotics and thought it was streptococcus or staphylococcus because of the sore and yellow black crust. I just think it's strange since it happens so regularly. Have had anti immune hepatitis before that probably burned out over years of getting better with steroids and imurelle. I struggle very much with fetigue and out of breath, but lungs are fine, liver function is fine now, I just wonder if a doctor like you could say if I can have angio edema or is it something else? I don't dare to mention it to my doctor, if I may be wrong. I just wish I knew why I m so exhausted all the time and this lip thing happens about 7 times now, maby when very stressed and exhausted. Single mom to an autistic youth, so I need my energy and can't spend money on myself, so if a doctor have any suspicions, I would be greatful. I only know if I get a like, but can unlike and I still get notification, I think. Don't expect answers, but hope ;-) :-)
Though yours seems a bit more severe than mine, I was misdiagnosed with this and told to take histamine blockers forever. Unrelated, I started eating clean. Before I ate alot of processed food, I would eat a whole box of salty snacks. I believe it was the amount of sodium in my diet. I eat fairly healthily now, and since doing this it has not happened since. This was 5 or more years ago. Clean up your lifestyle (if you haven't already) and see what happens. Doctors are alot less necessary than we have eaten ourselves into believing.
Mine happened a few times a year. Usually started while I was sleeping.
@@ThisHandleIsntTook ! Mine also while I was sleeping. Started with a tiny little seed sized mini mini lump deep inside the lip ,and it just starts filling up with blood or something until I look like a duck .a crust comes when it's so big it leaks...ugly .Hate to go out ,but usually have to. My dad is a surgeon, he doesn't know what it is . Gives two types of antibiotics incase of streptococcus or staph infections. I don't think it is that ,but I want to find out and stop it. I do eat salty liqurish, if that's why I m a bit surprised, but I know unhealthy foods gives unhealthy consequences. I thought it had to do with stress because it often comes in those times where it feels too much and that on top of everything 🙊🙈..Thank you for your reply and tip.I'll reduce my salt intake and see .🙂
@@lapis3834 diphenhydamine hcl helped reduce the sweeping but made me tired. Hope this helps, I feel your pain!
@@ThisHandleIsntTook Thank you so much ! 🙂I write that down !
I hope you are a better doctor than your teaching!
This is really helpful but a bit annoying as you talk and explain so fast!!!
Today's questions?
A. What type of hypersensitivity reaction is "serum sickness"?
1. What's the most reliable and cost-effective screening test for hereditary angioedema (HAE)
2. What distinguishes hereditary angioedema from allergic angioedema?
3. Why is fresh frozen plasma (FFP) NOT recommended in the acute treatment of hereditary angioedema?
Let me know the answers down below.
The answers to 1,2&3 are available NOW on www.patreon.com/medicosis/
I cant find the answers plz
1- high bradykinin level.
2-urticaria, itching not present
3- bradykinin would activate factor xII and coagulation cascade.
You mentioned renin inhibitors will cause angioedema by directing more ACE from angiotensin system towards bradykinin system. But more ACE at that arm will lead to less bradykinin and no angioedema.
Am I right?
A. serun sickness is type3 HSVR.
1: most cost effective test is C4 level in blood.
2: skin prick test differentiates HAE from Allergic AE
3: because FFP also contains coagulation factors and XIIa is gonna cause increase in kallikerin
Hypersensitivity type 3 Serum sickness like-reactions i.e fever, urticaria, arthalgia
ONLY INTERSTED IN THE CURE OR TRATMENTS TO KEEP IT FROM ATTACKING MY FACE,WHAT ARE THE BEST MEDICATIONS. 9-25-22.
I do really appreciate your effort in this series and the others, but I have get so much confused now, exactly in video #25 of Blood&Coagulation series talking about Hereditary Angioedema Treatment between minute 4:30 and minute 4:47. You pointed to that the mechanism of Renin inhibitor-induced Angioedema is that "all of the ACE is busy converting HMWK into ugly Bradikinin […] since renin is history". But being said, and known, that ACE inhibits the conversion of HMWK into Bradikinin and takes the already convertd Bradikinin to the cleaner, so how come that FREE OF OTHER DUTY (angitensin 1 coversion into angiotensin 2, since NO MORE angiotensin 1 is available due to inhibition of renin)-ACE converts HMWK into Bradikinin?!!
Please kindly clarify this point with full respect!
This is a repost of a previous comment because i too have the same doubt.