Carboxylic Acids: Crash Course Organic Chemistry #30
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- Опубликовано: 6 фев 2025
- What do the smells of feet, armpits, vomit, and goats all have in common? (Besides being super gross…) Carboxylic acids! Despite being responsible for some of our least favorite odors, carboxylic acids are also super useful in organic chemistry. In this episode of Crash Course Organic Chemistry, we’ll review carboxylic acid synthesis and nomenclature, react carboxylic acids to form salts, esters, and acid chlorides, and start our journey towards synthesizing one of the most important organic chemicals in medicine, penicillin!
Episode Sources:
Kennedy, J: Common names of carboxylic acids jameskennedymo...
Thomas, J: Mouldy Mary and the cantaloupe
mcdreeamiemusi...
C H Arnaud, C&EN: Penicillin
cen.acs.org/ar...
Series Penicillin References:
Nicolaou, K. C., & Sorensen, E. J. (1996). Classics in total synthesis: targets, strategies, methods. John Wiley & Sons.
Sheehan, J. C. (1982). The enchanted ring: the untold story of penicillin.
Primary literature for Sheehan’s penicillin synthesis: Sheehan, J.C. & Izzo, P.T. J. Am. Chem. Soc. 1948, 70, 1985; Sheehan, J.C. & Izzo, P.T. J. Am. Chem. Soc. 1949, 71, 4059; Sheehan, J.C. & Bose A.K. J. Am. Chem. Soc. 1950, 72, 5158; Sheehan, J.C., Buhle, E.L, Corey E.J., Laubach, G.D. & Ryan J.J. J. Am. Chem. Soc. 1950, 72, 3828; Sheehan, J.C. & Laubach, G.D. J. Am. Chem. Soc. 1951, 73, 4376; Sheehan, J.C. & Hoff, D.R. J. Am. Chem. Soc. 1957, 79, 237; Sheehan, J.C. & Corey E.J. J. Am. Chem. Soc. 1951, 73, 4756
Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.
Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.
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The Mold Medicine Map introduced at 10:49 has an error that is being corrected in subsequent episodes. The last structure in phase one should contain an NH2, rather than an OH2. It’s an amino acid! If you came in search of episodes 31 & 32, they will be reuploaded (corrected) next week!
I was literally just stressing out organic chemistry, in particular this. I'm actually so thankful for this-thank you so much!
Unpopular opinion: Ochem made more sense than gen chem
AGREED!
Thank you so much for the info. Although a microbiology student, I didn't know that penicillin had so many processes before coming up so far.
Would love to watch the further series, please bring it soon 🧠✨😺
Love these videos! Actually working on an organic chemistry course myself, super interesting topic!
I’ve never been so early here. This channel has helped me so much!
A lot of Europeans I've met aren't fans of US-made chocolate because it tastes 'vomity' ...makes sense now :)
Crash course biochemistry here we gooooo
Oh hey I actually have heard of some of this stuff before thanks to amateur chemists here on RUclips! Fischer esterification and decarboxylation are pretty approachable procedures.
I learn more from videos like these than I do from any class in school.
Very Amazing video Crash course 👍👍
you should do a series on criminology seen as how its a reletivley new but popular course
The way you talk and teach , amazing
IVE NEVER BEEN SO EARLY TO A CRASH COURSE VIDEO HI
Same :D hello
Best trics👏👏👏👏👏👏
Thank you for saving my like (again)
Yippee! Just in time for my MCAT!
It’s Hershey’s. Hershey’s has the puke compound. That’s the chocolate.
And it's why I won't eat almost any of the chocolate they make. I can taste it way too much and it's so unpleasant
Yay it was 45 mins ago when I usually see it at 1 or 2 days
So interesting!
Very well presented!
Keep going ♥️♥️♥️♥️♥️
I feel like I skipped a few classes... Decarboxylation, yep totally!
I enjoyed it thanku
Thank you.
Cool Video
Just Marvellous ....Keep Going Guys 😊😊😊😊😊
This is SOO COOL!!😮✨
Needed this
It is also what attacks mosquitoes.
1:00 LMAO at that goat!
Good video!
thanks!
Banana is awesome for penicillin
Where was this shit when I failed orgo though!?!? All I had was biology videos lmaooo. Thanks scishow! Might need to go back after this...
when is this org chem series scheduled to be finished ?
Le Chatelier is here
oh wow i’ve never watched one of these that isn’t 6 years old
nice💕
Drive that esterification forward with a Dean Stark apparatus full of molecular sieves.... But don't let them get in the main boiling flask....
I know a guy who made that mistake and ruined a bunch of molecular sieves...
And messed up his product besides.
.
I may or may not be that guy
Great video!
I wonder why don't deodourants convert smelly carboxylic acids to fragrant esters.
I don't think the reaction is that easy. It usually involves a strong acid like sulfuric acid as a catalyst, and it needs to be heated/refluxed.
NICE
Some salts aren't water soluble?
Moldy Mary 😭
good wrok keep going
Hello
For a moment, I thought this vlog was going to be sponsored by Lume deodorant.
Let's all thank Mary's Melons. HUZZAH!
How do you spell your name? 🤔 It sounds so unique when you introduce yourself at the start of the videos.
Her name is written in the credits at 11:24 - Dr. Deboki Chakravarti 🙂
I understood 0.1% of this video. My intelligence is unmatched.
😎
CrashCourse please post more videos about
-Islamic golden age
-Aristotle,Plato,Socrates wisdom and teachings
Thank you
Get your early tickets here.
Goats smell like car*baaaa*xylic acids
You’re the *baaaaaa*st
It’s a bit too fast.
👋👏👏👏👏
Hi
😎