Clearly one of the best SSRI lectures. Also worth mentioning at approx 8 minutes into video, “Cimetidine- contraindication w citalopram, but also 3A4 inhibitors such as omeprazole/Prilosec.
Hello! Is fluvoxamine activating or sedating? Are you able to wake up early in the morning to go the university / to your job? How much do you sleep each night? I have been on Paxil for 5 years. Amazing drug, but too sedating. I tried sertraline but it made me even more drowsy than paroxetine, even with a very low dose (perhaps because I am a poor CYP2C19 metabolizer). I would love to have your review on fluvoxamine's side effects.
Amazing video. I can tell once this channel has a larger library of videos behind it, it is going to pop off. Can't wait for a similar video on other psychotropic drugs like SNRIs.
I just had to leave a message at this point. You're making the best psychopharm series out right now. Currently listening to this video quite often so I can commit it to memory. This information is so relevant to my needs and so perfectly packaged.
Thank you so much for this detailed video! My psychiatrist did not go anywhere near this amount of detail when prescribing my medication. Now I have the knowledge to make the best choice for my mental health
the deadpan humor, the super nuanced yet concise information, and the obvious hip hop knowledge. 11/10 video, W content creator. thank you for all that u do 🙌
Bro!! Omg. Your videos man. 💯. My brain loves the way you explain things. I love the language and humor man. Bringing me so much knowledge to try to learn.
Paroxetine (Paxil) is an excellent medication and have helped many people, included me. For me it is sedating but not as much as other SSRIs that you just listed. Moreover, it helped tremendously for my depression and anxiety.
Strange how Luvox is only indicated for OCD in the US while it is one of the most prescribed SSRI's in Europe and Japan against depression (approved in a total of 80 countries world wide for this), as well for anxiety and panic disorders and is generally pretty successful at that. The side effects are usually very mild. Cognitive and sexual function are barely decreased if at all for example. It is true that you should not take it with other prescribed medications but if its the only medication you take it should be fine. You can still take over the counter painkillers with it. I guess it all comes down to lobbying and marketing in the US.
Great video . I really appreciate the detailed breakdown. I was scared to try Lexapro because of my bad experience with Zoloft. I like that Lexapro doesn't touch the dopamine receptor because I don't have a lack of energy. Zoloft made me feel like a Zombie and I used it for 3 months.
And its working for my issues I do y. Are what my ex says. . u try going to school caring fr a elderly dad and his brother who was also dying I do my vest ....I went through a hard time after both their. Deaths ...I'm just glad and blessed I have a roof over my head god bless drs .thru do save lives
I LOVE your descriptions! First from a professional standpoint but i love,love,.love that I must laugh so hard inbetween because of your humor and irony.:D
I had an absolutely horrific time trying to get used to citalopram and had to quit. I am also very allergic to some things so it might have to do something with that histamine property. Great video btw, this information is actually quite hard to find and I really wanted more information on these differences.
Can we say that the best predictor of a success antidepressant for a patient is if he / she is a normal metabolizer of the drug (and not a poor or an ultra rapid metabolizer)?
Hello! Is fluvoxamine activating or sedating? Are you able to wake up early in the morning to go the university / to your job? How much do you sleep each night? I have been on Paxil for 5 years. Amazing drug, but too sedating. I tried sertraline but it made me even more drowsy than paroxetine, even with a very low dose (perhaps because I am a poor CYP2C19 metabolizer). I would love to have your review on fluvoxamine's side effects.
@@vegetossgss1114 for me there hasn’t been any side effects to speck of. I have been on 50mg that take at night and sleep well. Maybe initial first week may have been a increase in anxiety but nothing bad and then it just helps me with the negative thoughts which gets you into the anxiety of worry. Also take buspirone 5mg once a day that is also beneficial. Never tried Paxil. I truly hope you find what works best for you
Eacitalopram 15 mg/day + lamictal 100 mg/day combined with psychotherapy has really helped me. I suffered and overachieved for 15 years. Now I am more stable and active and present, not stuck in venomous mental loops. Feels great not wanting to die 24/7.
Im in that current mood, don't want to die but I feel extreme anxiety /fear every minute of the day. Im also taking opiods, quite low dose for pain. I have been on Lamictal for some months, like 6 year's ago, didn't felt so much, does it help you with your moods? And does the SSRI esci, helps you enough to take them? (I don't want to take anything that will worsen my case that's why Im asking ❤🙏. I may suffer from panoc disorder?.. I have a feeling Im in danger all the time. All help is appreciated❤. Is Lexapro a good serotonin med?
So my doc gave me Paxil - it works great, but I'm scared to stop it, and scared of the dementia thing. Also, the anxiety isn't going away but the depression is.
Thanks for the great video! I have a question for you...I'm deciding between Prozac and Luvox to treat depression, body dysmorphia, social and generalized anxiety. Other SSRI's including Lexapro and Zoloft made me too drowsy in the past which led me to switch to SNRI's. Unfortunately the SNRI's have been less effective for my anxiety. I need a medication that isn't too sedating but works well for anxiety. Do you think Prozac is the better option?
Luvox did wonders for me against anxiety, depression, light OCD and panic atracks. They really don't seem to like it in the US, but in Europe it is one of the most prescribed SSRI's.
I've been on fluoxetine since 2015. I stopped taking fluoxetine on 12/05/23. I feel a lot better without it. Has anyone had withdrawal symptoms from stopping the fluoxetine?
I’ve been on 100 mg of Zoloft for months and didn’t help me at all!! I’m now on week 2 of switching to Prozac. I’m only on the 20 mg of Prozac right now and still no change but I know it can take awhile. At this point it feels as if I’ll never feel better
"Previous research has suggested limited improvement in tinnitus with SSRIs and that use of these drugs with tinnitus patients should be limited to the application of treatment of the co-morbid anxiety/depression and not for tinnitus directly. There are also reports of tinnitus onset or exacerbation with SSRI." www.audiology.org/ssri-and-tinnitus/#:~:text=Previous%20research%20has%20suggested%20limited,and%20not%20for%20tinnitus%20directly.
@@PsychoFarmI laughed when I read you had slowed it down as you talked far too fast for me on the newer video. Probably because I am from UK but thanks for the info, it’s very helpful even if I have to listen a few more times.
Fluvoxamine is Sigma 1 agonist, Sertraline a Sigma 1 antagonist. Covid long haulers are recommended to take Fluvoxamine. Based on the description Sertraline fits better for me. Would sertraline also have anti inflammatory benefits for long covid?
Excellent discussion. One error: in your summation you accidentally say sertraline, because of its NET, is especially good for atypical depression. But as you clearly know from your initial detailed discussion of sertraline, you mention its DAT, which is correct, thereby providing a mechanism suited for atypical depression. As far as I know, sertraline has minimal if any actions at NET.
Hello! Is fluvoxamine activating or sedating? Are you able to wake up early in the morning to go the university / to your job? How much do you sleep each night? I have been on Paxil for 5 years. Amazing drug, but too sedating. I tried sertraline but it made me even more drowsy than paroxetine, even with a very low dose (perhaps because I am a poor CYP2C19 metabolizer). I would love to have your review on fluvoxamine's side effects.
Great Video, very informative and easy to follow. Not sure if it’s a common side effect, worth mentioning that Lexapro stripped me of all sexual drive, made arousal and completion near impossible, and severely blunted my emotions. So, not a fan.
Not. It’s only clinically relevant in those with significant heart issues, and even then the link is inferred and hasn’t necessarily been proven to have adverse effects.
Definitely talk to your doctor about it, as they can answer specific questions and confirm your health. If you have a family history of heart issues or take other medications that prolong the QT segment, you might want to discuss this with your doctor. It's worth noting that Lexapro is pure escitalopram, while it is believed that arcitalopram (the opposite of escitalopram) is responsible for the QT prolonging effects. Citalopram is a mixture of both the es- and ar- molecules.
A lot of stuff about medications is theoretical, that being said 50mg of Zoloft and done wonders for panic attacks, which ruin most situations I’m in. So pseudoscience or not, there are effects.
Yeah, I second that, everyone reacts differently to SSRIs! It is allegedly the safest one, but I wildly DESPISE escitalopram, my body fully rejected it with something that felt like never-ending panic attack (that lasted full seven days with tremors, diarrhea, womiting, sweating like a pig, hot flashes and feelings of fear, anxiety, desperation, hopelessness, sadness and imminent doom, it got so bad i started planning my grand exit and it hasn't stopped when I stopped taking it, it stopped only when I got new antidepressant and alprazolam for the first few days) xD But venlafaxine, which is SNRI and is reported to be often badly tolerated seemed to not hate me at all. Sure, i felt bad for the first three days for which my head was spinning round round round but it went away relatively fastly and it was nothing compared to previous hell.
@@michaelsamo2849 when it comes to esci i didnt take any benzos with them despite the fact that i needed them. When i was taking venla I got xanax just in case. Turns out that with venlafaxine i didnt need it at all. I just couldnt stand for like two or three days because it messed with my sense of balance at the beginning but it was nothing compared to hell that esci put me through.
How do you explain being held hostage on Zoloft? Taken for 22 years. When I try to decrease or increase by any amount (5%, 10%, 25%, 50%) I get very irritable, anxious, can't sleep, and also tired. I believe there's permanent damage that's been done. I have constant jaw movements (dystonia).
Hey I wanted to know how these react differently when clubbed with clonazepam(0.25mg). I have been given 2 meds, one in the past both had clonazepam with the main part of a each ssri
Interesting, I was wondering how my psychs picked the ssri for me. I would love to see a video explaining mirtazapine and its mechanisms since i was on that for 8 months but it did literally nothing for me lol
Not sure if anyone knows but like from this which one would be most like fluoxetine? I was waiting to see if another of the 6 had the 5ht2c aspect, as fluoxetine is the only one I have tolerated so far, but was wondering about trying paroxetine
The awareness that taking antidepressants sooner or later will result in their discontinuation, which will result in a withdrawal syndrome, is not optimistic about this method of treating depression. Secondly - each antidepressant causes that the neurotransmitter system on which the drug affects becomes reactive and dominant during pharmacotherapy, e.g. drugs from the SSRI group cause that when we take them, the serotoninergic system begins to dominate over other neurotransmitter systems, pushing them to the defensive - while taking The defensive SSRI is a dopaminergic system - it results, among others, in apathy, cognitive impairment, emotional blunting, and sexual dysfunction. After discontinuation of SSRIs, the serotonergic system becomes overly reactive, in the initial period of abstinence there is a failure of this system, but over time (after a long time after discontinuation of the SSRI) its excessive activity will occur, unfortunately the dopaminergic system is defensive all the time after the discontinuation of the SSRI because there are changes in histone levels that promote the serotoninergic system in relation to the dopaminergic system.
😣Damn…. Any advice for me, I appreciate it. Just curious 😐👍🏻 I’m 45 , diagnosed with ADHD this week. Most likely going on some stimulant, and I’m okay with that. But I’m concerned about the co-morbidity, of depression, getting perscribed SSRI ( maybe Zoloft)… Hard to say, I know. I just feel like I can possibly push through with the help of stimulant. And avoid being on an SSRI? I’ve often heard what you comment on, & it sounds like another added problem.. the withdrawal and etc. Sorry if I made no sense. And I thank you .
Love the videos, though I'm a little confused about sertaline working best for atypical depression. From what I've read in research, sertraline has the best efficacy in melancholic depression.
everyone’s different. literature can say one thing but…. in real life it’s always diff. how they choose antidepressant is heavily dependent on symptoms as no 2 people with depression are an exact copy of another. saying sertraline is the best is downright dangerous for others whom sertraline have not worked well on.
hey pysch, ive had 2 seperate cases of severe panic disorder for about 3 years on and off, i used to take lexapro on the smallest dose, 2.5mg and then 5mg and it really helped me overcome my disorder completely the first time (end of 2019 into 2020) but when i got panic disorder a second time (end of 2020) from smoking weed, I noticed not much of an impact on the same dose 2.5mg but i was told multiple times to up my dose for it and i was too scared to so i quit the medication cold turkey, and got insane migraines/headaches (thinking someting in my head was gonna pop it was so bad) as a withdrawal i think and for the past year I’ve been medicine free but I still get panic attacks everyday (heart races everyday nonstop, evil bad thoughts), and I’m ready to get back on something, my doc prescribed me celexa but I’m very unsure about trying it Bc I’ve been so used to take lexapro and I’m just wondering what ur opinion would be, thank u so much for the video also u rock!!
Sertraline if horrible. I was only able to take it for three days before the massive sedation and crippling headaches became too much. Citalopram felt exactly the same as amphetamine complete with dilated pupils, violent shaking, not sleeping for days at a time, dripping with sweat. Nasty stuff.
@@alltheglory7854 as someone who's tapering off of paxil after decades of use, I would recommend only using psych drugs as a last resort (talk therapy, meditation, journaling, inner child work, EMDR... lots of non-drug treatments are available!) Then, if you're still suffering, I would recommend working with someone knowledgeable in both nutrition/supplements to make sure there isn't some physical ailment, gut issue, or allergy causing the mental health issues. Read up on how childhood trauma affects us as adults. "The Body Keeps the Score" is a popular book on this. If the problems still persist, I would suggest cannabis or psilocybin over psych drugs. Psych drugs disconnect us from ourselves. This can be life-saving during a particularly distressing time in life, but reconnecting must happen for true healing. And it's difficult to connect with yourself and your emotions when on an emotion-blocking (or dulling) drug. I wish you all the best.
@@alltheglory7854 right they monitor how you feel and keep track of you when doing cbt and see how you are doing on the medication, bit of exposure therapy too going through the triggers that make you anxious 1/10 how do you feel.
Fluvoxamine. COVID. Side effects: common cold symptoms. Hijacks the transmission system.? Keeps the changes “residue” out of an infected brain at the same time?
hahaaaa i thought i was the only one who referred to it as "squirtraline"! guess i'm not that clever. and yes, during the first few months the diarrhea was crazy. it did eventually subside though.
I have a severe case of ocd but only recently (1y ago) I started taking drugs for it. First it was sertraline which stopped working after some time, then venlafaxine which also stopped working after a few months. Then I went to another psychiatrist who prescribed me fluvoxamine + risperidone. It was terrible, one night I woke up feeling something is going on with my heart, my body was hot and I honestly thought I was going to die. Could anybody please explain why it was such a bad combination? (I'm not coming back to that psychiatrist :))
Hello! Is fluvoxamine activating or sedating? Are you able to wake up early in the morning to go the university / to your job? How much do you sleep each night? I have been on Paxil for 5 years. Amazing drug, but too sedating. I tried sertraline but it made me even more drowsy than paroxetine, even with a very low dose (perhaps because I am a poor CYP2C19 metabolizer). I would love to have your review on fluvoxamine's side effects.
I just started taking Sertraline like 2 weeks ago and I feel lazy and tired most of the time but I was told it is common side effect for the first weeks. Also my stomach is kinda upset because i made the mistake of taking it on empty stomach so beware and only take it after food. My mood is getting slightly better and I am more calm and my reactions to situations are improving and more calculated. I noticed an increase in time for me for ejaculation during sex which was not problem before but might be now because it is not good for my partner but i searching for solutions to that so if anyone know how to make ejaculation faster please reply to me. As for erection is OK nothing changed.
![Seungmin "그렇게, 천천히, 우리(As we are)" | [Stray Kids : SKZ-PLAYER]](http://i.ytimg.com/vi/kAzmhLHePqU/mqdefault.jpg)
Amazing video! I’m a psych intern, and there just aren’t enough resources like this online. Please keep it up!
👍 Appreciate people who work in mental health.
Thats for the clients
You have no idea how long I’ve waited to know the REAL differences in these drugs.
Clearly one of the best SSRI lectures. Also worth mentioning at approx 8 minutes into video, “Cimetidine- contraindication w citalopram, but also 3A4 inhibitors such as omeprazole/Prilosec.
Hello! Is fluvoxamine activating or sedating? Are you able to wake up early in the morning to go the university / to your job? How much do you sleep each night? I have been on Paxil for 5 years. Amazing drug, but too sedating. I tried sertraline but it made me even more drowsy than paroxetine, even with a very low dose (perhaps because I am a poor CYP2C19 metabolizer). I would love to have your review on fluvoxamine's side effects.
Amazing video. I can tell once this channel has a larger library of videos behind it, it is going to pop off. Can't wait for a similar video on other psychotropic drugs like SNRIs.
I just had to leave a message at this point. You're making the best psychopharm series out right now. Currently listening to this video quite often so I can commit it to memory. This information is so relevant to my needs and so perfectly packaged.
Thank you so much for this detailed video! My psychiatrist did not go anywhere near this amount of detail when prescribing my medication. Now I have the knowledge to make the best choice for my mental health
the deadpan humor, the super nuanced yet concise information, and the obvious hip hop knowledge. 11/10 video, W content creator. thank you for all that u do 🙌
Bro!! Omg. Your videos man. 💯. My brain loves the way you explain things. I love the language and humor man. Bringing me so much knowledge to try to learn.
Paroxetine (Paxil) is an excellent medication and have helped many people, included me. For me it is sedating but not as much as other SSRIs that you just listed. Moreover, it helped tremendously for my depression and anxiety.
Wow who are you
Bravo from resident in South Korea
Thank you so much for your dedication
Well explained, thank you. A similar video for a/typical anti-psychotics would be appreciated.
Your videos are just the best, thank you for all the hard work, research, and incredible effort you put into these!
Strange how Luvox is only indicated for OCD in the US while it is one of the most prescribed SSRI's in Europe and Japan against depression (approved in a total of 80 countries world wide for this), as well for anxiety and panic disorders and is generally pretty successful at that. The side effects are usually very mild. Cognitive and sexual function are barely decreased if at all for example.
It is true that you should not take it with other prescribed medications but if its the only medication you take it should be fine. You can still take over the counter painkillers with it.
I guess it all comes down to lobbying and marketing in the US.
Because someone in the U.S. that took Luvox committed a school shooting
This is an incredible video, the only one on the web that aims to explain the various SSRIs differences. Keep up the great work! 👏🏼
Great video . I really appreciate the detailed breakdown. I was scared to try Lexapro because of my bad experience with Zoloft. I like that Lexapro doesn't touch the dopamine receptor because I don't have a lack of energy. Zoloft made me feel like a Zombie and I used it for 3 months.
I had to change to citalopram because Zoloft made my stomach bleed and I love the zombie effect lol
I'm switching to fluvoxamine , Zoloft makes me feel like a zombie
@@Judgedbyall how'd you find out your stomach was bleeding ?
As an MS3 highly interested in psych, this video was awesome! Keep up the good work.
I had no idea that zoloft can cause diarrhea. Since I've taken it I get diarrhea very often I thought I eat something wrong. Thanks a lot.
And its working for my issues I do y. Are what my ex says. . u try going to school caring fr a elderly dad and his brother who was also dying I do my vest ....I went through a hard time after both their. Deaths ...I'm just glad and blessed I have a roof over my head god bless drs .thru do save lives
Excellent video (from a non medical person / inquisitive patient who loves understanding how these things work under the hood!)
Much appreciated!
This video is AMAZING!!!
Thanks!
Wow that was so awesome and the most informative video on SSRIs 🤓
this is amazing! Would love to see a chart version! Thank you again for making this information available!
Unreal video. I was looking for this exact information all over the internet but I had trouble finding it
I LOVE your descriptions! First from a professional standpoint but i love,love,.love that I must laugh so hard inbetween because of your humor and irony.:D
Thank you! Very valuable info, I didn’t know that paroxetine is anticholinergic and is linked to dementia. Thank you again 🙏
i had a terrible time using sertraline and citalopram. Both caused bladder weakness and tremors in my arms and legs and my hair started falling out!
A video explaining Buproprion with this kind of detail would be great!
Could you please do a video on the serotonin modulators? Loved this video!
Thank you for posting this. I’ve been looking for this info.
I just love your content, wealth of knowledge that's easy to understand. Great that you slid some Kanye theory in there😅
Glad you enjoy them! Kanye theory permeates all
Seriously really appreciate this
PLEASE do one of these videos with SNRI's
Most useful video about SSRI
I had an absolutely horrific time trying to get used to citalopram and had to quit. I am also very allergic to some things so it might have to do something with that histamine property. Great video btw, this information is actually quite hard to find and I really wanted more information on these differences.
Did you do better on a different SSRI? I also couldn’t tolerate citalopram
@@100rebeccaleanne Hey I was wondering which SSRI you ended up using? because citalopram also doesn't agree with me
@@100rebeccaleanne Lexapro worked great for me, but we are all different. Wish you the best
@@xxvvyyyy Lexapro worked great for me and I had no side effects, but everyone is different. I wish you the best
@@southerngirl1408 I have lexapro now but have been scared to take it. Did you try celexa/citalopram before the lexapro?
I stopped SSRIs. I tried them all. They just made me numb. No laughter. Now I microdose magic mushrooms and I feel great.
Can we say that the best predictor of a success antidepressant for a patient is if he / she is a normal metabolizer of the drug (and not a poor or an ultra rapid metabolizer)?
Thanks for this info. I’ve been looking for this exact information which is hard to find
Luvox was the best for me , I have since been doing mushrooms on occasions and is amazingly helpful
Hello! Is fluvoxamine activating or sedating? Are you able to wake up early in the morning to go the university / to your job? How much do you sleep each night? I have been on Paxil for 5 years. Amazing drug, but too sedating. I tried sertraline but it made me even more drowsy than paroxetine, even with a very low dose (perhaps because I am a poor CYP2C19 metabolizer). I would love to have your review on fluvoxamine's side effects.
@@vegetossgss1114 for me there hasn’t been any side effects to speck of. I have been on 50mg that take at night and sleep well. Maybe initial first week may have been a increase in anxiety but nothing bad and then it just helps me with the negative thoughts which gets you into the anxiety of worry. Also take buspirone 5mg once a day that is also beneficial. Never tried Paxil. I truly hope you find what works best for you
@@j0917DW Thanks brother!
Eacitalopram 15 mg/day + lamictal 100 mg/day combined with psychotherapy has really helped me. I suffered and overachieved for 15 years. Now I am more stable and active and present, not stuck in venomous mental loops.
Feels great not wanting to die 24/7.
Im in that current mood, don't want to die but I feel extreme anxiety /fear every minute of the day. Im also taking opiods, quite low dose for pain. I have been on Lamictal for some months, like 6 year's ago, didn't felt so much, does it help you with your moods? And does the SSRI esci, helps you enough to take them? (I don't want to take anything that will worsen my case that's why Im asking ❤🙏. I may suffer from panoc disorder?.. I have a feeling Im in danger all the time. All help is appreciated❤. Is Lexapro a good serotonin med?
Great 👍
😑😐😮
So my doc gave me Paxil - it works great, but I'm scared to stop it, and scared of the dementia thing. Also, the anxiety isn't going away but the depression is.
Awesome video, thank you sir!
Hi . I’m on citraline & amitriptyline. I’m finding that the have joint & muscle pain. Which one is causing this please.
Thanks for the great video! I have a question for you...I'm deciding between Prozac and Luvox to treat depression, body dysmorphia, social and generalized anxiety. Other SSRI's including Lexapro and Zoloft made me too drowsy in the past which led me to switch to SNRI's. Unfortunately the SNRI's have been less effective for my anxiety. I need a medication that isn't too sedating but works well for anxiety. Do you think Prozac is the better option?
Luvox did wonders for me against anxiety, depression, light OCD and panic atracks. They really don't seem to like it in the US, but in Europe it is one of the most prescribed SSRI's.
I've been on fluoxetine since 2015. I stopped taking fluoxetine on 12/05/23. I feel a lot better without it. Has anyone had withdrawal symptoms from stopping the fluoxetine?
I switched to Zoloft . Must better 😌👌
I’ve been on 100 mg of Zoloft for months and didn’t help me at all!! I’m now on week 2 of switching to Prozac. I’m only on the 20 mg of Prozac right now and still no change but I know it can take awhile. At this point it feels as if I’ll never feel better
I have a problem with insomnia,what AD will be good for me.
What’s your opinion on them causing long term harm after stopping them?
Sertraline DAT effects unlikely until hitting higher doses (200mg) Paroxetine NAT effects unlikely until hitting doses of 40mg or more.
Or so I read….
Do any of these meds cause tinnitus??
"Previous research has suggested limited improvement in tinnitus with SSRIs and that use of these drugs with tinnitus patients should be limited to the application of treatment of the co-morbid anxiety/depression and not for tinnitus directly. There are also reports of tinnitus onset or exacerbation with SSRI."
www.audiology.org/ssri-and-tinnitus/#:~:text=Previous%20research%20has%20suggested%20limited,and%20not%20for%20tinnitus%20directly.
Very best explained
you didnt speek about vortioxetin (trintlex) ?
No worth doing it is a useless AD.
do one for SNRI, and then another for atypical antidepressants!
Can you talk about dementia risk with these SSRIs
I could have sworn I've seen this one before. I remember you mentioning your hypothesis that Lexapro caused Kenye West's manic episode. Am I crazy?
You’re right.. I revamped it and slowed it down so it’d be easy listening. Or maybe you just came off your lexapro…
@@PsychoFarm Can You add Lexapro (escitolapram) to Concerta ( methylphenitade oros long acting) Dr ?
@@PsychoFarmI laughed when I read you had slowed it down as you talked far too fast for me on the newer video. Probably because I am from UK but thanks for the info, it’s very helpful even if I have to listen a few more times.
Fantastic !! Well done !
Fluvoxamine is Sigma 1 agonist, Sertraline a Sigma 1 antagonist. Covid long haulers are recommended to take Fluvoxamine. Based on the description Sertraline fits better for me. Would sertraline also have anti inflammatory benefits for long covid?
👆👆👆 deliver all kinds of 💊💉 to any destination
Very helpful, thank you
Thanks for commenting!
Excellent discussion. One error: in your summation you accidentally say sertraline, because of its NET, is especially good for atypical depression. But as you clearly know from your initial detailed discussion of sertraline, you mention its DAT, which is correct, thereby providing a mechanism suited for atypical depression. As far as I know, sertraline has minimal if any actions at NET.
Hello! Is fluvoxamine activating or sedating? Are you able to wake up early in the morning to go the university / to your job? How much do you sleep each night? I have been on Paxil for 5 years. Amazing drug, but too sedating. I tried sertraline but it made me even more drowsy than paroxetine, even with a very low dose (perhaps because I am a poor CYP2C19 metabolizer). I would love to have your review on fluvoxamine's side effects.
Great Video, very informative and easy to follow. Not sure if it’s a common side effect, worth mentioning that Lexapro stripped me of all sexual drive, made arousal and completion near impossible, and severely blunted my emotions. So, not a fan.
Could you do a snri difference and snri vs ssri
Which is best for high anxiety?
What about sexual side effects, especially permanent ones like PSSD (post ssri sexual dysfunction)
Why Lexapro 10 mg stopped working for me after one year. Do i need to increase or change other SSRI or any other type anti depressant?
How worried should someone with no heart issues worry about QT prolongation, I want to take Lexapro but I have heart/health anxiety
Not. It’s only clinically relevant in those with significant heart issues, and even then the link is inferred and hasn’t necessarily been proven to have adverse effects.
Definitely talk to your doctor about it, as they can answer specific questions and confirm your health. If you have a family history of heart issues or take other medications that prolong the QT segment, you might want to discuss this with your doctor. It's worth noting that Lexapro is pure escitalopram, while it is believed that arcitalopram (the opposite of escitalopram) is responsible for the QT prolonging effects. Citalopram is a mixture of both the es- and ar- molecules.
I hated Celexa when I was 13, it also had a horrible mix with the birth control pill, bad side effects in that case.
Why is zloft used for anxiety when it can make it worse?
Because it's pseudoscience
A lot of stuff about medications is theoretical, that being said 50mg of Zoloft and done wonders for panic attacks, which ruin most situations I’m in. So pseudoscience or not, there are effects.
How significant is 5 ht2c receptor blockade in the effects of prozac?
Can anyone discuss Trintellix and their experience on it?
is fluvoxamine (luvox) affective in treating GAD and Panic? Was prescribed this for anxiety and ocd but i only see it treats ocd
Yeah, I second that, everyone reacts differently to SSRIs! It is allegedly the safest one, but I wildly DESPISE escitalopram, my body fully rejected it with something that felt like never-ending panic attack (that lasted full seven days with tremors, diarrhea, womiting, sweating like a pig, hot flashes and feelings of fear, anxiety, desperation, hopelessness, sadness and imminent doom, it got so bad i started planning my grand exit and it hasn't stopped when I stopped taking it, it stopped only when I got new antidepressant and alprazolam for the first few days) xD But venlafaxine, which is SNRI and is reported to be often badly tolerated seemed to not hate me at all. Sure, i felt bad for the first three days for which my head was spinning round round round but it went away relatively fastly and it was nothing compared to previous hell.
Did you take benzos to cover the side effects on first two weeks?
@@michaelsamo2849 when it comes to esci i didnt take any benzos with them despite the fact that i needed them. When i was taking venla I got xanax just in case. Turns out that with venlafaxine i didnt need it at all. I just couldnt stand for like two or three days because it messed with my sense of balance at the beginning but it was nothing compared to hell that esci put me through.
I couldn’t tolerate citalopram, does that mean I will have the same problem with escitalopram as they are similar?
Fuckin loved Tony sayin "ere we go" on prozac
Thank you!
How do you explain being held hostage on Zoloft? Taken for 22 years. When I try to decrease or increase by any amount (5%, 10%, 25%, 50%) I get very irritable, anxious, can't sleep, and also tired. I believe there's permanent damage that's been done. I have constant jaw movements (dystonia).
Hey I wanted to know how these react differently when clubbed with clonazepam(0.25mg). I have been given 2 meds, one in the past both had clonazepam with the main part of a each ssri
Interesting, I was wondering how my psychs picked the ssri for me. I would love to see a video explaining mirtazapine and its mechanisms since i was on that for 8 months but it did literally nothing for me lol
everyone’s brain have diff needs so it’s not a one-size-fits-all
@@KAFaye-nk5tl ... but why? *Now that chemical imbalance theories have been debunked.
Lmao ask your doctor's pharma rep
Not sure if anyone knows but like from this which one would be most like fluoxetine? I was waiting to see if another of the 6 had the 5ht2c aspect, as fluoxetine is the only one I have tolerated so far, but was wondering about trying paroxetine
The awareness that taking antidepressants sooner or later will result in their discontinuation, which will result in a withdrawal syndrome, is not optimistic about this method of treating depression.
Secondly - each antidepressant causes that the neurotransmitter system on which the drug affects becomes reactive and dominant during pharmacotherapy, e.g. drugs from the SSRI group cause that when we take them, the serotoninergic system begins to dominate over other neurotransmitter systems, pushing them to the defensive - while taking The defensive SSRI is a dopaminergic system - it results, among others, in apathy, cognitive impairment, emotional blunting, and sexual dysfunction. After discontinuation of SSRIs, the serotonergic system becomes overly reactive, in the initial period of abstinence there is a failure of this system, but over time (after a long time after discontinuation of the SSRI) its excessive activity will occur, unfortunately the dopaminergic system is defensive all the time after the discontinuation of the SSRI because there are changes in histone levels that promote the serotoninergic system in relation to the dopaminergic system.
😣Damn….
Any advice for me, I appreciate it. Just curious 😐👍🏻
I’m 45 , diagnosed with ADHD this week. Most likely going on some stimulant, and I’m okay with that. But I’m concerned about the co-morbidity, of depression, getting perscribed SSRI ( maybe Zoloft)…
Hard to say, I know.
I just feel like I can possibly push through with the help of stimulant. And avoid being on an SSRI? I’ve often heard what you comment on, & it sounds like another added problem.. the withdrawal and etc.
Sorry if I made no sense. And I thank you .
Great video
Love the videos, though I'm a little confused about sertaline working best for atypical depression. From what I've read in research, sertraline has the best efficacy in melancholic depression.
everyone’s different. literature can say one thing but…. in real life it’s always diff. how they choose antidepressant is heavily dependent on symptoms as no 2 people with depression are an exact copy of another. saying sertraline is the best is downright dangerous for others whom sertraline have not worked well on.
hey pysch, ive had 2 seperate cases of severe panic disorder for about 3 years on and off, i used to take lexapro on the smallest dose, 2.5mg and then 5mg and it really helped me overcome my disorder completely the first time (end of 2019 into 2020) but when i got panic disorder a second time (end of 2020) from smoking weed, I noticed not much of an impact on the same dose 2.5mg but i was told multiple times to up my dose for it and i was too scared to so i quit the medication cold turkey, and got insane migraines/headaches (thinking someting in my head was gonna pop it was so bad) as a withdrawal i think and for the past year I’ve been medicine free but I still get panic attacks everyday (heart races everyday nonstop, evil bad thoughts), and I’m ready to get back on something, my doc prescribed me celexa but I’m very unsure about trying it Bc I’ve been so used to take lexapro and I’m just wondering what ur opinion would be, thank u so much for the video also u rock!!
I've had the same. Extreme general anxiety and depression as well. Luvox got rid all my symptoms.
Am I an SSRI at heart because I think of Parm when I see Pram?!!!
Did you mean nitric oxide synthase* ?
So.... lsd or acid?
What about Clomipramine (Anafranil)?
Have you heard of charlesmyco?
He gat some psychedelic products.
@charlesmyco
👆👆👆 deliver all kinds of 💊💉 to any destination
Zasto nema prevod?
What does mildly activating mean?
Sertraline if horrible. I was only able to take it for three days before the massive sedation and crippling headaches became too much. Citalopram felt exactly the same as amphetamine complete with dilated pupils, violent shaking, not sleeping for days at a time, dripping with sweat. Nasty stuff.
What happens once the patient finds a SSRI that works for him/her? Do they take it for life? Aren't these meds difficult to taper off?
That’s my fear to even start
@@alltheglory7854 as someone who's tapering off of paxil after decades of use, I would recommend only using psych drugs as a last resort (talk therapy, meditation, journaling, inner child work, EMDR... lots of non-drug treatments are available!) Then, if you're still suffering, I would recommend working with someone knowledgeable in both nutrition/supplements to make sure there isn't some physical ailment, gut issue, or allergy causing the mental health issues. Read up on how childhood trauma affects us as adults. "The Body Keeps the Score" is a popular book on this. If the problems still persist, I would suggest cannabis or psilocybin over psych drugs.
Psych drugs disconnect us from ourselves. This can be life-saving during a particularly distressing time in life, but reconnecting must happen for true healing. And it's difficult to connect with yourself and your emotions when on an emotion-blocking (or dulling) drug. I wish you all the best.
I was taking cbd
@@alltheglory7854 right they monitor how you feel and keep track of you when doing cbt and see how you are doing on the medication, bit of exposure therapy too going through the triggers that make you anxious 1/10 how do you feel.
First you have to adjust to the drug before it even takes effect, that’s the one part I hated
Fluvoxamine. COVID. Side effects: common cold symptoms. Hijacks the transmission system.? Keeps the changes “residue” out of an infected brain at the same time?
I want you at my next dinner party.
hahaaaa i thought i was the only one who referred to it as "squirtraline"! guess i'm not that clever. and yes, during the first few months the diarrhea was crazy. it did eventually subside though.
Thanx.
I have a severe case of ocd but only recently (1y ago) I started taking drugs for it. First it was sertraline which stopped working after some time, then venlafaxine which also stopped working after a few months. Then I went to another psychiatrist who prescribed me fluvoxamine + risperidone. It was terrible, one night I woke up feeling something is going on with my heart, my body was hot and I honestly thought I was going to die. Could anybody please explain why it was such a bad combination? (I'm not coming back to that psychiatrist :))
thank's a lot
Zoloft was the most commonly prescribed antidepressant in the USA in 2018 with over 38 million prescriptions.
u have used all type of ssri but sertraline is the best
Do antidepressants really change the situation that causes depression? No.
But do they change you to allow you to better cope or fix them? Sometimes.
Hello! Is fluvoxamine activating or sedating? Are you able to wake up early in the morning to go the university / to your job? How much do you sleep each night? I have been on Paxil for 5 years. Amazing drug, but too sedating. I tried sertraline but it made me even more drowsy than paroxetine, even with a very low dose (perhaps because I am a poor CYP2C19 metabolizer). I would love to have your review on fluvoxamine's side effects.
I just started taking Sertraline like 2 weeks ago and I feel lazy and tired most of the time but I was told it is common side effect for the first weeks. Also my stomach is kinda upset because i made the mistake of taking it on empty stomach so beware and only take it after food. My mood is getting slightly better and I am more calm and my reactions to situations are improving and more calculated. I noticed an increase in time for me for ejaculation during sex which was not problem before but might be now because it is not good for my partner but i searching for solutions to that so if anyone know how to make ejaculation faster please reply to me.
As for erection is OK nothing changed.