REPORTING IN 6 WEEKS AFTER WATCHING THIS: OMG! You guys are life savers. I've reduced my SNRI (Effexor) by 75% over the past 4 weeks, with my GPs guidance. Still on 50mg but the reduction in symptoms as you described have been amazing. SUCH A RELIEF. It's been 8 1/2 years on Effexor and I had no idea it could be adding to my symptoms. Going to stay on 50mg for a few weeks then drop it and probably introduce a SSRI as suggested (think I will need that at least for a while). Thank you so much. I've put my GP onto your channel so she can get herself up to spead for client's like myself. So grateful. 💖🐨💖🐨💖🐨💖🌞
hi there is it safe to take antidepressant especially SNRI for 8 years..... will it really reshape my brain??? i want to be more socially graceful especially when talking.... and my SNRI DULOXETIN MAKES ME ELOQUENT
@@barrymichaels2663 if you don't think they are working for you as well as they should, or causing some of the nasty side-effects in this video, it's definitely worth it. Please do it under the guidance of a well qualified professional, who know what they are talking about. My GP did not. Also... I took getting off the SNRI I was on VERY SLOWLY... it took nearly three months. Only the last week was hard to cope with. This is just from my experience... 💖🐨💖
Me watching this after taking cymbalta at night but it clearly said in the morning on the description 🤦🏽 🤦🏽🤦🏽 but thank you for the information. It's really helpful 😊
Nursing student here and i have an exam tomorrow for my mental health class. This video has been excellent in my understanding of SSRI and SNRI effects qnd medicines. Appreciate you and your team so much!
I have researched and found out that shrooms are very helpful , it has really helps to reduce anxiety and depression . I would love to try magic mushrooms but I can't easily get some , Is there any realiable source I can purchase one
I am feeling the same way too, I put too much on my plate and it definitely affects my stress and anxiety levels. I am also glad to be part of this community.
Thank you so much for posting this! It is EXACTLY what I've been looking for. I've been on SSRI's for a good portion of my life primarily due to anxiety/depression but have recently been diagnosed ADHD as well so I've been switched to SNRIs... and so my drug research began! Everything you have talked about with Noradrenaline is spot on with what I have personally experienced; however, I do understand how the noradrenaline can help the ADHD. Thank you again for the post and I look forward to listening to your other videos.
It’s an SSRI. The video explains the difference between SSRIs and SNRIs. Neither is “better” they are different. Is a hammer better than a mallet. They are different. Answer to How is SNRI better than SSRI? www.quora.com/How-is-SNRI-better-than-SSRI/answer/Al-Griskaitis?ch=99&share=200f3864&srid=sumLd
ADHD symptoms are commonly a direct result of SOME antidepressants, such as venlafaxine (Effexor) and mirtazapine ( has numerous brand names - Avanza is but one). Both are very dangerous when given abruptly in moderate to large dosage. One MUST begin lowest dose & SLOWLY increase, with best effects from 20 to 30 days. Once feeling better, NEVER increase the dose - even on very temporary relapse. I had been taking Effexor for 26 years & my personality quickly & drastically changed. Taking unwise rusks - gambling, speeding, unsafe sex, shoplifting, verbal anger/outbursts etc. All caused by Effexor and Avanza (mirtazapine). There are much better alternatives than these two which are linked to suicide ideation of all ages. Hope this helps.
Thank you for your brilliant videos. Your non-jargon explanation on the differences and similarities between SSRI’s & SNRI’s was easily understood. This is a wonderful public service, knowledge is understanding and may help patients diminish their levels of anxiety and depression in league with medication, professional help & guidance.
@@Iliketurtlezz It took a couple months for the physical effects to subside, but to this day, years later, I still have issues with certain things like regulating my body temperature. I took them between ages 18-23 and I think it may have impacted my endocrine system for life
I have ADHD that went undiagnosed and think it’s important to say that I was initially diagnosed depression. SSRI was the worst for me in terms of agitation, I couldn’t think and very hyperactive. SNRI worked for mood (believe impact it had on dopamine helped) so helped depressed mood and I was less anxious/agitated (a lot of ‘anxiety’ was racing thoughts from adhd). I am 30, diagnosed a few months ago. Mood dysregulation or sensitivity is a part of adhd not yet recognised in the dsm. I would not go to a doctor for difficulty organising or concentrating. I went because I felt sad and anxious. So that’s what I was treated for. Given limited access to psychiatrists in Australia, I never saw one and gps typically screen for mood/anxiety, not adhd especially in females. Your presentation was fantastic, in future could you please mention or make note of how SSRI’s are commonly prescribed by GP’s, and can make adhd symptoms worse, or aren’t right for certain populations. I think medication is important but the right medication even more so, and for us (adhders) SNRI’s typically preferred over SSRI. :)
Great comment. Our other talk might also be relevant: ADHD Stimulant Medication Secrets: The 10 secrets to how Dexamphetamine, Ritalin and Adderall work ruclips.net/video/LG_yD5SXuCg/видео.html
I have adhd and SSRIs helped. I was calmer, not anxious, hyper focus was improved. The hyperactivity on SSRI IS NOT how someone with true adhd reacts. YOU HAD A COMMON BIPOLAR REACTION TO SSRI. Bipolar is often confused with adhd. SSRI induces mania in bipolar patients exactly as you described. You should speak to a psychiatrist asap because typical depression treatments will have harmful consequences for undiagnosed bipolar / misdiagnosed adhd. It’s going to take some real honesty with yourself and with your doctor. Good luck.
I wish I had this information years ago, I lost years in a depression‘coma’. More medications were added, and I was told it just takes time. Even when 450 wellbrutrin was added still in bed or napping and only up 4-6 hours a day. Finally moved and my new psychiatrist moved me from the 5 medications to an MAOI, and finally got some relief, I am up 10 -12 hours a day for the last few years. Did not give up and have a new team and being tested for autism, and other underlying conditions.
Such a brilliant informative video. I was prescribed Venlafaxine for chronic pain. Been on 150mg for 16 months and wanting to get off it for at least 9 months of that time. The brain fog and zaps, insomnia and fatigue have been awful. I actually had to start taking it at night as I felt completely out of my body driving to work when I took it in the mornings. Day 5 of tapering off, now on 112.5mg - GP has advised doing this for a month before reducing to 75mg so will be 3 months before I'm off it. Interesting that you mention the anxiety because looking back my anxiety has been horrendous on this medication, especially since I wasn't put on it for mental health reasons. Thank you for the wonderful insight!
I've been on the Loxitane for 2 1/2 months. For the past two weeks I've been feeling unlike myself I thought I was going crazy. Thank you for this video.
Thank you for making this. My psychiatrist prescribed Effexor XR because he thinks SSRIs failed me in the past, which makes no sense to me. I have high anxiety, so putting me on a medication that makes it worse seems like a bad call on his part. I was initially on 75mg, but I didn't like the side effects, even after a month, so I asked to be taken off it, but he refused and upped my dose to 150. I'm feeling much worse now. I have an appointment with him tomorrow and I'm gonna stand firm on being taken off. I can't stand all this agitation, high BP, and insomnia (wired, but tired). Again, thank you for explaining how it works in an easy to understand format. It helped a lot. :)
Hi, I had a similar experience. How are you feeling today? Did you find a good medication for your symptoms? I have anxiety and I'm still treating it...
@@rickparizotto so you're on Effexor? If you have anxiety, it's not recommended, at least not by pill pushers. I eventually left that psychiatrist and got a new one. While she's definitely a lot nicer and more personable, she put me on two different SSRIs at the same time. Regular doctors are warning me about that, saying the two medications don't go well together. I actually asked her today if I could be taken off them, but she simply upped the doses. I'm not feeling like they're doing anything, unfortunately. I've had this issue for decades, where antidepressants do very little or nothing. My therapist says that some people simply don't respond to them, which sucks, but I guess I'm one of them. At this point, I'm wondering if I even need them. Yes, I have issues that need resolving, but it doesn't seem like medication is the answer. Anyway, enough about me. Have you talked to your psychiatrist about the side effects? They can't force you to take them, so I'd recommend asking for a different medication. I honestly wish you the best of luck. I've been on antidepressants and muscle relaxers off and on since I was 15. I'm 40 now, so you can imagine my experience. If you have any questions, please don't hesitate to ask me and I'll do my best to answer.
@@MidnightSonnet Hi, I've already tried almost 10 different antidepressants. I didn't take Effexor (venlafaxine), but I took one called Desvenlafaxine (Pristiq), which according to my doctor is similar to Effexor. And it was a bad experience. I'm taking Fluoxetine (Prozac 40mg), Trazodone XR (150mg), and atenolol (25mg) to help with my anxiety. It's like a roller coaster. Some days I feel good, others don't... And I've been sleeping a lot lately. I think it's because of trazodone. But I still don't feel 100% good. I feel there's something missing...
@@rickparizotto holy hell, that's a lot of medication. Seems like overkill unless you're extremely unwell. Are you seeing a therapist, as well? In my experience, discovering the root cause(s) of anxiety and depression and working to heal that is infinitely more helpful than medication. If you are seeing a therapist, did they have you take an anxiety/depression quiz and, if so, what were the scores? The past two therapists I've seen have me take the quiz around once a year or when something changes to see if I've made any progress. You can also express your concerns regarding your medication to your therapist, as it's helpful to them and you. Currently, I'm taking Vilazodone HCL 40mg (this is a new medication that no doctor I've spoken to has ever heard of) and Buspar 30mg.
We’re going to be putting out a whole series on root causes soon. But I’m the mean time here’s something we touched on a while ago: The root causes of depression. Address them now! ruclips.net/video/q4duMQMPG9Y/видео.html
My GP wanted me to stop my SSRI and go on Effexor. I asked him why. “Because I’m putting all my ssri patients on Effexor.” I said no way, and he said ok, he’d make an ‘exception’ for me. Weird way of prescribing, what? Because he’s putting all his patients in it... General practitioners should stay out of this stuff, anyway. When I went through very bad withdrawal (had sepsis, stopped taking Paxil having no idea this could be a problem) he had no idea what was going on so assumed, naturally, that the extreme nausea and everything else was “all in my head”. I can’t even think about that year, it’s still too upsetting. Let psychiatrists prescribe psychotropics, not family doctors.
Seems arbitrary and potentially destabilising if a patient is doing okay. Not to mention the noradrenergic effect on anxiety/distress. I wonder what their incentive is?
@@thePSYCHcollective of that GP? I would guess a pharmaceutical representative visited him with information about Effexor (which was fairly young, then - it was long ago) and either offered him a kickback or made him so enthusiastic he wanted all his patients to benefit from it. He was not happy that I declined.
That’s what I’ve been saying gps do not know enough about psychotropics, at least mine didn’t. And I’m sure most don’t, or are very careless in there prescribing. I have been through very traumatic events, and still not getting the right help. Antidepressants are causing havoc on my life, or it’s not the right one. I’m at the end of my rope, trying to prove what’s going on with me. It’s like talking to a wall, and people in my life are not making it any easier, the minimize what I’ve been through.
@@craftygirl17 Many of us have been there…I’ve just been through another awful year. And yes, loved ones can make it worse. The year was awful because I was trying to wean off my SSRI, over the course of 2 years in all, no less. I was extremely strong willed, went to the gym every day, took cold showers, ate only healthy food, no snacking, so smoking or drinking - nothing helped. Valium didn’t even touch it anymore. It is horrible and lonely. Back on SSRI and doing better again. Not great, but better. Has no SSRI ever helped you?
I know I can't take any of this stuff as peer reviewed information but it's still really interesting to see two professionals in my field talking about cool shit
I’ve recently tapered off venlafaxine and switched to a low dose of fluoxetine. Ever since taking Venlafaxine I struggled with health anxiety (came out of nowhere) panic attacks, low self esteem. First day today on fluoxetine only and I can honestly say I feel like myself again pre venlafaxine. Never going back to it again. The withdrawal wasn’t so bad as I tapered but I definitely had side effects like zaps, sweats and irritability. This video makes complete sense to me.
Wow and as a first timer, my doctor tried prescribing me effexor and knew practically nothing about it. Said there were no side effects or risks other than dry mouth! So glad I didn't blindly get it because these symptoms mentioned above are what I'm experiencing already and would've really messed it up more
I have been taking escitalopram and clomipramine for a while now. But I've had really disturbing dreams and my psychiatrist wasn't responding too well, he just used to say continue the meds. Today, I saw a new doctor and he just changed to a completely different antidepressant. And im just so scared now. I just really want a hug.
SSRIs are depressants for me. Incredibly sedating and brought on worse thoughts at the lowest dose. It always amazes me how people find them energizing and invigorating. We are all unique.
SSRI are great. I took them for my PTSD. helped me overcome my anxiety and panic . I get amazing sleep with them. Unfortunately melatonin or Benzos dont work on me. But a Low dose of paroxetine and i fall asleep in 10 mins and sleep through the night.
I tried a few SSRI's and bad reaction, but I was on Effexer/SNRI in 2000 for Depression and it worked really well, so we figured lets try that now for my anxiety and depression. So far I'm really glad I finally went on it. Still dealing with some side effects, but have my life back for now. Taking 75MG. Thanks for the feedback!
@@OhhhJP Hello I got off. I don't take them anymore. I dont experience any severe side effects. But do I seem to have a sugar craving which I can't seem to control.
@@OhhhJP Yes. There are minimum side effects once u leave the meds. But again I did not take them for a long period of time. I took it for a couple of months. There will be a strong urge to go back to the meds. But it you can stay off for a week, then u get more confident .
This explains a lot. I was on Luvox for over 15 years and became increasingly tired and brain foggy as time went on. I took a gene test that listed three different flags for Luvox (mainly slow metabolism), and have been transferred to Pristiq. It was hard going at first because I'd been so numb, but it's interesting being awake too. So I'm on Pristiq and Nuvigil now have to see how it plays out.
I was on Effexor for 5 years when I was 19 and came off it when I was 25. Then tried to go back on it, but the side effects were so severe, had really bad vertigo/dizziness. Wasn’t fun times. Love your videos
@@kaileyshaffer4381 sorry for late reply, didn’t see your comment. I tried at least 5 different SSRI’s and nothing seemed to work. Instead I started exercising a lot and stopped drinking, and haven’t looked back, I’m way better than I ever was.
EXACTLY the same 11 years on effexor,'after my son was born. they kept trying to up my dose up my dose 300mg in end. I was not improving. I saw this and not only have I been fighting anxiety and insomnia, but now I'm also on 2mg of clonazepam a day to sleep and help with agitation. I'm tapering off venlafaxine now by choice with gp. who didn't even know that effexor was an snri she told me it was s'sri. I found this vid at exactly the right moment. thank you. almost eleven years of my life gone. no enjoyment, turning into a social recluse. so we are down to 100mg effexor. introducing 10mg of escitalopram. first week OMG. not pleasant effexor withdrawl. brain zaps, ear and head ringing, black outs etc. . . I have tried many times to get off this antidepressant. I'm determined this time. I'm feeling relief.'sleeping allot to avoid the side effects of change. but this vid explains allot. great for people like me, on effexor for years, having no benefit from it but insomnia, anxiety. the change is starting to feel better. I know still early days. but gives me hope. and wish this info was available years ago. thanks so much guys. ❤ this new info needs to be spread. I've already shared this vid three times with other people having the same problem with venlafaxine. one almost suicidal. always to make a plan with g.p on how to taper and change over of course. this couple save people's lives. I was ready to give up at 42. my son has only seen me on effexor will he notice a diff mum?'hopefully a positive and happy mum that wants to engage with people and leave the house.
Interestingly, SSRIs like escitalopram and fluoxetine also relieve depression in mice lacking the serotonin transporter. In fact, they are just as effective in mice without serotonin transporters. Although hard to believe, serotonin reuptake inhibition may have nothing to do with the antidepressant effect of SSRIs. All SSRIs bind to TRK-B (as does ketamine). Fast acting antidepressants like ketamine and psilocybin, activate this receptor quickly. Slower acting antidepressants take a few weeks to produce conformal changes in the receptor to make it more responsive to BDNF.
I had the worst experience of my life when a psychiatrist advised me to quit Lexapro cold turkey after an ineffective transition from SSRI to SNRI. I would never consider either of these meds ever again.
See this is what I’m talking about even some psychiatrist don’t know what they are doing or just don’t care, you really have to look hard for good help. Really investigate who your dealing with not all psychiatrists are good at what they do. Or they misdiagnose you. I’ve been there with different psychiatrist went through all of them where I live and got a different diagnoses with all of them they didn’t take the time to listen to my situation. All started with my doctor saying I was depressed and gave me a antidepressant that I really didn’t need it was distress. And very hard to get off of. No one would listen they all were dismissive, when your dealing with one thing after another they don’t take the time to sit and listen and go from there to quick to hand you a perscription and you trust them.
Dang man your brain. I know someone who was in Benzos and then got real sick and stopped cold turkey. They were all messed up in the brain and we're hearing things. Took them a week to seem normal but they still were not quite there. Crazy stuff.
I’ve been on Effexor for about 10 years- 300mg/day. My anxiety is totally out of control! Can’t imagine coming off this stuff though, the withdrawals I have if I forget to take them, or even take them a bit late! Will talk to my GP about coming off them!
@@tutorialesguitarradelcielo9581 aww thank you. I did a bit of research myself and decided to try and wean off them. The capsules I have (2 x 150mg) have 12 x 12.5 mg mini tablets in them - so over the last 2 weeks, I’ve taken a few beads out, now I’m up to 5 beads out of one capsule today, which is a total decrease of 62.5mg! Will stay there for a week, then drop another 12.5mg. No side effects really as yet 🤞🏻🙏🏻
Effexor first helped me greatly. The problem I have with all psychiatric drugs is that no Psychiatrist ever tells the patient anything what to expect. Effexor began making me so sick, severe nausea, almost passing out if you didn't take it exactly on time everyday. Worst drug I was ever on.
I've been on venlafaxine for years,I have weaned myself off over a year yes going back on is a nightmare manic for 6days my Dr wants me to just up the dose I'm getting a second opinion, this is so helpful thank you 🙏
The woman "psychologist" in the video is so unnecessary and distracting. Doesn't let the actual doctor finish a single sentence. And judging by other ppls comments I'm not the only one who sees this. I feel sorry for her clients, her tactless behaviour is annoying and destabilizing even for healthy, stable individuals.
This woman is so friggin irritating. She won't let him talk, she can't stop herself interrupting. He is great. Why the hell is she even in this video????
Wish I never started on these as a teenager. How irresponsible it was for my Dr. to have prescribed these to me. I needed council and guidance but instead I was given drugs. Now I can't gett off them without twitching uncontrollably when I try to sleep. Also for those considering Ativam, my experience is terrible almost unbearable rebound anxiety and despair so proceed with caution.
Reporting here! I have been effexor 75mg all my life (can't go less or more of that dose otherwise I get depressed/disctrated), this med gave me a lot of intellectual, focus, creativity, consciousness, lessen depressed good for my uni/work. The problem is that it FLAT my emotions, makes me angry, anxiety irritable person, with a little of ocd, obssesive, so is hard for me to stablish relationships even with all the therapy, this pills makes my body agitated so is my voice, plus i sweat like a pork lol. I found this video, so decided to try it with my psiquiatrist. Even if i try to take 2 beads of the capsule, my concentration/alertness goes to hell, I added the Luvox 50mg and started to feel a bit better like my emotions kinda, but for this context, I ask you base on your experience, because not all the doctors has the ability, they just do whats in the "book". that means that if i cannot reduce my effexor due to loss of concentration? or will luvox will increase that as passes the time (im just 4 days on this). Thank you.
SAME, i was on pristiq for like 2 years and was totally fine, them i stopped taking them, now a few months later i tried again and im like very sensitive to things like sounds or smells
Also, I find that researching these things on credible online sources ends up providing me with more knowledge than any GP that I have had. I get it though, they are a jack of all trades, instead of a King of one thing, but man.... It's not a good feeling to always feel more knowledgeable than the DR.
It’s very interesting, I feel like GPs are lacking this understanding. I also feel there should be more awareness around pharmaco genetics testing. This can help reduce the trial and error process. Also it would be nice if you guys could do a video on it .
First of all I'm 71, work out, walk everywhere, good blood pressure etc. My ENT prescribed Venlafaxine 37.5 mg for my Vestibular Migraine that came out of nowhere. He said take it for 2 weeks. I took one at 10am and by Noon my Vertigo was 80% gone. I thought cool.. 2am the next morning I woke up with a blinding headache, and I don't get headaches. But I did read on Web MD you might want to watch your Blood Pressure if you take this. So I decided to take my Blood pressure. 196/121. Yeah off to the Emergency room I went. I realize different medications can work differently in different people.. Just a Heads up.
Thanks for sharing your story. Based on the timing of the events of your story, my guess is that the headache was some sort of rebound effect to the drug wearing off and the high BP was a result of the severe headache pain. Does that seem about right to you?
@@thePSYCHcollective Not sure I've been misdiagnosed 3 times. First it was a Vestibular Neuritis, then it was a crystal floating around in my right ear, now it's Vestibular Migraine. Ive been to two ENT's next up a neurologist. I have had this now for just over a year. If I thought this was permanent I would have already put a bullet in my head.
Anti-psychotics turned me into a zombie. I think I could still benefit from them as I have very severe Bipolar I, but I'm scared of the side-effects. I take a mood stabilizer and an SNRI now. I still experience hypo-mania and can obsess over things big time, but it's manageable. I'll never take an atypical anti-psychotic again. They terrify me.
Gawd ive been on Cymbalta for years and spend a lot of days just miserable. Also can be possible rsd reactive. Love to go back to SSRI but the Cymbalta gives huge withdrawal effects. Swimmy, sad, zappy, feels like my head catches up after my vision. Do I have to go turkey before possibly swapping?
A slow crossover can work. You’ll need to discuss with your doc how that might be done. Generally the dose of the snri is lowered a touch and after a week or so a tiny bit of ssri is commenced. Then the snri is lowered again etc. it’s not always smooth sailing and it’s a good idea to get your reflexes checked before and as this process takes place. Increasing reflexes, nightly sleep starts or day time jerks are signs of serotonin excess.
I disagree. I felt like he kept interrupting her. as soon as she started talking he would manexplain what she just said and you could see it in him was insecure. Her information as a psychologist is just as important as the psychiatrist.
@@thePSYCHcollective Disagreed. She obviously wanted to talk more but he kept interrupting. Both had great information I just wish I heard more from the psychologist.
Great video, can you please do a video that discusses psychomotor stimulants and Antidepressant meds, what happens when both are being taken? Also I've heard about new trials of ketamines and psilocybe to treat depression from John's Hopkins University, it would be great to understand that at a 1000 foot view. Watched a few Ted Talks on problems of treating the entire brain and it’s neurotransmitters as a kind of pea soup, rather than being able to specifically target brain regions. The analogy used by the Neuroscientist in the Ted Talk was that it was a litte like opening the hood of your car and pouring oil all over the engine block, in order to fill the oil tank, potentially damaging and sometimes ineffective, are these medications getting smarter and able to target areas or regions? The small amount of research I've done into brain chemistry I realise what an amazingly complex subject it is but fascinating and love to understand it more. Are there ways now to selectively target brain regions with meditation, also are things like MRI scans used these days? I love this marriage of psychology (with awesome schema Therepy) and psychiatry, it's awesome and helpful, hope GP's watch this. I think you need a Neuroscientist to complete the dream team and marry up practical with theoretical. Thank you both for producing this!
Thank you so much!!!!! This totally explains the experience in having with the Effexor! I finally understand why my panic attacks were actually getting worse. This confirms my decision to come off the Effexor. ***Update: it's been 14 days without my normal 37.5mg of Effexor and I feel like a new person! The 20mg bridge of Flouxitine most definitely helped. I actually only used both on day 1 and then only Flouxitine since then. I'm gonna wait to about the 2 month mark, before trying to wean of the Flouxitine, just to ensure I'm only dealing with it's withdrawals. Thxs again for this. 🤗
I'm so glad you've been able to recognise what it was doing to you and be able to take action about it. Panic attacks are terrible enough without finding out they've been worsened by a drug prescribed to supposedly help you feel better.
Did you feel emotions and like yourself again after getting of them.. Since 4 years i cant feel joy, happiness, love or cant feel myself...taper down now...
@@Butterfly-vd4tg Yes, once off the Effexor I slowly got back to a "pre-effexor" state. But it did take about 3 months to lose all traces. I did end up deciding to stay on 20mg of flouxitine as it really helps keep me balanced and feel great. Of course, everyone is different and it take longer or shorter.
Recently started Duloxetine for general anxiety and fibromyalgia first week or so the side effects were challenging , constipation and tired but eventually that got better. 30 mg twice daily. After six weeks I am feeling really good . My anxiety level has dropped , I'm coping with stress, my sensitivity to pain is less. If this medication continues to benefit me , the chances are I will be taking it for some time.
SNRI are better for me than SSRI! Too many side affects with SSRI insomnia, restlessness, sexual disfunction, both can quite dull your mood sometimes but I'm on venlafaxine X2 75mg a day, wow dreams are insanely good!
I've been on 15 different mental tablets in twenty years. It was only in the past year that I was offered psychology. I wonder how it might have helped had I been given psychology sooner. Now I have a consultant psychologist every two weeks.
Yeah David I feel your pain! As a preteen till I was in my late teens I was put on all sorts of meds. I had trauma related issues but the pill pusher diagnosed me with bipolar incorrectly. So I was having rang if emotions trying different crap and horrible side effects. Seeing a shrink to actually process that crap is HUGE. I say meds just push down the feelings but never heal them. In fact if I missed a dose I would feel really depressed really fast. Now that I've been going to the RIGHT therapist I don't need psych meds personally. Although it took me a handful of therapists to find my right match it was worth it. Through some trauma based work I'm bringing up crap I never thought was still an issue. I think I also feel better in my self knowing the happiness I feel is real and not due to a med. Although some people seem to need them. Getting my vitamin levels healthy, eating better, and working out helped a lot. I seriously wouldn't be this well of though without therapy. Therapy is what helped me feel like bricks were removed from my back I never knew I was carrying. Hopefully you find the right psychologist to help. Training and skill is good but you need to click with them. There are several wise ones making YT videos I enjoy but could never be a client. Good luck!
I have anxiety and adhd. Not sure why after my history of anxiety attacks (not fun) my doc would prescribe this SNRI to me:/ lexapro had cruddy side effects, Ritalin was too strong for me.
Best video explains neurotransmitters ever. I used to get jittery from a half a can of Coca-Cola, after being on Paxil, caffeine doesn’t affect me at all, drinking the strongest triple espresso ever is like drinking water now. I can’t find any explanation anywhere about that subject?
Don’t know exactly, but I’d suggest the Paxil may reduce ones sensitivity to a point where one is more tolerant to the sensitising effect of caffeine. Just speculating. Here’s a discussion about sensitivity: ruclips.net/video/cqBAZwy5EwA/видео.html
Cymbalta leveled me out, preventing high anxiety, but it was not good for lifting my mood. Also, I had some irritability. BTW, the best mood lifters I've ever used were imipramine and amitriptyline. Presently, after many years on imipramine I'm switching to Paxil. Hopefully my obsessive thinking will diminish but not my good mood. Also, I'm hoping my tinnitus will diminish, and I know imipramine was a contributor to my tinnitus.
I take 300mg a day for 4,years now and in my first 6 weeks of taking them I almost gave up !! Thank god I didn’t . This drug saved my life and changed me from a person constantly in the throes of depression almost daily to someone who maybe as a minor episode every month or 2 . The first 6 weeks where truly awful and gettin through that takes guts and true grit to get thought but my personal experience makes me say keep going as I literally woke up one day and it was like a light switch went off !!! I was suddenly normal and it got better from there !!!
To add I started on 75mg and went up to my current dose over my first year . Now my dose feels perfect and has been that way for 2 years . I’ve never felt like I’ve had to go up Just another thing is that last night I helped he-man fight the nazi regime along with the British and Americans !! I was only a professional football player for Real Madrid and then I was he mans right hand man in the fight against racism and fascists
I started Effexor 37.5 last Wednesday and I couldn’t sleep thanks to the anxiety, vomiting, and diarrhea. I felt like I wanted to run as fast as I could and scream. Such a terrible night 😢 Needless to say I stopped taking it. I’m so scared of medications.
@@woody6791 Hi, I started feeling better like two days later. I’m now taking Trintellix. It hasn’t been perfect because this one has many side effects too, but I’ve been able to deal with them. The anxiety is still bad, I’m going to stick to this medication for a few more weeks to see if it starts working.
I have been taking Cymbalta, 30 mg, for three months. It is excellent for depression with fatigue. I think Nerodrenaine is essential for suppressed depression as it allows more of a kind of expression and reaction.
Im on the left end and its so helpful to see it on the scale, I don’t wanna lose my intense emotions and temper but I feel a lot anxiety and sadness as well, Im now on 50mg sertraline
This might interest you: Reducing Sensitivity improves Resilience to Distress; here's how to improve sensitivity/resilience. ruclips.net/video/cqBAZwy5EwA/видео.html
Cymbalta was the worst thing I ever took. Total anxiety insomniac nightmare with brain zaps that still happen years after stopping it. I think it actually gave me permanent brain damage.
Ive Increased from 60 to 90mg Cymbalta. After 2 weeks had Increased anxiety and then into depression. Now at 4 weeks on new dose 90mg. Anxiety and depression bad. Should I drop back to 60 or persist. Can this noradrenergic effect happen at 90mg?
The serotonergic effect is mostly to reduce sensitivity. Sometimes that means things don’t seem so bad and one is then “antidepressed” as there is less negative emotion. The noradrenergic effect is to increase arousal energy. If that means doing things one enjoys then that means positive emotions. So long as they don’t cause too much anxiety (a negative emotion). Plenty of noradrenergic effect at 90mg in most people. One doesn’t feel so depressed if one has reduced negativity emotion and increased positive emotion
Great info. I’ve been on cymbalta for 6 months and doubled dose, from 15mg, 3 separate times. Started researching because of the sensitivity issue. I’m getting critical of things a little. But I have also been taking 500mg panax ginseng extract for the past week. I have issues with fatigue from illness and thats why I was put on cymbalta. I thought the ginseng wouldn’t hurt but the sensitivity and hyper activity started in the past few days so Im interested in seeing if it is the ginseng (probably is). If not, the luvox or an ssri is something to run by my psych. Thanks for your work.
Excellent video. I'm currently tapering off Effexor XR (from 150 to 112.5 at present). 150 is too much for me, I get sort of a buzzing sensation that's annoying and agitating. Seeing my Doc in a couple weeks, and will discuss maybe switching to just an SSRI.
I'm also considering tapering off Effexor at (currently at 175). I feel like I've gotten good at coping with stressors + my life/environment is just... less stressful now (finished school & work is less exploitative). Last time I tried tapering off, I got into some beef with my manager and had to move sites (LOL). Part of me thinks I wasn't managing my emotions well because of the tapering off symptoms but... my job then was too demanding for a CPTSD person. This time I'm going to taper off much slower and plan ahead to make it as comfortable as possible. I just bought an elliptical to help start my days with something stabilizing
Hi there this video had been great I was on lexapro ssri 30mg little anxiety came back so touched base with pyciatrist he suggested we try Effexor been on 150mg for 5 weeks I’m ten times worse with physical anxiety symptoms worry scared complete pain
Its because this video is showing a simpler perspective of how the antidepressants work for various disorders. They don't cover ADHD medications and their effects on the cortex.
@@roybelovoskey well, bupropion and reboxetine for example are also known for drowsiness. It doesn't happen always but it does happen often. Anyways this is really good video that cleared some things out.
Could be adrenal fatigue- also different people get different reactions to these meds the only way of seeing what helps for somebody can be to suck it and see
Hello, Thank you for the informative video. Is it correct to conclude that SNRI (Venlafaxine) causes higher sensitivity and reactivity than any other Antidepressant? if yes, does the dose matter such as 37.5g?
It’s generally thought that at 37.5mg there’s not a great deal of noradrenergic effect. The SNRIs do tend to reduce sensitivity (owing to the serotonergic effect) but when a stress/overwhelm threshold is eventually crossed: the noradrenergic effect may exacerbate distress.
I have a question, I was told that your only suppose to be on antidepressants for a year, is this true? I’ve been taking Effexor xr for about 6 years and it just causes grogginess, and not into my crafts or other hobbies, I think it’s causing issues with my natural dopamine, can this be possible, that’s what I’m getting from your video.
@ Sandy Smith - The general “wisdom” is that depression episode runs it’s course over 6-9 months hence some guidelines suggest treatment for 9-12 months. In reality many people start meds and stay on them indefinitely.
Very well explained, I am a 65 y on the 37.5 starter dose of venlafaxine as a regular dose as 75 is too much for me. I have bouts of being numb, brain fog and lots of naps and feeling generally stoned for much of the day. I always wanted to last longer before climaxing and I am able to climax which I could not do on 75mg. I will talk to my doctor about Luvox as an alternative medication. Thank you for this most informative video
Well glad I watched this before I picked up my new Rx for Effexor to treat my anxiety! Wonder why it would even be prescribed for anxiety then if it will make it worse? I am guessing that will only happen if the does it too high though?
My dad started taking it. Made his depression and anxiety worse. Won’t eat. Trip to the hospital. Just sitting and staring into the distance. Will hardly talk. Won’t smile. Obsessive over small weird things like a closet door track being broke and him saying that he’s absolutely screwed and doesn’t know that there’s anything that can be done. Thought people were following him. Thought his legs were too small all of a sudden. And more. Super zombie. Totally gone mentally. Worst drug ever. Getting him off this ASAP with the help of a Naturopathic psychiatrist. If family wasn’t there for him he would wouldn’t even have the mental capacity to understand something is wrong and would be stuck the rest of his life. Super scary shit.
@@tidyguys223 Sorry to hear that. I had that when I was on Prozac. I actually finally gave in a few weeks ago and started taking my Effexor, was tired of trying to deal with my depression/anxiety holistically for the past year, tried everything Kava, Kratom, THC, intense EMDR therapy for past 14 months, got sober after 25yrs of being a drug addict, all helped short term, but nothing worked so I said fuck it, if it doesn't work then can't say I didn't try. The first week sucked, sent me in panic and felt like I was tripping, called my Psychiatrist and asked what do I do, of course he said keep taking it so I did, but I also refilled my valium which I was on for 7 yrs and that fucked my brain up, but I only took if that first week, then started to feel better and today I feel great! I'm glad I decided to try it, but also glad I tried everything else first to before jumping right on it. I know this is short term also, and once they start upping the dose when it stops working I will not keep taking it. I know how these work, the first six months are great, then comes the zombie mode and that's when I'm out! Hope your dad can find the right meds, I tried a handful and they really messed me up so everyone is different for sure! Good luck! I''m sure I will check in about 6months from now and say fuck this shit don't take LOL, but it's working today!
Worsened anxiety is a known side effect at first, when your brain is getting used to the spike in serotonin and norepinephrine. The desired effects of reducing anxiety and depression appear after a few weeks. It gets a bit worse before it gets better, and it doesn't work well in everyone.
@@schok51 Yeh that's what happened. I finally went on it for my depression and hopefully anxiety too. The first week I had to go back on a benzo, but now after month and half feeling really good at 75MG and off the benzo. We'll see how long it works for but so far so good. Thanks for the info!! Good to know
I’m struggling. I feel numb all the time. I use to be quick witted and funny and now it seems that is lost. My social anxiety and in turn my self esteem is worse than it’s ever been. Add brain fog to the mix. I switched from Effexor to Pristiq over a year ago. Currently on 100mg of Pristiq and 10mg of trinalex. I seeked out your video because my gut is telling me that Pristiq is the cause of mental illness.
@@thePSYCHcollective The problem with talking to your prescriber most don’t know how to tapper properly, I went to a compound pharmacist trying to tapper off Pristq when I was prescribed this medication, and it didn’t go well at all. And now on Effexor with the same side effects, grogginess and blurred vision, this is not acceptable, and scared to try tappering again off this medication, it’s a shame there’s not smaller doses to do a proper tapper. The withdrawl from these awful meds is real!
I'm so sorry you have to go through this. I relate to you. I really hope you get better, we all get better. It feels so tiring at times but stay strong you got this 💜
As ADHD person i would say that noradrenaline is so overrated. I remember when i started my adhd medication and my doc asked to try higher dose and i could not tolerate that. It was like i was way too irretable, aggressive and could not focus due to adrenaline. It would be better if we would have meds that are les noradrenalinergic and more dopaminergic.
Was on 175mg Luvox for 4 months, tapered down slowly over a 6-7 week period to 100mg which I've now been on for 8 weeks. Had some great days and some not so good days...last 2 days of horrible rebound sensitivity. Is this normal at 8 weeks since decreasing?
It is not uncommon with long term use especially at higher ssri doses. Might be an indication to go slower with the incremental reductions. Morning dosing may be helpful. On bad days, if stressed or unwell etc I sometimes offer a top up dose of 25-50mg to get through difficult days and as a respite from the sensitivity. But can slow the weaning process down.
@thePSYCHcollective thanks. I prefer to stay on 100mg for at least 4 months and then re-asess. On bad days I sometimes take 10-20mg Propronolol to combat the physical symptoms.
Psychiatric prescriber in the US here. Loved the explanation and would really appreciate an expanse on noradrenaline effect on pain. Is there more to it than just more energy leading to increased motivation and less fixation on pain?
Can “discontinuation syndrome” or withdrawl from Venlafaxine last for months? Say theoretically someone has been on 300mg Venlafaxine for many many years and tapers correctly could the withdrawal be protracted? Literature suggests 2-6 weeks for withdrawal, but user reviews seem to be much longer. I would like to know your opinion on this? Many thanks
It seems in some people it can last months. Slow weaning reduces the intensity of symptoms and prolongs the process. Cold turkey can be torture. Use at higher doses x longer durations seems to predispose to increased problems/need for slower weaning.
The reality seems different than explained in this video. It seems its a paradox that SNRIs, although increasing adrenaline in the synapse, can help patients become more calm and less anxious.
REPORTING IN 6 WEEKS AFTER WATCHING THIS: OMG! You guys are life savers. I've reduced my SNRI (Effexor) by 75% over the past 4 weeks, with my GPs guidance. Still on 50mg but the reduction in symptoms as you described have been amazing. SUCH A RELIEF. It's been 8 1/2 years on Effexor and I had no idea it could be adding to my symptoms. Going to stay on 50mg for a few weeks then drop it and probably introduce a SSRI as suggested (think I will need that at least for a while). Thank you so much. I've put my GP onto your channel so she can get herself up to spead for client's like myself. So grateful. 💖🐨💖🐨💖🐨💖🌞
Delighted to hear that things are going well and that you’re collaborating with your gp on this. Great feedback. Thanks!
hi there is it safe to take antidepressant especially SNRI for 8 years..... will it really reshape my brain??? i want to be more socially graceful especially when talking.... and my SNRI DULOXETIN MAKES ME ELOQUENT
I was 23 years old when I was first prescribed this I'm now 40 and feel that I really need to come off it but the withdrawal symptoms are evil!!!
@@barrymichaels2663 if you don't think they are working for you as well as they should, or causing some of the nasty side-effects in this video, it's definitely worth it. Please do it under the guidance of a well qualified professional, who know what they are talking about. My GP did not. Also... I took getting off the SNRI I was on VERY SLOWLY... it took nearly three months. Only the last week was hard to cope with. This is just from my experience... 💖🐨💖
@@permissiontoshine if I can get down to 150 mg that will be an achievement for me.
I wish our doctors explained it like this and asked questions based off some kind of chart such as this when prescribing! 👏
Thank you
Me too but there is no way a doc would have the time to explain this to every patient.
You guys are so good at explaining, and you are right on the noradrenaline.
This is such an excellent breakdown of the neurotransmitters and their effects!
Very nice way to structure the conversation around symptoms. Thank you.
Me watching this after taking cymbalta at night but it clearly said in the morning on the description 🤦🏽 🤦🏽🤦🏽 but thank you for the information. It's really helpful 😊
Nursing student here and i have an exam tomorrow for my mental health class. This video has been excellent in my understanding of SSRI and SNRI effects qnd medicines. Appreciate you and your team so much!
Anxiety happens when you think you have to figure out everything all at once . Breathe . You're strong . You got this . Take it day by day .
I have researched and found out that shrooms are very helpful , it has really helps to reduce anxiety and depression . I would love to try magic mushrooms but I can't easily get some , Is there any realiable source I can purchase one
I am feeling the same way too, I put too much on my plate and it definitely affects my stress and anxiety levels. I am also glad to be part of this community.
@@tomrandell2979 Does he ship?
@@tomrandell2979 This whole thing is pretty new to me, can I try 3 grams?
@@vincentgiovanni1963 Reach out to him, he will give you the best satisfactory responses...
its cool seeing the difference of how a psychiatrist think vs how a psychologist thinks
Thank you so much for posting this! It is EXACTLY what I've been looking for. I've been on SSRI's for a good portion of my life primarily due to anxiety/depression but have recently been diagnosed ADHD as well so I've been switched to SNRIs... and so my drug research began! Everything you have talked about with Noradrenaline is spot on with what I have personally experienced; however, I do understand how the noradrenaline can help the ADHD. Thank you again for the post and I look forward to listening to your other videos.
You’re welcome.
We appreciate your feedback.
@@thePSYCHcollective so is lexapro better?
It’s an SSRI. The video explains the difference between SSRIs and SNRIs. Neither is “better” they are different. Is a hammer better than a mallet. They are different.
Answer to How is SNRI better than SSRI?
www.quora.com/How-is-SNRI-better-than-SSRI/answer/Al-Griskaitis?ch=99&share=200f3864&srid=sumLd
hi I hope you're feeling better, what snri did you switch to? and did it work without stimulants?
ADHD symptoms are commonly a direct result of SOME antidepressants, such as venlafaxine (Effexor) and mirtazapine ( has numerous brand names - Avanza is but one). Both are very dangerous when given abruptly in moderate to large dosage. One MUST begin lowest dose & SLOWLY increase, with best effects from 20 to 30 days. Once feeling better, NEVER increase the dose - even on very temporary relapse. I had been taking Effexor for 26 years & my personality quickly & drastically changed. Taking unwise rusks - gambling, speeding, unsafe sex, shoplifting, verbal anger/outbursts etc. All caused by Effexor and Avanza (mirtazapine). There are much better alternatives than these two which are linked to suicide ideation of all ages. Hope this helps.
Thank you for your brilliant videos. Your non-jargon explanation on the differences and similarities between SSRI’s & SNRI’s was easily understood. This is a wonderful public service, knowledge is understanding and may help patients diminish their levels of anxiety and depression in league with medication, professional help & guidance.
Thanks for your feedback.
We recently looked at some sleeping medications actions. This might be of interest.
ruclips.net/video/a4LgPQNXKzo/видео.html
SSRI Escitalopram has been great for me, 20mg for 5years now. Virtually eliminated OCD, anxiety, panic and crying at nothing.
This is an amazing video and deserves more views. Best i have seen on this subject.
Life ruiner. I am so lucky and grateful i was able to get off SNRI’s and rebuild my life.
how long did recovery take you?
@@Iliketurtlezz It took a couple months for the physical effects to subside, but to this day, years later, I still have issues with certain things like regulating my body temperature. I took them between ages 18-23 and I think it may have impacted my endocrine system for life
Great video team. Clear real world examples and information.
Thanks Matt!!
Great discussion. Am a family practitioner in US and found it spot on relevant to my practice..
I have ADHD that went undiagnosed and think it’s important to say that I was initially diagnosed depression. SSRI was the worst for me in terms of agitation, I couldn’t think and very hyperactive. SNRI worked for mood (believe impact it had on dopamine helped) so helped depressed mood and I was less anxious/agitated (a lot of ‘anxiety’ was racing thoughts from adhd). I am 30, diagnosed a few months ago. Mood dysregulation or sensitivity is a part of adhd not yet recognised in the dsm. I would not go to a doctor for difficulty organising or concentrating. I went because I felt sad and anxious. So that’s what I was treated for. Given limited access to psychiatrists in Australia, I never saw one and gps typically screen for mood/anxiety, not adhd especially in females. Your presentation was fantastic, in future could you please mention or make note of how SSRI’s are commonly prescribed by GP’s, and can make adhd symptoms worse, or aren’t right for certain populations. I think medication is important but the right medication even more so, and for us (adhders) SNRI’s typically preferred over SSRI. :)
Great comment. Our other talk might also be relevant:
ADHD Stimulant Medication Secrets: The 10 secrets to how Dexamphetamine, Ritalin and Adderall work
ruclips.net/video/LG_yD5SXuCg/видео.html
@@thePSYCHcollective cool thank you I will check it out 😊
I have had a similar experience with ADHD and depression.
I have adhd and SSRIs helped. I was calmer, not anxious, hyper focus was improved. The hyperactivity on SSRI IS NOT how someone with true adhd reacts. YOU HAD A COMMON BIPOLAR REACTION TO SSRI. Bipolar is often confused with adhd. SSRI induces mania in bipolar patients exactly as you described. You should speak to a psychiatrist asap because typical depression treatments will have harmful consequences for undiagnosed bipolar / misdiagnosed adhd. It’s going to take some real honesty with yourself and with your doctor. Good luck.
@@xeathenia8539 I doubt that as SNRIs are even worse for bipolars. Brings on mania even faster.
I wish I had this information years ago, I lost years in a depression‘coma’. More medications were added, and I was told it just takes time. Even when 450 wellbrutrin was added still in bed or napping and only up 4-6 hours a day. Finally moved and my new psychiatrist moved me from the 5 medications to an MAOI, and finally got some relief, I am up 10 -12 hours a day for the last few years. Did not give up and have a new team and being tested for autism, and other underlying conditions.
Such a brilliant informative video. I was prescribed Venlafaxine for chronic pain. Been on 150mg for 16 months and wanting to get off it for at least 9 months of that time. The brain fog and zaps, insomnia and fatigue have been awful. I actually had to start taking it at night as I felt completely out of my body driving to work when I took it in the mornings. Day 5 of tapering off, now on 112.5mg - GP has advised doing this for a month before reducing to 75mg so will be 3 months before I'm off it. Interesting that you mention the anxiety because looking back my anxiety has been horrendous on this medication, especially since I wasn't put on it for mental health reasons. Thank you for the wonderful insight!
Thanks for the feedback!
Omg who would give it to you for pain 😮 its a very strong pill for ppl with clinical depression who stare at the wall all day
Did pain go away?
I've been on the Loxitane for 2 1/2 months. For the past two weeks I've been feeling unlike myself I thought I was going crazy. Thank you for this video.
Amazing thank you so much, i appreciate you taking your time to educate for free, you are awesome.
Thank you for making this. My psychiatrist prescribed Effexor XR because he thinks SSRIs failed me in the past, which makes no sense to me. I have high anxiety, so putting me on a medication that makes it worse seems like a bad call on his part. I was initially on 75mg, but I didn't like the side effects, even after a month, so I asked to be taken off it, but he refused and upped my dose to 150. I'm feeling much worse now. I have an appointment with him tomorrow and I'm gonna stand firm on being taken off. I can't stand all this agitation, high BP, and insomnia (wired, but tired). Again, thank you for explaining how it works in an easy to understand format. It helped a lot. :)
Hi, I had a similar experience. How are you feeling today? Did you find a good medication for your symptoms? I have anxiety and I'm still treating it...
@@rickparizotto so you're on Effexor? If you have anxiety, it's not recommended, at least not by pill pushers. I eventually left that psychiatrist and got a new one. While she's definitely a lot nicer and more personable, she put me on two different SSRIs at the same time. Regular doctors are warning me about that, saying the two medications don't go well together. I actually asked her today if I could be taken off them, but she simply upped the doses.
I'm not feeling like they're doing anything, unfortunately. I've had this issue for decades, where antidepressants do very little or nothing. My therapist says that some people simply don't respond to them, which sucks, but I guess I'm one of them. At this point, I'm wondering if I even need them. Yes, I have issues that need resolving, but it doesn't seem like medication is the answer.
Anyway, enough about me. Have you talked to your psychiatrist about the side effects? They can't force you to take them, so I'd recommend asking for a different medication. I honestly wish you the best of luck. I've been on antidepressants and muscle relaxers off and on since I was 15. I'm 40 now, so you can imagine my experience. If you have any questions, please don't hesitate to ask me and I'll do my best to answer.
@@MidnightSonnet Hi, I've already tried almost 10 different antidepressants. I didn't take Effexor (venlafaxine), but I took one called Desvenlafaxine (Pristiq), which according to my doctor is similar to Effexor. And it was a bad experience. I'm taking Fluoxetine (Prozac 40mg), Trazodone XR (150mg), and atenolol (25mg) to help with my anxiety. It's like a roller coaster. Some days I feel good, others don't... And I've been sleeping a lot lately. I think it's because of trazodone. But I still don't feel 100% good. I feel there's something missing...
@@rickparizotto holy hell, that's a lot of medication. Seems like overkill unless you're extremely unwell. Are you seeing a therapist, as well? In my experience, discovering the root cause(s) of anxiety and depression and working to heal that is infinitely more helpful than medication.
If you are seeing a therapist, did they have you take an anxiety/depression quiz and, if so, what were the scores? The past two therapists I've seen have me take the quiz around once a year or when something changes to see if I've made any progress. You can also express your concerns regarding your medication to your therapist, as it's helpful to them and you.
Currently, I'm taking Vilazodone HCL 40mg (this is a new medication that no doctor I've spoken to has ever heard of) and Buspar 30mg.
We’re going to be putting out a whole series on root causes soon. But I’m the mean time here’s something we touched on a while ago:
The root causes of depression.
Address them now!
ruclips.net/video/q4duMQMPG9Y/видео.html
My GP wanted me to stop my SSRI and go on Effexor. I asked him why. “Because I’m putting all my ssri patients on Effexor.” I said no way, and he said ok, he’d make an ‘exception’ for me. Weird way of prescribing, what? Because he’s putting all his patients in it...
General practitioners should stay out of this stuff, anyway. When I went through very bad withdrawal (had sepsis, stopped taking Paxil having no idea this could be a problem) he had no idea what was going on so assumed, naturally, that the extreme nausea and everything else was “all in my head”.
I can’t even think about that year, it’s still too upsetting.
Let psychiatrists prescribe psychotropics, not family doctors.
Seems arbitrary and potentially destabilising if a patient is doing okay. Not to mention the noradrenergic effect on anxiety/distress. I wonder what their incentive is?
@@thePSYCHcollective of that GP? I would guess a pharmaceutical representative visited him with information about Effexor (which was fairly young, then - it was long ago) and either offered him a kickback or made him so enthusiastic he wanted all his patients to benefit from it. He was not happy that I declined.
That’s what I’ve been saying gps do not know enough about psychotropics, at least mine didn’t. And I’m sure most don’t, or are very careless in there prescribing. I have been through very traumatic events, and still not getting the right help. Antidepressants are causing havoc on my life, or it’s not the right one. I’m at the end of my rope, trying to prove what’s going on with me. It’s like talking to a wall, and people in my life are not making it any easier, the minimize what I’ve been through.
Sorry to hear about your predicament. I hope some of content helps.
@@craftygirl17 Many of us have been there…I’ve just been through another awful year. And yes, loved ones can make it worse. The year was awful because I was trying to wean off my SSRI, over the course of 2 years in all, no less. I was extremely strong willed, went to the gym every day, took cold showers, ate only healthy food, no snacking, so smoking or drinking - nothing helped. Valium didn’t even touch it anymore. It is horrible and lonely.
Back on SSRI and doing better again. Not great, but better.
Has no SSRI ever helped you?
I know I can't take any of this stuff as peer reviewed information but it's still really interesting to see two professionals in my field talking about cool shit
That’s my all time favourite comment!
I’ve recently tapered off venlafaxine and switched to a low dose of fluoxetine. Ever since taking Venlafaxine I struggled with health anxiety (came out of nowhere) panic attacks, low self esteem.
First day today on fluoxetine only and I can honestly say I feel like myself again pre venlafaxine. Never going back to it again. The withdrawal wasn’t so bad as I tapered but I definitely had side effects like zaps, sweats and irritability. This video makes complete sense to me.
Thanks for posting.
Sadly it’s a common experience.
@@thePSYCHcollective thank you for making the video and helping me see clearly that I wasn’t going crazy! I was just on the wrong drug.
Hi, what dose of Venlafaxine where you on and how long for? Glad your feeling better
@@ethompson5061 thank you! I was on 75mg for 3 years and then 112.5mg for another year
Hey I am where you are a month ago … health anxiety 😟 came of snri. They had me on devs … has the fluoxetine helped u chill out?
Wow and as a first timer, my doctor tried prescribing me effexor and knew practically nothing about it. Said there were no side effects or risks other than dry mouth!
So glad I didn't blindly get it because these symptoms mentioned above are what I'm experiencing already and would've really messed it up more
I love this and thank you but also you two are so funny. There is so much tension in this room!
the best video on the topic. Really good
thanks for the info actually found a helpful youtube video that made sense. underappreciated channel
I have been taking escitalopram and clomipramine for a while now. But I've had really disturbing dreams and my psychiatrist wasn't responding too well, he just used to say continue the meds. Today, I saw a new doctor and he just changed to a completely different antidepressant. And im just so scared now. I just really want a hug.
SSRIs are depressants for me. Incredibly sedating and brought on worse thoughts at the lowest dose. It always amazes me how people find them energizing and invigorating. We are all unique.
SSRI are great. I took them for my PTSD. helped me overcome my anxiety and panic .
I get amazing sleep with them. Unfortunately melatonin or Benzos dont work on me. But a Low dose of paroxetine and i fall asleep in 10 mins and sleep through the night.
I tried a few SSRI's and bad reaction, but I was on Effexer/SNRI in 2000 for Depression and it worked really well, so we figured lets try that now for my anxiety and depression. So far I'm really glad I finally went on it. Still dealing with some side effects, but have my life back for now. Taking 75MG. Thanks for the feedback!
Do you still take them??? Or did you get better and get off of them?
@@OhhhJP Hello I got off. I don't take them anymore. I dont experience any severe side effects. But do I seem to have a sugar craving which I can't seem to control.
@@dbyajitroy so you took your meds and after awhile got off of them and now you feel better?
@@OhhhJP Yes. There are minimum side effects once u leave the meds. But again I did not take them for a long period of time. I took it for a couple of months.
There will be a strong urge to go back to the meds. But it you can stay off for a week, then u get more confident .
This explains a lot. I was on Luvox for over 15 years and became increasingly tired and brain foggy as time went on. I took a gene test that listed three different flags for Luvox (mainly slow metabolism), and have been transferred to Pristiq. It was hard going at first because I'd been so numb, but it's interesting being awake too. So I'm on Pristiq and Nuvigil now have to see how it plays out.
US healthcare needs your help.
I was on Effexor for 5 years when I was 19 and came off it when I was 25. Then tried to go back on it, but the side effects were so severe, had really bad vertigo/dizziness. Wasn’t fun times. Love your videos
If you don’t mind sharing, what did you end up doing after retrying the Effexor?
@@kaileyshaffer4381 sorry for late reply, didn’t see your comment. I tried at least 5 different SSRI’s and nothing seemed to work. Instead I started exercising a lot and stopped drinking, and haven’t looked back, I’m way better than I ever was.
@@mstringer90I’m having a battle…withdrawl is killing me
@@rustymullins6623is it from Effexor?
EXACTLY the same 11 years on effexor,'after my son was born. they kept trying to up my dose up my dose 300mg in end. I was not improving. I saw this and not only have I been fighting anxiety and insomnia, but now I'm also on 2mg of clonazepam a day to sleep and help with agitation. I'm tapering off venlafaxine now by choice with gp. who didn't even know that effexor was an snri she told me it was s'sri. I found this vid at exactly the right moment. thank you. almost eleven years of my life gone. no enjoyment, turning into a social recluse. so we are down to 100mg effexor. introducing 10mg of escitalopram.
first week OMG. not pleasant effexor withdrawl.
brain zaps, ear and head ringing, black outs etc. . . I have tried many times to get off this antidepressant. I'm determined this time. I'm feeling relief.'sleeping allot to avoid the side effects of change. but this vid explains allot. great for people like me, on effexor for years, having no benefit from it but insomnia, anxiety. the change is starting to feel better. I know still early days. but gives me hope. and wish this info was available years ago. thanks so much guys. ❤ this new info needs to be spread. I've already shared this vid three times with other people having the same problem with venlafaxine. one almost suicidal. always to make a plan with g.p on how to taper and change over of course. this couple save people's lives. I was ready to give up at 42. my son has only seen me on effexor will he notice a diff mum?'hopefully a positive and happy mum that wants to engage with people and leave the house.
This was an excellent explanation. Thank you for making this vid!
You’re welcome!
Interestingly, SSRIs like escitalopram and fluoxetine also relieve depression in mice lacking the serotonin transporter. In fact, they are just as effective in mice without serotonin transporters. Although hard to believe, serotonin reuptake inhibition may have nothing to do with the antidepressant effect of SSRIs. All SSRIs bind to TRK-B (as does ketamine). Fast acting antidepressants like ketamine and psilocybin, activate this receptor quickly. Slower acting antidepressants take a few weeks to produce conformal changes in the receptor to make it more responsive to BDNF.
boy I wish I could have you both to treat me
I had the worst experience of my life when a psychiatrist advised me to quit Lexapro cold turkey after an ineffective transition from SSRI to SNRI. I would never consider either of these meds ever again.
See this is what I’m talking about even some psychiatrist don’t know what they are doing or just don’t care, you really have to look hard for good help. Really investigate who your dealing with not all psychiatrists are good at what they do. Or they misdiagnose you. I’ve been there with different psychiatrist went through all of them where I live and got a different diagnoses with all of them they didn’t take the time to listen to my situation. All started with my doctor saying I was depressed and gave me a antidepressant that I really didn’t need it was distress. And very hard to get off of. No one would listen they all were dismissive, when your dealing with one thing after another they don’t take the time to sit and listen and go from there to quick to hand you a perscription and you trust them.
Dang man your brain. I know someone who was in Benzos and then got real sick and stopped cold turkey. They were all messed up in the brain and we're hearing things. Took them a week to seem normal but they still were not quite there. Crazy stuff.
Great video. I suspected this was the case with SNRI. Thanks for the good info
Thanks for the feedback
My SNRI helped my anxiety so much more than SSRIs
Which SNRI? Effexor? I'm on it and surprised it works. 75mg 3months and I feel great 👍
Same here and SNRI no sexual side affects either
Which one is it ? Please reply
I’ve been on Effexor for about 10 years- 300mg/day. My anxiety is totally out of control! Can’t imagine coming off this stuff though, the withdrawals I have if I forget to take them, or even take them a bit late! Will talk to my GP about coming off them!
It's seems kind of high. Hope it goes well. After all sometimes we have to risk it. You got this
@@tutorialesguitarradelcielo9581 aww thank you. I did a bit of research myself and decided to try and wean off them.
The capsules I have (2 x 150mg) have 12 x 12.5 mg mini tablets in them - so over the last 2 weeks, I’ve taken a few beads out, now I’m up to 5 beads out of one capsule today, which is a total decrease of 62.5mg! Will stay there for a week, then drop another 12.5mg. No side effects really as yet 🤞🏻🙏🏻
Effexor first helped me greatly. The problem I have with all psychiatric drugs is that no Psychiatrist ever tells the patient anything what to expect. Effexor began making me so sick, severe nausea, almost passing out if you didn't take it exactly on time everyday. Worst drug I was ever on.
I've been on venlafaxine for years,I have weaned myself off over a year yes going back on is a nightmare manic for 6days my Dr wants me to just up the dose I'm getting a second opinion, this is so helpful thank you 🙏
The woman "psychologist" in the video is so unnecessary and distracting. Doesn't let the actual doctor finish a single sentence. And judging by other ppls comments I'm not the only one who sees this. I feel sorry for her clients, her tactless behaviour is annoying and destabilizing even for healthy, stable individuals.
U sound jelly
This woman is so friggin irritating. She won't let him talk, she can't stop herself interrupting. He is great. Why the hell is she even in this video????
Wish I never started on these as a teenager. How irresponsible it was for my Dr. to have prescribed these to me. I needed council and guidance but instead I was given drugs. Now I can't gett off them without twitching uncontrollably when I try to sleep. Also for those considering Ativam, my experience is terrible almost unbearable rebound anxiety and despair so proceed with caution.
Reporting here! I have been effexor 75mg all my life (can't go less or more of that dose otherwise I get depressed/disctrated), this med gave me a lot of intellectual, focus, creativity, consciousness, lessen depressed good for my uni/work. The problem is that it FLAT my emotions, makes me angry, anxiety irritable person, with a little of ocd, obssesive, so is hard for me to stablish relationships even with all the therapy, this pills makes my body agitated so is my voice, plus i sweat like a pork lol. I found this video, so decided to try it with my psiquiatrist. Even if i try to take 2 beads of the capsule, my concentration/alertness goes to hell, I added the Luvox 50mg and started to feel a bit better like my emotions kinda, but for this context, I ask you base on your experience, because not all the doctors has the ability, they just do whats in the "book". that means that if i cannot reduce my effexor due to loss of concentration? or will luvox will increase that as passes the time (im just 4 days on this). Thank you.
Pristiq helps to treat depression but made anxiety much more severe and made me more sensitive to sensory issues (noises, lights and smells).
SAME, i was on pristiq for like 2 years and was totally fine, them i stopped taking them, now a few months later i tried again and im like very sensitive to things like sounds or smells
very good review guys well done
Cymbalta ruined my life. Gave me severe akathisia for 3 years. Incredible that I survived it.
So true.
Have some more,
Add this,
Stop this take this.
Quite maddening when you already feel down .
Great vid, very helpful and interesting!
Also, I find that researching these things on credible online sources ends up providing me with more knowledge than any GP that I have had. I get it though, they are a jack of all trades, instead of a King of one thing, but man.... It's not a good feeling to always feel more knowledgeable than the DR.
It’s very interesting, I feel like GPs are lacking this understanding. I also feel there should be more awareness around pharmaco genetics testing. This can help reduce the trial and error process. Also it would be nice if you guys could do a video on it .
Ok y 5ZE a s6
First of all I'm 71, work out, walk everywhere, good blood pressure etc. My ENT prescribed Venlafaxine 37.5 mg for my Vestibular Migraine that came out of nowhere. He said take it for 2 weeks. I took one at 10am and by Noon my Vertigo was 80% gone. I thought cool.. 2am the next morning I woke up with a blinding headache, and I don't get headaches. But I did read on Web MD you might want to watch your Blood Pressure if you take this. So I decided to take my Blood pressure. 196/121. Yeah off to the Emergency room I went.
I realize different medications can work differently in different people.. Just a Heads up.
Thanks for sharing your story.
Based on the timing of the events of your story, my guess is that the headache was some sort of rebound effect to the drug wearing off and the high BP was a result of the severe headache pain. Does that seem about right to you?
@@thePSYCHcollective Not sure I've been misdiagnosed 3 times. First it was a Vestibular Neuritis, then it was a crystal floating around in my right ear, now it's Vestibular Migraine. Ive been to two ENT's next up a neurologist. I have had this now for just over a year. If I thought this was permanent I would have already put a bullet in my head.
Anti-psychotics turned me into a zombie. I think I could still benefit from them as I have very severe Bipolar I, but I'm scared of the side-effects. I take a mood stabilizer and an SNRI now. I still experience hypo-mania and can obsess over things big time, but it's manageable. I'll never take an atypical anti-psychotic again. They terrify me.
Gawd ive been on Cymbalta for years and spend a lot of days just miserable. Also can be possible rsd reactive. Love to go back to SSRI but the Cymbalta gives huge withdrawal effects. Swimmy, sad, zappy, feels like my head catches up after my vision. Do I have to go turkey before possibly swapping?
A slow crossover can work. You’ll need to discuss with your doc how that might be done. Generally the dose of the snri is lowered a touch and after a week or so a tiny bit of ssri is commenced. Then the snri is lowered again etc. it’s not always smooth sailing and it’s a good idea to get your reflexes checked before and as this process takes place. Increasing reflexes, nightly sleep starts or day time jerks are signs of serotonin excess.
I wish she'd just let him talk instead of constantly interrupt him
Thanks for your feedback, some people find the questions to be clarifying. It’s impossible to make everyone happy!
I disagree. I felt like he kept interrupting her. as soon as she started talking he would manexplain what she just said and you could see it in him was insecure. Her information as a psychologist is just as important as the psychiatrist.
@@thePSYCHcollective Disagreed. She obviously wanted to talk more but he kept interrupting. Both had great information I just wish I heard more from the psychologist.
Great video, can you please do a video that discusses psychomotor stimulants and Antidepressant meds, what happens when both are being taken? Also I've heard about new trials of ketamines and psilocybe to treat depression from John's Hopkins University, it would be great to understand that at a 1000 foot view. Watched a few Ted Talks on problems of treating the entire brain and it’s neurotransmitters as a kind of pea soup, rather than being able to specifically target brain regions. The analogy used by the Neuroscientist in the Ted Talk was that it was a litte like opening the hood of your car and pouring oil all over the engine block, in order to fill the oil tank, potentially damaging and sometimes ineffective, are these medications getting smarter and able to target areas or regions? The small amount of research I've done into brain chemistry I realise what an amazingly complex subject it is but fascinating and love to understand it more. Are there ways now to selectively target brain regions with meditation, also are things like MRI scans used these days?
I love this marriage of psychology (with awesome schema Therepy) and psychiatry, it's awesome and helpful, hope GP's watch this. I think you need a Neuroscientist to complete the dream team and marry up practical with theoretical. Thank you both for producing this!
Thank you so much!!!!! This totally explains the experience in having with the Effexor! I finally understand why my panic attacks were actually getting worse. This confirms my decision to come off the Effexor.
***Update: it's been 14 days without my normal 37.5mg of Effexor and I feel like a new person! The 20mg bridge of Flouxitine most definitely helped. I actually only used both on day 1 and then only Flouxitine since then. I'm gonna wait to about the 2 month mark, before trying to wean of the Flouxitine, just to ensure I'm only dealing with it's withdrawals. Thxs again for this. 🤗
I'm so glad you've been able to recognise what it was doing to you and be able to take action about it. Panic attacks are terrible enough without finding out they've been worsened by a drug prescribed to supposedly help you feel better.
Good luck. You are on the right course.
Did you feel emotions and like yourself again after getting of them.. Since 4 years i cant feel joy, happiness, love or cant feel myself...taper down now...
@@Butterfly-vd4tg Yes, once off the Effexor I slowly got back to a "pre-effexor" state. But it did take about 3 months to lose all traces. I did end up deciding to stay on 20mg of flouxitine as it really helps keep me balanced and feel great. Of course, everyone is different and it take longer or shorter.
@@AaronWakely thanks so much ☺️ and i asked myself why i feel since 4 years like a zombie and always ill and not like myself...
Recently started Duloxetine for general anxiety and fibromyalgia first week or so the side effects were challenging , constipation and tired but eventually that got better. 30 mg twice daily.
After six weeks I am feeling really good . My anxiety level has dropped , I'm coping with stress, my sensitivity to pain is less.
If this medication continues to benefit me , the chances are I will be taking it for some time.
SNRI are better for me than SSRI! Too many side affects with SSRI insomnia, restlessness, sexual disfunction, both can quite dull your mood sometimes but I'm on venlafaxine X2 75mg a day, wow dreams are insanely good!
Does it help with social anxiety? If you even had that. Thank you
@@josmith5419 it helps but benzodiazipines were the best for social anxiety
@@Pazuzu82 damn. Have you tried buspar?
@@josmith5419 no
@@josmith5419 37.5mg helped me tremendously with anxiety. Works different for everyone. But remember it took 4 weeks to work.
I've been on 15 different mental tablets in twenty years. It was only in the past year that I was offered psychology. I wonder how it might have helped had I been given psychology sooner. Now I have a consultant psychologist every two weeks.
why would you have a consult every 2 weeks lol usuallu they are a one time thing and they just inform your family doc on how to medicate you
@@fogpimp I think you might have confused consultant psychologist with a psychiatrist.
Which tablet do you rate best for depression?
Doctors defend big Pharma & their profession only.
Yeah David I feel your pain! As a preteen till I was in my late teens I was put on all sorts of meds. I had trauma related issues but the pill pusher diagnosed me with bipolar incorrectly. So I was having rang if emotions trying different crap and horrible side effects.
Seeing a shrink to actually process that crap is HUGE. I say meds just push down the feelings but never heal them. In fact if I missed a dose I would feel really depressed really fast. Now that I've been going to the RIGHT therapist I don't need psych meds personally. Although it took me a handful of therapists to find my right match it was worth it.
Through some trauma based work I'm bringing up crap I never thought was still an issue. I think I also feel better in my self knowing the happiness I feel is real and not due to a med. Although some people seem to need them. Getting my vitamin levels healthy, eating better, and working out helped a lot. I seriously wouldn't be this well of though without therapy. Therapy is what helped me feel like bricks were removed from my back I never knew I was carrying. Hopefully you find the right psychologist to help. Training and skill is good but you need to click with them. There are several wise ones making YT videos I enjoy but could never be a client.
Good luck!
I have anxiety and adhd. Not sure why after my history of anxiety attacks (not fun) my doc would prescribe this SNRI to me:/ lexapro had cruddy side effects, Ritalin was too strong for me.
i take escitalopram 5mg to counteract the emotional side effects of venlafaxine 75mg. now i can feel pleasure while being energetic and motivational.
Chart is too small 😔 i appreciate your explanation. Dr too often assume pt are not interested or not capable of understanding these things🙄
Best video explains neurotransmitters ever. I used to get jittery from a half a can of Coca-Cola, after being on Paxil, caffeine doesn’t affect me at all, drinking the strongest triple espresso ever is like drinking water now. I can’t find any explanation anywhere about that subject?
Don’t know exactly, but I’d suggest the Paxil may reduce ones sensitivity to a point where one is more tolerant to the sensitising effect of caffeine. Just speculating.
Here’s a discussion about sensitivity: ruclips.net/video/cqBAZwy5EwA/видео.html
I noticed when I was on Paxil I could drink 10 coffees and it would not effect me. Normally if I drink one coffee or tea the caffeine is too strong.
I’ve come across that phenomenon. The serotonergic drugs reduce sensitivity and thereby lessen anxiety from stimulants like caffeine.
Cymbalta leveled me out, preventing high anxiety, but it was not good for lifting my mood. Also, I had some irritability. BTW, the best mood lifters I've ever used were imipramine and amitriptyline. Presently, after many years on imipramine I'm switching to Paxil. Hopefully my obsessive thinking will diminish but not my good mood. Also, I'm hoping my tinnitus will diminish, and I know imipramine was a contributor to my tinnitus.
I take 300mg a day for 4,years now and in my first 6 weeks of taking them I almost gave up !! Thank god I didn’t . This drug saved my life and changed me from a person constantly in the throes of depression almost daily to someone who maybe as a minor episode every month or 2 . The first 6 weeks where truly awful and gettin through that takes guts and true grit to get thought but my personal experience makes me say keep going as I literally woke up one day and it was like a light switch went off !!! I was suddenly normal and it got better from there !!!
To add I started on 75mg and went up to my current dose over my first year . Now my dose feels perfect and has been that way for 2 years . I’ve never felt like I’ve had to go up
Just another thing is that last night I helped he-man fight the nazi regime along with the British and Americans !! I was only a professional football player for Real Madrid and then I was he mans right hand man in the fight against racism and fascists
@@gump5ter01 I just started this. Did you get any weight gain?
I really enjoy y’all. Do you make any videos on how to taper off of venlafaxine
Compounding pharmacy
At the End, You All know, they feed You with Poison
I started Effexor 37.5 last Wednesday and I couldn’t sleep thanks to the anxiety, vomiting, and diarrhea. I felt like I wanted to run as fast as I could and scream. Such a terrible night 😢 Needless to say I stopped taking it. I’m so scared of medications.
Dont take it, the withdrawals are absolutely horrible. Cymbalta is another hell of a drug, wish never took it
@@woody6791 Hi, I started feeling better like two days later. I’m now taking Trintellix. It hasn’t been perfect because this one has many side effects too, but I’ve been able to deal with them. The anxiety is still bad, I’m going to stick to this medication for a few more weeks to see if it starts working.
I have been taking Cymbalta, 30 mg, for three months. It is excellent for depression with fatigue. I think Nerodrenaine is essential for suppressed depression as it allows more of a kind of expression and reaction.
Excellent video and information for my exams on Venlafaxine "Medical Valley" 75 mg. Thank you both very much.
Im on the left end and its so helpful to see it on the scale, I don’t wanna lose my intense emotions and temper but I feel a lot anxiety and sadness as well, Im now on 50mg sertraline
This might interest you:
Reducing Sensitivity improves Resilience to Distress; here's how to improve sensitivity/resilience. ruclips.net/video/cqBAZwy5EwA/видео.html
@@thePSYCHcollective thx!!
Cymbalta was the worst thing I ever took. Total anxiety insomniac nightmare with brain zaps that still happen years after stopping it. I think it actually gave me permanent brain damage.
Excellent discussion. Do the Venlafaxine withdrawal horror stories come about because there's an increase in adrenaline and hence anxiety?
Ive Increased from 60 to 90mg Cymbalta. After 2 weeks had Increased anxiety and then into depression. Now at 4 weeks on new dose 90mg. Anxiety and depression bad. Should I drop back to 60 or persist. Can this noradrenergic effect happen at 90mg?
The serotonergic effect is mostly to reduce sensitivity. Sometimes that means things don’t seem so bad and one is then “antidepressed” as there is less negative emotion.
The noradrenergic effect is to increase arousal energy. If that means doing things one enjoys then that means positive emotions. So long as they don’t cause too much anxiety (a negative emotion). Plenty of noradrenergic effect at 90mg in most people.
One doesn’t feel so depressed if one has reduced negativity emotion and increased positive emotion
@@thePSYCHcollective Yes but I am feeling more depressed and more anxious. Should I drop back or could this effect pass?
Great info. I’ve been on cymbalta for 6 months and doubled dose, from 15mg, 3 separate times. Started researching because of the sensitivity issue. I’m getting critical of things a little. But I have also been taking 500mg panax ginseng extract for the past week. I have issues with fatigue from illness and thats why I was put on cymbalta. I thought the ginseng wouldn’t hurt but the sensitivity and hyper activity started in the past few days so Im interested in seeing if it is the ginseng (probably is). If not, the luvox or an ssri is something to run by my psych. Thanks for your work.
I wonder what effects would the combination between SNRI and antipsychotics like Seroquel has. It definitely helped me deal with childhood trauma
She curing my depression rn🥴
😂😂😂🫡
This is a great video. I am on Mirtazapine 15mg, and Duloxetine 30mg.
Delighted you found it!
Excellent video. I'm currently tapering off Effexor XR (from 150 to 112.5 at present).
150 is too much for me, I get sort of a buzzing sensation that's annoying and agitating.
Seeing my Doc in a couple weeks, and will discuss maybe switching to just an SSRI.
Good luck. Would love to hear about how things progress.
I'm also considering tapering off Effexor at (currently at 175). I feel like I've gotten good at coping with stressors + my life/environment is just... less stressful now (finished school & work is less exploitative). Last time I tried tapering off, I got into some beef with my manager and had to move sites (LOL). Part of me thinks I wasn't managing my emotions well because of the tapering off symptoms but... my job then was too demanding for a CPTSD person. This time I'm going to taper off much slower and plan ahead to make it as comfortable as possible. I just bought an elliptical to help start my days with something stabilizing
@@Julian-st4cz I started weaning my Effexor 150mg a month ago. I’m now at 120mg. Very motivated. Good luck!
I am at 225 lol
Hi there this video had been great I was on lexapro ssri 30mg little anxiety came back so touched base with pyciatrist he suggested we try Effexor been on 150mg for 5 weeks I’m ten times worse with physical anxiety symptoms worry scared complete pain
I just would like to know, why pure SNRI's like Strattera actually make you drowsy?
Its because this video is showing a simpler perspective of how the antidepressants work for various disorders. They don't cover ADHD medications and their effects on the cortex.
@@roybelovoskey well, bupropion and reboxetine for example are also known for drowsiness. It doesn't happen always but it does happen often.
Anyways this is really good video that cleared some things out.
Could be adrenal fatigue- also different people get different reactions to these meds the only way of seeing what helps for somebody can be to suck it and see
Hello, Thank you for the informative video. Is it correct to conclude that SNRI (Venlafaxine) causes higher sensitivity and reactivity than any other Antidepressant? if yes, does the dose matter such as 37.5g?
It’s generally thought that at 37.5mg there’s not a great deal of noradrenergic effect. The SNRIs do tend to reduce sensitivity (owing to the serotonergic effect) but when a stress/overwhelm threshold is eventually crossed: the noradrenergic effect may exacerbate distress.
I have a question, I was told that your only suppose to be on antidepressants for a year, is this true? I’ve been taking Effexor xr for about 6 years and it just causes grogginess, and not into my crafts or other hobbies, I think it’s causing issues with my natural dopamine, can this be possible, that’s what I’m getting from your video.
@ Sandy Smith - The general “wisdom” is that depression episode runs it’s course over 6-9 months hence some guidelines suggest treatment for 9-12 months. In reality many people start meds and stay on them indefinitely.
Very well explained, I am a 65 y on the 37.5 starter dose of venlafaxine as a regular dose as 75 is too much for me. I have bouts of being numb, brain fog and lots of naps and feeling generally stoned for much of the day. I always wanted to last longer before climaxing and I am able to climax which I could not do on 75mg. I will talk to my doctor about Luvox as an alternative medication. Thank you for this most informative video
@stephen castles
Delighted that you found it informative
Well glad I watched this before I picked up my new Rx for Effexor to treat my anxiety! Wonder why it would even be prescribed for anxiety then if it will make it worse? I am guessing that will only happen if the does it too high though?
My dad started taking it. Made his depression and anxiety worse. Won’t eat. Trip to the hospital. Just sitting and staring into the distance. Will hardly talk. Won’t smile. Obsessive over small weird things like a closet door track being broke and him saying that he’s absolutely screwed and doesn’t know that there’s anything that can be done. Thought people were following him. Thought his legs were too small all of a sudden. And more. Super zombie. Totally gone mentally. Worst drug ever. Getting him off this ASAP with the help of a Naturopathic psychiatrist. If family wasn’t there for him he would wouldn’t even have the mental capacity to understand something is wrong and would be stuck the rest of his life. Super scary shit.
@@tidyguys223 Sorry to hear that. I had that when I was on Prozac. I actually finally gave in a few weeks ago and started taking my Effexor, was tired of trying to deal with my depression/anxiety holistically for the past year, tried everything Kava, Kratom, THC, intense EMDR therapy for past 14 months, got sober after 25yrs of being a drug addict, all helped short term, but nothing worked so I said fuck it, if it doesn't work then can't say I didn't try. The first week sucked, sent me in panic and felt like I was tripping, called my Psychiatrist and asked what do I do, of course he said keep taking it so I did, but I also refilled my valium which I was on for 7 yrs and that fucked my brain up, but I only took if that first week, then started to feel better and today I feel great! I'm glad I decided to try it, but also glad I tried everything else first to before jumping right on it. I know this is short term also, and once they start upping the dose when it stops working I will not keep taking it. I know how these work, the first six months are great, then comes the zombie mode and that's when I'm out! Hope your dad can find the right meds, I tried a handful and they really messed me up so everyone is different for sure! Good luck! I''m sure I will check in about 6months from now and say fuck this shit don't take LOL, but it's working today!
@@planetnone24 nice to know
Worsened anxiety is a known side effect at first, when your brain is getting used to the spike in serotonin and norepinephrine. The desired effects of reducing anxiety and depression appear after a few weeks. It gets a bit worse before it gets better, and it doesn't work well in everyone.
@@schok51 Yeh that's what happened. I finally went on it for my depression and hopefully anxiety too. The first week I had to go back on a benzo, but now after month and half feeling really good at 75MG and off the benzo. We'll see how long it works for but so far so good. Thanks for the info!! Good to know
I’m struggling. I feel numb all the time. I use to be quick witted and funny and now it seems that is lost. My social anxiety and in turn my self esteem is worse than it’s ever been. Add brain fog to the mix. I switched from Effexor to Pristiq over a year ago. Currently on 100mg of Pristiq and 10mg of trinalex. I seeked out your video because my gut is telling me that Pristiq is the cause of mental illness.
Could I be right about the Pristiq causing this?
That’s the message of the video. It’s possible. Be careful. Sudden cessation is usually a problem.
Talk to your prescriber.
@@thePSYCHcollective The problem with talking to your prescriber most don’t know how to tapper properly, I went to a compound pharmacist trying to tapper off Pristq when I was prescribed this medication, and it didn’t go well at all. And now on Effexor with the same side effects, grogginess and blurred vision, this is not acceptable, and scared to try tappering again off this medication, it’s a shame there’s not smaller doses to do a proper tapper. The withdrawl from these awful meds is real!
My 19yo daughter became acutely suicidal on Pristiq! (When she was 16)
I'm so sorry you have to go through this. I relate to you. I really hope you get better, we all get better. It feels so tiring at times but stay strong you got this 💜
Last 6 years i a m taking ssri or snri but it's increasing my fear and anxiety I dnt knw why now I stopped and I feel better
As ADHD person i would say that noradrenaline is so overrated. I remember when i started my adhd medication and my doc asked to try higher dose and i could not tolerate that. It was like i was way too irretable, aggressive and could not focus due to adrenaline. It would be better if we would have meds that are les noradrenalinergic and more dopaminergic.
Was on 175mg Luvox for 4 months, tapered down slowly over a 6-7 week period to 100mg which I've now been on for 8 weeks. Had some great days and some not so good days...last 2 days of horrible rebound sensitivity. Is this normal at 8 weeks since decreasing?
It is not uncommon with long term use especially at higher ssri doses. Might be an indication to go slower with the incremental reductions. Morning dosing may be helpful.
On bad days, if stressed or unwell etc I sometimes offer a top up dose of 25-50mg to get through difficult days and as a respite from the sensitivity. But can slow the weaning process down.
@thePSYCHcollective thanks. I prefer to stay on 100mg for at least 4 months and then re-asess. On bad days I sometimes take 10-20mg Propronolol to combat the physical symptoms.
Makes me anxiety better
Psychologist interrupts alot! Let him complete his thoughts. Then ask your questions. Wait for your turn lady.
Psychiatric prescriber in the US here. Loved the explanation and would really appreciate an expanse on noradrenaline effect on pain. Is there more to it than just more energy leading to increased motivation and less fixation on pain?
pubmed.ncbi.nlm.nih.gov/17030082/
Can “discontinuation syndrome” or withdrawl from Venlafaxine last for months? Say theoretically someone has been on 300mg Venlafaxine for many many years and tapers correctly could the withdrawal be protracted? Literature suggests 2-6 weeks for withdrawal, but user reviews seem to be much longer. I would like to know your opinion on this?
Many thanks
It seems in some people it can last months. Slow weaning reduces the intensity of symptoms and prolongs the process.
Cold turkey can be torture.
Use at higher doses x longer durations seems to predispose to increased problems/need for slower weaning.
I’m just starting desvenlefaxine but am nervous about the brain zap that RUclipsrs talk about with weaning. I can’t find much about it.
How was it , I started it today for panic and GAD
The reality seems different than explained in this video. It seems its a paradox that SNRIs, although increasing adrenaline in the synapse, can help patients become more calm and less anxious.
That likely the serotonin effect rather that the noradrenergic effect