great video, just wanted to let you know that your mic is picking upp a high pitch ringing. You should be able to see it in a setting software and remove it
Would be interesting to look at how emotional states affect gene expression, and how gene expression runs in families... would be interesting to see how generational projection of emotional trauma in families affects what many call genetically inherited gene disorders. A study could look at identical twins adoped by different families
If you make a video about this subject that lasts a month, I would watch it. This is a great video and a subject of big interest to me. My mother is nearing 96, she ate everything, lots of sugar, and she has no disease, strong grip, can go up and down stairs or hill, and get up from the floor with ease so always hoped someone would study her. Interested? 😂
@@Physionicif I'm already a double mutant on FOXO3a snps, would that mean the gene is always active? I'm already on low carb diet and my last year's fasting insulin was 4.1uIU/mL,. Would low insulin levels have a negative effect on mutant foxo3a or would it activate it even more? Exercise didn't matter to my paternal grandfather who was obese, smoked tobacco, never exercised and laughed at people who brisked walk for exercise, but he did eat plenty of fish. He lived to 99.
The pritikin diet was basically high vegetable, high complex carbohydrate, low protein and very low fat. Not sure about calorie limitation. The focus was reduced cardiovascular disease, and it has at times been said you are as old as your arteries. At his autopsy, results reported in the NEJM, he was pretty much atherosclerosis free save for some fatty streaks in his aorta.
Very cool, will study the transcript. The whole video I was thinking about Bryan Johnson and then bingo, he appears at the end. Thrilling information. New reading subject for me, FOXO. Thanks again.
I'm an 80 year old female living on fruit...greens ...oats..and a small amount of beans a few times a week... I am.very thin and had muscle loss. I started working out...I'm gaining muscle rapidly. Still skinny...but much stronger. I can see and feel the muscle growth. I have much more strength.. I did not add more protein at any time. So...how much protein does anyone actually need I wonder.
If you send your dna for genetic analysis to any of the on-line services available, your genetic profile will be sold and available to the government or anyone who purchases that data.
Agreed. There must be open source Python code that can do the analysis locally on your machine without having to upload and share your data. Finding the FOXO3 alleles is trivial though and can be done with a text editor. ChatGPT can explain what you should look for and what the different variants imply.
@@Zuluknob c60 forms an adduct with unsaturated fatty acids. It is normally consumed in a form that is reacted with olive oil, which is mostly oleic acid. It has a number of positive effects. I don't know if telomere extension is even one of them.
So how do we interpret the raw genetic data for the FOXO3 gene? Is it just the existence of those mutations (for example rs2802292 is present) or is the genotype of that mutation (G/T/A/C) ? I am asking for a friend...
I certainly do … I call them stretchy jeans are probably going to add maybe six months to a year onto my life just by letting the my digestion system relax and flow …
ALL 4 grandparents lived to 85. One to 96 5 alcoholics quit drinking in their 50s No strokes or heartaches I'm partial to heinliens series with the longevity foundation matchmaking based on long lived grandparents
Im adding this coment to this vid because it your most recent and I wanted you to see it. Id like you to do someting on Anthony Chaffee, when I first started to watch him I thought very well off him but over time my opnion started to change. I suspect hes on the payrool of the beef councle, and any opinions no carnavor you care to make thanks MZ
Love your channel...but wondering why you eat animal products? They are not necessary for good health. You've got a big scientific brain, but your heart needs a little work. Compassion for the humane treatment of animals.
Meat is just about the most nutrient dense food one can eat. Human-beings would not be what we are today, if not for the consumption of meat that allowed our brains to grow so large. Look at so-called "Cro-Magnon" (now referred to "Anatomically Modern Humans", larger brains and larger stature than modern-day humans, and they ate almost exclusively meat (being that they lived during the Ice Age in Northern Europe). You cannot live a healthy long-life as a vegan without artificial supplementation, that should really tell you something about what we are designed to eat.
![Is forever food restriction the key to longer life? [10 Studies]](http://i.ytimg.com/vi/6DKQpfqODEg/mqdefault.jpg)
![Is forever food restriction the key to longer life? [10 Studies]](/img/tr.png)
Previous video in the series: ruclips.net/video/6DKQpfqODEg/видео.html
Next video in the series: Wednesday, 22nd
Thank you for such a great content you are creating. I would like to see a take on Dr. Steven Gundry and his 'Plant paradox' theory. Thanks!
great video, just wanted to let you know that your mic is picking upp a high pitch ringing. You should be able to see it in a setting software and remove it
Would be interesting to look at how emotional states affect gene expression, and how gene expression runs in families... would be interesting to see how generational projection of emotional trauma in families affects what many call genetically inherited gene disorders. A study could look at identical twins adoped by different families
If you make a video about this subject that lasts a month, I would watch it. This is a great video and a subject of big interest to me. My mother is nearing 96, she ate everything, lots of sugar, and she has no disease, strong grip, can go up and down stairs or hill, and get up from the floor with ease so always hoped someone would study her. Interested? 😂
It's really hard to say how valuable the content on your channel is because any word would to too less. Thank you and keep doing that amazing job.
Wow, thank you. :)
If "any word would to too less" means no words are adequate I would absolutely concur. Thanks for what you do!!!!!!
14:25 My great grandparents and grandparents lived 99-106. I'm double dominant in Foxo3a genes rs2802292, rs2764264, rs13217795
That's so cool - thanks for sharing!
@@Physionicif I'm already a double mutant on FOXO3a snps, would that mean the gene is always active? I'm already on low carb diet and my last year's fasting insulin was 4.1uIU/mL,. Would low insulin levels have a negative effect on mutant foxo3a or would it activate it even more? Exercise didn't matter to my paternal grandfather who was obese, smoked tobacco, never exercised and laughed at people who brisked walk for exercise, but he did eat plenty of fish. He lived to 99.
The pritikin diet was basically high vegetable, high complex carbohydrate, low protein and very low fat. Not sure about calorie limitation. The focus was reduced cardiovascular disease, and it has at times been said you are as old as your arteries. At his autopsy, results reported in the NEJM, he was pretty much atherosclerosis free save for some fatty streaks in his aorta.
Hi Nick I wanted to note that 20 years in jail are nothing if your lifespan is 500 years
Lol
But doctor will be in jailed not recepient
@@iraklimgeladze5223 "medice, cura te ipsum" doctor, cure yourself
20 years, what are I planning on doing tearing that tag off a pillow, or worse a mattress?
@@marknasia5293 😄
Love your content. Keep up the good work
Very cool, will study the transcript. The whole video I was thinking about Bryan Johnson and then bingo, he appears at the end. Thrilling information. New reading subject for me, FOXO. Thanks again.
Good video. Thanks, Mr. V!
Love this series
I'm glad - 3 more videos to go...
good day, can you speak about insuline resistance
I'm an 80 year old female living on fruit...greens ...oats..and a small amount of beans a few times a week... I am.very thin and had muscle loss. I started working out...I'm gaining muscle rapidly. Still skinny...but much stronger. I can see and feel the muscle growth. I have much more strength.. I did not add more protein at any time. So...how much protein does anyone actually need I wonder.
1.6 g per kg
@antoninmiquelis4420 I like eating...I don't do math while doing so.
Wait, so CRISPR isn't really working out? Just noticed I haven't heard about that in awhile.
Much thanks.
EXT1 contains the tumor supressor gene.
If you send your dna for genetic analysis to any of the on-line services available, your genetic profile will be sold and available to the government or anyone who purchases that data.
I don’t care … they’re welcome to it.
@@jp7357I don't care either😂
You might not care, but it also links to anyone in your family. Perhaps they care.@@jp7357
YOU CAN OPT OUT your genetic analysis is covered under HIPAA you have control of your own information!!!
Agreed. There must be open source Python code that can do the analysis locally on your machine without having to upload and share your data. Finding the FOXO3 alleles is trivial though and can be done with a text editor. ChatGPT can explain what you should look for and what the different variants imply.
Great video. Now, how much do these genes cost per month and how many times per day do I have to take them?
Thoughts on increased longevity due to C60 related to maintaining telomere length? 🖖😎
@@Zuluknob c60 forms an adduct with unsaturated fatty acids. It is normally consumed in a form that is reacted with olive oil, which is mostly oleic acid. It has a number of positive effects. I don't know if telomere extension is even one of them.
What about siRNA to manipulate the expression of certain proteins?
Genes are design but not destiny. How genes affect us can be changed and influenced to change outcomes.
So how do we interpret the raw genetic data for the FOXO3 gene? Is it just the existence of those mutations (for example rs2802292 is present) or is the genotype of that mutation (G/T/A/C) ? I am asking for a friend...
I have great grandparents and grandparents from both side living 99-106. I'm double dominant GG rs2802292 Foxo3a
Could you make video abou RLT / NIR ?
Is there a genie?
I certainly do … I call them stretchy jeans are probably going to add maybe six months to a year onto my life just by letting the my digestion system relax and flow …
What's the story on Retatrutide? Sounds too good to be true.
"There can be only one, may it be Earl the Highlander".
Will you make a video about the Russian scientist who inherited himself with a 3.5 million year old living virus, with of course, your thoughts?
What is your full name? I would like to read your papers.
How about sirtuin 6?
Daft Too! That seems to be a common gene.
Yeahhh good study for politicians. They could live as twice as long. :)))))
Is it worth storing a child's umbilical cord stem cells? Could they be utilised in the future for some antiageing purpose?
ALL 4 grandparents lived to 85. One to 96
5 alcoholics quit drinking in their 50s
No strokes or heartaches
I'm partial to heinliens series with the longevity foundation matchmaking based on long lived grandparents
youtube vids that create braincells are the best, always love the level headed aproach and then the illustrations as well!
Nice.
Why do you and and Andrew huberman post at the same time at the same day.
Because Andrew is jealous of me and I'm so handsome!
If I join the insiders, will you manipulate my genes?
We can give hormone suppressor to a kid, but adult can't consent changing their body?
Im adding this coment to this vid because it your most recent and I wanted you to see it. Id like you to do someting on Anthony Chaffee, when I first started to watch him I thought very well off him but over time my opnion started to change. I suspect hes on the payrool of the beef councle, and any opinions no carnavor you care to make thanks MZ
My Dad is 104, his Ilittle brother is 102. I'm betting on my gene pool.
excercise cannot extend maximum lifespan so it is overated old tech . just like sailing can cross the sea but it is obsolete.
I identify as nematode.
And you're the best nematode.
all this talk about genes, but i am more of a shorts guy
She gots worms!
Henry Kissinger?
Fox gene. 😉
Pluripotent stem cell...
Sleep ??❤
I think he is a bit nervous when he presented his content, can hear his breathing :)
I am a worm... in the bedroom (if you know what I mean)
Love your channel...but wondering why you eat animal products? They are not necessary for good health. You've got a big scientific brain, but your heart needs a little work. Compassion for the humane treatment of animals.
Meat is just about the most nutrient dense food one can eat. Human-beings would not be what we are today, if not for the consumption of meat that allowed our brains to grow so large.
Look at so-called "Cro-Magnon" (now referred to "Anatomically Modern Humans", larger brains and larger stature than modern-day humans, and they ate almost exclusively meat (being that they lived during the Ice Age in Northern Europe).
You cannot live a healthy long-life as a vegan without artificial supplementation, that should really tell you something about what we are designed to eat.