*1 AMENDMENT & 1 NOTE* NOTE: Some people seem to be under the impression (and upset) that the ratings offered are based on how these supplements impact a person in their thirties. This is incorrect. The ratings consider the totality of the evidence to date, and are not low or high because they relate less or more to someone in their thirties. I added a few personal points of why I don’t take certain supplements, but me not taking supplements has no bearing on the rating. Please listen to the video when I say the ratings are based on the evidence at hand. I say it multiple times and offer context. AMENDMENT: @7:46, I say the rating is out of '10' - that is a mistake, it should be 'out of 5' - I misspoke. My bad for the confusion! Before people ask: this is not an all encompassing list - next year I'll add to this list after I've read more research. 😄
thank you so muchhh for this insight on what suppliments help and what suppliments don't help!!! going through allthose studies that is incredible task! i'm very very grateful!!!
Your comments on Glynac are understandable. Got a stroke at 56 years old. Left side impairment/weakness. Balance problems etc. Started Glynac at 64, 1 year ago. After 10 months at 7 grams each I've seen a drastic recovery, almost complete reversal of post stroke symptoms. Another benefit is about 95% improvement of COPD. Now i walk for at least 1 hour each day which was unthinkable for me in the past 9 years. I feel much younger and stronger today. Glynac is a wonder treatment for people like me. Before this i took NMN for 6 months but did not notice any improvements.
I’m an old (octogenarian) retired scientist (hard sciences physics, mathematics, electronic engineering, computer sciences). Had an infarct in my youth (65yo) limiting me to bed/recliner cycle. Also noticed brain decline from 35yo to present, getting worse in past decade. I began research on longevity, heart regeneration, etc. NMN 500mg, Organic Extra Virgin Olive Oil, Creatine, Collagen Peptides 10-20g/day, Magnesium L-Threonate 2000mg/day (Brain), Magnesium Taurate 125mg (heart) plus some others have had a major positive impact on my life. My cardiologist of 40 years, says he is “Astounded that the heart has healed itself!”. I like your analyses. I believe you could become a great scientist. Good luck! Post Script: people say I look 60yo, I feel like I’m 50yo.
@@enalo6261 I am not a medical doctor and cannot advise anything. I can only share what I experience. I could not detect any bp lowering effect. I take it because it makes the muscle cells stronger. I was in mild heart failure. Proper exercise (with bands), MOST IMPORTANT DIET good sleep follows then…. my bp went down. My weight went from 320 lbs to 195 lbs over several years. It’s difficult but it worked for me.
I know it is off topic but my dog 14 years and healthy and fit has a genetic heart murmur which has in the last few months become worse and the vet put her on cardisure-would anyone know if magnesium Taurate could help
I'm almost 72, so I take Glycine and NAC at the recommended dosages (2 grams NAC and up to 12 grams of glycine). They are not at all expensive compared to other similar supplements (like NMN). I also take creatine, collagen, D-3, K-2, Magnesium, fish oil, L-Citrulline, Turmeric (natural form), and Taurine with other assorted supplements (not always every day on the others -- ones like Zinc, Vit A, etc -- are maybe 3 times a week). I feel healthy, workout a lot (resistance and cardio), and use a sauna regularly and red light therapy also. It is hard to say if I am getting results from the GlyNac because of all that I include in my regimen. Great video!
Just FYI I'm 63 (male) and take no supplements or medicines (though have been told I need them). Anyway, I switched to Carnivore diet (more like KETOvore, heavy on the vore) A year later, many aging symtoms were improved or gone, I was down to a more healthy weight (40# less) and long time high blood pressure was now normal.
I thought I would give my experience using NMN. I am 54 years old and in pretty good shape. At 50 I rode Lotoja, which is 207 miles in one day. Averaged 19mph. For the next 2 years I was injured and that kept me off the bike. At the beginning of 2023 I started taking NMN. In March I was riding my trainer and was achieving higher watts then the year before. Got injured. Off for a month. I started riding without NMN and forgot about taking it. I was riding terrible. Did a relay through Utah in June and I struggled. In June I almost hung up my bike. Then I remembered the NMN. Started taking it again. In July I was riding up the mountains without tiring out. My times were close to my 2019 times when I was riding 100 miles every Sunday. In August there is a tough ride we do. I counted 21 very small climbs but they are between 9-13% incline. I went from 44 minutes to 36 minutes. The only explanation is the NMN. So now I take it all the time. I take 1000mg of NMN, 1000 Rostvertol, and 500mg of TMG. Its the ProHealth Complete. I have had others take it and they all said it gave them energy. But some had digestive issues and stopped using it. I don't know about Age Reversal, but it sure seems to have helped my endurance.
I'm 62. I had very similar results in martial arts training, much of which for me consists of leg raises, kicks, high speed strikes, crunches, push-ups. The difference of taking nmn versus not is huge! Particularly regarding my leg muscles. Definitely more flexibility, more muscular endurance, much less soreness, etc.
You have to watch these endurance sports. They are damaging , as far as I read on the net. You need exercise, like a car needs to be used regularly and some higher speed driving. Parking in the garage and not using it , it will rust and fall apart and over working the car will also damage it. You need the happy medium. I don't know exactly what that happy medium is but you can figure it out, there is plenty of advice and studies on this topic.
Rather counterintuitively, my favorite part about this video is that lots of the conclusions you come to are kinda boring. Thanks for taking such a level-headed approach to relaying the info you gathered and not cherry-picking positive data for clicks. Love it!
I take glycine, and NAC. 43. Work: dusty environments. These were a game changer for.me. sleep better, increased lung capacity, running faster. Complete game changer
@@eggbenedict-gt7mw Nac cancers?? Supplementation with NAC or vitamin E AFTER the development of cancer was found to increase cancer progression and reduce survival in mouse models of both BRAF- and KRAS-induced lung cancer. This holds true for all antioxidants that suppress ROS. Nac does not cause cancer, but can support already developed cancers by suppressing ROS, particularly lung. liver or pancreatic cancers.
my early mid60s dad started taking NMN on a whim and he jokingly said he was worried he'd accidentally ordered something like cocaine that's how profound and fast the positive effects were, says he feels 10 years younger
NMN did have noticeable effect. GLYNAC had huge effects. No more inflammation in any joint or muscles. Never any after hard core gym workouts. I am 54 and not in shape. Started going to the gym after a 3 year pause.
NAC is a huge and obvious booster for lung capacity. It enlongates breathing capaticy a lot and very noticably. I'm 32 and regularly train at the gym. It actually helps getting more reps in some exercises because getting out of breath is much less of a limiting factor.
Many of those watching you, including myself, actually ARE older. So what I heard was that I probably should take several of these things. About Omega 3, I take 6 grams of Omega 3 every day - 3 when I rise and 3 when I go to bed. I don’t even take it for brain health. I take it for aches and pains. I’ve found that it drastically reduces inflammation and pain. It makes a great remedy for the muscle/joint pain which comes along with taking statins.
@@chrismyers9951There's no evidence that supplementing CoQ10 has an impact on muscle pain for users of statins. E.g., www.ncbi.nlm.nih.gov/pmc/articles/PMC9495827/
Im fairly certain GlyNac is one of the best supplements I have ever used. NMN was good but the effects reduced over time until I was getting almost no effect. GlyNac and NMN also doesn't work for me if I don't get enough sleep. I use Methylene blue, GlyNac, NAC and Tongkat Ali with creatine and I get amazing results in brain function and strength
I'm 49 and I don't even take gly/nac all the time. I take 1.2g each on and off and I can see the difference in how quickly I recover from heavy lifting as well as how quick I am in aerobic exercise. So I do think gly/nac works for me.
My current stack: Fishoil - 2gr. GlyNac - 1gr. + 1gr. Glutamin - 1gr. Curcumin - 0.75gr Palmetto - 0.6gr. VitaminD - 1500iu Half a multivitamin-pill. ... Thinking of adding both NMN and Taurine, while retirering Glutamin. I'm 58, in good shape and slender, but with a recent diagnose of psoriasis and no less than 4 stents in my heart.
@@venicebeachsurfer I was always fit and slender, but also a heavy smoker from around 16 y.o. I quit after my first massive heart attack at 48, giving me three stents. At 56 I had another, less severe attack, giving me a stent more. Doctor says, that I'm genetically inclined, and it runs in my family. Not much I can do about that. So, I'm aiming for healthspan rather than lifespan :)
41 years old here. I noticed great results from NMN, 500-1000mg per day. Daytime drowsiness disappeared, more clean energy, more desire to move and do stuff. Sadly, very expensive. Solution? Plain old flushing Niacin. Same results for $3 a month, works just as well, and I actually enjoy the flush.
I have started with Glycine + NAC a few weeks after the study was published. 40yo male, BMI borderline to obese. As you noted taking NAC is a pain in the ass, so I started encapsulating the powder in 1g pills. That made it better but it made it complicated to take. I decided to not change my routing for the first 3 months (no change in diet, no change in exercise). The first side effect I seen was that it essentially killed a chronic knee inflammation that I have been carrying for 8 years after a LCA surgery. That's said I never went over half of the dose (50mg/kg daily). I also found that my 1-hour week tennis sessions would not leave me exhaust to the level of having to take a nap after it. Fast forward 6 months I started strength training 1-hour week, I progressed as expected, but everything changed after changing the protocol to add Taurine into the mix. Including Taurine and even diminished the amount of NAC the difference was absurd. My personal trainer had to start adding weight every single session. The max weight was just not enough every 2 weeks apart (not enough time to do everything on a single week, so my rotations takes 2 weeks). I went from 25kg to 60kg in press bench in a matter of 2 months, 70kg for leg press to 130kg and so on. I first investigated Taurine because my wife wanted to take it, but doesn't tolerate well NAC, so I was looking for something that could make the amount of cysteine she already eat in food to have a larger effect. As hepatocytes would react faster to the availability of cysteine, I decided to go the Taurine route. Then I said, what if I do that with mine too? The rest is history, I haven't lose a kg, but the amount of muscle (fat/muscle ratio change) and health benefits were massive. My current protocol is: 33 mg/kg Glycine 33 mg/kg Taurine 25 mg/kg NAC Would be interesting for you to look into how those 3 may be linked together to have provided such a boost.
I take L-Citrulline along with Taurine for the nitric oxide. As we age, we produce less of it kind of like Taurine. L-Citrulline is pretty cheap; I wonder if it would extend your results even further.
NMN is of GREAT benefit for people 50 years old and beyond. Someone younger doesn't need it. I am over 60 years old. I started taking it and had incredible results. As a tennis player who competes one is always looking for an advantage. With NMN l can honestly say that l became lighter on my feet and noticeably faster along with an overall improvement in well being. It's been really amazing. I have also seen improvements in lean body mass. Others whose stories l have learned of have experienced things like healthy weight loss and gray hair turning back to it's natural color. NMN is not meant for people under 50. But for anyone 50 and beyond it's a godsend. Many times evaluators of things like NMN have other alterior motives. Anyone over 50 should try NMN themselves for 3 months and then make a decision.
I’d suggest that you may experiencing placebo effect. I’ve taken 1-2 grams of NMN for almost 2 years. I’ve seen no improvement in energy or any other claim that some make. I’m 69 and I exercise and take other supplements but I’m reducing or eliminating NMN. The hype about NMN is overblown in my view.
Since I am taking almost all of the supplements you mention, I was holding my breath to hear your recommendations based on your recent findings. However, as I am close to turning 70, I will continue to take them as it sounds like I could benefit from doing so.
One more comment about Glynac. I am hypothyroid and one thing I noticed after taking it is that for the first time in decades my thyroid function tests were coming in totally normal. I have never had them come in normal. I have an older friend who is hypothyroid and has been for decades. She takes thyroid meds unlike me. She started glynac supplementation and her thyroid tests are now coming in on the hyper side, which has never happened for her. Her doctor basically told her to decide between the glynac or her thyroid med. I know the thyroid is super sensitive to toxins and toxins can affect it's function. I know that glutathione is an excellent detoxifier. So I am wondering if glynac supplementation can correct thyroid dysfunction that is linked to environmental toxins? My best guess is that my thyroid was over burdened by environmental toxins and the glutathone helps to detox it. Or maybe glutathione levels helps boost thyroid function in other ways?
@@gabbygabbygirl I was taking 1000mgs/day but you can take up to 2000/day I think. Double check that on the internet. I think 2000 is safe though. The effects were very pronounced in the beginning but tapered off over time. I suspect that is because of the glutathione levels increased sharply at first and then tapered off. Also, if you research glutathione is critical for detox and we have depleted levels because of all the toxins in our environment, so I suspect that is why it's good for your thyroid. Your thyroid is very sensitive to toxins so improving the levels of the main molecule your body uses to detox helps the thyroid. There may be other mechanisms as well, I think it helps with thyroid inflammation too which helps it function better. Search thyroid + NAC. NAC + detox, NAC boosting glutathione etc. Hope it helps you! Also, you don't have to always take the glycine but it think it does work a little better with both. Glycine is very abundant in the diet already.
@gabbygabbygirl Sorry, you can match the doses 50/50. No more than 2000mgs of NAC daily, and you can match that with 2000mgs of glycine. I take less now, but i have taken the full dose in the past. I don't seem to need the higher doses anymore to keep my thyroid in line. This might be because my glutathione levels are higher now? Glycine can be taken in large doses, so there's no issue there, and taking more than a match dose won't affect the absorbability of the NAC. Glycine is abundant in food, so it's not required. it just helps.
NAC helps me with my Asthma especially the Mucus part. Plus, it adds Cysteine and sulfur to the body which helps to raise Glutathione. Thanks for your perspective, though.
@@sarahrosen4985 well, I had been a gym freak since the past 10 years and I would get these tremors or weird shakes on any part of my body and I showed it to many doctors who thought that it was a neurological or a spinal issue and these tremors would come out of nowhere, shake me and disappear so I never had it persistent enough to show to anyone as a proof. I came across a video of Dr. Eric Berg about Magnesium's role in that. I started with Magnesium Citrate every night and believe me, the tremors vanished. Whenever, I get those now, I know for sure that I have to take my Magnesium supplement. For my asthma, I rely on modern medicine but I also dose on Ayurvedic herbs like Adulsa, Andrographis and even Boswellia Serata for my asthma. Helps me immensely.
Just a warning, do not take GlyNac at the amounts they used in the papers if you are relatively young. I made that mistake a few years ago (I was about 36/37) when one of the main papers came out, and after a few days my body was full of bruises. Granted both Gly and Nac are blood thinners, but the issue was probably also that i already had healthy levels of those and it must have been a big overdose for my body. Once I reduced the doses the bruises went away, but eventually I stopped taking it, especially NAC. I still took 1g of glycine for a a couple of years and recently I switched to collagen which is rich in glycine anyway so no longer take it. Might be great for people that are depleted and/or have low protein diets (that's another thing, my diet is protein rich, so the amounts were even higher), but not for a healthy, young(ish), well fed person.
Thank your for the warning. I'm 36 and just getting into supplements. It's easy for me to want to rush out and take everything. Videos like this make it tempting.
Being in my 40s, GlyNAC might be the only supplement where I noticed an immediate improvement. I have more energy, metabolism is up, on a diet I lose more weight while supplementing GlyNAC. I tried a month worth of NR (should be similar to NMN) once, noticed literally nothing and it was also the most expensive supp I ever took, so I stopped.
@@planttheseed2129 NAC is from Now Foods, Glycin is a German brand I don't remember and you won't likely be able to buy anyway. I just look for 1g capsules for a good price.
@@brianwnc8168 there is study on the web where nac reduced sensecent cells , for anti aging, but later in 50% people the same cells turned cancerous, i want to take nac , bcoz here in india it's very cheap, bcoz of the study i have not bought nac, i want a clear utube video on nac and cancer
At 61 I enjoy all those supplements and quite a large Nootropic stack with constant change with time off to notice differences and integrate new research. Thanks for all your heavy lifting research sorting through the misunderstandings in statistical analysis! You're guiding those of us not steeped in a high bar of clinical research excellence for supplemental nutrition! We're navigating a world of nutritional deficiency both in the soil, food, processing and misguided lifestyles.💫 Salute ❤
Your comments on Glynac make sense because, at your age, you likely do not have a glutathione deficiency. I, however, at 73, am jumping into that pool with both feet
5:26 "Better to have a little than to have nothing. Except cyanide. I'd prefer 'nothing', when it comes to cyanide." Folks should be careful about taking B12 supplements that have Cyanocobalamin in them. The "cobalamin" part is the Cobalt, which is the real vitamin, and the "Cyano" part is the _cyanide_ which is acting as a cheap carrier. A "better" form of B12 is Methylcobalamin, but about ten percent of the population are prone to _overmethylation,_ which can cause agitation and severe mood cycles (ask me how I know...). At that point, the more expensive Adenosylcobalamin is needed.
I love your content, especially the attention to detail in assessing the quality of the studies you reference in your videos. Could we perhaps get a video on your opinions and insights on various whole food diets, and the feasibility of acquiring all required vitamins, minerals and other potentially beneficial micronutrients from whole food sources? For example there are many healthy, natural sources of collagen and creatine. How do they compare to supplementation? Or for example, I use about half a teaspoon of natural turmeric in cooking each evening, in combination with black pepper and olive or coconut oil. How does that compare to curcumin supplementation? How does total abstinence from ultra processed foods affect the gut microbiome, and how does that affect the bio-availability of nutrients from whole foods, compared to people who eat ultra-processed foods and/or rely on supplements? Those kind of questions...
@@videoagogo1been taking 500-1000mg of nicotinic acid to raise my HDL and after the first couple of days of intense flushing cos of immediate vasodilation, I feel amazing. My face always looked very young and I'm convinced I look even younger within a week. Amazing stuff but of course no one can patent it or overprice it so no one talks about it even though it was the standard doctor treatment for high LDL and high blood pressure till the early ninenties when statins were created.
I've been taking collagen for about a year now. I was just starting to wonder if it was actually worth it. Nice to hear it hasn't been a waste of money.
For collagen I buy heavy beef leg bones with lots of bone marrow and boil them at home for bone broth. You can reboil the bones as many as 7 times before getting fresh ones.
Could you do a video on Ca-AKG? I find everyone who talks about it only has positive things to say, yet I find it hard to find any concrete evidence to believe its actually worth taking.
Thank you for that summary. :) I sometimes think, an issue with studies is that average-based results is the only thing that's mostly being looked at. In quite a few cases (too many, in my opinion), a specific substance only affects specific groups of people which can't always be categorized (ie. if it's due to specific genetics required for a certain substance to work in a specific way). A study like this would not necessarily tell them that a substance they would benefit from is actually good for them. For example, for about 20 years I've been doing frequent double-blind-studies together with a few friends, just to find out what individually affects us and how. And for me personally, we found that GlyNAC does wonders. I am just 41 and we were repeatedly able to show that it helps me get out of extended phases of chronically missing motivation or of "mental inactivity". BUT this simply doesn't apply to everyone. I know people who don't benefit from GlyNAC at all, EVEN in this exact situation. So in my humble opinion, even though quite a few of those substances do benefit most people (and average-based studies shows us this), people need to individually find out what they benefit from. They may have a rare genetic detail that helps them benefit from a specific substance more than the average person. Average-based studies can't tell them everything, though they are a good starting point.
I have been taking glyNAC for autoimmune symptoms and have seen great results but I am looking to find another solution because I am starting to feel better and it is for removing the reactive species. It has also help to improved my menstrual issues, though I am also taking selenium and collagen for support for my extracellular matrix.
I stopped taking GLYNAC (which I took for over a year) due to osteoarthritis in one of my my knees and a month later it went away. Studies has shown increase of osteoarthitis taking NAC. As for glycine I also am cautions about taking this since it can increase oxalates.
Excellent explanation for those of us who like to supplement ourselves. Could you please make a video about the supposed health benefits of consuming DMSO (dimethyl sulfoxide) orally?
I've been taking MSM which is a more refined version of DMSO and I love it. Lots of new spiky hair on my head and general wellness. Just be careful and buy a reputable brand cos a lot of it comes in bulk from china and isn't pure.
Extra strength turmeric did a little for me. However I definitely had improved arthritic symptoms after taking high molecular weight hyaluronic acid 200 mg for 6-8 weeks. Introduced it to 2 others who also had same positive effect.
This came up in a different comment thread, but I thought I'd post a separate comment on it. The take-away is that when evaluating these supplements based on outcomes, it might make sense to divide them into two categories: The first (and probably most common) category would be supplements that have expected direct measurable outcomes, such as reduced insulin resistance, increased muscle-building ability, triggering autophagy or reduction of senescent cells, etc. The second category would be supplements that have the intended outcome of restoring levels of certain important substances that change with age, which could be either increasing them (e.g., NAD, glutathione) or decreasing them (e.g., oxidative stress metabolites). In this case, it's those changes that are the direct outcomes, and other outcomes are indirect results of these changes, which may or may not be noticeable in daily life or levels of health in the near term but have been shown, usually in mouse models, to have longer-term benefits for healthspan or lifespan. In the case of GlyNAC, there have been more demonstrated indirect benefits on health markers than with NMN, albeit from a limited number of studies so far. Nick is correct that these supplements don't have much value for younger folks, but should possibly not be written off for older folks. Since evaluating lifespan and healthspan is difficult and time-consuming in humans, trusting these supplements to be worth what you spend on them, even if they're considered to be safe, is inherently going to be more subjective and dependent on your assessment of the data, and possibly on your current physical condition.
Thanks for the list. Only thing I take at the moment is collagen. I might try the creatine. As far as strolls though radiation fields, if I don't keep taking them then how will I keep my youthful glow?
Fish oil is mostly consumed for cardiovascular health, in the 3g per day dosage. You should look at that versus just brain health which only the DHA fraction is important for.
Try to take them 3x1 gram each morning, noon, evening separated because they are also blood thinning. When I take multiple ones and then I might also take some other supplement that thins the blood I might get a racy heart. I don't when I spread the Omega 3 doses out and be more careful of Ginkgo, Garlic and liquorice for example.
Glycine has been great at helping me cut back on benzodiazepines……without freaking out. Was on three Benz daily but now just 1 nightly…with magnesium taurate and glycine…1,000 mg. I’m also over 60.
NAC seems to be very powerful at reducing my blood creatinine and ALP/AST blood levels, so I'm not sure if it only applies to older people (I'm 34). Maybe for other outcomes, but on biomarkers NAC (so I bet GlyNAC) seems to be good.
Thank you for your presentations. I wish I had more time to go through more of your videos. But so far you are helping me understand what I should be taking at my age.
I knew why you were going to say you don't take GlyNAC when you mentioned it at the beginning!🤣 I'm far from an expert, but just reading about what it does I figured it wouldn't be beneficial to anyone that isn't over 50 or so. I'm 55 and take it, but not in the quantities used in that study. It is kinda cheap in smaller quantities, but I'd sure like to see more studies.
You mostly give the results for people over 60 or 70 as well as younger. I am almost 73 with poor health. You forgot to mention the benefit and dosage of GlyNac for older persons. The next one you mentioned, I never heard of it before but I think the seniors were forgotten regarding any benefit for them. I'm sure I'm not the only senior who finds your channel interesting. Kindly think of us also. 😊 Thank you. ⚘️
Im using Taurine and Resveratrol, going to start with Shijalit and Fisetin aswell as Glycine and Cysteine later on, been thinking about Spermidine, Berberine, Piceatannol and well i have friend who uses Metahlyne blue but the side effects from that has thrown me a bit off trying it. Really like your vids as they are really informative and since they are based off of so many studies and even though im not here to increase muscle mass you have really good advices on nutrients that increase stem cell production.
I am 64 and soon to be 65 years of age , I just started taking GlyNac twice a Day at the dosage a Doctor recommended for my weight about a Month ago and have already started getting improvement with my joints all over but especially my right hip which would keep me up at night ( especially when cold fronts were approaching my area ) I also started with magnesium that has 7 different types, but that stuff is worse than Ambien for trying to wake up , I can sleep from 10 P.M. to 10 A.M. and still have to force myself out of bed and avoid it all together if I have to get up before 8 a.m. !
Eggshell membrane and Wobenzyme are two of the best things for your issue, so something worth looking into and trying. Also same with increasing potassium intake can have a significant affect on reducing pain. Getting a salt mix with potassium chloride can help, or just no salt and do a dash on food. Not safe to do much more than a dash with pure potassium chloride or potassium supplements, food is the only real source to increase it safely.
I am on the wrong side of 50. NMN and 1000mg does help remove age related fatigue to make me feel, umm l, late 30s. I also stack it with TMG so I don’t deplete my levels plus Creatine and O keep moderate levels of carbs in the diet. I have also substituted the NMN with Vitamin B3 with the same stack. Seems to work the same.
It would be good to know not only the dose in a study or other, but the delivery methods used. So we are assuming every study does once a day? 1500 mg once per day is not the same as 500 mg 3 times a day. What about regular capsule vs an enteric coated one, when required, when not. Or even nano or liposomal? Bioavailability and absorption. You should make a video on this.
Curious about what you think about Omega supplements now after the newer information of cardiac events. I'm 52 and I have congenital heart failure and several years ago my cardiologist told me to stay away from Omegas. Seems like he was right in saying so.
Thanks for your analysis/overviews here. I would though definitely disagree with the age at which one might consider NMN for sure. I'm turning 49 next week and can say it makes a rather large difference for me at least. When I started taking a few years ago prior to the pandemic I was riding my bike into work everyday from (Clinton Hill in Brooklyn into the Lower East side of Manhattan in NYC). I noticed a rather striking improvement within like only a couple days. That being when riding up the incline side of the Manhattan Bridge(going to work and then the opposite side coming home), my stamina was hugely improved and I felt like I would have 10 or 15 years prior. - I used to play basketball in my 20's so at that age I was more fit then nearly the entire population - I did some small amount of wieght lifting and a lot of plyometric training for hoops in my 20's - I rode my bike a lot in my 20's on up Caveat's - at the time I started NMN I still drank 1 or maybe 2 beers most days - I ate grubhib/seamless orders for dinner way too much during that time as well But's - I also ate a lot of Pasta(I'm Italian American), with a lot of Olive Oil and absolutely only use Pasta from Italy(Or my ancestors would haunt me... LOL) - I'm naturally skinny/lean I think the biggest BUT is that of human variability because anecdotally at least NMN is working amazingly for some and rather lackluster for others. The other is of course what you mentioned. We need much better trials of NMN which are not so general and more specific in age groups and a whole cohort of lifestyle variabilities IE: diet, exercise, work stress, family stress, income level stress.
I used you video on GlyNAC to start supplementing. 72 yo and supped for 6 mths. I had good results initially but ended up with very cold hands and lower legs n feet from what appeared to be constructed blood vessels. I was taking a copper supp at the time and on ceasing both I recovered a couple of months later.
I get circulation issues stemming from low thyroid, mainly Tomatoe Juice and Citrulline seem to have a big alleviating effect on it. And of course working on the thyroid itself. But Tomato products and Citrulline can be a more quick fix for it.
On curcumin, I take it mainly for it's ability to cause apoptosis, one of the things I'm most scared off is cancer. Cancer seems to be virtually unpreventable, even with good diet and healthy lifestyle people can get it Another thing I wonder about is long term effects, what's the effect compounded over like 50 years of taking a supplement? Few studies look at scales of a lifetime.
Maybe they do, they just take lifetime(s) to report. The longest study I've heard of is the Harvard study on happiness, which ran for 85 years. Take into consideration all the advancement and changes to studies themselves over that period. Does the initial data and collection methodology bear any value by today's standards?
@@NightFlight1973 Yeah, but i also mean, the NMN showing little results of improvement for younger people. But perhaps it compounds over 50 years and you end up being biologically 15 years younger by the time you reach 60. Because the effect may be immeasurable in a study of only a few months or years, but very visible in a span of decades. If that makes sense. Or rather, lets say there is a compound that completely stops aging, but has no other effect. And they do a study with 100000 25 year old's for 1 year, and the conclude it has no significant effect in 1 year because there's no statistically significant difference between healthy 25y and 26y old people.
@@zazethe6553 Unfortunately this stuff is all new science, the product studies don't really have the luxury of having had the time available even if we wanted for example, a 10yr study. And so, at age 50, do you want to wait 10 years to find out what you should have been doing 10 years ago? You kind of just have to learn as best you can and hedge your bets.
I started taking NAC in June then added glycine in August and Taurine in September. There's definitely an effect, like hgh and better sleep. However, I noticed glycine has calories which goes against my extended fasting periods. I'm generally healthy and, like multi-vitamins and speed walking (I now walk about 7mph normally as I started doing this in college), figure if I start now the effects will eventually snowball later in life. Assuming this is accurate science and not just snake oil.
@@winsonlim4586 I use NOW glycine powder 1 lb and dirt cheap It taste like sugar and dissolves easily in coffee . A level teaspoon is about 5 grams. I also use Bestvite n-acetyl cysteine also cheap (120 caps per bottle). Both from Amazon. I take 4 grams of glycine and 600 mg of nac every morning.
I tend to take more Glycine when I consume foods that contain Methionine (animal products) because it's going to counter the cancerogenic effect of that
I take a turmeric supplement to help reduce overall inflammation. I also take it as a preventative to reduce risk of dementia - I read somewhere that it was good for that. The loss of muscle with use of curcumin is concerning. Are there other supplements that help to reduce inflammation in the body?
Great. That helps. Perhaps it makes sense to split the rating for old and young...when I listen to you....and thinking of many studies. I know how hard it is for a scientist to give compressed advice, thanks for doing it. Thousands other things to say and hundred thousands that are unknown, but in the end we need advice. And we'll never know enough or test in a 'complete' way. Or as aunt sally says: I went to the forest to look for mushrooms and didn't find any. Therefore, there are no mushrooms in forests.
Regarding NMN. I think there is so much hype around it that the real benefits are getting lost. I exercise a lot, both in weight training and running. It has not helped me build muscle, but it has noticeably helped in my recovery. I continue to be much less susceptible to soft tissue injuries from running than I had in the past, and I've been pushing harder because of it. I also have noticeably more endurance. The benefits I have noticed are recovery and endurance. I'm 57 years old.
About NMN: Energy, I feel I can walk or perform many tasks non stop. And that’s on demand. I don’t have to wait for three or five days for it to start working it just works every thousand grams. People that are not active won’t harvest benefits except at a molecular level.
@@ladye2818 I doesn’t matter. I have even taken it at 18:00 and had a great sleep. Stress doesn’t let anything work optimally so I believe it is the first thind to regulate. Stress is the new smoking.
I think you need to moderate your intake of NAC. I used to take 1200mg a day combined with +/- 5gr of glycine. After a few months, I started to have quite annoying runny noses. I had my suspicions about the NAC and I stopped taking it and after a while the problem was solved. Today I'm happy with 300mg/day and everything's fine. I imagine that this can vary from one person to another? In Mr Verhoeven's list, I would add an important supplement such as glucosamine, which I've been taking since I was 37 years old - I'm now almost 62. People are often surprised when I say how old I am. I'm easily 10 years younger, and that's probably due to this supplement (which also contains chondroitin and MSM), in fact, it is credited with almost 17% improvement, all causes of death taken together.
![Anti-Aging through the ‘Power of Three’. [3 Studies]](http://i.ytimg.com/vi/FexQYKZP3ZQ/mqdefault.jpg)
![Anti-Aging through the ‘Power of Three’. [3 Studies]](/img/tr.png)
*1 AMENDMENT & 1 NOTE*
NOTE: Some people seem to be under the impression (and upset) that the ratings offered are based on how these supplements impact a person in their thirties. This is incorrect. The ratings consider the totality of the evidence to date, and are not low or high because they relate less or more to someone in their thirties. I added a few personal points of why I don’t take certain supplements, but me not taking supplements has no bearing on the rating. Please listen to the video when I say the ratings are based on the evidence at hand. I say it multiple times and offer context.
AMENDMENT: @7:46, I say the rating is out of '10' - that is a mistake, it should be 'out of 5' - I misspoke. My bad for the confusion!
Before people ask: this is not an all encompassing list - next year I'll add to this list after I've read more research. 😄
Jesus Christ, I may be dead next year. And I'm not joking, I have major problems.
Please, only one joke per video :).
I thought 2 out of 10 is a euphemism for 1 out of 5🤣🤣
There is a high pitch ringing sound that is painful for my ears in the background, same as last video
thank you so muchhh for this insight on what suppliments help and what suppliments don't help!!! going through allthose studies that is incredible task! i'm very very grateful!!!
Your comments on Glynac are understandable. Got a stroke at 56 years old. Left side impairment/weakness. Balance problems etc. Started Glynac at 64, 1 year ago. After 10 months at 7 grams each I've seen a drastic recovery, almost complete reversal of post stroke symptoms. Another benefit is about 95% improvement of COPD. Now i walk for at least 1 hour each day which was unthinkable for me in the past 9 years. I feel much younger and stronger today. Glynac is a wonder treatment for people like me. Before this i took NMN for 6 months but did not notice any improvements.
Thank you for speaking up - I'm thrilled to hear you've had improvements in symptoms!
Your work helps many like me, thank you!@@Physionic
Thank you very much for sharing your story. Which brand of NMN did you try? All best wishes ^_^
You are welcome. I used Renue by science@@Aurla-R2-D2
Did you opt for 7grams based in weight?
I’m an old (octogenarian) retired scientist (hard sciences physics, mathematics, electronic engineering, computer sciences). Had an infarct in my youth (65yo) limiting me to bed/recliner cycle. Also noticed brain decline from 35yo to present, getting worse in past decade. I began research on longevity, heart regeneration, etc. NMN 500mg, Organic Extra Virgin Olive Oil, Creatine, Collagen Peptides 10-20g/day, Magnesium L-Threonate 2000mg/day (Brain), Magnesium Taurate 125mg (heart) plus some others have had a major positive impact on my life. My cardiologist of 40 years, says he is “Astounded that the heart has healed itself!”. I like your analyses. I believe you could become a great scientist. Good luck! Post Script: people say I look 60yo, I feel like I’m 50yo.
Very interesting, thanks for sharing! 👍
@@enalo6261 I am not a medical doctor and cannot advise anything. I can only share what I experience. I could not detect any bp lowering effect. I take it because it makes the muscle cells stronger. I was in mild heart failure. Proper exercise (with bands), MOST IMPORTANT DIET good sleep follows then…. my bp went down. My weight went from 320 lbs to 195 lbs over several years. It’s difficult but it worked for me.
❤😊
I know it is off topic but my dog 14 years and healthy and fit has a genetic heart murmur which has in the last few months become worse and the vet put her on cardisure-would anyone know if magnesium Taurate could help
@@dcjohnson2208 Yes, lack of use and age rob us of many gifts. ☹️
I'm almost 72, so I take Glycine and NAC at the recommended dosages (2 grams NAC and up to 12 grams of glycine). They are not at all expensive compared to other similar supplements (like NMN). I also take creatine, collagen, D-3, K-2, Magnesium, fish oil, L-Citrulline, Turmeric (natural form), and Taurine with other assorted supplements (not always every day on the others -- ones like Zinc, Vit A, etc -- are maybe 3 times a week). I feel healthy, workout a lot (resistance and cardio), and use a sauna regularly and red light therapy also. It is hard to say if I am getting results from the GlyNac because of all that I include in my regimen. Great video!
NAC and Glycine powder is super cheap.
You missed Berberine in your list and Lions Mane mushroom.
Sounds like you are doing all the right stuff, congratulations and thanks for sharing. 👍
Just FYI
I'm 63 (male) and take no supplements or medicines (though have been told I need them).
Anyway, I switched to Carnivore diet (more like KETOvore, heavy on the vore)
A year later, many aging symtoms were improved or gone, I was down to a more healthy weight (40# less) and long time high blood pressure was now normal.
Lion’s Mane mushroom can wreak havoc on one’s hormones.
I thought I would give my experience using NMN. I am 54 years old and in pretty good shape. At 50 I rode Lotoja, which is 207 miles in one day. Averaged 19mph. For the next 2 years I was injured and that kept me off the bike. At the beginning of 2023 I started taking NMN. In March I was riding my trainer and was achieving higher watts then the year before. Got injured. Off for a month. I started riding without NMN and forgot about taking it. I was riding terrible. Did a relay through Utah in June and I struggled. In June I almost hung up my bike. Then I remembered the NMN. Started taking it again. In July I was riding up the mountains without tiring out. My times were close to my 2019 times when I was riding 100 miles every Sunday. In August there is a tough ride we do. I counted 21 very small climbs but they are between 9-13% incline. I went from 44 minutes to 36 minutes. The only explanation is the NMN. So now I take it all the time. I take 1000mg of NMN, 1000 Rostvertol, and 500mg of TMG. Its the ProHealth Complete. I have had others take it and they all said it gave them energy. But some had digestive issues and stopped using it. I don't know about Age Reversal, but it sure seems to have helped my endurance.
I'm 62. I had very similar results in martial arts training, much of which for me consists of leg raises, kicks, high speed strikes, crunches, push-ups.
The difference of taking nmn versus not is huge!
Particularly regarding my leg muscles. Definitely more flexibility, more muscular endurance, much less soreness, etc.
Brilliant job!! Could you suggest some brands,please?
Do Not Age
You have to watch these endurance sports. They are damaging , as far as I read on the net. You need exercise, like a car needs to be used regularly and some higher speed driving. Parking in the garage and not using it , it will rust and fall apart and over working the car will also damage it. You need the happy medium. I don't know exactly what that happy medium is but you can figure it out, there is plenty of advice and studies on this topic.
Rather counterintuitively, my favorite part about this video is that lots of the conclusions you come to are kinda boring. Thanks for taking such a level-headed approach to relaying the info you gathered and not cherry-picking positive data for clicks. Love it!
Good point.
I take glycine, and NAC. 43. Work: dusty environments. These were a game changer for.me. sleep better, increased lung capacity, running faster. Complete game changer
NAC is known to help clear lungs of crap.
Nobody talks about nac cancers
@@eggbenedict-gt7mw Nac cancers?? Supplementation with NAC or vitamin E AFTER the development of cancer was found to increase cancer progression and reduce survival in mouse models of both BRAF- and KRAS-induced lung cancer.
This holds true for all antioxidants that suppress ROS. Nac does not cause cancer, but can support already developed cancers by suppressing ROS, particularly lung. liver or pancreatic cancers.
@@jimb3457 so most senior citizens, will get cancer if they use nac ,
@@jimb3457 yes and people are using it for copd, study claims it reduced senescent cells , later caused cancer in 50 % people
my early mid60s dad started taking NMN on a whim and he jokingly said he was worried he'd accidentally ordered something like cocaine that's how profound and fast the positive effects were, says he feels 10 years younger
Haha, that's amazing!
Wow, that's wonderful :) Which brand is he taking? Cheers ^_^
Me too. The high doesn’t last though. But that first week was amazing.
@@stargazerbird ~ Do you take it with TMG? Cheers ^_^
My dad tried nmn + resveratrol for a month and said he felt absolutely nothing (he was above 60 at the time)
NMN did have noticeable effect. GLYNAC had huge effects. No more inflammation in any joint or muscles. Never any after hard core gym workouts. I am 54 and not in shape. Started going to the gym after a 3 year pause.
NAC is a huge and obvious booster for lung capacity. It enlongates breathing capaticy a lot and very noticably.
I'm 32 and regularly train at the gym. It actually helps getting more reps in some exercises because getting out of breath is much less of a limiting factor.
Brilliant job! Please suggest the brands,thank you.
Many of those watching you, including myself, actually ARE older. So what I heard was that I probably should take several of these things. About Omega 3, I take 6 grams of Omega 3 every day - 3 when I rise and 3 when I go to bed. I don’t even take it for brain health. I take it for aches and pains. I’ve found that it drastically reduces inflammation and pain. It makes a great remedy for the muscle/joint pain which comes along with taking statins.
If your on statins make sure you take CQ10.
@@chrismyers9951There's no evidence that supplementing CoQ10 has an impact on muscle pain for users of statins. E.g.,
www.ncbi.nlm.nih.gov/pmc/articles/PMC9495827/
Instead of taking Omega 3 , Just eat some fish
@@Gamer3172 Mercury in large fish.
@@Gamer3172
Some people don't like the taste of fish.
Im fairly certain GlyNac is one of the best supplements I have ever used. NMN was good but the effects reduced over time until I was getting almost no effect. GlyNac and NMN also doesn't work for me if I don't get enough sleep. I use Methylene blue, GlyNac, NAC and Tongkat Ali with creatine and I get amazing results in brain function and strength
What’s methylene blue for?
GlyNAC has been a complete game changer for me. I felt the effects after only a few days.
what brand and where do you source your glynac?
I'm 49 and I don't even take gly/nac all the time. I take 1.2g each on and off and I can see the difference in how quickly I recover from heavy lifting as well as how quick I am in aerobic exercise. So I do think gly/nac works for me.
Tongkat Ali / what breand please ?
As someone who takes NMN daily and walks through radiation fields. I can definitely say it works!
Why take it without hard evidence?
☢
My current stack:
Fishoil - 2gr.
GlyNac - 1gr. + 1gr.
Glutamin - 1gr.
Curcumin - 0.75gr
Palmetto - 0.6gr.
VitaminD - 1500iu
Half a multivitamin-pill.
... Thinking of adding both NMN and Taurine, while retirering Glutamin.
I'm 58, in good shape and slender, but with a recent diagnose of psoriasis and no less than 4 stents in my heart.
Glutamin forms more glutimates in the brain skip that get D from sun and butter oil
Look into vitamin K2(the MK7) version as well.
Why the stents? Were you always slender...or a smoker?
@@venicebeachsurfer I was always fit and slender, but also a heavy smoker from around 16 y.o. I quit after my first massive heart attack at 48, giving me three stents. At 56 I had another, less severe attack, giving me a stent more.
Doctor says, that I'm genetically inclined, and it runs in my family. Not much I can do about that. So, I'm aiming for healthspan rather than lifespan :)
@@ZappyOh Smoking..Shrinks blood vessels like crazy.
41 years old here. I noticed great results from NMN, 500-1000mg per day. Daytime drowsiness disappeared, more clean energy, more desire to move and do stuff. Sadly, very expensive. Solution? Plain old flushing Niacin. Same results for $3 a month, works just as well, and I actually enjoy the flush.
Bro what about liver health
@@eggbenedict-gt7mwI think that's about niacinimide not regular niacin. Look into what was used for that research.
I have started with Glycine + NAC a few weeks after the study was published. 40yo male, BMI borderline to obese. As you noted taking NAC is a pain in the ass, so I started encapsulating the powder in 1g pills. That made it better but it made it complicated to take. I decided to not change my routing for the first 3 months (no change in diet, no change in exercise). The first side effect I seen was that it essentially killed a chronic knee inflammation that I have been carrying for 8 years after a LCA surgery. That's said I never went over half of the dose (50mg/kg daily). I also found that my 1-hour week tennis sessions would not leave me exhaust to the level of having to take a nap after it. Fast forward 6 months I started strength training 1-hour week, I progressed as expected, but everything changed after changing the protocol to add Taurine into the mix.
Including Taurine and even diminished the amount of NAC the difference was absurd. My personal trainer had to start adding weight every single session. The max weight was just not enough every 2 weeks apart (not enough time to do everything on a single week, so my rotations takes 2 weeks). I went from 25kg to 60kg in press bench in a matter of 2 months, 70kg for leg press to 130kg and so on. I first investigated Taurine because my wife wanted to take it, but doesn't tolerate well NAC, so I was looking for something that could make the amount of cysteine she already eat in food to have a larger effect. As hepatocytes would react faster to the availability of cysteine, I decided to go the Taurine route. Then I said, what if I do that with mine too? The rest is history, I haven't lose a kg, but the amount of muscle (fat/muscle ratio change) and health benefits were massive.
My current protocol is:
33 mg/kg Glycine
33 mg/kg Taurine
25 mg/kg NAC
Would be interesting for you to look into how those 3 may be linked together to have provided such a boost.
Check out the channel Pottenger’s Human- he does an excellent job informing about all three supplements you listed. 🙂
NAC ...whai was amount for you?
What about liver health
@@vladislavroytapel2830 I am 90kg, therefore 2g
I take L-Citrulline along with Taurine for the nitric oxide. As we age, we produce less of it kind of like Taurine. L-Citrulline is pretty cheap; I wonder if it would extend your results even further.
NAC also helps a lot for detoxing from heavy metals in your food / environment, so that’s not age related.
It's one of the most obvious supplements with how it instantly just extends my breath at 32 years old.
@@BitZapple what do you mean?
NMN is of GREAT benefit for people 50 years old and beyond. Someone younger doesn't need it. I am over 60 years old. I started taking it and had incredible results. As a tennis player who competes one is always looking for an advantage. With NMN l can honestly say that l became lighter on my feet and noticeably faster along with an overall improvement in well being. It's been really amazing.
I have also seen improvements in lean body mass. Others whose stories l have learned of have experienced things like healthy weight loss and gray hair turning back to it's natural color.
NMN is not meant for people under 50. But for anyone 50 and beyond it's a godsend. Many times evaluators of things like NMN have other alterior motives. Anyone over 50 should try NMN themselves for 3 months and then make a decision.
What about NAD+ ? Always confused about NMN and NAD+
NMN is a pre ursor which helps your body increase the amount of NAD+ @user-uk6db3mb2f
What dosage are you taking please? Thank you for the intel :)
I'm 32 and NMN has been a gamechanger for my physical fitness and work performance.
I’d suggest that you may experiencing placebo effect. I’ve taken 1-2 grams of NMN for almost 2 years. I’ve seen no improvement in energy or any other claim that some make. I’m 69 and I exercise and take other supplements but I’m reducing or eliminating NMN. The hype about NMN is overblown in my view.
Since I am taking almost all of the supplements you mention, I was holding my breath to hear your recommendations based on your recent findings. However, as I am close to turning 70, I will continue to take them as it sounds like I could benefit from doing so.
One more comment about Glynac. I am hypothyroid and one thing I noticed after taking it is that for the first time in decades my thyroid function tests were coming in totally normal. I have never had them come in normal. I have an older friend who is hypothyroid and has been for decades. She takes thyroid meds unlike me. She started glynac supplementation and her thyroid tests are now coming in on the hyper side, which has never happened for her. Her doctor basically told her to decide between the glynac or her thyroid med. I know the thyroid is super sensitive to toxins and toxins can affect it's function. I know that glutathione is an excellent detoxifier. So I am wondering if glynac supplementation can correct thyroid dysfunction that is linked to environmental toxins? My best guess is that my thyroid was over burdened by environmental toxins and the glutathone helps to detox it. Or maybe glutathione levels helps boost thyroid function in other ways?
Hi Nick! Could you please tell me how much Glynac you took that repaired your thyroid? Thanks so much for your help! xo
@@gabbygabbygirl I was taking 1000mgs/day but you can take up to 2000/day I think. Double check that on the internet. I think 2000 is safe though. The effects were very pronounced in the beginning but tapered off over time. I suspect that is because of the glutathione levels increased sharply at first and then tapered off. Also, if you research glutathione is critical for detox and we have depleted levels because of all the toxins in our environment, so I suspect that is why it's good for your thyroid. Your thyroid is very sensitive to toxins so improving the levels of the main molecule your body uses to detox helps the thyroid. There may be other mechanisms as well, I think it helps with thyroid inflammation too which helps it function better. Search thyroid + NAC. NAC + detox, NAC boosting glutathione etc. Hope it helps you! Also, you don't have to always take the glycine but it think it does work a little better with both. Glycine is very abundant in the diet already.
@@gabbygabbygirl 1000mgs to 2000mgs per day. Now I'm on a maintenance dose and only take 600mgs every so often. I take it a lot when I am sick though.
@@nick68231 Nick, you are awesome for answering! Did you mean a thousand milligrams of glycine? And how many milligrams of NAC?
@gabbygabbygirl Sorry, you can match the doses 50/50. No more than 2000mgs of NAC daily, and you can match that with 2000mgs of glycine. I take less now, but i have taken the full dose in the past. I don't seem to need the higher doses anymore to keep my thyroid in line. This might be because my glutathione levels are higher now? Glycine can be taken in large doses, so there's no issue there, and taking more than a match dose won't affect the absorbability of the NAC. Glycine is abundant in food, so it's not required. it just helps.
NAC helps me with my Asthma especially the Mucus part.
Plus, it adds Cysteine and sulfur to the body which helps to raise Glutathione.
Thanks for your perspective, though.
How much does magnesium help? Helps (prevents) my asthma and migraines tremendously.
@@sarahrosen4985 well, I had been a gym freak since the past 10 years and I would get these tremors or weird shakes on any part of my body and I showed it to many doctors who thought that it was a neurological or a spinal issue and these tremors would come out of nowhere, shake me and disappear so I never had it persistent enough to show to anyone as a proof.
I came across a video of Dr. Eric Berg about Magnesium's role in that.
I started with Magnesium Citrate every night and believe me, the tremors vanished.
Whenever, I get those now, I know for sure that I have to take my Magnesium supplement.
For my asthma, I rely on modern medicine but I also dose on Ayurvedic herbs like Adulsa, Andrographis and even Boswellia Serata for my asthma.
Helps me immensely.
I’ll pass this on. Thx
@@jmc8076 nobody asked you to pass or hold on to it. This is a community to share our experiences. Keep your rant to yourself 🙏🏻
@@sarahrosen4985magnesium doesn't help astahama, and nac worsens asthama that's the side effects written on it
Great review! How about TMG?
Just a warning, do not take GlyNac at the amounts they used in the papers if you are relatively young. I made that mistake a few years ago (I was about 36/37) when one of the main papers came out, and after a few days my body was full of bruises. Granted both Gly and Nac are blood thinners, but the issue was probably also that i already had healthy levels of those and it must have been a big overdose for my body. Once I reduced the doses the bruises went away, but eventually I stopped taking it, especially NAC. I still took 1g of glycine for a a couple of years and recently I switched to collagen which is rich in glycine anyway so no longer take it. Might be great for people that are depleted and/or have low protein diets (that's another thing, my diet is protein rich, so the amounts were even higher), but not for a healthy, young(ish), well fed person.
Thank your for the warning. I'm 36 and just getting into supplements. It's easy for me to want to rush out and take everything. Videos like this make it tempting.
@@aubreyelf87i am also new to supplementation,
It's very difficult to eat a protein deficient diet if you are eating a normal amount of any food every day.
Nattokinase, Astaxanthin and Kurkuma for Spike Protein protection 🕵️♀️
Turmeric
Nice bicep flex my dude.
You're the most buff nerd I know and I absolutely love it!
needs to hit his shoulders more. Unless he flexes - he looks weak.
@@albertcamus5970omg are you serious? What a shitty thing to say.
Being in my 40s, GlyNAC might be the only supplement where I noticed an immediate improvement. I have more energy, metabolism is up, on a diet I lose more weight while supplementing GlyNAC. I tried a month worth of NR (should be similar to NMN) once, noticed literally nothing and it was also the most expensive supp I ever took, so I stopped.
What brand do you consume? Could you share?
@@planttheseed2129 NAC is from Now Foods, Glycin is a German brand I don't remember and you won't likely be able to buy anyway. I just look for 1g capsules for a good price.
What about cancer and nac nobody talks about it
@@eggbenedict-gt7mwwhat about in NAC and cancer?
@@brianwnc8168 there is study on the web where nac reduced sensecent cells , for anti aging, but later in 50% people the same cells turned cancerous, i want to take nac , bcoz here in india it's very cheap, bcoz of the study i have not bought nac, i want a clear utube video on nac and cancer
Please do more ranking lists like this one with more supplements!
Can you take a look at sulphorafane? I get it from broccoli sprouts.
I'm impressed with Taurine 😀
At 61 I enjoy all those supplements and quite a large Nootropic stack with constant change with time off to notice differences and integrate new research. Thanks for all your heavy lifting research sorting through the misunderstandings in statistical analysis! You're guiding those of us not steeped in a high bar of clinical research excellence for supplemental nutrition! We're navigating a world of nutritional deficiency both in the soil, food, processing and misguided lifestyles.💫 Salute ❤
I mostly take Berberine, Fish Oil and Multivitamins, mostly.
Remember never take berberine with antibiotics it's deadly. Most people don't know this.
Your comments on Glynac make sense because, at your age, you likely do not have a glutathione deficiency. I, however, at 73, am jumping into that pool with both feet
There are a lot of people that have the MTHFR genetic polymorphism, so age doesn't matter.
5:26 "Better to have a little than to have nothing. Except cyanide. I'd prefer 'nothing', when it comes to cyanide."
Folks should be careful about taking B12 supplements that have Cyanocobalamin in them. The "cobalamin" part is the Cobalt, which is the real vitamin, and the "Cyano" part is the _cyanide_ which is acting as a cheap carrier. A "better" form of B12 is Methylcobalamin, but about ten percent of the population are prone to _overmethylation,_ which can cause agitation and severe mood cycles (ask me how I know...). At that point, the more expensive Adenosylcobalamin is needed.
Yes I have to use the adenosyl/hydroxy mix as well
My experience with Gly/NAC at 68. I lost 3-4 inches of my waist without changing my current decent diet and exercise profile.
I love your content, especially the attention to detail in assessing the quality of the studies you reference in your videos. Could we perhaps get a video on your opinions and insights on various whole food diets, and the feasibility of acquiring all required vitamins, minerals and other potentially beneficial micronutrients from whole food sources? For example there are many healthy, natural sources of collagen and creatine. How do they compare to supplementation? Or for example, I use about half a teaspoon of natural turmeric in cooking each evening, in combination with black pepper and olive or coconut oil. How does that compare to curcumin supplementation? How does total abstinence from ultra processed foods affect the gut microbiome, and how does that affect the bio-availability of nutrients from whole foods, compared to people who eat ultra-processed foods and/or rely on supplements? Those kind of questions...
Love your attention to detail. Great work. Please add chapters so when i come back later I can go right to a specific area. TY
Thanks, L2S. I'd like to add chapters to these shorter videos, but they hurt the video performance, unfortunately. I've tested it many times.
NMN is also very expensive a cheaper alternative is Nicotinamide (B3), which is the precursor to NAD+, or acts higher up in the process.
Niacin (Nictotinic Acid) is 'better' in that regard and unlikely to inhibit Sirtuin generation
@@videoagogo1been taking 500-1000mg of nicotinic acid to raise my HDL and after the first couple of days of intense flushing cos of immediate vasodilation, I feel amazing. My face always looked very young and I'm convinced I look even younger within a week. Amazing stuff but of course no one can patent it or overprice it so no one talks about it even though it was the standard doctor treatment for high LDL and high blood pressure till the early ninenties when statins were created.
Niacinamide bro
They raise TMAO significantly so can give people heart issues, a warning.
Do you have a video on antioxidants and muscle growth because both are important! How do you use both and maximize their benefits?
Thanks so much for this! Can you recommend a brand of creatine?
This fellow knows what he's talking about, he's 97 but looks as though he's barely out of his teens! I hope I look like that when I'm his age.
😂
I've been taking collagen for about a year now. I was just starting to wonder if it was actually worth it. Nice to hear it hasn't been a waste of money.
Do you take vitamin C with your collagen?
@@lpg12338 would that be the right way to take?
For collagen I buy heavy beef leg bones with lots of bone marrow and boil them at home for bone broth.
You can reboil the bones as many as 7 times before getting fresh ones.
Awesome I'll keep taking all of those since I'm 55 and not in great health. You totally convinced me to keep taking them all!
Could you do a video on Ca-AKG? I find everyone who talks about it only has positive things to say, yet I find it hard to find any concrete evidence to believe its actually worth taking.
Thank you for that summary. :) I sometimes think, an issue with studies is that average-based results is the only thing that's mostly being looked at. In quite a few cases (too many, in my opinion), a specific substance only affects specific groups of people which can't always be categorized (ie. if it's due to specific genetics required for a certain substance to work in a specific way). A study like this would not necessarily tell them that a substance they would benefit from is actually good for them. For example, for about 20 years I've been doing frequent double-blind-studies together with a few friends, just to find out what individually affects us and how. And for me personally, we found that GlyNAC does wonders. I am just 41 and we were repeatedly able to show that it helps me get out of extended phases of chronically missing motivation or of "mental inactivity". BUT this simply doesn't apply to everyone. I know people who don't benefit from GlyNAC at all, EVEN in this exact situation. So in my humble opinion, even though quite a few of those substances do benefit most people (and average-based studies shows us this), people need to individually find out what they benefit from. They may have a rare genetic detail that helps them benefit from a specific substance more than the average person. Average-based studies can't tell them everything, though they are a good starting point.
I have been taking glyNAC for autoimmune symptoms and have seen great results but I am looking to find another solution because I am starting to feel better and it is for removing the reactive species. It has also help to improved my menstrual issues, though I am also taking selenium and collagen for support for my extracellular matrix.
I use Curcumin every Meals,2Meal a day 18 hours fasting every day.
I stopped taking GLYNAC (which I took for over a year) due to osteoarthritis in one of my my knees and a month later it went away. Studies has shown increase of osteoarthitis taking NAC. As for glycine I also am cautions about taking this since it can increase oxalates.
What do you think about Berberine for a 50 year old with high cholesterol who takes 20mg simvastatin daily?
Do they work well together?
Good day to you, Nicholas. What are your thoughts or knowledge on creatine monohydrate versus creatine HCL?
Another amazing vídeo, thanks for that. I wonder if you have done any analysis on Berberine to reduce glycose levels. Thanks
Excellent explanation for those of us who like to supplement ourselves. Could you please make a video about the supposed health benefits of consuming DMSO (dimethyl sulfoxide) orally?
I've been taking MSM which is a more refined version of DMSO and I love it. Lots of new spiky hair on my head and general wellness. Just be careful and buy a reputable brand cos a lot of it comes in bulk from china and isn't pure.
Be careful with DMSO I'd only orally ingest if my life were horrible already with nothing to lose.
Curcumin is an excellent anti-inflammatory and helped my husband's thumb arthritis a lot
Extra strength turmeric did a little for me. However I definitely had improved arthritic symptoms after taking high molecular weight hyaluronic acid 200 mg for 6-8 weeks. Introduced it to 2 others who also had same positive effect.
Great information as always.
How about berberine, and TMG, and blue methyline?
This came up in a different comment thread, but I thought I'd post a separate comment on it. The take-away is that when evaluating these supplements based on outcomes, it might make sense to divide them into two categories: The first (and probably most common) category would be supplements that have expected direct measurable outcomes, such as reduced insulin resistance, increased muscle-building ability, triggering autophagy or reduction of senescent cells, etc. The second category would be supplements that have the intended outcome of restoring levels of certain important substances that change with age, which could be either increasing them (e.g., NAD, glutathione) or decreasing them (e.g., oxidative stress metabolites). In this case, it's those changes that are the direct outcomes, and other outcomes are indirect results of these changes, which may or may not be noticeable in daily life or levels of health in the near term but have been shown, usually in mouse models, to have longer-term benefits for healthspan or lifespan. In the case of GlyNAC, there have been more demonstrated indirect benefits on health markers than with NMN, albeit from a limited number of studies so far. Nick is correct that these supplements don't have much value for younger folks, but should possibly not be written off for older folks. Since evaluating lifespan and healthspan is difficult and time-consuming in humans, trusting these supplements to be worth what you spend on them, even if they're considered to be safe, is inherently going to be more subjective and dependent on your assessment of the data, and possibly on your current physical condition.
I really like this suggestion. Wonderful idea. Thank you.
Much thanks for the regular updates.
Watch out for the mood flattening of NAC
I love this channel because when I get over hyped about supplements and other stuff, he brings me right back down to Ground Zero where I need to be..
Thanks Ryan :)
Excellent and unbiased,no promotion agenda, the score assigned for each molecule is very neutral. Keep it up 💪 💯
Already looking forward to your collagen deep dive. I am hoping for content on bone density, osteoarthritis and gut health
Thanks for the list. Only thing I take at the moment is collagen. I might try the creatine. As far as strolls though radiation fields, if I don't keep taking them then how will I keep my youthful glow?
Curcumin is also good for joint health, as it helps protect the chondrocytes in cartilage.
Taking 20 g of collagen before sleep helps my insomnia because of glycine in it. Interestingly it might work even better than melatonin for me.
Fish oil is mostly consumed for cardiovascular health, in the 3g per day dosage. You should look at that versus just brain health which only the DHA fraction is important for.
Try to take them 3x1 gram each morning, noon, evening separated because they are also blood thinning. When I take multiple ones and then I might also take some other supplement that thins the blood I might get a racy heart. I don't when I spread the Omega 3 doses out and be more careful of Ginkgo, Garlic and liquorice for example.
Surprised that you didn't speak on Resveratrol, CA AKG, Hyaluronic Acid, TMG and Berberine.
My stack: NMN (Energy), MSM (anti-inflammatory), creatine, whey protein, Vit: (K2, Magnesium glycinate, D3). Sucks getting old 😬
Please keep us updated if you come across any new studies on Taurine 🤔
Great summary Nick, appreciate your work.
Thanks, Rich!
Glycine has been great at helping me cut back on benzodiazepines……without freaking out. Was on three Benz daily but now just 1 nightly…with magnesium taurate and glycine…1,000 mg. I’m also over 60.
It helped me come off valium 😊 it's great nervous system support
What kind of doctor should i consult if im interested to take meds like these?
NMN for energy. All day no energy lag. It’s amazing.
NAC seems to be very powerful at reducing my blood creatinine and ALP/AST blood levels, so I'm not sure if it only applies to older people (I'm 34). Maybe for other outcomes, but on biomarkers NAC (so I bet GlyNAC) seems to be good.
Thank you for your presentations. I wish I had more time to go through more of your videos. But so far you are helping me understand what I should be taking at my age.
Is there any point to creatine supplementation while on the ketogenic diet?
Yes
I knew why you were going to say you don't take GlyNAC when you mentioned it at the beginning!🤣
I'm far from an expert, but just reading about what it does I figured it wouldn't be beneficial to anyone that isn't over 50 or so.
I'm 55 and take it, but not in the quantities used in that study. It is kinda cheap in smaller quantities, but I'd sure like to see more studies.
There's a study showing NAC is good to neutralize spike protein.
Damn, nice muscles! Thanks for wading through all the data. Can you sometimes do videos for older people?
You mostly give the results for people over 60 or 70 as well as younger. I am almost 73 with poor health. You forgot to mention the benefit and dosage of GlyNac for older persons. The next one you mentioned, I never heard of it before but I think the seniors were forgotten regarding any benefit for them.
I'm sure I'm not the only senior who finds your channel interesting. Kindly think of us also. 😊
Thank you. ⚘️
Im using Taurine and Resveratrol, going to start with Shijalit and Fisetin aswell as Glycine and Cysteine later on, been thinking about Spermidine, Berberine, Piceatannol and well i have friend who uses Metahlyne blue but the side effects from that has thrown me a bit off trying it.
Really like your vids as they are really informative and since they are based off of so many studies and even though im not here to increase muscle mass you have really good advices on nutrients that increase stem cell production.
I am 64 and soon to be 65 years of age , I just started taking GlyNac twice a Day at the dosage a Doctor recommended for my weight about a Month ago and have already started getting improvement with my joints all over but especially my right hip which would keep me up at night ( especially when cold fronts were approaching my area ) I also started with magnesium that has 7 different types, but that stuff is worse than Ambien for trying to wake up , I can sleep from 10 P.M. to 10 A.M. and still have to force myself out of bed and avoid it all together if I have to get up before 8 a.m. !
Eggshell membrane and Wobenzyme are two of the best things for your issue, so something worth looking into and trying. Also same with increasing potassium intake can have a significant affect on reducing pain. Getting a salt mix with potassium chloride can help, or just no salt and do a dash on food. Not safe to do much more than a dash with pure potassium chloride or potassium supplements, food is the only real source to increase it safely.
I am on the wrong side of 50. NMN and 1000mg does help remove age related fatigue to make me feel, umm l, late 30s. I also stack it with TMG so I don’t deplete my levels plus Creatine and O keep moderate levels of carbs in the diet. I have also substituted the NMN with Vitamin B3 with the same stack. Seems to work the same.
You take both NMN & TMG pills together? Empty stomach first thing in the morning, pre-workout, or with food?
Many thanks for this video!
It would be good to know not only the dose in a study or other, but the delivery methods used. So we are assuming every study does once a day? 1500 mg once per day is not the same as 500 mg 3 times a day. What about regular capsule vs an enteric coated one, when required, when not. Or even nano or liposomal? Bioavailability and absorption. You should make a video on this.
How about Quercetin?
I consume 600mg per day of NAC and I feel my exercise recovery time is improved. I am 60 years old and enjoy weight training daily.
Curious about what you think about Omega supplements now after the newer information of cardiac events.
I'm 52 and I have congenital heart failure and several years ago my cardiologist told me to stay away from Omegas. Seems like he was right in saying so.
Thanks for your analysis/overviews here. I would though definitely disagree with the age at which one might consider NMN for sure. I'm turning 49 next week and can say it makes a rather large difference for me at least. When I started taking a few years ago prior to the pandemic I was riding my bike into work everyday from (Clinton Hill in Brooklyn into the Lower East side of Manhattan in NYC). I noticed a rather striking improvement within like only a couple days. That being when riding up the incline side of the Manhattan Bridge(going to work and then the opposite side coming home), my stamina was hugely improved and I felt like I would have 10 or 15 years prior.
- I used to play basketball in my 20's so at that age I was more fit then nearly the entire population
- I did some small amount of wieght lifting and a lot of plyometric training for hoops in my 20's
- I rode my bike a lot in my 20's on up
Caveat's
- at the time I started NMN I still drank 1 or maybe 2 beers most days
- I ate grubhib/seamless orders for dinner way too much during that time as well
But's
- I also ate a lot of Pasta(I'm Italian American), with a lot of Olive Oil and absolutely only use Pasta from Italy(Or my ancestors would haunt me... LOL)
- I'm naturally skinny/lean
I think the biggest BUT is that of human variability because anecdotally at least NMN is working amazingly for some and rather lackluster for others.
The other is of course what you mentioned. We need much better trials of NMN which are not so general and more specific in age groups and a whole cohort of lifestyle variabilities IE: diet, exercise, work stress, family stress, income level stress.
Totally fair. I'm just guesstimating.
No worries, and I do appreciate you diving into these things. Still early days for some of these supplements @@Physionic
Can people with elevated uric acid take creatine ? Is there any studies on this ?
I used you video on GlyNAC to start supplementing. 72 yo and supped for 6 mths. I had good results initially but ended up with very cold hands and lower legs n feet from what appeared to be constructed blood vessels.
I was taking a copper supp at the time and on ceasing both I recovered a couple of months later.
B-Vitamins, Iron, B12, folate for blood mass and Citrulline, Glycerol, Taurine, Ginkgo for circulation.
I get circulation issues stemming from low thyroid, mainly Tomatoe Juice and Citrulline seem to have a big alleviating effect on it.
And of course working on the thyroid itself. But Tomato products and Citrulline can be a more quick fix for it.
Was looking down taking notes when you mentioned nmn, I thought you said m&ms..had me going there for a minute.😆
I’ve had good results with M&Ms 😋
On curcumin, I take it mainly for it's ability to cause apoptosis, one of the things I'm most scared off is cancer. Cancer seems to be virtually unpreventable, even with good diet and healthy lifestyle people can get it
Another thing I wonder about is long term effects, what's the effect compounded over like 50 years of taking a supplement? Few studies look at scales of a lifetime.
Maybe they do, they just take lifetime(s) to report. The longest study I've heard of is the Harvard study on happiness, which ran for 85 years. Take into consideration all the advancement and changes to studies themselves over that period. Does the initial data and collection methodology bear any value by today's standards?
@@NightFlight1973 Yeah, but i also mean, the NMN showing little results of improvement for younger people. But perhaps it compounds over 50 years and you end up being biologically 15 years younger by the time you reach 60. Because the effect may be immeasurable in a study of only a few months or years, but very visible in a span of decades. If that makes sense.
Or rather, lets say there is a compound that completely stops aging, but has no other effect. And they do a study with 100000 25 year old's for 1 year, and the conclude it has no significant effect in 1 year because there's no statistically significant difference between healthy 25y and 26y old people.
@@zazethe6553 Unfortunately this stuff is all new science, the product studies don't really have the luxury of having had the time available even if we wanted for example, a 10yr study. And so, at age 50, do you want to wait 10 years to find out what you should have been doing 10 years ago? You kind of just have to learn as best you can and hedge your bets.
What about taurine?
I consume collagen powder and it works for the skin for sure.
im on glynac 500+500mg, omega fish oil, asthaxanthin, and 500mg of taurine. works pretty good
I started taking NAC in June then added glycine in August and Taurine in September. There's definitely an effect, like hgh and better sleep. However, I noticed glycine has calories which goes against my extended fasting periods. I'm generally healthy and, like multi-vitamins and speed walking (I now walk about 7mph normally as I started doing this in college), figure if I start now the effects will eventually snowball later in life. Assuming this is accurate science and not just snake oil.
is it the same if i get a glycine and nac supplement separate or should i buy a glynac supplement?
@@winsonlim4586 I use NOW glycine powder 1 lb and dirt cheap It taste like sugar and dissolves easily in coffee . A level teaspoon is about 5 grams. I also use Bestvite n-acetyl cysteine also cheap (120 caps per bottle). Both from Amazon. I take 4 grams of glycine and 600 mg of nac every morning.
@@winsonlim4586
I do separate.
3 glycine to 1 nac
Glycine is the limiting factor for glutathione production.
I tend to take more Glycine when I consume foods that contain Methionine (animal products) because it's going to counter the cancerogenic effect of that
Good stuff man, thank you for the videos and the info, it's been very useful.
I take a turmeric supplement to help reduce overall inflammation. I also take it as a preventative to reduce risk of dementia - I read somewhere that it was good for that.
The loss of muscle with use of curcumin is concerning. Are there other supplements that help to reduce inflammation in the body?
Useless i am indian don't take that crap
Great. That helps. Perhaps it makes sense to split the rating for old and young...when I listen to you....and thinking of many studies. I know how hard it is for a scientist to give compressed advice, thanks for doing it. Thousands other things to say and hundred thousands that are unknown, but in the end we need advice. And we'll never know enough or test in a 'complete' way. Or as aunt sally says: I went to the forest to look for mushrooms and didn't find any. Therefore, there are no mushrooms in forests.
Regarding NMN. I think there is so much hype around it that the real benefits are getting lost. I exercise a lot, both in weight training and running. It has not helped me build muscle, but it has noticeably helped in my recovery. I continue to be much less susceptible to soft tissue injuries from running than I had in the past, and I've been pushing harder because of it. I also have noticeably more endurance. The benefits I have noticed are recovery and endurance. I'm 57 years old.
About NMN:
Energy, I feel I can walk or perform many tasks non stop. And that’s on demand. I don’t have to wait for three or five days for it to start working it just works every thousand grams. People that are not active won’t harvest benefits except at a molecular level.
First thing in the morning on an empty stomach, pre-workout, or with food?
@@ladye2818 I doesn’t matter. I have even taken it at 18:00 and had a great sleep. Stress doesn’t let anything work optimally so I believe it is the first thind to regulate. Stress is the new smoking.
You are a sweet, funny nerd. Thank you for your info.
I think you need to moderate your intake of NAC. I used to take 1200mg a day combined with +/- 5gr of glycine. After a few months, I started to have quite annoying runny noses. I had my suspicions about the NAC and I stopped taking it and after a while the problem was solved. Today I'm happy with 300mg/day and everything's fine. I imagine that this can vary from one person to another? In Mr Verhoeven's list, I would add an important supplement such as glucosamine, which I've been taking since I was 37 years old - I'm now almost 62. People are often surprised when I say how old I am. I'm easily 10 years younger, and that's probably due to this supplement (which also contains chondroitin and MSM), in fact, it is credited with almost 17% improvement, all causes of death taken together.