*1 AMENDMENT & 1 NOTE* NOTE: Some people seem to be under the impression (and upset) that the ratings offered are based on how these supplements impact a person in their thirties. This is incorrect. The ratings consider the totality of the evidence to date, and are not low or high because they relate less or more to someone in their thirties. I added a few personal points of why I don’t take certain supplements, but me not taking supplements has no bearing on the rating. Please listen to the video when I say the ratings are based on the evidence at hand. I say it multiple times and offer context. AMENDMENT: @7:46, I say the rating is out of '10' - that is a mistake, it should be 'out of 5' - I misspoke. My bad for the confusion! Before people ask: this is not an all encompassing list - next year I'll add to this list after I've read more research. 😄
thank you so muchhh for this insight on what suppliments help and what suppliments don't help!!! going through allthose studies that is incredible task! i'm very very grateful!!!
Your comments on Glynac are understandable. Got a stroke at 56 years old. Left side impairment/weakness. Balance problems etc. Started Glynac at 64, 1 year ago. After 10 months at 7 grams each I've seen a drastic recovery, almost complete reversal of post stroke symptoms. Another benefit is about 95% improvement of COPD. Now i walk for at least 1 hour each day which was unthinkable for me in the past 9 years. I feel much younger and stronger today. Glynac is a wonder treatment for people like me. Before this i took NMN for 6 months but did not notice any improvements.
I’m an old (octogenarian) retired scientist (hard sciences physics, mathematics, electronic engineering, computer sciences). Had an infarct in my youth (65yo) limiting me to bed/recliner cycle. Also noticed brain decline from 35yo to present, getting worse in past decade. I began research on longevity, heart regeneration, etc. NMN 500mg, Organic Extra Virgin Olive Oil, Creatine, Collagen Peptides 10-20g/day, Magnesium L-Threonate 2000mg/day (Brain), Magnesium Taurate 125mg (heart) plus some others have had a major positive impact on my life. My cardiologist of 40 years, says he is “Astounded that the heart has healed itself!”. I like your analyses. I believe you could become a great scientist. Good luck! Post Script: people say I look 60yo, I feel like I’m 50yo.
@@enalo6261 I am not a medical doctor and cannot advise anything. I can only share what I experience. I could not detect any bp lowering effect. I take it because it makes the muscle cells stronger. I was in mild heart failure. Proper exercise (with bands), MOST IMPORTANT DIET good sleep follows then…. my bp went down. My weight went from 320 lbs to 195 lbs over several years. It’s difficult but it worked for me.
I know it is off topic but my dog 14 years and healthy and fit has a genetic heart murmur which has in the last few months become worse and the vet put her on cardisure-would anyone know if magnesium Taurate could help
I'm almost 72, so I take Glycine and NAC at the recommended dosages (2 grams NAC and up to 12 grams of glycine). They are not at all expensive compared to other similar supplements (like NMN). I also take creatine, collagen, D-3, K-2, Magnesium, fish oil, L-Citrulline, Turmeric (natural form), and Taurine with other assorted supplements (not always every day on the others -- ones like Zinc, Vit A, etc -- are maybe 3 times a week). I feel healthy, workout a lot (resistance and cardio), and use a sauna regularly and red light therapy also. It is hard to say if I am getting results from the GlyNac because of all that I include in my regimen. Great video!
Just FYI I'm 63 (male) and take no supplements or medicines (though have been told I need them). Anyway, I switched to Carnivore diet (more like KETOvore, heavy on the vore) A year later, many aging symtoms were improved or gone, I was down to a more healthy weight (40# less) and long time high blood pressure was now normal.
Rather counterintuitively, my favorite part about this video is that lots of the conclusions you come to are kinda boring. Thanks for taking such a level-headed approach to relaying the info you gathered and not cherry-picking positive data for clicks. Love it!
I thought I would give my experience using NMN. I am 54 years old and in pretty good shape. At 50 I rode Lotoja, which is 207 miles in one day. Averaged 19mph. For the next 2 years I was injured and that kept me off the bike. At the beginning of 2023 I started taking NMN. In March I was riding my trainer and was achieving higher watts then the year before. Got injured. Off for a month. I started riding without NMN and forgot about taking it. I was riding terrible. Did a relay through Utah in June and I struggled. In June I almost hung up my bike. Then I remembered the NMN. Started taking it again. In July I was riding up the mountains without tiring out. My times were close to my 2019 times when I was riding 100 miles every Sunday. In August there is a tough ride we do. I counted 21 very small climbs but they are between 9-13% incline. I went from 44 minutes to 36 minutes. The only explanation is the NMN. So now I take it all the time. I take 1000mg of NMN, 1000 Rostvertol, and 500mg of TMG. Its the ProHealth Complete. I have had others take it and they all said it gave them energy. But some had digestive issues and stopped using it. I don't know about Age Reversal, but it sure seems to have helped my endurance.
I'm 62. I had very similar results in martial arts training, much of which for me consists of leg raises, kicks, high speed strikes, crunches, push-ups. The difference of taking nmn versus not is huge! Particularly regarding my leg muscles. Definitely more flexibility, more muscular endurance, much less soreness, etc.
You have to watch these endurance sports. They are damaging , as far as I read on the net. You need exercise, like a car needs to be used regularly and some higher speed driving. Parking in the garage and not using it , it will rust and fall apart and over working the car will also damage it. You need the happy medium. I don't know exactly what that happy medium is but you can figure it out, there is plenty of advice and studies on this topic.
NMN did have noticeable effect. GLYNAC had huge effects. No more inflammation in any joint or muscles. Never any after hard core gym workouts. I am 54 and not in shape. Started going to the gym after a 3 year pause.
NAC is a huge and obvious booster for lung capacity. It enlongates breathing capaticy a lot and very noticably. I'm 32 and regularly train at the gym. It actually helps getting more reps in some exercises because getting out of breath is much less of a limiting factor.
my early mid60s dad started taking NMN on a whim and he jokingly said he was worried he'd accidentally ordered something like cocaine that's how profound and fast the positive effects were, says he feels 10 years younger
I take glycine, and NAC. 43. Work: dusty environments. These were a game changer for.me. sleep better, increased lung capacity, running faster. Complete game changer
@@eggbenedict-gt7mw Nac cancers?? Supplementation with NAC or vitamin E AFTER the development of cancer was found to increase cancer progression and reduce survival in mouse models of both BRAF- and KRAS-induced lung cancer. This holds true for all antioxidants that suppress ROS. Nac does not cause cancer, but can support already developed cancers by suppressing ROS, particularly lung. liver or pancreatic cancers.
One more comment about Glynac. I am hypothyroid and one thing I noticed after taking it is that for the first time in decades my thyroid function tests were coming in totally normal. I have never had them come in normal. I have an older friend who is hypothyroid and has been for decades. She takes thyroid meds unlike me. She started glynac supplementation and her thyroid tests are now coming in on the hyper side, which has never happened for her. Her doctor basically told her to decide between the glynac or her thyroid med. I know the thyroid is super sensitive to toxins and toxins can affect it's function. I know that glutathione is an excellent detoxifier. So I am wondering if glynac supplementation can correct thyroid dysfunction that is linked to environmental toxins? My best guess is that my thyroid was over burdened by environmental toxins and the glutathone helps to detox it. Or maybe glutathione levels helps boost thyroid function in other ways?
@@gabbygabbygirl I was taking 1000mgs/day but you can take up to 2000/day I think. Double check that on the internet. I think 2000 is safe though. The effects were very pronounced in the beginning but tapered off over time. I suspect that is because of the glutathione levels increased sharply at first and then tapered off. Also, if you research glutathione is critical for detox and we have depleted levels because of all the toxins in our environment, so I suspect that is why it's good for your thyroid. Your thyroid is very sensitive to toxins so improving the levels of the main molecule your body uses to detox helps the thyroid. There may be other mechanisms as well, I think it helps with thyroid inflammation too which helps it function better. Search thyroid + NAC. NAC + detox, NAC boosting glutathione etc. Hope it helps you! Also, you don't have to always take the glycine but it think it does work a little better with both. Glycine is very abundant in the diet already.
@gabbygabbygirl Sorry, you can match the doses 50/50. No more than 2000mgs of NAC daily, and you can match that with 2000mgs of glycine. I take less now, but i have taken the full dose in the past. I don't seem to need the higher doses anymore to keep my thyroid in line. This might be because my glutathione levels are higher now? Glycine can be taken in large doses, so there's no issue there, and taking more than a match dose won't affect the absorbability of the NAC. Glycine is abundant in food, so it's not required. it just helps.
Im fairly certain GlyNac is one of the best supplements I have ever used. NMN was good but the effects reduced over time until I was getting almost no effect. GlyNac and NMN also doesn't work for me if I don't get enough sleep. I use Methylene blue, GlyNac, NAC and Tongkat Ali with creatine and I get amazing results in brain function and strength
I'm 49 and I don't even take gly/nac all the time. I take 1.2g each on and off and I can see the difference in how quickly I recover from heavy lifting as well as how quick I am in aerobic exercise. So I do think gly/nac works for me.
Since I am taking almost all of the supplements you mention, I was holding my breath to hear your recommendations based on your recent findings. However, as I am close to turning 70, I will continue to take them as it sounds like I could benefit from doing so.
NAC helps me with my Asthma especially the Mucus part. Plus, it adds Cysteine and sulfur to the body which helps to raise Glutathione. Thanks for your perspective, though.
@@sarahrosen4985 well, I had been a gym freak since the past 10 years and I would get these tremors or weird shakes on any part of my body and I showed it to many doctors who thought that it was a neurological or a spinal issue and these tremors would come out of nowhere, shake me and disappear so I never had it persistent enough to show to anyone as a proof. I came across a video of Dr. Eric Berg about Magnesium's role in that. I started with Magnesium Citrate every night and believe me, the tremors vanished. Whenever, I get those now, I know for sure that I have to take my Magnesium supplement. For my asthma, I rely on modern medicine but I also dose on Ayurvedic herbs like Adulsa, Andrographis and even Boswellia Serata for my asthma. Helps me immensely.
Many of those watching you, including myself, actually ARE older. So what I heard was that I probably should take several of these things. About Omega 3, I take 6 grams of Omega 3 every day - 3 when I rise and 3 when I go to bed. I don’t even take it for brain health. I take it for aches and pains. I’ve found that it drastically reduces inflammation and pain. It makes a great remedy for the muscle/joint pain which comes along with taking statins.
@@chrismyers9951There's no evidence that supplementing CoQ10 has an impact on muscle pain for users of statins. E.g., www.ncbi.nlm.nih.gov/pmc/articles/PMC9495827/
I have started with Glycine + NAC a few weeks after the study was published. 40yo male, BMI borderline to obese. As you noted taking NAC is a pain in the ass, so I started encapsulating the powder in 1g pills. That made it better but it made it complicated to take. I decided to not change my routing for the first 3 months (no change in diet, no change in exercise). The first side effect I seen was that it essentially killed a chronic knee inflammation that I have been carrying for 8 years after a LCA surgery. That's said I never went over half of the dose (50mg/kg daily). I also found that my 1-hour week tennis sessions would not leave me exhaust to the level of having to take a nap after it. Fast forward 6 months I started strength training 1-hour week, I progressed as expected, but everything changed after changing the protocol to add Taurine into the mix. Including Taurine and even diminished the amount of NAC the difference was absurd. My personal trainer had to start adding weight every single session. The max weight was just not enough every 2 weeks apart (not enough time to do everything on a single week, so my rotations takes 2 weeks). I went from 25kg to 60kg in press bench in a matter of 2 months, 70kg for leg press to 130kg and so on. I first investigated Taurine because my wife wanted to take it, but doesn't tolerate well NAC, so I was looking for something that could make the amount of cysteine she already eat in food to have a larger effect. As hepatocytes would react faster to the availability of cysteine, I decided to go the Taurine route. Then I said, what if I do that with mine too? The rest is history, I haven't lose a kg, but the amount of muscle (fat/muscle ratio change) and health benefits were massive. My current protocol is: 33 mg/kg Glycine 33 mg/kg Taurine 25 mg/kg NAC Would be interesting for you to look into how those 3 may be linked together to have provided such a boost.
I take L-Citrulline along with Taurine for the nitric oxide. As we age, we produce less of it kind of like Taurine. L-Citrulline is pretty cheap; I wonder if it would extend your results even further.
I love your content, especially the attention to detail in assessing the quality of the studies you reference in your videos. Could we perhaps get a video on your opinions and insights on various whole food diets, and the feasibility of acquiring all required vitamins, minerals and other potentially beneficial micronutrients from whole food sources? For example there are many healthy, natural sources of collagen and creatine. How do they compare to supplementation? Or for example, I use about half a teaspoon of natural turmeric in cooking each evening, in combination with black pepper and olive or coconut oil. How does that compare to curcumin supplementation? How does total abstinence from ultra processed foods affect the gut microbiome, and how does that affect the bio-availability of nutrients from whole foods, compared to people who eat ultra-processed foods and/or rely on supplements? Those kind of questions...
5:26 "Better to have a little than to have nothing. Except cyanide. I'd prefer 'nothing', when it comes to cyanide." Folks should be careful about taking B12 supplements that have Cyanocobalamin in them. The "cobalamin" part is the Cobalt, which is the real vitamin, and the "Cyano" part is the _cyanide_ which is acting as a cheap carrier. A "better" form of B12 is Methylcobalamin, but about ten percent of the population are prone to _overmethylation,_ which can cause agitation and severe mood cycles (ask me how I know...). At that point, the more expensive Adenosylcobalamin is needed.
Could you do a video on Ca-AKG? I find everyone who talks about it only has positive things to say, yet I find it hard to find any concrete evidence to believe its actually worth taking.
Thank you for that summary. :) I sometimes think, an issue with studies is that average-based results is the only thing that's mostly being looked at. In quite a few cases (too many, in my opinion), a specific substance only affects specific groups of people which can't always be categorized (ie. if it's due to specific genetics required for a certain substance to work in a specific way). A study like this would not necessarily tell them that a substance they would benefit from is actually good for them. For example, for about 20 years I've been doing frequent double-blind-studies together with a few friends, just to find out what individually affects us and how. And for me personally, we found that GlyNAC does wonders. I am just 41 and we were repeatedly able to show that it helps me get out of extended phases of chronically missing motivation or of "mental inactivity". BUT this simply doesn't apply to everyone. I know people who don't benefit from GlyNAC at all, EVEN in this exact situation. So in my humble opinion, even though quite a few of those substances do benefit most people (and average-based studies shows us this), people need to individually find out what they benefit from. They may have a rare genetic detail that helps them benefit from a specific substance more than the average person. Average-based studies can't tell them everything, though they are a good starting point.
Just a warning, do not take GlyNac at the amounts they used in the papers if you are relatively young. I made that mistake a few years ago (I was about 36/37) when one of the main papers came out, and after a few days my body was full of bruises. Granted both Gly and Nac are blood thinners, but the issue was probably also that i already had healthy levels of those and it must have been a big overdose for my body. Once I reduced the doses the bruises went away, but eventually I stopped taking it, especially NAC. I still took 1g of glycine for a a couple of years and recently I switched to collagen which is rich in glycine anyway so no longer take it. Might be great for people that are depleted and/or have low protein diets (that's another thing, my diet is protein rich, so the amounts were even higher), but not for a healthy, young(ish), well fed person.
Thank your for the warning. I'm 36 and just getting into supplements. It's easy for me to want to rush out and take everything. Videos like this make it tempting.
41 years old here. I noticed great results from NMN, 500-1000mg per day. Daytime drowsiness disappeared, more clean energy, more desire to move and do stuff. Sadly, very expensive. Solution? Plain old flushing Niacin. Same results for $3 a month, works just as well, and I actually enjoy the flush.
I have been taking glyNAC for autoimmune symptoms and have seen great results but I am looking to find another solution because I am starting to feel better and it is for removing the reactive species. It has also help to improved my menstrual issues, though I am also taking selenium and collagen for support for my extracellular matrix.
Excellent explanation for those of us who like to supplement ourselves. Could you please make a video about the supposed health benefits of consuming DMSO (dimethyl sulfoxide) orally?
I've been taking MSM which is a more refined version of DMSO and I love it. Lots of new spiky hair on my head and general wellness. Just be careful and buy a reputable brand cos a lot of it comes in bulk from china and isn't pure.
My current stack: Fishoil - 2gr. GlyNac - 1gr. + 1gr. Glutamin - 1gr. Curcumin - 0.75gr Palmetto - 0.6gr. VitaminD - 1500iu Half a multivitamin-pill. ... Thinking of adding both NMN and Taurine, while retirering Glutamin. I'm 58, in good shape and slender, but with a recent diagnose of psoriasis and no less than 4 stents in my heart.
@@venicebeachsurfer I was always fit and slender, but also a heavy smoker from around 16 y.o. I quit after my first massive heart attack at 48, giving me three stents. At 56 I had another, less severe attack, giving me a stent more. Doctor says, that I'm genetically inclined, and it runs in my family. Not much I can do about that. So, I'm aiming for healthspan rather than lifespan :)
I heard an interview with Professor Charles Brenner, he said that in studies NMN has shown to not going into the cells and that they therfor dont work, he says instead one should use NR and that this goes into the cells. What do you think about that?
NMN is of GREAT benefit for people 50 years old and beyond. Someone younger doesn't need it. I am over 60 years old. I started taking it and had incredible results. As a tennis player who competes one is always looking for an advantage. With NMN l can honestly say that l became lighter on my feet and noticeably faster along with an overall improvement in well being. It's been really amazing. I have also seen improvements in lean body mass. Others whose stories l have learned of have experienced things like healthy weight loss and gray hair turning back to it's natural color. NMN is not meant for people under 50. But for anyone 50 and beyond it's a godsend. Many times evaluators of things like NMN have other alterior motives. Anyone over 50 should try NMN themselves for 3 months and then make a decision.
I’d suggest that you may experiencing placebo effect. I’ve taken 1-2 grams of NMN for almost 2 years. I’ve seen no improvement in energy or any other claim that some make. I’m 69 and I exercise and take other supplements but I’m reducing or eliminating NMN. The hype about NMN is overblown in my view.
Being in my 40s, GlyNAC might be the only supplement where I noticed an immediate improvement. I have more energy, metabolism is up, on a diet I lose more weight while supplementing GlyNAC. I tried a month worth of NR (should be similar to NMN) once, noticed literally nothing and it was also the most expensive supp I ever took, so I stopped.
@@planttheseed2129 NAC is from Now Foods, Glycin is a German brand I don't remember and you won't likely be able to buy anyway. I just look for 1g capsules for a good price.
@@brianwnc8168 there is study on the web where nac reduced sensecent cells , for anti aging, but later in 50% people the same cells turned cancerous, i want to take nac , bcoz here in india it's very cheap, bcoz of the study i have not bought nac, i want a clear utube video on nac and cancer
Thanks for the list. Only thing I take at the moment is collagen. I might try the creatine. As far as strolls though radiation fields, if I don't keep taking them then how will I keep my youthful glow?
For me, I’m 65, I took NMN for 2 years and felt great, but I wasn’t sure if NMN was helping. So I stopped taking it. After about 6 weeks I noticed I had less energy and more joint pain. I started taking NMN again and my energy returned and the joint pain subsided. It may not work for others but it certainly works for me.
I've been taking collagen for about a year now. I was just starting to wonder if it was actually worth it. Nice to hear it hasn't been a waste of money.
Thank you for your presentations. I wish I had more time to go through more of your videos. But so far you are helping me understand what I should be taking at my age.
If curcumine inhibits muscle synthesis because it is antioxidant, does that mean I should avoid too many fruits and vegetables if I want to build muscles?
Can you share the curcumin study you referenced? I looked at your other video but there's no link to the actual study. It would be helpful to use when I'm talking to my clients :) Thanks much
@@videoagogo1been taking 500-1000mg of nicotinic acid to raise my HDL and after the first couple of days of intense flushing cos of immediate vasodilation, I feel amazing. My face always looked very young and I'm convinced I look even younger within a week. Amazing stuff but of course no one can patent it or overprice it so no one talks about it even though it was the standard doctor treatment for high LDL and high blood pressure till the early ninenties when statins were created.
I stopped taking GLYNAC (which I took for over a year) due to osteoarthritis in one of my my knees and a month later it went away. Studies has shown increase of osteoarthitis taking NAC. As for glycine I also am cautions about taking this since it can increase oxalates.
5:36 is this actually the recommendation for "fish oil" or rather "epa"? I don't quite get how it works, but I often find omega3 supplements with a very different ratio of FishOil vs EPA+DHA
Thanks as always you offer some of the most useful information back by data, your channel needs more exposure so more people can benefit again Thank you 🙏🏽
Excellent analysis. I was wondering, I am 60 and do need some antioxidants it seems for chronic inflammation as the body struggles to exist with all the stuff that happens. What would you think would be a good time/strategy, just basically thinking, to take it (time and in relation to working out that we still have to do or wither away). Thanks a million, keep up the good work and happy Christmas season to you!
Can you provide me a link that shows antioxidants is anti muscle development?? I am new to your channel and i have been taking curcumin for a while now! Basically, for its anti inflammatory effects on the body!!?
It would be good to know not only the dose in a study or other, but the delivery methods used. So we are assuming every study does once a day? 1500 mg once per day is not the same as 500 mg 3 times a day. What about regular capsule vs an enteric coated one, when required, when not. Or even nano or liposomal? Bioavailability and absorption. You should make a video on this.
Curious about what you think about Omega supplements now after the newer information of cardiac events. I'm 52 and I have congenital heart failure and several years ago my cardiologist told me to stay away from Omegas. Seems like he was right in saying so.
I am on the wrong side of 50. NMN and 1000mg does help remove age related fatigue to make me feel, umm l, late 30s. I also stack it with TMG so I don’t deplete my levels plus Creatine and O keep moderate levels of carbs in the diet. I have also substituted the NMN with Vitamin B3 with the same stack. Seems to work the same.
Great video! Well, I've been consuming curcumin for the past 8 years and I've even gained more muscle. I'm into natural muscle-building and have been working out for over 20 years. The major downside of this spice I've come to learn is that it can interfere with iron absorption so my ferritin went down. Since that finding, I've been trying to work out the hours I take it given my tendon issues it's fantastic for. (Too much info there right? Lol)
Im using Taurine and Resveratrol, going to start with Shijalit and Fisetin aswell as Glycine and Cysteine later on, been thinking about Spermidine, Berberine, Piceatannol and well i have friend who uses Metahlyne blue but the side effects from that has thrown me a bit off trying it. Really like your vids as they are really informative and since they are based off of so many studies and even though im not here to increase muscle mass you have really good advices on nutrients that increase stem cell production.
NAC seems to be very powerful at reducing my blood creatinine and ALP/AST blood levels, so I'm not sure if it only applies to older people (I'm 34). Maybe for other outcomes, but on biomarkers NAC (so I bet GlyNAC) seems to be good.
Thanks for some wonderful and interesting videos. Very helpful. Don't understand all of it but I'm trying! I'm now taking Curcumin (Meriva) because diabeties runs in my family. But a thought on your comment on Curcumin reducing muscle building potential... I've seem some recent studies that show that Curcumin has an anti-catabolic effect so it helps in keeping your body in an anabolic state which of course is great for building/keeping muscles! The studies showed the end results of those on Curcumin gained more muscle than those not. Thoughts on this seemingly contradictory effect?
Great to have this type of info video based on trusted objective research. I take 500mg/d (split) turmeric for GI issue (one new OK study but seems to help). Now I’m worried it may impede muscle rebuilding after a long phase of illness and chronic pain. I’ll look into it. Thx. FYI Physionic emails are good summaries of new videos.
I am in the midst of a fairly large base phase. I tried NMN this month. About a week left. No significant increase in aerobic capacity during this time that I would not have otherwise seen. I have actually seen performance increases from alpha GPC, which I take for something unrelated, and am unsure why or if I am confounding variables with that.
I'm 61 years old, I have seen most of your videos on NMN, Creatine and Glynac, do any of these supplements have an bad affect on prostate cancer in which I have ? Thanks in advance.
Ok so no GlyNac. But what about just bog standard glycine? I’m seeing a lot of videos about how younger people do not need glynac, but siim land has a lot of great things to say about glycine alone? Any ideas ? Thanks 😊
This came up in a different comment thread, but I thought I'd post a separate comment on it. The take-away is that when evaluating these supplements based on outcomes, it might make sense to divide them into two categories: The first (and probably most common) category would be supplements that have expected direct measurable outcomes, such as reduced insulin resistance, increased muscle-building ability, triggering autophagy or reduction of senescent cells, etc. The second category would be supplements that have the intended outcome of restoring levels of certain important substances that change with age, which could be either increasing them (e.g., NAD, glutathione) or decreasing them (e.g., oxidative stress metabolites). In this case, it's those changes that are the direct outcomes, and other outcomes are indirect results of these changes, which may or may not be noticeable in daily life or levels of health in the near term but have been shown, usually in mouse models, to have longer-term benefits for healthspan or lifespan. In the case of GlyNAC, there have been more demonstrated indirect benefits on health markers than with NMN, albeit from a limited number of studies so far. Nick is correct that these supplements don't have much value for younger folks, but should possibly not be written off for older folks. Since evaluating lifespan and healthspan is difficult and time-consuming in humans, trusting these supplements to be worth what you spend on them, even if they're considered to be safe, is inherently going to be more subjective and dependent on your assessment of the data, and possibly on your current physical condition.
So are the antioxidants in food the same as supplement form in respects to reducing muscle building potential? Ex. blueberries in my protein post workout?
*1 AMENDMENT & 1 NOTE*
NOTE: Some people seem to be under the impression (and upset) that the ratings offered are based on how these supplements impact a person in their thirties. This is incorrect. The ratings consider the totality of the evidence to date, and are not low or high because they relate less or more to someone in their thirties. I added a few personal points of why I don’t take certain supplements, but me not taking supplements has no bearing on the rating. Please listen to the video when I say the ratings are based on the evidence at hand. I say it multiple times and offer context.
AMENDMENT: @7:46, I say the rating is out of '10' - that is a mistake, it should be 'out of 5' - I misspoke. My bad for the confusion!
Before people ask: this is not an all encompassing list - next year I'll add to this list after I've read more research. 😄
Jesus Christ, I may be dead next year. And I'm not joking, I have major problems.
Please, only one joke per video :).
I thought 2 out of 10 is a euphemism for 1 out of 5🤣🤣
There is a high pitch ringing sound that is painful for my ears in the background, same as last video
thank you so muchhh for this insight on what suppliments help and what suppliments don't help!!! going through allthose studies that is incredible task! i'm very very grateful!!!
Your comments on Glynac are understandable. Got a stroke at 56 years old. Left side impairment/weakness. Balance problems etc. Started Glynac at 64, 1 year ago. After 10 months at 7 grams each I've seen a drastic recovery, almost complete reversal of post stroke symptoms. Another benefit is about 95% improvement of COPD. Now i walk for at least 1 hour each day which was unthinkable for me in the past 9 years. I feel much younger and stronger today. Glynac is a wonder treatment for people like me. Before this i took NMN for 6 months but did not notice any improvements.
Thank you for speaking up - I'm thrilled to hear you've had improvements in symptoms!
Your work helps many like me, thank you!@@Physionic
Thank you very much for sharing your story. Which brand of NMN did you try? All best wishes ^_^
You are welcome. I used Renue by science@@Aurla-R2-D2
Did you opt for 7grams based in weight?
I’m an old (octogenarian) retired scientist (hard sciences physics, mathematics, electronic engineering, computer sciences). Had an infarct in my youth (65yo) limiting me to bed/recliner cycle. Also noticed brain decline from 35yo to present, getting worse in past decade. I began research on longevity, heart regeneration, etc. NMN 500mg, Organic Extra Virgin Olive Oil, Creatine, Collagen Peptides 10-20g/day, Magnesium L-Threonate 2000mg/day (Brain), Magnesium Taurate 125mg (heart) plus some others have had a major positive impact on my life. My cardiologist of 40 years, says he is “Astounded that the heart has healed itself!”. I like your analyses. I believe you could become a great scientist. Good luck! Post Script: people say I look 60yo, I feel like I’m 50yo.
Very interesting, thanks for sharing! 👍
@@enalo6261 I am not a medical doctor and cannot advise anything. I can only share what I experience. I could not detect any bp lowering effect. I take it because it makes the muscle cells stronger. I was in mild heart failure. Proper exercise (with bands), MOST IMPORTANT DIET good sleep follows then…. my bp went down. My weight went from 320 lbs to 195 lbs over several years. It’s difficult but it worked for me.
❤😊
I know it is off topic but my dog 14 years and healthy and fit has a genetic heart murmur which has in the last few months become worse and the vet put her on cardisure-would anyone know if magnesium Taurate could help
@@dcjohnson2208 Yes, lack of use and age rob us of many gifts. ☹️
I'm almost 72, so I take Glycine and NAC at the recommended dosages (2 grams NAC and up to 12 grams of glycine). They are not at all expensive compared to other similar supplements (like NMN). I also take creatine, collagen, D-3, K-2, Magnesium, fish oil, L-Citrulline, Turmeric (natural form), and Taurine with other assorted supplements (not always every day on the others -- ones like Zinc, Vit A, etc -- are maybe 3 times a week). I feel healthy, workout a lot (resistance and cardio), and use a sauna regularly and red light therapy also. It is hard to say if I am getting results from the GlyNac because of all that I include in my regimen. Great video!
NAC and Glycine powder is super cheap.
You missed Berberine in your list and Lions Mane mushroom.
Sounds like you are doing all the right stuff, congratulations and thanks for sharing. 👍
Just FYI
I'm 63 (male) and take no supplements or medicines (though have been told I need them).
Anyway, I switched to Carnivore diet (more like KETOvore, heavy on the vore)
A year later, many aging symtoms were improved or gone, I was down to a more healthy weight (40# less) and long time high blood pressure was now normal.
Lion’s Mane mushroom can wreak havoc on one’s hormones.
Rather counterintuitively, my favorite part about this video is that lots of the conclusions you come to are kinda boring. Thanks for taking such a level-headed approach to relaying the info you gathered and not cherry-picking positive data for clicks. Love it!
Good point.
I thought I would give my experience using NMN. I am 54 years old and in pretty good shape. At 50 I rode Lotoja, which is 207 miles in one day. Averaged 19mph. For the next 2 years I was injured and that kept me off the bike. At the beginning of 2023 I started taking NMN. In March I was riding my trainer and was achieving higher watts then the year before. Got injured. Off for a month. I started riding without NMN and forgot about taking it. I was riding terrible. Did a relay through Utah in June and I struggled. In June I almost hung up my bike. Then I remembered the NMN. Started taking it again. In July I was riding up the mountains without tiring out. My times were close to my 2019 times when I was riding 100 miles every Sunday. In August there is a tough ride we do. I counted 21 very small climbs but they are between 9-13% incline. I went from 44 minutes to 36 minutes. The only explanation is the NMN. So now I take it all the time. I take 1000mg of NMN, 1000 Rostvertol, and 500mg of TMG. Its the ProHealth Complete. I have had others take it and they all said it gave them energy. But some had digestive issues and stopped using it. I don't know about Age Reversal, but it sure seems to have helped my endurance.
I'm 62. I had very similar results in martial arts training, much of which for me consists of leg raises, kicks, high speed strikes, crunches, push-ups.
The difference of taking nmn versus not is huge!
Particularly regarding my leg muscles. Definitely more flexibility, more muscular endurance, much less soreness, etc.
Brilliant job!! Could you suggest some brands,please?
Do Not Age
You have to watch these endurance sports. They are damaging , as far as I read on the net. You need exercise, like a car needs to be used regularly and some higher speed driving. Parking in the garage and not using it , it will rust and fall apart and over working the car will also damage it. You need the happy medium. I don't know exactly what that happy medium is but you can figure it out, there is plenty of advice and studies on this topic.
Can you take a look at sulphorafane? I get it from broccoli sprouts.
NMN did have noticeable effect. GLYNAC had huge effects. No more inflammation in any joint or muscles. Never any after hard core gym workouts. I am 54 and not in shape. Started going to the gym after a 3 year pause.
NAC is a huge and obvious booster for lung capacity. It enlongates breathing capaticy a lot and very noticably.
I'm 32 and regularly train at the gym. It actually helps getting more reps in some exercises because getting out of breath is much less of a limiting factor.
Brilliant job! Please suggest the brands,thank you.
Nice bicep flex my dude.
You're the most buff nerd I know and I absolutely love it!
needs to hit his shoulders more. Unless he flexes - he looks weak.
@@albertcamus5970omg are you serious? What a shitty thing to say.
my early mid60s dad started taking NMN on a whim and he jokingly said he was worried he'd accidentally ordered something like cocaine that's how profound and fast the positive effects were, says he feels 10 years younger
Haha, that's amazing!
Wow, that's wonderful :) Which brand is he taking? Cheers ^_^
Me too. The high doesn’t last though. But that first week was amazing.
@@stargazerbird ~ Do you take it with TMG? Cheers ^_^
My dad tried nmn + resveratrol for a month and said he felt absolutely nothing (he was above 60 at the time)
Please do more ranking lists like this one with more supplements!
Great review! How about TMG?
I take glycine, and NAC. 43. Work: dusty environments. These were a game changer for.me. sleep better, increased lung capacity, running faster. Complete game changer
NAC is known to help clear lungs of crap.
Nobody talks about nac cancers
@@eggbenedict-gt7mw Nac cancers?? Supplementation with NAC or vitamin E AFTER the development of cancer was found to increase cancer progression and reduce survival in mouse models of both BRAF- and KRAS-induced lung cancer.
This holds true for all antioxidants that suppress ROS. Nac does not cause cancer, but can support already developed cancers by suppressing ROS, particularly lung. liver or pancreatic cancers.
@@jimb3457 so most senior citizens, will get cancer if they use nac ,
@@jimb3457 yes and people are using it for copd, study claims it reduced senescent cells , later caused cancer in 50 % people
One more comment about Glynac. I am hypothyroid and one thing I noticed after taking it is that for the first time in decades my thyroid function tests were coming in totally normal. I have never had them come in normal. I have an older friend who is hypothyroid and has been for decades. She takes thyroid meds unlike me. She started glynac supplementation and her thyroid tests are now coming in on the hyper side, which has never happened for her. Her doctor basically told her to decide between the glynac or her thyroid med. I know the thyroid is super sensitive to toxins and toxins can affect it's function. I know that glutathione is an excellent detoxifier. So I am wondering if glynac supplementation can correct thyroid dysfunction that is linked to environmental toxins? My best guess is that my thyroid was over burdened by environmental toxins and the glutathone helps to detox it. Or maybe glutathione levels helps boost thyroid function in other ways?
Hi Nick! Could you please tell me how much Glynac you took that repaired your thyroid? Thanks so much for your help! xo
@@gabbygabbygirl I was taking 1000mgs/day but you can take up to 2000/day I think. Double check that on the internet. I think 2000 is safe though. The effects were very pronounced in the beginning but tapered off over time. I suspect that is because of the glutathione levels increased sharply at first and then tapered off. Also, if you research glutathione is critical for detox and we have depleted levels because of all the toxins in our environment, so I suspect that is why it's good for your thyroid. Your thyroid is very sensitive to toxins so improving the levels of the main molecule your body uses to detox helps the thyroid. There may be other mechanisms as well, I think it helps with thyroid inflammation too which helps it function better. Search thyroid + NAC. NAC + detox, NAC boosting glutathione etc. Hope it helps you! Also, you don't have to always take the glycine but it think it does work a little better with both. Glycine is very abundant in the diet already.
@@gabbygabbygirl 1000mgs to 2000mgs per day. Now I'm on a maintenance dose and only take 600mgs every so often. I take it a lot when I am sick though.
@@nick68231 Nick, you are awesome for answering! Did you mean a thousand milligrams of glycine? And how many milligrams of NAC?
@gabbygabbygirl Sorry, you can match the doses 50/50. No more than 2000mgs of NAC daily, and you can match that with 2000mgs of glycine. I take less now, but i have taken the full dose in the past. I don't seem to need the higher doses anymore to keep my thyroid in line. This might be because my glutathione levels are higher now? Glycine can be taken in large doses, so there's no issue there, and taking more than a match dose won't affect the absorbability of the NAC. Glycine is abundant in food, so it's not required. it just helps.
Im fairly certain GlyNac is one of the best supplements I have ever used. NMN was good but the effects reduced over time until I was getting almost no effect. GlyNac and NMN also doesn't work for me if I don't get enough sleep. I use Methylene blue, GlyNac, NAC and Tongkat Ali with creatine and I get amazing results in brain function and strength
What’s methylene blue for?
GlyNAC has been a complete game changer for me. I felt the effects after only a few days.
what brand and where do you source your glynac?
I'm 49 and I don't even take gly/nac all the time. I take 1.2g each on and off and I can see the difference in how quickly I recover from heavy lifting as well as how quick I am in aerobic exercise. So I do think gly/nac works for me.
Tongkat Ali / what breand please ?
This channel has one of the best comments sections I have seen many posters offering specific evidence to consider.
They're awesome - I'm incredibly proud of how impressive so many commenters are
Since I am taking almost all of the supplements you mention, I was holding my breath to hear your recommendations based on your recent findings. However, as I am close to turning 70, I will continue to take them as it sounds like I could benefit from doing so.
As someone who takes NMN daily and walks through radiation fields. I can definitely say it works!
Why take it without hard evidence?
☢
NAC helps me with my Asthma especially the Mucus part.
Plus, it adds Cysteine and sulfur to the body which helps to raise Glutathione.
Thanks for your perspective, though.
How much does magnesium help? Helps (prevents) my asthma and migraines tremendously.
@@sarahrosen4985 well, I had been a gym freak since the past 10 years and I would get these tremors or weird shakes on any part of my body and I showed it to many doctors who thought that it was a neurological or a spinal issue and these tremors would come out of nowhere, shake me and disappear so I never had it persistent enough to show to anyone as a proof.
I came across a video of Dr. Eric Berg about Magnesium's role in that.
I started with Magnesium Citrate every night and believe me, the tremors vanished.
Whenever, I get those now, I know for sure that I have to take my Magnesium supplement.
For my asthma, I rely on modern medicine but I also dose on Ayurvedic herbs like Adulsa, Andrographis and even Boswellia Serata for my asthma.
Helps me immensely.
I’ll pass this on. Thx
@@jmc8076 nobody asked you to pass or hold on to it. This is a community to share our experiences. Keep your rant to yourself 🙏🏻
@@sarahrosen4985magnesium doesn't help astahama, and nac worsens asthama that's the side effects written on it
Love your attention to detail. Great work. Please add chapters so when i come back later I can go right to a specific area. TY
Thanks, L2S. I'd like to add chapters to these shorter videos, but they hurt the video performance, unfortunately. I've tested it many times.
Many of those watching you, including myself, actually ARE older. So what I heard was that I probably should take several of these things. About Omega 3, I take 6 grams of Omega 3 every day - 3 when I rise and 3 when I go to bed. I don’t even take it for brain health. I take it for aches and pains. I’ve found that it drastically reduces inflammation and pain. It makes a great remedy for the muscle/joint pain which comes along with taking statins.
If your on statins make sure you take CQ10.
@@chrismyers9951There's no evidence that supplementing CoQ10 has an impact on muscle pain for users of statins. E.g.,
www.ncbi.nlm.nih.gov/pmc/articles/PMC9495827/
Instead of taking Omega 3 , Just eat some fish
@@Gamer3172 Mercury in large fish.
@@Gamer3172
Some people don't like the taste of fish.
I have started with Glycine + NAC a few weeks after the study was published. 40yo male, BMI borderline to obese. As you noted taking NAC is a pain in the ass, so I started encapsulating the powder in 1g pills. That made it better but it made it complicated to take. I decided to not change my routing for the first 3 months (no change in diet, no change in exercise). The first side effect I seen was that it essentially killed a chronic knee inflammation that I have been carrying for 8 years after a LCA surgery. That's said I never went over half of the dose (50mg/kg daily). I also found that my 1-hour week tennis sessions would not leave me exhaust to the level of having to take a nap after it. Fast forward 6 months I started strength training 1-hour week, I progressed as expected, but everything changed after changing the protocol to add Taurine into the mix.
Including Taurine and even diminished the amount of NAC the difference was absurd. My personal trainer had to start adding weight every single session. The max weight was just not enough every 2 weeks apart (not enough time to do everything on a single week, so my rotations takes 2 weeks). I went from 25kg to 60kg in press bench in a matter of 2 months, 70kg for leg press to 130kg and so on. I first investigated Taurine because my wife wanted to take it, but doesn't tolerate well NAC, so I was looking for something that could make the amount of cysteine she already eat in food to have a larger effect. As hepatocytes would react faster to the availability of cysteine, I decided to go the Taurine route. Then I said, what if I do that with mine too? The rest is history, I haven't lose a kg, but the amount of muscle (fat/muscle ratio change) and health benefits were massive.
My current protocol is:
33 mg/kg Glycine
33 mg/kg Taurine
25 mg/kg NAC
Would be interesting for you to look into how those 3 may be linked together to have provided such a boost.
Check out the channel Pottenger’s Human- he does an excellent job informing about all three supplements you listed. 🙂
NAC ...whai was amount for you?
What about liver health
@@vladislavroytapel2830 I am 90kg, therefore 2g
I take L-Citrulline along with Taurine for the nitric oxide. As we age, we produce less of it kind of like Taurine. L-Citrulline is pretty cheap; I wonder if it would extend your results even further.
I love your content, especially the attention to detail in assessing the quality of the studies you reference in your videos. Could we perhaps get a video on your opinions and insights on various whole food diets, and the feasibility of acquiring all required vitamins, minerals and other potentially beneficial micronutrients from whole food sources? For example there are many healthy, natural sources of collagen and creatine. How do they compare to supplementation? Or for example, I use about half a teaspoon of natural turmeric in cooking each evening, in combination with black pepper and olive or coconut oil. How does that compare to curcumin supplementation? How does total abstinence from ultra processed foods affect the gut microbiome, and how does that affect the bio-availability of nutrients from whole foods, compared to people who eat ultra-processed foods and/or rely on supplements? Those kind of questions...
Do you have a video on antioxidants and muscle growth because both are important! How do you use both and maximize their benefits?
5:26 "Better to have a little than to have nothing. Except cyanide. I'd prefer 'nothing', when it comes to cyanide."
Folks should be careful about taking B12 supplements that have Cyanocobalamin in them. The "cobalamin" part is the Cobalt, which is the real vitamin, and the "Cyano" part is the _cyanide_ which is acting as a cheap carrier. A "better" form of B12 is Methylcobalamin, but about ten percent of the population are prone to _overmethylation,_ which can cause agitation and severe mood cycles (ask me how I know...). At that point, the more expensive Adenosylcobalamin is needed.
Yes I have to use the adenosyl/hydroxy mix as well
Could you do a video on Ca-AKG? I find everyone who talks about it only has positive things to say, yet I find it hard to find any concrete evidence to believe its actually worth taking.
Thank you for that summary. :) I sometimes think, an issue with studies is that average-based results is the only thing that's mostly being looked at. In quite a few cases (too many, in my opinion), a specific substance only affects specific groups of people which can't always be categorized (ie. if it's due to specific genetics required for a certain substance to work in a specific way). A study like this would not necessarily tell them that a substance they would benefit from is actually good for them. For example, for about 20 years I've been doing frequent double-blind-studies together with a few friends, just to find out what individually affects us and how. And for me personally, we found that GlyNAC does wonders. I am just 41 and we were repeatedly able to show that it helps me get out of extended phases of chronically missing motivation or of "mental inactivity". BUT this simply doesn't apply to everyone. I know people who don't benefit from GlyNAC at all, EVEN in this exact situation. So in my humble opinion, even though quite a few of those substances do benefit most people (and average-based studies shows us this), people need to individually find out what they benefit from. They may have a rare genetic detail that helps them benefit from a specific substance more than the average person. Average-based studies can't tell them everything, though they are a good starting point.
Just a warning, do not take GlyNac at the amounts they used in the papers if you are relatively young. I made that mistake a few years ago (I was about 36/37) when one of the main papers came out, and after a few days my body was full of bruises. Granted both Gly and Nac are blood thinners, but the issue was probably also that i already had healthy levels of those and it must have been a big overdose for my body. Once I reduced the doses the bruises went away, but eventually I stopped taking it, especially NAC. I still took 1g of glycine for a a couple of years and recently I switched to collagen which is rich in glycine anyway so no longer take it. Might be great for people that are depleted and/or have low protein diets (that's another thing, my diet is protein rich, so the amounts were even higher), but not for a healthy, young(ish), well fed person.
Thank your for the warning. I'm 36 and just getting into supplements. It's easy for me to want to rush out and take everything. Videos like this make it tempting.
@@aubreyelf87i am also new to supplementation,
It's very difficult to eat a protein deficient diet if you are eating a normal amount of any food every day.
41 years old here. I noticed great results from NMN, 500-1000mg per day. Daytime drowsiness disappeared, more clean energy, more desire to move and do stuff. Sadly, very expensive. Solution? Plain old flushing Niacin. Same results for $3 a month, works just as well, and I actually enjoy the flush.
Bro what about liver health
@@eggbenedict-gt7mwI think that's about niacinimide not regular niacin. Look into what was used for that research.
Bulk supplements NMN is decently priced. I’m 45 and use their brand.
Nattokinase, Astaxanthin and Kurkuma for Spike Protein protection 🕵️♀️
Turmeric
Your information is first class❤
Thanks so much for this! Can you recommend a brand of creatine?
Awesome I'll keep taking all of those since I'm 55 and not in great health. You totally convinced me to keep taking them all!
What about taurine?
How about Quercetin?
Already looking forward to your collagen deep dive. I am hoping for content on bone density, osteoarthritis and gut health
Another amazing vídeo, thanks for that. I wonder if you have done any analysis on Berberine to reduce glycose levels. Thanks
Damn, nice muscles! Thanks for wading through all the data. Can you sometimes do videos for older people?
I consume 600mg per day of NAC and I feel my exercise recovery time is improved. I am 60 years old and enjoy weight training daily.
I have been taking glyNAC for autoimmune symptoms and have seen great results but I am looking to find another solution because I am starting to feel better and it is for removing the reactive species. It has also help to improved my menstrual issues, though I am also taking selenium and collagen for support for my extracellular matrix.
Excellent explanation for those of us who like to supplement ourselves. Could you please make a video about the supposed health benefits of consuming DMSO (dimethyl sulfoxide) orally?
I've been taking MSM which is a more refined version of DMSO and I love it. Lots of new spiky hair on my head and general wellness. Just be careful and buy a reputable brand cos a lot of it comes in bulk from china and isn't pure.
Be careful with DMSO I'd only orally ingest if my life were horrible already with nothing to lose.
My current stack:
Fishoil - 2gr.
GlyNac - 1gr. + 1gr.
Glutamin - 1gr.
Curcumin - 0.75gr
Palmetto - 0.6gr.
VitaminD - 1500iu
Half a multivitamin-pill.
... Thinking of adding both NMN and Taurine, while retirering Glutamin.
I'm 58, in good shape and slender, but with a recent diagnose of psoriasis and no less than 4 stents in my heart.
Glutamin forms more glutimates in the brain skip that get D from sun and butter oil
Look into vitamin K2(the MK7) version as well.
Why the stents? Were you always slender...or a smoker?
@@venicebeachsurfer I was always fit and slender, but also a heavy smoker from around 16 y.o. I quit after my first massive heart attack at 48, giving me three stents. At 56 I had another, less severe attack, giving me a stent more.
Doctor says, that I'm genetically inclined, and it runs in my family. Not much I can do about that. So, I'm aiming for healthspan rather than lifespan :)
@@ZappyOh Smoking..Shrinks blood vessels like crazy.
Much thanks for the regular updates.
Watch out for the mood flattening of NAC
I heard an interview with Professor Charles Brenner, he said that in studies NMN has shown to not going into the cells and that they therfor dont work, he says instead one should use NR and that this goes into the cells. What do you think about that?
Great summary Nick, appreciate your work.
Thanks, Rich!
Great information as always.
How about berberine, and TMG, and blue methyline?
NMN is of GREAT benefit for people 50 years old and beyond. Someone younger doesn't need it. I am over 60 years old. I started taking it and had incredible results. As a tennis player who competes one is always looking for an advantage. With NMN l can honestly say that l became lighter on my feet and noticeably faster along with an overall improvement in well being. It's been really amazing.
I have also seen improvements in lean body mass. Others whose stories l have learned of have experienced things like healthy weight loss and gray hair turning back to it's natural color.
NMN is not meant for people under 50. But for anyone 50 and beyond it's a godsend. Many times evaluators of things like NMN have other alterior motives. Anyone over 50 should try NMN themselves for 3 months and then make a decision.
What about NAD+ ? Always confused about NMN and NAD+
NMN is a pre ursor which helps your body increase the amount of NAD+ @user-uk6db3mb2f
What dosage are you taking please? Thank you for the intel :)
I'm 32 and NMN has been a gamechanger for my physical fitness and work performance.
I’d suggest that you may experiencing placebo effect. I’ve taken 1-2 grams of NMN for almost 2 years. I’ve seen no improvement in energy or any other claim that some make. I’m 69 and I exercise and take other supplements but I’m reducing or eliminating NMN. The hype about NMN is overblown in my view.
Good day to you, Nicholas. What are your thoughts or knowledge on creatine monohydrate versus creatine HCL?
NAC also helps a lot for detoxing from heavy metals in your food / environment, so that’s not age related.
It's one of the most obvious supplements with how it instantly just extends my breath at 32 years old.
@@BitZapple what do you mean?
@@BitZapple Gets rid of mucus congestion.
Being in my 40s, GlyNAC might be the only supplement where I noticed an immediate improvement. I have more energy, metabolism is up, on a diet I lose more weight while supplementing GlyNAC. I tried a month worth of NR (should be similar to NMN) once, noticed literally nothing and it was also the most expensive supp I ever took, so I stopped.
What brand do you consume? Could you share?
@@planttheseed2129 NAC is from Now Foods, Glycin is a German brand I don't remember and you won't likely be able to buy anyway. I just look for 1g capsules for a good price.
What about cancer and nac nobody talks about it
@@eggbenedict-gt7mwwhat about in NAC and cancer?
@@brianwnc8168 there is study on the web where nac reduced sensecent cells , for anti aging, but later in 50% people the same cells turned cancerous, i want to take nac , bcoz here in india it's very cheap, bcoz of the study i have not bought nac, i want a clear utube video on nac and cancer
Was looking down taking notes when you mentioned nmn, I thought you said m&ms..had me going there for a minute.😆
I’ve had good results with M&Ms 😋
Thanks for the list. Only thing I take at the moment is collagen. I might try the creatine. As far as strolls though radiation fields, if I don't keep taking them then how will I keep my youthful glow?
What do you think about Berberine for a 50 year old with high cholesterol who takes 20mg simvastatin daily?
Do they work well together?
Good stuff man, thank you for the videos and the info, it's been very useful.
My experience with Gly/NAC at 68. I lost 3-4 inches of my waist without changing my current decent diet and exercise profile.
I love this channel because when I get over hyped about supplements and other stuff, he brings me right back down to Ground Zero where I need to be..
Thanks Ryan :)
Excellent and unbiased,no promotion agenda, the score assigned for each molecule is very neutral. Keep it up 💪 💯
For me, I’m 65, I took NMN for 2 years and felt great, but I wasn’t sure if NMN was helping. So I stopped taking it. After about 6 weeks I noticed I had less energy and more joint pain. I started taking NMN again and my energy returned and the joint pain subsided. It may not work for others but it certainly works for me.
What kind of doctor should i consult if im interested to take meds like these?
I've been taking collagen for about a year now. I was just starting to wonder if it was actually worth it. Nice to hear it hasn't been a waste of money.
Do you take vitamin C with your collagen?
@@lpg12338 would that be the right way to take?
Can people with elevated uric acid take creatine ? Is there any studies on this ?
Thank you so much for sharing. It really made us feel very helpful.
Thank you for your presentations. I wish I had more time to go through more of your videos. But so far you are helping me understand what I should be taking at my age.
If curcumine inhibits muscle synthesis because it is antioxidant, does that mean I should avoid too many fruits and vegetables if I want to build muscles?
Is there any point to creatine supplementation while on the ketogenic diet?
Yes
I'm impressed with Taurine 😀
Can you share the curcumin study you referenced? I looked at your other video but there's no link to the actual study. It would be helpful to use when I'm talking to my clients :) Thanks much
NMN is also very expensive a cheaper alternative is Nicotinamide (B3), which is the precursor to NAD+, or acts higher up in the process.
Niacin (Nictotinic Acid) is 'better' in that regard and unlikely to inhibit Sirtuin generation
@@videoagogo1been taking 500-1000mg of nicotinic acid to raise my HDL and after the first couple of days of intense flushing cos of immediate vasodilation, I feel amazing. My face always looked very young and I'm convinced I look even younger within a week. Amazing stuff but of course no one can patent it or overprice it so no one talks about it even though it was the standard doctor treatment for high LDL and high blood pressure till the early ninenties when statins were created.
Niacinamide bro
They raise TMAO significantly so can give people heart issues, a warning.
I stopped taking GLYNAC (which I took for over a year) due to osteoarthritis in one of my my knees and a month later it went away. Studies has shown increase of osteoarthitis taking NAC. As for glycine I also am cautions about taking this since it can increase oxalates.
Many thanks for this video!
5:36 is this actually the recommendation for "fish oil" or rather "epa"? I don't quite get how it works, but I often find omega3 supplements with a very different ratio of FishOil vs EPA+DHA
Good stuff as usual
Thanks as always you offer some of the most useful information back by data, your channel needs more exposure so more people can benefit again Thank you 🙏🏽
So what's your rating on GlyNAC for people 65+? Also, please do a video on DHEA. Effective or not? Thanks.
Excellent analysis.
I was wondering, I am 60 and do need some antioxidants it seems for chronic inflammation as the body struggles to exist with all the stuff that happens. What would you think would be a good time/strategy, just basically thinking, to take it (time and in relation to working out that we still have to do or wither away).
Thanks a million, keep up the good work and happy Christmas season to you!
What about alpha lipoic acid + acetyl-L-carnitine???
What about high dose melatonin?
Can you provide me a link that shows antioxidants is anti muscle development??
I am new to your channel and i have been taking curcumin for a while now! Basically, for its anti inflammatory effects on the body!!?
This fellow knows what he's talking about, he's 97 but looks as though he's barely out of his teens! I hope I look like that when I'm his age.
😂
It would be good to know not only the dose in a study or other, but the delivery methods used. So we are assuming every study does once a day? 1500 mg once per day is not the same as 500 mg 3 times a day. What about regular capsule vs an enteric coated one, when required, when not. Or even nano or liposomal? Bioavailability and absorption. You should make a video on this.
Surprised that you didn't speak on Resveratrol, CA AKG, Hyaluronic Acid, TMG and Berberine.
You are a sweet, funny nerd. Thank you for your info.
Curious about what you think about Omega supplements now after the newer information of cardiac events.
I'm 52 and I have congenital heart failure and several years ago my cardiologist told me to stay away from Omegas. Seems like he was right in saying so.
I am on the wrong side of 50. NMN and 1000mg does help remove age related fatigue to make me feel, umm l, late 30s. I also stack it with TMG so I don’t deplete my levels plus Creatine and O keep moderate levels of carbs in the diet. I have also substituted the NMN with Vitamin B3 with the same stack. Seems to work the same.
You take both NMN & TMG pills together? Empty stomach first thing in the morning, pre-workout, or with food?
So interesting, thx man!
Great video! Well, I've been consuming curcumin for the past 8 years and I've even gained more muscle. I'm into natural muscle-building and have been working out for over 20 years. The major downside of this spice I've come to learn is that it can interfere with iron absorption so my ferritin went down. Since that finding, I've been trying to work out the hours I take it given my tendon issues it's fantastic for. (Too much info there right? Lol)
Im using Taurine and Resveratrol, going to start with Shijalit and Fisetin aswell as Glycine and Cysteine later on, been thinking about Spermidine, Berberine, Piceatannol and well i have friend who uses Metahlyne blue but the side effects from that has thrown me a bit off trying it.
Really like your vids as they are really informative and since they are based off of so many studies and even though im not here to increase muscle mass you have really good advices on nutrients that increase stem cell production.
Very interesting, but what about omega-3s for cardiovascular health? Thanks.
Useless
NAC seems to be very powerful at reducing my blood creatinine and ALP/AST blood levels, so I'm not sure if it only applies to older people (I'm 34). Maybe for other outcomes, but on biomarkers NAC (so I bet GlyNAC) seems to be good.
Would love to hear more from you about the studied benefits of Glynac. For any age. And C-15?
Thanks for some wonderful and interesting videos. Very helpful. Don't understand all of it but I'm trying! I'm now taking Curcumin (Meriva) because diabeties runs in my family. But a thought on your comment on Curcumin reducing muscle building potential... I've seem some recent studies that show that Curcumin has an anti-catabolic effect so it helps in keeping your body in an anabolic state which of course is great for building/keeping muscles! The studies showed the end results of those on Curcumin gained more muscle than those not. Thoughts on this seemingly contradictory effect?
Great to have this type of info video based on trusted objective research. I take 500mg/d (split) turmeric for GI issue (one new OK study but seems to help). Now I’m worried it may impede muscle rebuilding after a long phase of illness and chronic pain. I’ll look into it. Thx. FYI Physionic emails are good summaries of new videos.
Where is the video he tells us to watch at the end of this video?
Thanks!!
I am in the midst of a fairly large base phase. I tried NMN this month. About a week left. No significant increase in aerobic capacity during this time that I would not have otherwise seen. I have actually seen performance increases from alpha GPC, which I take for something unrelated, and am unsure why or if I am confounding variables with that.
I'm 61 years old, I have seen most of your videos on NMN, Creatine and Glynac, do any of these supplements have an bad affect on prostate cancer in which I have ? Thanks in advance.
Ok so no GlyNac. But what about just bog standard glycine? I’m seeing a lot of videos about how younger people do not need glynac, but siim land has a lot of great things to say about glycine alone? Any ideas ?
Thanks 😊
Please keep us updated if you come across any new studies on Taurine 🤔
This came up in a different comment thread, but I thought I'd post a separate comment on it. The take-away is that when evaluating these supplements based on outcomes, it might make sense to divide them into two categories: The first (and probably most common) category would be supplements that have expected direct measurable outcomes, such as reduced insulin resistance, increased muscle-building ability, triggering autophagy or reduction of senescent cells, etc. The second category would be supplements that have the intended outcome of restoring levels of certain important substances that change with age, which could be either increasing them (e.g., NAD, glutathione) or decreasing them (e.g., oxidative stress metabolites). In this case, it's those changes that are the direct outcomes, and other outcomes are indirect results of these changes, which may or may not be noticeable in daily life or levels of health in the near term but have been shown, usually in mouse models, to have longer-term benefits for healthspan or lifespan. In the case of GlyNAC, there have been more demonstrated indirect benefits on health markers than with NMN, albeit from a limited number of studies so far. Nick is correct that these supplements don't have much value for younger folks, but should possibly not be written off for older folks. Since evaluating lifespan and healthspan is difficult and time-consuming in humans, trusting these supplements to be worth what you spend on them, even if they're considered to be safe, is inherently going to be more subjective and dependent on your assessment of the data, and possibly on your current physical condition.
I really like this suggestion. Wonderful idea. Thank you.
So are the antioxidants in food the same as supplement form in respects to reducing muscle building potential? Ex. blueberries in my protein post workout?
No rating for taurine?