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Julie Huang (Stanford U.): H. pylori finds its home
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- Опубликовано: 18 авг 2024
- www.ibiology.o...
Most microorganisms cannot survive in the hostile environment of the stomach. But, what happens when bacteria survives the gastric lumen and are able to call the stomach its home? Dr. Julie Huang tells us the story of H. pylori, eccentric bacteria that are able to colonize human stomach. These bacteria are the leading cause of stomach ulcers in humans and are associated with stomach cancer. Huang discovered TlpB, a chemoreceptor in H. pylori that enables bacteria to detect suitable environments and thereafter “swim” toward their home, the epithelial cells. She showed that TlpB detects the presence of urea, allowing H. pylori to find a more neutral environment where it can survive. This demonstrates that bacteria not only can sense potentially harmful cues, like low pH, but can also react to favorable factors, like urea, when finding their new home. This innovative understanding on how H. pylori find their niche opens new routes to develop novel approaches to prevent stomach ulcers and cancer.
Speaker Biography:
Dr. Julie Huang completed her Bachelor degree at the California Institute of Technology. Given her scientific merits, she was granted a Fulbright scholarship in 2009 to work at the Max Planck Institute for Marine Microbiology in Germany. After this experience, Huang joined the Microbiology and Immunology doctorate program at Stanford University, where she started to work with Dr. Manuel Amieva. At Stanford, she studied how the pathogen H. pylori survive in the stomach. Her outreach interests led her to be involved in different mentoring initiatives, including co-founding the Stanford First Gen/Low-Income (FLI) Undergraduate Mentoring Program.
I’ve been recently diagnosed with H pylori after suffering for 4 years. My symptoms range from stomach upset, nausea, discomfort after eating, nausea, bloating, joint pains, headaches, pain in the abdominal area, etc..
My doctor completely missed the diagnosis for all these years. It took a visit to a Gastro and an endoscopy to find out.
Now I am finally on my road to recovery.
You have to be your own health advocate, some doctors are clueless!
I'm with u...
My partner & I were just diagnosed this week after years of suffering. I study Psychology in my hometown & for years have been stumped by our physical & mental state, high & chronic anxiety. I am just starting to learn about H. Pylori.
@@BusyBee-er5pp this is a serious bacteria. I had no idea the extension of the problems it will generate if left untreated.
I hope you are recovering from this!
@@AnaCrisHammer thank you for replying. Do you know what combination meds finally eradicated it?
@@BusyBee-er5pp I am still taking it.. Amoxicillin 500mg tablets - 2 tablets twice a day together with Clarithromycin 500mg - 1 tablet twice a day, and Pantoprazole 40mg -
1 tablet twice a day.
For 14 days, all 3 meds together.
I normally don’t comment, yet I couldn’t resist to compliment this hard work and so microscopic questions and answers hidden beyond our imagination. Truly best work deserves Gold Medal !!
I think Julie Huang is an incredible scientist, this is such good information. It is so great to live in an age we have such brilliant scientists working on these fundamental problems sharing their information with the world. Thank you for this! You are awesome Julie!
Miss Huang your presentation is a hpylori, master piece, it left no stone unturned , Im a sufferer , thank you
May God Almighty bless your work.
Both my husband and I have H. Pylori. And I honestly hate the thought of having to take the pharma drugs with their crazy long list of side effects.
I appreciate this research. I would like more information on how we can help our bodies fight this ugly bugs? and protect them from getting reinfected?
What foods can help? Or natural meds.?
Or drugs that don’t have a crazy long list of side effects.
If anyone has any ideas, please point us in the right direction.
Just diagnosed with h pylori. Have you found help naturally? Dr.prescribed P y l e r a , A medication. Cost is $1400 insurance will not pay. I had rather do this naturally.
I wish this information was more easily considered by physicians. It's so frustrating that it seems beyond the logic of most doctors I have discussed it with and extremely unfortunate for people trying to find solutions.
So true.
Pure science and logic. Great work. Huge respect 🙏
What a brilliant mind!!! This was incredible to watch and to see how Ms Huang broke it down to be understood!
Such amazing presentation! Thank you Julie for the hard work ! It's so nice to see brillant young scientists with so much passion and devotion to a better future and better life for the humankind! ❤
Julie Huang seems to have a passion and curiosity which will make her a great scientist.
I wish she had info on how to successfully eradicate it
@@MBAM02 She said it, antibiotics. However, now that they are antibiotic resistant probably need extra help like NAC and Oregano Oil.
How is oregano oil used? Diagnosed with h pylori. I don't want to take pharmaceuticals.
@@because_someone_prayed Lactobacillus Reuteri, Mediterranean oil of oregano(80%+ carvacrol), mastik gum and broccoli sprouts/sulforaphane are known to kill it
Lactobacillus Reuteri, Mediterranean oil of oregano(80%+ carvacrol), mastik gum and broccoli sprouts/sulforaphane are known to kill it
This can lead to another Nobel prize if a successful medicine is developed to kill H pylori based on the findings.
There is already a medicine: Lactobact. reuteri. Take it for approx. 2 month and the Helicobacter is gone ( and will be gone away for a very long time)...
@@k.s.421 OK thanks
Great presentation. It makes sense to me, when I first started having pylori symptoms was 4-5 years ago, I had lots of acid reflux, burping, gastritis etc, I never treated it because I didn’t know a bacteria could cause this and I thought all this was a response to my high fat/carb diet, after cleaning my diet I still had the symptoms.. 4 years from that and those symptoms have been greatly reduced without any treatment, but I got other diseases (confirmed) like candida and bacterial overgrowth, which IMO were caused by low stomach acid, thanks to the pylori. The scary part for me is that I believe that my chronic pylori, has made its way through the bottom of my stomach cells.. I believe this because, A) I no longer have acid related symptoms, B) I’ve done different tests to catch the infection with 2 positive tests and several false negatives (including a biopsy and blood) C) I have low stomach acid based on tests I’ve tried..
My question is, is there any protocol which incorporates urea with abx to attract pylori to the surface, out of the gastric glands roots?
brilliant question
i use interfase by klaire labs to break down biofilm. then an hour later, take ox bile to kill pylori and candida. been helping a lot . I will integrate colostrum into the mix
My question exactly now that quad treatment has failed.
@@user-dk2zx9nr2g quad treatment will never ever work. Its wrong.
You need to start taking digestive enzymes and HCL
@@JohnQPublic345 are you cured now?
This video is 6 years old. We still use antibiotics 🤷♀️ not nessesarly effective, dangerous for developing antibiotic resistance, and not protecting from getting it again. Its so easy to get it! I asked my gastro, what about if i will get it again after antibiotic therapy?? Will i have to use antibiotics again, and again?? Only got blink blink with her eyes for an answer🤷♀️ is there new treatment for H.pylori based on these wonderful discoveries?
this is legit fascinating - congrats on your findings
Really nice presentation. Never thought H.pylori would be so interesting. Keep up the good work!
Great work! I would love to hear more about the new treatment!
This is very informative. Thanks for this excellent research. Keep up the good work.
I have had 8 episodes of this disease over a 10 yr span, antibiotics never helped but TODAY I had a scope to find out why I am resistant to antibiotics. I’m actually apart of a study. Hopefully they can find some answers so I can get rid of the horrible disease once and for all! Fingers crossed
What happened?? Were you taking amoxyclom clarithym and omeprzole?
@colleensmith1327 did you find answers and a treatment that works?
Oh my God, thank you to teach us all this information
Great work! Fascinating and tenacious research. I, too, had stomach ulcers in the late eighties and benefited from antibiotic therapy. It is great to see that there will be another way to fight h. pylori in the future.
@Lisa Marie meds
We need to get rid of it not just treat the symptoms.
Thank you for this great presenation!
Thanks for sharing your research. Well presented
Such an amazing presentation! Thank you Julie for the hard work! It's so nice to see brilliant young scientists with so much passion and devotion to a better future and better life for humankind!
Great work, I would love to hear more about the new treatment!
Fascinating information. Enjoyed hearing about your process. Thanks for sharing!
THANK YOU FOR SUCH AN AMAZING PRESENTATION!!!!
fantastic work.great insight about H.pylori.
I can see that you were very nervous in this presentation However you are brilliant and an excellent speaker and did an excellent job in this presentation. Thank you very much for sharing this important information to the world, as well as your beautiful character!
God bless you and your team. If it were up to me I would give you a nobel prize too.
Congratulations! Well done! Really Interesting piece of work. Thank you for sharing.
this is super! thank you so much!
Could you please talk about those drugs you mentioned? Perhaps also what other natural things have healed, and maybe how it is really passed on. Thank you. Fabulous presentation.
Please we need to know what is the cure for this infection
@@juanitavazquez6527 you need to see a Dr. he will test you and if your positive, you will need to take medicine for a month.
GREAT presentation and fascinating, and well thought-out studies! It’s high level science experimentation explained simply. I really cannot imagine why anyone would thumbs down this video. I have a degree in biology so maybe that’s why I could follow this and why some people didn’t like it.
I have a self-certified degree in listening intently. Maybe that's why I could follow this and others didn't like it.
Beede Bawng
That’s what it takes, listening to her intently. I was interested because I was diagnosed with HP and was treated. Eliminating the bacteria has improved my health in several unexpected ways. Besides eliminating bleeding ulcers it (treatment) eliminated virtually all gas and gas odor, muscle cramping, and reduced auto immune ailments such as rheumatoid arthritis. I think this is related to the improvement in nutrition absorption, eliminating intestinal inflammation, and improving electrolyte balance. Wow, unexpected improvements.
Thank you so much... really riveting presentation.
I have just completed a 2 week antibiotic course against Hp... surprisingly I actually had no prior symptoms . The Hp was detected by scope
Thank you for your great work dr.Huang, particularly the microneedle injection assay, so straightforward and effective!
Great study, nice labelling and confocal microscopy.
Thanks, well explained and quite informative
Very good presentation. I was able to easily understand the process of it all. Thank you for this.
Awesome work! Thank you!
Amazing introduction and explanation.
How did we GET h.pylori?
Very interesting research!
I don't mind asking this very serious question. If high quantities of urea literally overwhelm the sensing mechanism of the bacteria, then would ingesting one's own urine (that is 95% urea) slow down the stomach colonization or even aid in flushing out the bacteria?
I was going to suggest the same thing… Urea with a CO2 tracer is used for the breath test to diagnosis H Pylori infection.
I just looked up the molarity of urea in the urine. It’s .008 M so no where near the 1M used in her experiment.
Lol, you could extract it from your urine.
Thank you ♡♡ team
Absolutly amazing video! I suppose the key question is how do we utilise this information in the fight against it once it!
awesome presentation. It was explained in detail and in such a way that was understandable for the less scientific mind.
It makes no sense....Most people get H. Pylori at childhood and live with it all life..
Great work
best presentation I have seen in a while.
Excellent presentation and information! Now, better cures!
What a fantastic story. Gotta respect H. pylori :)
Good work. You made it interesting Thank You.!!
Well done! If only my path were different I know I would have been a happy and productive scientist!! I enjoy through people like you and all the many other like minded individuals Thank you 😁
I love your presentation, it was so fascinating and educative.
Amazing work and information. Thank you so much.
Great Job
Many thanks
Very helpful, thank you!
If I do happen to have any of this, have you found what I can do to actually heal it or kill it all before it possibly getting any worst? I know that even over a decade ago I was feeling sudden sharp pains at certain times that would spring up under my heart I believe then would go away but while there, it would lead me to breathe diffidently cause it didn’t allow me or so I’d think, to breathe in all the way in without feeling that pain, then it’d leave. I know also got impacted by a minivan that nearly missed hitting me dead on at around 20mph; this was about 10 or more years ago. I never went to get checked. But after getting hit I felt like something started leaking behind my sternum downwards; I started hopping thinking that would stop that; it stopped, I felt I’d be fine and things got better. Things went back to normal. But it was before that accident that I was already feeling these sudden sharp pains that would come and go. Years after the accident; btw I was just crossing a street where I ran into the side of that minivan; I also noticed that if I jumped rope or ran, after a certain time or distance I’d start feeling like behind my abdomen there was an injury that would start hurting. Fast forwarding: I had a reaction 3 weeks ago that felt like my heart was under attack; a sudden uprising that lead to this sudden sharp attack underneath the heart; I didn’t say anything or get checked; then last Saturday I had another reaction that lead me to then goto emergency. They checked and said my heart, lungs were fine, blood pressure and all was almost perfect. So they prescribed 3 meds “Tylenol, Pepcid and maalox” because when they gave it to me it did me well; took away this ill stuffy feeling; but it hasn’t gone fully away; I didn’t continue taking the meds although they were purchased for me, and last night I had another reaction but not as bad. Me also googling doesn’t seem to help that much because I get back and forth statements from different people. Some say the meds are good as long as I don’t overuse while others say I shouldnt be taking them at all.
How are you now? I have the same feeling, and i got testet positive for H. P.. I allways thougt it Was my heart and sometimes i still think it is.
Good information thanks xxx
Excellent great presentation and work!
Fabulous work, well done
Thank you for enlightening me....too good
Where to find this ChePep protein...this miracle medicine..?great work!!
It was really interesting and although I'm not a biologist I couldn't help but to watch it until the end. One question that came to my mind is why this bacterium also doesn't live in the urinary system? Because of too high urea concentration not being useful for anything?
Please do experiments, to eradicate or reduce h pylori.
Really great work
Having this bacteria I understand it's causing stomach and intestinal gas, what about burping to the point of chest pain... is that also a common symptom ?
yes , it can also lead to breathing difficulties, feeling full after having little food, frequent head-aches etc
Loved this. Not a biologist myself
this was really awesome, having h.pylori for over 10 years. what can I do? taking urease enzyme? please answer
Did you find help?
I’m searching the comments for a recommendation of what we can take as well
@@rachelreyes4128 Subscribe to Dr Sten Ekberg and look at his previous videos.
ruclips.net/video/fgX31OdPaUo/видео.html
Fasting and keto diet. I do OMAD and IF.
No sugar, carbs or processed foods.
Also, eat raw ginger, garlic, coconut oil, black seed oil.
Cabbage juice, celery juice, lemon juice.
Acv and Hcl with pepsin before meals.
Avoid msm and social media.
Quality sleep.
Eliminate stress.
Change routines.
R u fine now?
interesting work.
Any new drugs yet found?
How can i contact this doctor?
Great video and easy to understand. I just tested +.
Well, I'm also a patient of H Pylori.
Now the important thing is that, how to eradicate completely by following natural way instead of intake the antibiotics.
Kindly let me know pls.
Have you got free of this infection yet?
@@raghavendrapatil3795
Yes,
I took antibiotics 14 days compulsory, the prescription is with me, will send detailed if you need.
Natural way is,
Drink 1 litre of water right after waking up in the morning without brushing.
At 7 am, drink pure yoghurt 500 ml,
Drink cabbage + broccoli + Ash gourd juice
Stop drinking milk and milk products and Sugar products
Eat saffron colour sweet potato
Eat red Simla Mirch capsicums
Ginger mixed hot water
Eat 3 hours once in light quantity
What were your symptoms
@@raghavendrapatil3795
You will have pain in stomach after empty stomach, your stool colour will be black
Your breath will be smelly
Be careful with your family members,
It's contagious and they also can get immediately while you kiss them, using same eating utensils or eating your remnants.
Bro send me your prescription
So h pylori lowers stomach acid,witch the can increase your risk for other gut infection like sibo??
That's really cool! I wonder where is this study now, any successful products coming?
Thank you for the video brilliant mind.
Thank you so much for this informative lecture! This bacterium is one heck of a problem! The Government health admin., should go to war on this infectious microbe!
Small amounts of urea and strong essential oils oraly?
So is there a therapy that combines urea (for attraction of the hp) with an antibiotic?
I got the same question
Not urea but the only thing I have heard are biofilm disruptors like NAC.
I tested for h. Pylori because I was having stomach pains and nausea but I believe it's from my calcium supplements because I slow down on those and not as much symptoms so I wonder if I would have ever known and just been ok for life because now I'm stressing over it 🥺
can HP can cause diarrhea crises? ive been disgosnosed with Hp a few mouths ago but with the uper syntoms like acid relux and feeling super full after meals and bloating im also with diarrhea sometimes! i tried antibiotic treatment but fails :( im trying a second aproach soon
It causes low stomach acid, which can increase your risk of stomach infections + bacterial overgrowth where both can affect your digestion causing diarrhea
consult s doctor 1st.
@ so what you are saying h pylori lowers the stomach acid,therefore bacteria and candida can florish? I got diagnosed with sibo,but i think the h pylori is the underlying cause, i have constant low stomach acid
@@gigafia5358 If you have/had pylori, its almost certain your stomach acid levels arent optimal, the reasoning behind that is because pylori actually lowers stomach acid for its survival and there is a theory that almost all of us have pylori but it only affects some people, and the reason is because the epigenetics of the person can contribute to it. Some drs claim that the reason people get pylori is because low stomach acid in first place, its like the chicken or the egg question. But in my case, yes pylori tend to lower stomach acid, yes SIBO can be caused by low stomach acid and candida too. Candida is just opportunistic, flourishes when somethings off for a long time, it could be chronic infections, low stomach acid, stress, antibiotics, high carb diet, and of course the MIX of 2 or more of those..
@ yeah that makes sense,thanks. I need to say i also tested high in mercury toxicety on a hair test ,maby thats my underlying cause for the constant candida/SIBO problem...its a constsnt battle,because there are not many good doctors here i live so i kinda fighting my own battle and get some help from a naturopath.. and aloooy of reaserch
Thank you
Should I be treated if I have no symptoms
I have h.pylori since 15 years my daijestic system is very bad I'm not sleep a relaxing mood all night I seen v.bad nd denjirous memory all night my stool not passing well. I have too much gas in my stomach.
you should take antibiotics and get it cleared.
Mastic gum has proven to be very effective in killing h pylori as well as healing ulcers
@@lyntaylor4131 are you chewing it or literally swallowing the gum crystals?
Hi @@mattzere78 I bought the capsules that contain the ground up gum. It made such a difference. You have to stay on them for a couple of months. There are several different strengths. I started with a low dose of 50mg then increased to the 1000mg ones. Then tried the 300mg ones, because I had read that some people had experienced kidney problems, but I think that is very rare.
I found the 300mg ones were best. Good luck with what you choose 🤗
How many years u sick?
I like her
Dr Julie , please consider culturing a bacteriophage that can help eradicate h pylori resistant to antibiotics..Thanks
Very informative video 👍
Amazing work of all these amazing scientists. Just wonder what new therapies besides the 14 days triple therapy and 10 days therapy ( Bismuth subcitrate potassium 140mg
Metronidazole 125 mg, tetracycline HCI 125 mg) do we have? since it seems that eradication of this bacteria is difficult.
I found this video because I have an H Pylori infection, and I have a naturopathic doctor that is helping me with probiotics, a food regimen and supplements. It sounds wild but I think this should be our first line of defense so I figure it's worth sharing. Antibiotics also kill healthy bacteria that our gut bicrobiome thrive from which takes months or even years to come back from with guidance, so taking that into account makes it extra worthwhile to try other methods first with less drastic consequences.
@@Literallywhateverahhhhh Sounds good, in my case I had h Pilory but also gallbladder stones. Gallbladder removed and heartburn disappeared.
@@Literallywhateverahhhhh Did you have any luck with a natural path treatment? If so would you mind sharing what supplements you took? I also have h pylori and am researching better ways to treat naturally, the prescribed antibiotics will be my last resort as you said it can kill good bacteria too and throw off the gut microbios
@@sofiaolguin6776 Lactobacillus Reuteri, Mediterranean oil of oregano(80%+ carvacrol), mastik gum and broccoli sprouts/sulforaphane are known to kill it
The quad treatment with Bismuth did not work for me, but medukha honey with 16+ factor and mastic seem to help.
Excuisite research, really skillful in your presentation as well! But please hurry up to find a solution other than antibiotics for us with h. pylori since we suffer hell and risk our lives ! I know your'e doing your best.
Well said! Couldn’t agree more!
Very good
Hi, very interresting talk, there was one thing i was wondering about though.
You describe that the urea gradient directly affects the bacteria, is it not possible that a ph gradient from urea+urease is causing this ? As you showed also that they react to a ph gradient.
ahhh a terrain theorist confronts the germ theory i wondered also if the bug is the fireman
you guys are doing such a great job , keep it up, there are so many peoples in the world who are suffering with lots of problem like ulcers, gastritis, etc.. and i am one of them , cant be there some method which killed this bacteria and cure all of us :(
Are you sure that completely eradicating helicobacter would be a good thing? These things usually exist symbiotically. Best to fully understand its existential context before attempting to eradicate it.
At the moment, in my view the better approach would be to figure out why those who don't succumb to it don't and why those who do, do.
@@beedebawng2556 That's very interesting I had never looked at it that way.
Bhai kamal. Apka sahi hua kya yaar H.pylori?
@@sarveshchronic2604 yes brother by god grace now I’m 95percent fine 🙏
@@kamalupadhyay1095 I'm stressing out. Could you plz tell me how you managed to eradicate it. I would be highly obliged
Hi im diagnosed with ulsirtive colitis and test show heavy low iron levels. Also h pylory. So any advice to kill it in the tissue??
Hi Can you get this from.Sinus fr. Nose not cure on n off long time?
Than why my Dr, keep prescribing more anti acid?
trained in rockefeller snake oil system?
Hi. I’m going through something now although I’am not perfectly sure if it’s this. I should hopefully be able to be seen today by a gastroenterologist. But in case: do you know now of a solution, or can this be cleansed out, healed ex ex?
All that brilliant research and then she drops the ball by suggesting the only remedy is drugs!
which she implied may be resistant
so what is the protein that helps disable HP ??
I’m currently on treatment for H.pylori. This is extremely informative and interesting. Thank you for posting.
Did you eradicate it completely?
@@Sarashorts2 yes, my follow up breath test was negative
@@iamkristensmith please can you help me what did you do
@iamkristensmith was it antibiotics that helped?
@@ss104 yes
OUTSTANDING KNOWLEDGE...
Is there any new treatment ?