Are Turmeric And Black Pepper Bad For Health?

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  • Опубликовано: 27 апр 2024
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Комментарии • 242

  • @James-ke5sx
    @James-ke5sx 26 дней назад +17

    I am 74 years old and in perfect health and I haven't been to a doctor since 1972. I eat black pepper and turmeric in every single thing from salads and eggs to meat. No problem.

    • @Mikolas649
      @Mikolas649 23 дня назад

      Does it affect your iron level,like lower it?

    • @Michael_RareZebra
      @Michael_RareZebra 22 дня назад +1

      @@Mikolas649He won’t know because he hasn’t been to a doctor since 1972.

    • @SafeEffective-ls2pl
      @SafeEffective-ls2pl 22 дня назад

      @Michael_RareZebra Seems like he's pretty healthy

  • @mjs28s
    @mjs28s Месяц назад +38

    Debunk was already done as soon as I saw it was Paul Saladino

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +8

      I didn't set out to debunk Paul-I would've posted the data even if it worked against me...

    • @user-cr4pz5yg7y
      @user-cr4pz5yg7y Месяц назад +6

      ​@conqueragingordietrying1797 we all know paul is a pick me. He talks loud and looks around when speaking so he knows everyone knows he is talking. He is a talker, not a doctor. I agree with very little he says.

    • @stx7389
      @stx7389 Месяц назад

      ​@@user-cr4pz5yg7y he is flat earther anti science 🤡

  • @monnoo8221
    @monnoo8221 Месяц назад +54

    yes, that's a perfect demonstration of the superiority of science over bro science, abbreviated B.S., and perhaps an eye opener for those vulnerable to click-baiters and gossypers

    • @singularity6761
      @singularity6761 Месяц назад +11

      I don't think it will be an eye opener for the mentioned group, because this folks don't watch channels like this.

    • @nicklam66
      @nicklam66 Месяц назад +4

      Perfect? From a study of n=1? Really?

    • @monnoo8221
      @monnoo8221 Месяц назад +2

      @@nicklam66 it's not an experiment targeting a population, no generalisation onto the population level is intended, nor possible... For that the N would be =1, sure. However, here we have a time series analysis, with enough data points to calculate associations, and for some key components he also performed recently repeated On/Off experiments. Those allow conclusions on the level of causality, which often are not possible for simple RCT. In fact, time series are the only type of experiment that unequivocally allow to talk about causality. Of course, it would be nicer if everything he is doing would include 11+ other people. Then it would start to be possible to have generalisation to population level

    • @willnitschke
      @willnitschke Месяц назад

      ​@@monnoo8221keep dreaming 😅

    • @monnoo8221
      @monnoo8221 Месяц назад +1

      @@willnitschke nothing to say to a guy not knowing anything, have a good rest....

  • @adamesd3699
    @adamesd3699 19 дней назад +1

    Be careful with large amounts of black pepper. I tried a similar experiment where I gradually increased my intake of black pepper. I ended up taking too much and got heartburn that took months to go away. I still like black pepper, but now know to have it in low amounts.

  • @andymilkowski7682
    @andymilkowski7682 Месяц назад +3

    Awesome advancement of this discussion. Good for you and your work.

  • @viracocha2021
    @viracocha2021 Месяц назад +26

    This is awesome. I wish we had this kind of analysis for the rest of nutrients :)

    • @grugnotice7746
      @grugnotice7746 Месяц назад +5

      Soon enough we will have a "scientific AI" into which we can dump all of the data and it will spit out a total analysis like this.

    • @ChessMasterNate
      @ChessMasterNate Месяц назад +2

      @@grugnotice7746 Or it will just make up stuff. I was trying to get the percentages of kinds of sugars in various fruits and berries. And it completely fabricated the numbers. So, some time when I have 6 hours, I guess I will have to do it myself (I was trying to reduce fructose intake, but still have enjoyable fruit).

    • @grugnotice7746
      @grugnotice7746 Месяц назад +1

      @@ChessMasterNate That's first gen large language models, not 2nd or 3rd gen models hand crafted for scientific analysis.

    • @ChessMasterNate
      @ChessMasterNate Месяц назад

      @@grugnotice7746 I was just emphasizing that they are not ready, not that they will never be. Clearly, they are improving rapidly.

    • @monnoo8221
      @monnoo8221 Месяц назад

      @@grugnotice7746 that are LLM, first, and second, handcrafted means, there is no AI, just an automation of the limited understanding of the programmer. Thus those meta algorithms are not able to do scientific work for the foreseeable future==some 200 years

  • @philmartz
    @philmartz Месяц назад +8

    Gotta buy you a coffee! Excellent, as always! Highly instructive! I'm following closely, as always, even though my optimal diet is far different from yours. Considering the large number of t-tests you are doing, I appreciate you applying here and in the future additional advanced statistics of FDR and multiple linear regression to remove false discovery and confounders. Much thanks!

  • @myrrhsolace5875
    @myrrhsolace5875 Месяц назад +6

    My biggest question about turmeric is: why does nobody pronounce the first “r”?

  • @christiancrafoord
    @christiancrafoord Месяц назад +2

    this video is much appreciated, a lot of turmeric controversy going on(or more specifically curcumin), thx!

  • @williamhoffer9277
    @williamhoffer9277 Месяц назад +1

    Great, comprehensive presentation.

  • @agy3504
    @agy3504 Месяц назад +17

    Very quality analysis 👏 Thank you for all your efforts and sharing your very rigorous journey

  • @pimacanyon6208
    @pimacanyon6208 26 дней назад +1

    excellent analysis and video! thank you.

  • @hereticsaint100
    @hereticsaint100 Месяц назад +1

    That's a phenomenal level of tracking!

  • @drlorishemek
    @drlorishemek Месяц назад +1

    What a wonderful presentation! Thank you for all you do. What is your feeling about curcumin the active compound in turmeric?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +2

      Thanks @drlorishemek. Potentially positive based on the turmeric amounts in the video, at least in my case. I'd encourage others to test biomarkers in conjunction with any supplement addition, to see if it's detrimental, neutral, or potentially a positive for health

  • @consciousnessawake505
    @consciousnessawake505 Месяц назад +2

    Amazing work, congratulations! Would you mind to give the links for the data in each body marker ?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      Thanks @consciousnessawake505. i'd start by searching the YT channel for each biomarker
      What you don't find I can send

  • @frankfeather8548
    @frankfeather8548 Месяц назад

    Great presentation - would love to see the link you mentioned about the markers that increase/decrease with aging.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      Hi @frankfeather8548, I'd start by searching for each biomarker on the YT channel. What you can't find, I'll send

  • @tunneloflight
    @tunneloflight Месяц назад +1

    It would be interesting to look at ternary plots of the data (age corrected) for Turmeric and Black Pepper versus each parameter. Visually, real correlations should jump out. And any threshold effects or compound effects should as well.

  • @hvglaser
    @hvglaser Месяц назад +3

    In many eastern countries they use a lot more spices than we do in the west. 1,3 grams is quite low compared to someone from a culture that use more spices, so it would be interesting to see the numbers from that.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +3

      Yep, definitely. The data currently suggests that I can go higher for both, too-maybe there's an upper limit for potential health effects

  • @decimusmeridius88
    @decimusmeridius88 Месяц назад

    Thnx for the work and the vid. Weren't there lots of other aspects of your lifestyle, besides bodyweight, that you improved besides turmeric during this period as well that could have contributed to the beneficial outcomes on the different markers? As in, couldnt there be more confounders you didnt adjust for?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      I'm not sure what the other confounders could be, but a lower body weight seems to have the largest impact on these biomarkers.

  • @johnvanderpol2
    @johnvanderpol2 Месяц назад +10

    It would be great to run all the data through a Data mining AI to find all the correlations, you did not notice yourself yet.
    Also good you checked against body weight.
    It would be great to have this kind of detailed open data research done by many people, to get away from the N=1.

    • @nuovoaccount998
      @nuovoaccount998 Месяц назад

      @@quantifiedmax What makes you think that these correlations are generated by randomness after 30 blood tests?

  • @earx23
    @earx23 Месяц назад

    You are totally methodical. This is awesome. I like Kurkumapepper, but I've heard that it inhibits muscle growth?

  • @glutenfree4713
    @glutenfree4713 Месяц назад +2

    I'm wondering if some of the red arrows was because your levels were already too low or too high? For example, an adaptogen can increase or decrease a biomarker depending on what is optimal for you.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      Yep, that's definitely possible-arguments can be made that both platelets and RBCs are actually green, but to play it by the book (age-related changes), they're technically red.

  • @natfat9064
    @natfat9064 Месяц назад +3

    I have seen women who had to come to the ER for vaginal bleeding that won’t stop. All of them were told to stop turmeric by the doctor

    • @avibhagan
      @avibhagan 28 дней назад

      Anything in excess is bad for you. Even water. Yes, overconsumption of water can kill.
      Does the few cases of people dying from overconsumption of water mean that water is bad for your health ?

  • @wjjansen6393
    @wjjansen6393 Месяц назад +1

    As always the quaility analysis of Dr Lustgarden!

  • @abdelilahbenahmed4350
    @abdelilahbenahmed4350 Месяц назад +3

    Great analysis as usual.A Moroccan tagine would be tasty even if it includes only 3 spices, turmeric,black pepper and ginger.And even if Prof.Lustgarten is not a fan of olive oil, adding some of it in the tagine makes the spices more bioavailable and increases their préventive , anti-aging, and maybe healing power as we can see through the decrease in hsCRP, glucose and RDW 😊.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +3

      Thanks Abdelilah. Note that I'm generally anti- all oils, not just olive oil-I prefer whole foods instead, including olives...

  • @user-yl7kl7sl1g
    @user-yl7kl7sl1g Месяц назад +2

    I can't wait for your bodyweight video. I've suspected a lower bodyweight would slow aging.

    • @jamesgilmore8192
      @jamesgilmore8192 Месяц назад

      I think Mike has already discussed some of that in a previous video...lower body weight is generally beneficial if your preserving muscle mass, but there seems to be a limit of CR beyond which some important marker start to decline like strength, muscle mass. Also reserves become limited which is something else to consider.

  • @bosman6456
    @bosman6456 Месяц назад

    thanks for the detailed analysis. Most people would consider lower platelets to be a good thing as it keeps blood from clotting ?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      Thanks @bosman6456. There's a U-shaped curve for platelets in terms of all-cause mortality risk, with < 200 and > 300 associated with increased risk.
      In my case, is closer to 200 or 300 better? An argument could be made that the platelet associations could be green, as lower within the 200-300 range is associated with more biomarkers going in the right direction vs wrong.

  • @ttfan3257
    @ttfan3257 24 дня назад +4

    @James-ke5sx
    1 day ago
    I am 74 years old and in perfect health and I haven't been to a doctor since 1972. I eat black pepper and turmeric in every single thing from salads and eggs to meat. No problem.

  • @Icarianbrother
    @Icarianbrother Месяц назад +3

    Paul Saladino- "We've been told that vegetables, nuts and grains (aka plant leaves, roots, stems and seeds) are essential for optimal health. I strongly believe that these parts of the plant are a net negative for humans, and that the only part of the plant we should be eating is the fruit." Paul Saladino is a national treasure. His information is part of a eugenics program to improve the genetic quality of America's population through dolt reduction.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      Don't get me wrong, i appreciate Paul. But, the point of the video is to objectively assess whether turmeric or black pepper may be bad for health by tracking one's own biomarkers over a long time period.

    • @Icarianbrother
      @Icarianbrother Месяц назад +1

      @@conqueragingordietrying1797 I'm just kidding. Thank you for another great video!

  • @bhut1571
    @bhut1571 Месяц назад +4

    Thanks for the info. Wish I had your statistical smarts. I'm 78 and started using a small amount (say 1/2 to 1 tsp) of turmeric to me morning oats some 30 years ago when my companion "Arther" was bothering me knees. I then started adding a snort of black pepper some 15 years ago. Now this is just and "n" of 1, but my blood lipids are great, great H1ac, no statins or drugs and Arther hardly bothers me. However I have had a tad of afib over the last year. It probably all depends on one's genetics, for example if one is a kidney stone former one wouldn't want to put turnmeric on their beets.

    • @bones642
      @bones642 Месяц назад

      That’s inspiring :)

  • @DBMMMMM
    @DBMMMMM Месяц назад +1

    I used kurkumapepper daily before, and changed to only use it whenever I have flu or Covid, inflammation etc, it's extremely powerful like antibiotics but it needs a pretty high dose. Say some 3000 mg minimum. But since it could interact with several other nutrients/supplements, and to raise effectivity in case of inflammation/viruses, only use when necessary. Definitely not on daily basis.

  • @KTPurdy
    @KTPurdy Месяц назад +1

    gotta love the power of statistics

  • @erastvandoren
    @erastvandoren Месяц назад +3

    Weird, scientific literature says turmeric increases the platelets count.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      Interesting, can you please post that link? Platelets decline during aging...

    • @monnoo8221
      @monnoo8221 Месяц назад +1

      it does a lot of things... for instance, it makes macrophages hungry, such that they are cleaning waste more effectively

  • @loungezinger
    @loungezinger Месяц назад +1

    Is there a way to analyze the data with weights attached, not just an overall 'net' positive or negative? If something drops by a small amount relative to what the correlative studies have shown, shouldnt it be less 'valuable' in evaluation vs something that has a huge impact and needle move?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      Good question-I've experimented with summing the actual correlations, but I'm not sure that's a better approach

  • @jamesgilmore8192
    @jamesgilmore8192 Месяц назад +1

    The bioavailability of curcumin makes this all quite interesting. The use of turmeric powder + black pepper means you are probably targeting the GI tract and liver (e.g. CRP is made in the liver) with the GI effects hard to measure. Some of the more bioavailable formulations, which reach higher circulating concentrations, could better target the brain and other body systems, although you'd need to go the supplement route.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +4

      The bioavailability of turmeric (or not) is somewhat over-popularized. What isn't absorbed can be metabolized by gut bacteria, potentially also benefitting health.

    • @jamesgilmore8192
      @jamesgilmore8192 Месяц назад

      ​@@conqueragingordietrying1797 My take on the bioavailability science was ground turmeric or curcumin extract powder itself are useful even if not well absorbed as they collect in GI tissues more than the high bioavailability supplements. If however you want high circulating amounts, then using something like Theracurmin is a reasonable choice. However these high bioavailability supplements seem to have more pronounced side effects in some people. Its a shame they don't have clear use cases with associated biomarkers.

  • @DBMMMMM
    @DBMMMMM Месяц назад +8

    What is also not taken into account is longterm use, for example oxalatecrystal buildup. Even when uric acid goes down, kurkuma is still very high in oxalates. Longterm use could lead to more permeable colon lining?.....

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +17

      Up-to 6 years of biomarker data in the video...
      There would be a pattern in the biomarkers of that, i.e. higher uric acid because of decreased kidney function, or increased inflammation with a more permeable gut lining. There's no evidence for that being true in my data atm...

    • @DBMMMMM
      @DBMMMMM Месяц назад +2

      @@conqueragingordietrying1797 oxalate build-up effects I think depends on our Microbiome... True?.. Oxalate build-up may become an issue after a very long time just like cancers..
      But hey i highly appreciate your videos... It's just an idea I had

    • @jamesgilmore8192
      @jamesgilmore8192 Месяц назад

      @@conqueragingordietrying1797 Maybe when you have a couple more years of data you can split the analysis into first 5, last 3 and see if the same relationships hold across time. Or alternatively add a variable of total curcumin intake over time and see if anything shows up.

    • @skincraftorganicsllc8537
      @skincraftorganicsllc8537 Месяц назад +5

      Most curcumin supplements are made with turmeric extract, and therefore extremely low in oxalates.

    • @DBMMMMM
      @DBMMMMM Месяц назад

      @@skincraftorganicsllc8537 I press my own organic kurkuma as 1000mg per capsule caps, mixed with black pepper 20:1 ratio, ingest it with fish oil caps mostly. Its high in oxalates

  • @DCGreenZone
    @DCGreenZone Месяц назад

    Liposomal curcumin sourced from India with the liposomes stabilized with fenugreek seed galactomannan fiber gel has a half life of 7.5 hours instead of 15 to 18 minutes as does standard curcumin. I read that somewhere.

  • @jamesgilmore8192
    @jamesgilmore8192 Месяц назад

    Mike, maybe for videos like this you could list the correlations of say e.g. turmeric intake with other dietary changes over the same time period. That might indicate to viewers there could be some other potential factors. I'm not sure what the data looks like, but it could be messy I suppose.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      Hmm, thanks James, I'll have to think about how to present that, as It could get messy with even more data

  • @mannmstorm
    @mannmstorm Месяц назад +3

    Regarding turmeric and platelets: At what platelet count would you reduce or stop your turmeric supplementation?
    I am already low on platelet count (usually right at the lower range 150),

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +2

      Below 200 for platelets, as 200-300 is associated with lowest ACM risk

    • @yeoyeodere1
      @yeoyeodere1 Месяц назад

      Why does tumeric and black pepper affect RBC and platelet count?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  26 дней назад

      @@yeoyeodere1 They're correlations, I can't say if it's causation, but it could be that higher levels of both may be too high, and slightly lower levels may be a more healthful profile. If/how that happens, beyond the correlation, not sure

  • @fluffyheed9166
    @fluffyheed9166 23 дня назад +1

    I know you showed your inflammation markers were reduced but were the reductions significant? Were your inflammation levels ever high?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  23 дня назад

      3x higher than now at its peak, about 2x higher than now (< 0.3 mg/L for 17 consecutive tests) on average

  • @Sammyli99
    @Sammyli99 21 день назад +1

    GOLD

  • @friedux2065
    @friedux2065 Месяц назад

    For someone like me who has intolerance to oxalates due to a dearth of oxalate degrading bacteria after antibiotic use I tend to avoid turmeric and black pepper as both are high in oxalate, white pepper less so.

    • @MPM6785ChitChat
      @MPM6785ChitChat 18 дней назад

      To help with oxalate removal / allievation - eat organic cheeses , butter, yogurt from Goats, Ewes/ Sheep.
      Avoid dairy from Cows.
      Cows eat grass - in nature they dont eat any grains which causes them terrible health issues , rhe inflammation contaminates their flesh and milk.
      If l eat beef its in small amounts and always Aberdeen Angus or Bovines that are feed ib grass from start to finish of their lives.

  • @Seeker_of_sense
    @Seeker_of_sense Месяц назад +1

    Interesting.

  • @iotanb1772
    @iotanb1772 28 дней назад

    Im 40 yrs old.
    My Lymphocytes have always been slightly high for the last 15 years 42-46%, with everything else normal.
    Recently they were 64% with limit being 40% with 4,500 to max of 3000.
    No symptoms.
    Should i get further testing or nothing to worry about?

  • @HarryJensen-kr4qz
    @HarryJensen-kr4qz Месяц назад +2

    Been hearing a lot about melatonin lowering dementia risk. Your video covering sws 5 months ago confirmed importance of sleep, js.

    • @BR-hi6yt
      @BR-hi6yt Месяц назад

      Someone told me in a cafe "don't take stains, they give you dementia". She seemed an intelligent 65 year old.

    • @lauchlanguddy1004
      @lauchlanguddy1004 Месяц назад

      @@BR-hi6yt statins are vary scary with very very little benefit but high profitability,

    • @elizabethezell8749
      @elizabethezell8749 18 дней назад

      ​@@BR-hi6yt I don't know about dementia, but they sure make your body hurt. I had a heart attack they put me on Lipator , I had a second one, they asked are you taking your cholesterol medicine? I said yes why, well you had a burst of cholesterol to clog your artery. Why am I taken it if it doesn't do it's job......I haven't in roughly 2 mths

  • @AnonMedic
    @AnonMedic Месяц назад

    The only negative with Tumeric is its oxalate content for people with oxalate toxicity or issues with oxalates.

  • @mindcache5650
    @mindcache5650 Месяц назад

    I take a daily teaspoon of 12 ground spices and herbs per day ( including turmeric and black pepper). Cloves and have an incredibly high anti oxidant score. But all spices are hundreds of times better than blueberries in terms of antioxidants.

  • @samuelerivardi1326
    @samuelerivardi1326 Месяц назад

    Do you track anti-nutrients intake? If yes, which ones?

  • @ComeAlongKay
    @ComeAlongKay Месяц назад

    Turmeric I’ve heard can chelate iron, a thing you may already be getting a lot of without high iron foods as it’s fortified in stuff.

  • @johnsyoutube23
    @johnsyoutube23 Месяц назад +1

    Amazing... this is the way healthcare work should be done.

  • @colinvankeith4814
    @colinvankeith4814 24 дня назад

    After developing idiopathic pulmonary embolism (PE) and deep vein thrombosis (DVT) I suspected turmeric and black pepper that I had added significantly to my diet believing it to be highly beneficial. I dropped the turmeric and black pepper and have not had a recurrence of the symptoms, however I have also been on low dose blood thinners so that is a confounder. Now that this case study shows that both turmeric and black pepper lower platelets so 16:19 this lends credibility that the combination of turmeric with black pepper were responsible for the increased risk of the blood clotting problem leading to PE and DVT. In my case the adverse effects were potentially life-threatening and far outweighed any possible improvement in other bio-markers.

  • @jamesgilmore8192
    @jamesgilmore8192 Месяц назад +1

    To clarify you are using ground turmeric, not the curcumin extract powder (95% curcumin) that is commonly available?

  • @chris-lk4ml
    @chris-lk4ml Месяц назад

    After watching the half of the video, I have had a strong feeling that I just need a tumeric-drink with 2g black pepper, 12g tumeric powder, 10g cocoa, 30g almonds and oats milk.
    I think I should adjust it a little bit more for the tast.

  • @andrewtaylor9799
    @andrewtaylor9799 Месяц назад +1

    Nice analysis. Maybe I'll start taking tumeric again. The thing that bothers me is that its mechanism is reportedly stressing the cell. Good to see vascular health in the scores.

    • @barbiekat6352
      @barbiekat6352 Месяц назад

      Could you please state more about its (turmeric) “mechanism stressing the cell”? Where could I find more info? What terms to search? 🙏 Thank you!

    • @andrewtaylor9799
      @andrewtaylor9799 Месяц назад

      @@barbiekat6352 Google "tumeric oxidative stress"

  • @sabasalih5514
    @sabasalih5514 22 дня назад +1

    wow ... Awesome science!

  • @JohnDoe-os3mc
    @JohnDoe-os3mc Месяц назад

    my concern with turmeric is affecting telomerase in healthy cells, and black pepper increasing gut permeability

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +5

      Some of the correlations for turmeric were with a longer telomere length, not shorter, and if black pepper increased gut permeability, I'd expect to see increased systemic inflammation, but that's not the case based on the associations in the video.

  • @sabincioflec8413
    @sabincioflec8413 Месяц назад +2

    Turmeric is probably good IF you have a good microbiome that deals with the oxalate content, just like most vegetables. Also it's a known chelator and lowers the availability of iron to be absorbed so depending on iron status it can be good or it can be bad for you.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +1

      Watch the video?

    • @sabincioflec8413
      @sabincioflec8413 Месяц назад +1

      @@conqueragingordietrying1797 I've watched it, can you direct me to the minute where you talk about iron or microbiome and the interaction with turmeric? Just a boring video where you hide behind "data" and think that tells the whole story, in most double blinded randomized controlled studies you will see people that have very good response to the intervention and people who have very bad, including low carb, high carb or other nutrients. I believer it's called a waterfall plot. That's why that is science and this is playtime.
      If you have a good microbiome you will have the good response, like you do here with a lot of biomarkers but if we take 50 people and do the same controlled diet/turmeric diet you will see people having 10 negative markers and 1-2 good.
      This is perfectly exemplified in the stanford microbiome studies where people with low diversity have more inflammation with more fiber and people with high diversity have less inflammation and more benefits.

    • @matttee1319
      @matttee1319 Месяц назад

      I watched the video also. I'd love to get the positive benefits the data revealed, but I'm personally at greater risk for the negatives, possibly..? Snarky(?) replies to viewers' comments aren't helpful. Taking the comments seriously is an opportunity to advance the conversation for everyone. That said, great video. Bad reply.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +1

      @@matttee1319 I'm not trying to be snarky,
      but your comment, "Turmeric is probably good IF you have a good microbiome that deals with the oxalate content, just like most vegetables"
      has nothing to do with what's in the video, which is an objective, data-driven analysis.

    • @lauchlanguddy1004
      @lauchlanguddy1004 Месяц назад

      well i have Hemochromatosis, hope it lowers iron. Im 71 and platelets etc low...

  • @OnlyKaerius
    @OnlyKaerius 23 дня назад

    I see a weakness in the methodology, both consumptions closely match, so the data points for them are the combined effect of both, you haven't isolated them individually.

  • @ChessMasterNate
    @ChessMasterNate Месяц назад +2

    Recently, I saw a video where an expert said that fructose creates a lot of Advanced Glycation End-products in the body. I am fully convinced that AGEs are bad news, and I have engineered my diet to reduce the intake of AGEs and engineered my supplement stack to reduce their formation in the body. The diet adjustment is already difficult, cutting out fructose would add additional difficulty and reduce diet satisfaction. Could you use your data to see what it says about the various sugar forms and their associations with your biomarkers?
    I just want some evidence before I upend my life.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      I'm not sure if it's because of AGE products, but I track fructose intake, which has a -7 correlative score with these 26 biomarkers. To follow the correlation, my current intake is about half of my highest, and I'm working on bringing it lower.

    • @ChessMasterNate
      @ChessMasterNate Месяц назад

      @@conqueragingordietrying1797 Thanks. -7 sounds pretty bad. It probably is the AGEs. They stiffen tissues and are thus associated with just about every negative condition common in aging.
      Obstruction is probably also a factor, slowing hydration, removal of wastes and oxygenation.
      The effects probably overlap with amyloids, as they both are useless proteins that build up, the body has difficulty getting rid of.
      I found an interesting study: : "Advanced glycation end-products, measured as skin autofluorescence, associate with vascular stiffness in diabetic, pre-diabetic and normoglycemic individuals: a cross-sectional study."
      Bryan Johnson has one of those arm gadgets. He rarely mentions it, so I am curious where it puts him. Heck, I want to know where I am at.
      I have been reasonably good the last, almost 6 years, regarding consuming AGEs. But when I was a kid and in my 20s, and 30s even, I was not so good. I did not eat fried stuff and BBQ every day, but I liked buffets, and ate a lot of Hometown Buffet, which cannot have been good. I even did their breakfast a few times and ate mounds of bacon. One pile of that probably adds up to a year of AGEs. I figured the only issue was the saturated fat. I did not know anything about AGEs. I focused back then on getting every nutrient my body might need, and exercise. I exercised, including weight training, from 1984 to 2007. Crap happened in 2007, and I haven't completely put things together.
      I am hoping they are wrong and glucosepane actually can be removed from the body, just very slowly. Then, there is every reason to think decades of being good will enhance my health rather than just slowing decline.
      Reducing AGEs in the diet, improved my kidney function dramatically. GFR of 72 brought up to 108 (111 a few months back).
      Oh, that albumen pill did increase my albumen, but some other numbers went backward. I don't know if that is connected, though. I am moving too many variables at the same time.

  • @ailfawka6278
    @ailfawka6278 Месяц назад +1

    Both black pepper and tumeric appear to be anti-androgenic (eg. Dihydrotestosterone inhibitors/blockers), anything that interfers with my anndrogens gets heavily reduced or completely avoided.

    • @32GaugeSlug
      @32GaugeSlug Месяц назад

      But at the same time, Turmeric has been shown to block the action of highly estrogen substances like Bisphenol-A.

    • @BitZapple
      @BitZapple 29 дней назад

      you don't need much DHT as an adult
      It's not Finasteride or Saw Palmetto
      Very weak and insignificant DHT inhibition

  • @zardoz7900
    @zardoz7900 16 дней назад

    Turmeric and black pepper are high in oxalates. Especially black pepper. That's why they tell kidney patients to avoid black pepper. I'm really surprised you didn't mention that.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  16 дней назад

      For the 3g of turmeric and 2g of black pepper that I eat per day, that's 81 mg of oxalate, which is a very small amount when compared to 1oz of spinach (325 mg).
      Oxalate binds to calcium, followed by their excretion, so it's essential to ensure a far higher calcium intake. In my case, I aim for at least 600-700 more calcium relative to oxalate.

  • @HiloBoiz808
    @HiloBoiz808 Месяц назад

    This video reminds me of when I ate a vegan diet, over complicated.I now eat a carnivore diet for over a year and am never looking back.Starting to eat a carnivore diet has greatly simplified my life when it comes to eating and preparing meals not to mention huge improved health.

  • @allurbase
    @allurbase Месяц назад +4

    I don't know if you take them together, like how big is the correlation between pepper and tumeric, but it's interesting that they show the same correlations.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +2

      I take them together, albeit in slightly different amounts.

    • @jamesgilmore8192
      @jamesgilmore8192 Месяц назад

      @@conqueragingordietrying1797 Its worth taking them together because of the increase in curcumin bioavailability.

    • @allurbase
      @allurbase Месяц назад

      @@conqueragingordietrying1797 wonder what happens if you measure correlation of one independent on the other.

  • @darrenparis8314
    @darrenparis8314 Месяц назад +1

    What is the correlation strength of your daily black pepper intake with your daily turmeric intake?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +2

      Great question, very high over the 6yr period: r=0.92, p=4E-15

    • @bixinho199
      @bixinho199 Месяц назад +1

      ​@@conqueragingordietrying1797 So it could be a possible confounding? Did you adjust for it?

    • @jamesgilmore8192
      @jamesgilmore8192 Месяц назад +1

      Its tricky here regarding confounding as its well known pepper increases the bioavailability of curcumin. One analysis would be to analyse pepper and turmeric together see what is stronger, maybe in a combined endpoint. Other experiments are supplements without pepper and taking pepper and turmeric at different meals.

    • @jamesgilmore8192
      @jamesgilmore8192 Месяц назад

      ​@@conqueragingordietrying1797 It would be worth checking mediation with back pepper here.

  • @slainiae
    @slainiae Месяц назад

    Are you considering doing a red-light trial to see if it impacts on any key biomarkers?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      Not yet, but red light therapy is definitely on the to-do list in terms of potential experiments. Which biomarkers it will improve, if any (in my case) is debatable.

    • @jamesgilmore8192
      @jamesgilmore8192 Месяц назад +1

      @@conqueragingordietrying1797 Probably measures of skin health, recovery and possibly detoxification markers, Although you could argue each of those has higher priority interventions, and some of markers are hard to measure.

  • @BR-hi6yt
    @BR-hi6yt Месяц назад

    My experience with turmeric and black pepper is generally negative, turmeric is oxalic acidy imo & notice no good outcomes with black pepper. Its just my n=1 personal tests.

  • @btlmail1969
    @btlmail1969 19 дней назад

    Great work but, you did nit address the issue of the amount of turmeric per day, which is what you initially presented and never returned to.

  • @domagojJugovic
    @domagojJugovic Месяц назад +1

    Turmeric, mybe good , as anti-inflammatory
    Black Pepper, very very bad, agravates gut, if you have leaky gut stay away
    It's not important do you trust me, if this info makes you wonder try to avoid black pepper and see are your skin symptoms better. (Leaky gut is seen as eczema, psoriasis etc)

  • @bowmastah5169
    @bowmastah5169 Месяц назад +2

    What about oxalate content from turmeric?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +4

      Oxalate is a potential problem, but based on the data in the video, the net effect of turmeric is potentially positive.

    • @lauchlanguddy1004
      @lauchlanguddy1004 Месяц назад

      @@conqueragingordietrying1797 i take high long term curcumin and pepper with no oxalates problems yet

    • @32GaugeSlug
      @32GaugeSlug Месяц назад

      @@conqueragingordietrying1797 Surely Oxalate isn't a problem in an extract?

  • @glorgau
    @glorgau Месяц назад

    It seems to me that it's very difficult to get a control on dietary intake. Perhaps there should be a study on an incarcerated population - there you could really control the intakes.

  • @yeoyeodere1
    @yeoyeodere1 Месяц назад +1

    Why does tumeric affect .RBC and platelet count adversely?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +1

      They're correlations, I can't say if they're causative, but one possibility is that both were too high, and lowering them may be a part of a healthier systemic environment.

  • @dabig_guy2204
    @dabig_guy2204 Месяц назад +1

    Benefits of science

  • @ttfan3257
    @ttfan3257 24 дня назад +1

    Nepal, Bhutam India and Sri Lanka have among the lowest cancer rates in the world. And they eat curry 2-3X daily
    Curry contains Turmeric + BlackPepper.
    Is PS saying , India has been doing it wrong for 100+ years?

    • @Sammyli99
      @Sammyli99 21 день назад

      try 5,000 years way ahead of other nations in natural cuisine and herbs, but never min I am sures Gates and Bros, will have the west eating soylent green, blue and yellow before long.

  • @willnitschke
    @willnitschke Месяц назад +1

    Why did you add ground turmeric to your diet to begin with? Anti inflammatory?

  • @matttee1319
    @matttee1319 Месяц назад

    I'm torn about this. I'm low on rbc's but i like the other positive effects

    • @jamesgilmore8192
      @jamesgilmore8192 Месяц назад +3

      Its hard to know if the lower RBC is important or casual. For example, the reduction in CRP could mediate the reduction in RBC through reduced inflammation. Directly increasing RBCs would be worth exploring.

    • @matttee1319
      @matttee1319 Месяц назад

      That's an interesting take. I don't know why I have lower rbc's. I'm tempted to add the turmeric and see if my labs change.

    • @jamesgilmore8192
      @jamesgilmore8192 Месяц назад +2

      @@matttee1319 You have your answer then -- figuring out the why is the most important thing, for rbcs its usually related to iron intake, b vitamins and membrane substrates (saturated fats etc). Make sure you measure hsCRP and consider 3-4g/day turmeric equivalents (e.g. like Mike above with turmeric(3-4g)+black pepper(~1-2g), or bioavailable supplements) and consider it as an "intervention" otherwise you'll be needing to measure over and over again to form a linear model.

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +1

      The only way to know is to do the experiment...

    • @monnoo8221
      @monnoo8221 Месяц назад

      @@matttee1319 you may take a few days into the mountains, above 3000m altitude, and do a zone 2 training. Or you restrict breath while doing exercise, by increasing air\breathing resistance. Or you can do breathwork with extended holds

  • @Sheena1234ization
    @Sheena1234ization Месяц назад

    Love Saladino

  • @juliawigger9796
    @juliawigger9796 28 дней назад

    As soon as i saw the word saladino🤣🤣🤣🤣🤣

  • @dbpook
    @dbpook Месяц назад

    Seems like I'd need an advanced mathematics degree to be able to do this for myself - we need an AI that can crunch all the numbers for us, just feed it lab reports and it tells us what to eat for optimal health.

  • @russianprincess3673
    @russianprincess3673 Месяц назад +1

    FAKE NEWS FAKE REPORT ♥️

  • @dms8504
    @dms8504 Месяц назад

    Dr Paul Saladino...lmao

  • @ATT935
    @ATT935 Месяц назад +1

    but is responding to lidl liver king really even worth?

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +1

      It's not about Paul, it's about the idea-in my case, there's no evidence that either turmeric or black pepper may be bad for health

    • @ATT935
      @ATT935 Месяц назад

      @@conqueragingordietrying1797 based and blue pilled

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      @@ATT935 lol, blue vs red pill is a false choice

    • @ATT935
      @ATT935 Месяц назад

      @@conqueragingordietrying1797 no worries is just meming... we are all longevity pilled here no cap on a stack 👍

    • @adhizzle9985
      @adhizzle9985 Месяц назад

      @@conqueragingordietrying1797 it burns my throat and causes gerd for me. is that a way of being healthy? feeling like shit? lol

  • @lincolntrewethey
    @lincolntrewethey Месяц назад

    TUHR' muh rik, not TOO muh rik.

  • @sooooooooDark
    @sooooooooDark Месяц назад +12

    once u find this channel u realize how low quality the other """scientific""" channels truely are 😂
    that awkward moment when N=1 is more thorough than a whole sector of government 😒

    • @monnoo8221
      @monnoo8221 Месяц назад +2

      if you are honest, you do proper science, otherwise you engage in meta analysis and crappy epidemiology.
      Michal is not doing N=1.... that's a paper tiger or straw man argument. He has enough data points, usually>20 to check for associations. Since everybody is an individual, it is anyway practically impossible to find anything interesting using a generalized approach on the population level via epidemiological studies.

    • @jamesgilmore8192
      @jamesgilmore8192 Месяц назад +1

      There are pros and cons to all methodological approaches. The key is to understand the limitations and not inflate the evidence. Those are tough skills to acquire, and even well respected scientists misunderstand the nuances of results on first pass, and it sometimes takes multiple peer reviews to sort things out.

    • @sooooooooDark
      @sooooooooDark Месяц назад

      @@monnoo8221 reading cherry picked paper isnt science
      science requires scientific method, not spoonfed (often times cherry picked) data (to justify one's world-view), michael is doing very very well with the way he does it, i wouldnt do it much different if i had the funds to do all the testings 😂ive to rely on intuition more (less reliable/slower, but teaches u intuitiveness in everyday life as well so its got its merits too i guess)

    • @monnoo8221
      @monnoo8221 Месяц назад

      @@sooooooooDark you probably misunderstood it before, i am quite scepticaal against meta analyses, cllecting large N, but neglecting any important details. (using "you" in the earlier post was not the personal pronoun, it was the generalizing one) I completely agree, what you are saying here

    • @sooooooooDark
      @sooooooooDark Месяц назад

      @@monnoo8221 meta studies r good if u cant measure it urself like michael does it tho xD, im not claiming that it will yield the best possibly results... but its better than nothing 😅

  • @daves2624
    @daves2624 Месяц назад

    Be safe... DON'T EAT ANYTHING.

  • @adhizzle9985
    @adhizzle9985 Месяц назад +1

    Where can you get these spices WITHOUT heavy metals?

  • @blackfam972
    @blackfam972 Месяц назад

    Did you get the covid19 shots?

  • @smarzig
    @smarzig 24 дня назад

    Your such a cool 😎

  • @darkpatches
    @darkpatches Месяц назад

    Tumor Rick!

  • @denmar355
    @denmar355 28 дней назад

    TuRmeric

  • @wmp3346
    @wmp3346 Месяц назад +1

    Stop listening to Paul and Fox noise

  • @frostar701
    @frostar701 16 дней назад

    I can debunk that BS with one word: “India”

  • @MorningClarity
    @MorningClarity Месяц назад +1

    Hasn't that Dr. P. S. been misguided or done multiple about-faces multiple times? 🤣 Nothing wrong with learning and correcting course, but at some point ... 🙄

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад +7

      I don't see it like that-I appreciate Paul. We can't always be right-I've had plenty of hypotheses that have fallen flat on my face (grape seed powder, fish oil to increase NAD). But I think the takeaway is doing the experiment, rather than relying on opinion, to find the truth...

  • @squarz
    @squarz Месяц назад +2

    Another Saladino bs

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      In my case, perhaps, but I'd encourage others to track their own data to see if it's true, or not...

  • @rickspalding3047
    @rickspalding3047 Месяц назад +1

    Have you ever heard of Bryan Johnson who spends millions to try to live "forever"? Integrated in your thoughts

    • @conqueragingordietrying1797
      @conqueragingordietrying1797  Месяц назад

      Yes @rickspalding3047, of course, Bryan and I have chatted a couple of times. I appreciate Bryan being in this space, shining the spotlight on living long enough to live forever.

  • @ATT935
    @ATT935 Месяц назад

    lol

  • @blue-gx5tm
    @blue-gx5tm Месяц назад +2

    I originally blocked physionic's channel because the advice was consistently terrible... but now I follow him and do the opposite of whatever he recommends. I've never felt better!

  • @EternallyThankful-os6pz
    @EternallyThankful-os6pz Месяц назад

    I think Paul is being swayed and convinced with every "wind" of diverse information from various sources and kind of struggling to make sense of it all AND get some balance to his conclusions....he is flailing like a fish out of water in other words. He needs to SLOW DOWN and do more analysis of a greater source of findings before he jumps onto any bandwagon of "new" advice. I don't think he is purposefully misleading anyone - I honestly feels he is trying to genuinely help people and not be contrary just for contrary's sake - but he does need to SLOW DOWN and analyze a little more before posting his next "do or don't do" vid.

  • @Mrwan13
    @Mrwan13 Месяц назад

    You’re part of the conspiracy too !!! 😜

  • @MisterProducts
    @MisterProducts Месяц назад +2

    Paul is a clown, dont waste your time lol

    • @domagojJugovic
      @domagojJugovic Месяц назад

      Yes , he is a clown, just sometimes is right , like about black pepper.
      But it is not important if you believe him or me, if you have problems with black pepper you should notice it. BTW it wrecks your gut, and aggravates leaky gut greatly

  • @user-jy2sz1jr9p
    @user-jy2sz1jr9p Месяц назад +1

    Thanks for the meta-analysis - however the assumption is that these source investigations are being reported after performing due diligence and adherence to strict laboratory protocols - which may not always be the case. The data could be unreliable..