Love your channel. I’ve done shrooms a couple times and have had a great amd bad experience. I can do as low as .1 grams or even smoke some pot and I get great visuals with my eyes closed. Sometimes when I’m super tired I can have these visuals. They didn’t start happening until I first did shrooms. It’s a cool experience but I don’t know why this happens.
Nice talk Manesh it brings up some interesting ideas. I remember reading the papers on compounds that are psychoplastogens. It seems like theoretically, you may not need the psychedelic experience for therapeutic benefits if and only if the compounds promote neurogenesis without producing a psychedelic experience. From the literature, you could do this by designing an mTOR, AMPA, and TrkB agonist. Are there any papers in the literature that have designed compounds that are agonist at these targets that are not psychedelic? I know there are mTOR, AMPA, and TrkB antagonists out there and they have shown that by inhibiting these pathways you can take away the psychoplastogenic effects of psychedelics.
Great video, liked as always! Couple of thoughts..., you conflate psychedelic experience with mystical experience. It is possible to use classics and micro and mid-tier levels without mystical talk. The research misses out on micro and mid-tier dosing (micro in particular and dosing in general) as a means to induce changes to things like TRD (lets be frank, we should be measuring dose dependent effects fully across the range and longitudinally, on thousands of peoole, before talking about using anaesthesia on patients!), which removes mystical from the equation (I appreciate there is a reason this is missing and there are currently trials underway at micro dose levels). As with most things, the truth usually lies somewhere in the middle and this is not a 1 or the other situation for 100% of humans. However, when you go to the extremes, with things like TRD where a persons life lies in the balance, literally, sitting around and having a jolly about mystical experiences is a ridiculous thing to do, as a priority focus... For researchers...
Hey Padraig, thanks for the comment. The reason for the emphasis on mystical experience in the research to date is because - as I described - the most positive outcomes have been with people who underwent more of a mystical experience during their treatment. The more they had mystical-type phenomena happen to them, the more they improved in their depression, smoked less, had less end of life anxiety, etc. So the emphasis on mystical experience is not 'ridiculous' - the quantitative (and qualitative) evidence suggests that these experiences lead individuals to change their perspective on themselves, their life, other people, the world, etc., and this results in lasting positive benefits - even a year+ later after a single experience. It's also undoubtedly the case that subjects don't go straight to mystical experiences in their sessions - these experiences often come after or are intertwined with personal (psychodynamic) content (i.e., memories, repressed emotions, etc.). Of course you're right in that a lot more research is needed to explore other facets of the experience at different dosage ranges. This is what will likely happen over the next decade.
Well, psychedelics without the mystical experience happens every week ends in club and festivals and do not seem to produce levels of change in people that proper mystical experiences influenced by proper set and setting do.
How are they "mind-manifesting" without the trip. They would fundamentally not be PSYCHEDELIC. They would be 5-HT2A agonists merely without any psychedelic effects, assuming they are still 5-HT2A agonists?
Love that T-shirt ❤️
You did an amazing job of shining light on both sides of the coin! Interesting new research that you're sharing! 🙏🏽
Cheers brother!
Thank you. 🙏🏽❤️🙏🏽
Great videos... hope to make more of them! :-)
Love your channel man. I hope you keep making videos!!!
Thank you for another great video! I was wondering if there's a place, where you link the studies you're referring to in the video? 😊😊
Your videos are great! Keep it up👍
Love your channel. I’ve done shrooms a couple times and have had a great amd bad experience. I can do as low as .1 grams or even smoke some pot and I get great visuals with my eyes closed. Sometimes when I’m super tired I can have these visuals. They didn’t start happening until I first did shrooms. It’s a cool experience but I don’t know why this happens.
Nice talk Manesh it brings up some interesting ideas. I remember reading the papers on compounds that are psychoplastogens. It seems like theoretically, you may not need the psychedelic experience for therapeutic benefits if and only if the compounds promote neurogenesis without producing a psychedelic experience. From the literature, you could do this by designing an mTOR, AMPA, and TrkB agonist. Are there any papers in the literature that have designed compounds that are agonist at these targets that are not psychedelic? I know there are mTOR, AMPA, and TrkB antagonists out there and they have shown that by inhibiting these pathways you can take away the psychoplastogenic effects of psychedelics.
Not that I know of. A cool idea though. There must at the least be some in development
Great video, liked as always!
Couple of thoughts..., you conflate psychedelic experience with mystical experience. It is possible to use classics and micro and mid-tier levels without mystical talk.
The research misses out on micro and mid-tier dosing (micro in particular and dosing in general) as a means to induce changes to things like TRD (lets be frank, we should be measuring dose dependent effects fully across the range and longitudinally, on thousands of peoole, before talking about using anaesthesia on patients!), which removes mystical from the equation (I appreciate there is a reason this is missing and there are currently trials underway at micro dose levels).
As with most things, the truth usually lies somewhere in the middle and this is not a 1 or the other situation for 100% of humans. However, when you go to the extremes, with things like TRD where a persons life lies in the balance, literally, sitting around and having a jolly about mystical experiences is a ridiculous thing to do, as a priority focus... For researchers...
Hey Padraig, thanks for the comment.
The reason for the emphasis on mystical experience in the research to date is because - as I described - the most positive outcomes have been with people who underwent more of a mystical experience during their treatment. The more they had mystical-type phenomena happen to them, the more they improved in their depression, smoked less, had less end of life anxiety, etc.
So the emphasis on mystical experience is not 'ridiculous' - the quantitative (and qualitative) evidence suggests that these experiences lead individuals to change their perspective on themselves, their life, other people, the world, etc., and this results in lasting positive benefits - even a year+ later after a single experience.
It's also undoubtedly the case that subjects don't go straight to mystical experiences in their sessions - these experiences often come after or are intertwined with personal (psychodynamic) content (i.e., memories, repressed emotions, etc.).
Of course you're right in that a lot more research is needed to explore other facets of the experience at different dosage ranges. This is what will likely happen over the next decade.
Well, psychedelics without the mystical experience happens every week ends in club and festivals and do not seem to produce levels of change in people that proper mystical experiences influenced by proper set and setting do.
How are they "mind-manifesting" without the trip. They would fundamentally not be PSYCHEDELIC. They would be 5-HT2A agonists merely without any psychedelic effects, assuming they are still 5-HT2A agonists?
💫✨💫
Not farmacologicaly induced mystical experiences have positive psicosocial effects similar to those inducen by psychedelics.
How are those induced?
Psy!!!!
Psychodelics aren't the solution Jesus is