The 'books' are right :) TGF-b ligand binds R2 and the p-receptor (R2)-ligand complex subsequently phosphorylates R1. p-R1 activates SMADS and the downstream signalling progresses. Also, R1 and R2 are hetero-dimers themselves and the R1-R2 complex is a hetero-tetramer.
I tested positive for loeys dietz syndrome (SMAD3) in 2009 I had an aortic root replacement in 2009,and because I was in a study with the N.I.H. they used my damaged aorta tissue to make a blood/saliva test for this disease. My father died from an aortic dissection at age32
A detail that would have been nice to add would have been that TGFbetaR is different than RTKs because their kinase domains phosphorylate serines and threonines I only know because I just looked it up. I know that usually kinase domains where the target amino acid isn’t stated usually phosphorylate serines and threonines but because of the similarity to RTKs I wasn’t sure. Thanks for the concise video!
Great video, nice and concise. Your series is helping with M1 biochem and I will definitely revisit for USMLE stuff later
Thank you! Glad the channel is helping you, Chelsea.
But in some books it is mention that TGF is binding to the Type-2 receptor then they bind to the receptor type-1
The 'books' are right :) TGF-b ligand binds R2 and the p-receptor (R2)-ligand complex subsequently phosphorylates R1. p-R1 activates SMADS and the downstream signalling progresses. Also, R1 and R2 are hetero-dimers themselves and the R1-R2 complex is a hetero-tetramer.
Well done! Helpful info for my current research project. Thank you.
You explained it with very energetic voice and way, that made it interesting to understand.
Receptors are wrong here i think, dimers are R1 and R2 not dimers of 1 R1 and 1R2
Just go through your video. It is very clear and easy to understand. Please make more videos
Thank you, and I always am!
That crispy 1440p
Studying for cell bio right now..
I tested positive for loeys dietz syndrome (SMAD3) in 2009
I had an aortic root replacement in 2009,and
because I was in a study with the N.I.H.
they used my damaged aorta tissue to make a blood/saliva test for this disease.
My father died from an aortic dissection at age32
Oh my god you are the best thank you from algeria 🥰🥰
Do you mind if I ask you whak kind of genes are promoted when TGF-beta signalling pathways are activated?
CDK inhibitors are turned on while MYC, CDK, and cyclins are inactivated
Good video!keep going!
Thanks for the encouragement!
i love you man
A detail that would have been nice to add would have been that TGFbetaR is different than RTKs because their kinase domains phosphorylate serines and threonines I only know because I just looked it up. I know that usually kinase domains where the target amino acid isn’t stated usually phosphorylate serines and threonines but because of the similarity to RTKs I wasn’t sure. Thanks for the concise video!
Yes, good point.
i noticed the tgfbr genes have several forms, like tgfbr1, tgfbr2, and tgfbr3, are there any differences btw them?
i wish i talked this smooth and clear haha
Need to mention nuclear localization signal for the nuclear import
yes and the importin and rad GDP