Prions | Mechanisms and Theories of Alzheimers Disease (Amyloid & Tau)

Alzheimer's disease is a neurodegenerative prion disease in which affected individuals suffer destruction of cortical neurons due to accumulation of prions of both beta-amyloid and Tau type. In this video, I will explain the acquisition and progression of Alzheimer's disease and basic reasons for associated dementia.

[@chineduachimalo391]

The intro killed me😂

[@israelduarte1189]

It's stupid

[@rafnavi4500]

@@israelduarte1189 and that's why it's (somehow) funny

[@TheChubbyDoe]

That intro was all I needed to subscribe lol

[@palwashasahar1146]

Very well explained both pathways, thank you

[@timblackburn1593]

Fantastic summary, thank you

[@NMKL211]

Means a lot to me. Thank you respected sir for such an informative video it really helps me a lot in clearing my confusion and in my assignment making.

[@atijorogloria4070]

So helpful

[@rivamuhammad794]

Thank you soooo much

[@auroradiaz3148]

Muy buen video ! Thank you so much ...greetings from Perú :)

[@CatalystUniversity]

Thank you, Aurora!

[@leila189]

merci beaucoup !

[@MuhammadNaeem-lr4vp]

well, as per my knowledge you have missed the work of secretases as Alpha and Gamma secretases cause a healthy breakdown of protein while beta cleavage is misdirected. But in the video, you said gamma-secretase cleavage cause disturbance that's not true. Please go through the latest articles and correct me if I am wrong. Thanks

[@killianpapail9324]

Hi, very good work, thank you.
I have a question : what is the link between Tau misfloding and hyperphosphorylation of Tau ? Does Tau is hyperphosphorylated because it is misfloding ?
If someone anserw to my question, I thank him in advance.
Happy new year 2022!

[@dartholiver]

Hey Kevin, could you post a link to the articles that you used for this video, i would like to credit the pictures :)

[@CatalystUniversity]

No problem:
1) molecular characteristics of alzheimer's disease: science.sciencemag.org/content/358/6359/45/tab-figures-data
2) Tau microtubules: www.sciencedirect.com/science/article/pii/S0531556516305800
Other picture:
3) molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-2-22

[@omargarciafernandez7376]

I was wondering, why does the calcium influx cause apoptosis and not necrosis?

[@hydrocarrot229]

Thanks man, but I have a question what is sAPP

[@johnmandrake8829]

the intro made me question everything

[@liamflaherty6362]

Thanks for the informative video, the intro is a bit fucked but everything else is gold. Cheers Cobba

[@kandiceblu1]

Is ALS a Prion Disease?

[@robertchampy3489]

Filamin A

[@ryanrohrbacker7431]

this is honestly not right at all in regards to pathophysiology and microphysiology of how plaques and tangles are caused . The basics are mentioned just not the intricacies on how everything comes together. for example tau proteins don't unfold , they’re hyper polarized through hyperphosphorylation from the amyloid beta plaques outside the neurons themselves causing clumps giving a weak cytoskeleton within the neuron. Then with the weak and half dead neurons they clump up and cause neurofibrillary tangles. Amyloid beta plaques are a whole other beast, they’re outside the neuron not within the neuron.

[@celinat8622]

Had exactly this doubt, I'm learning about prions and the diseases they cause. I think the PrP protein has nothing to do with tau and amyloid beta right?