Prions | The General Mechanism of Prion Formation and Disease
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- Опубликовано: 8 мар 2019
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Well done.
I didn't know Alzheimer's Disease is caused by Prions. Thank you for a clear, comprehensible explanation.
What a scary disease.
One very important point I believe might not have been mentioned. The mis-folded prion causes normal prions to mis-fold too thus causing a proverbial “domino effect”. Absolutely frightening and one of the cruelest tricks of nature. As strange as the odds are, I personally know of three (3) people who have succumbed to TSE’s.
Likely man-made disease
@@iknowwhatsup2880 Scrapie was first discovered in 1732. BSE was first discovered in 1923. Scrapie in sheep has a 50/50 chance of infecting humans depending on the strain (theres 20 strains). Atypical L and H BSE cause non familial SCJD in humans. C-BSE causes new variant CJD. CWD in deer can cause SCJD. So, you re wrong about it being man made.
@@truthxposed8975 I recall that they speculated this when they brought back samples from Papau New Guina of deceased to try and understand this brain eating disease. Also, it was speculated that feeding cows other cow parts or animals created this disease in cows. Very similar response for which they didn't understand at first. They thought it was either viral or bacterial and brought back samples to labs and didn't dispose of it properly. They later found that anything that touches this prion must be incinerated. All disease come from man not following natural law and thinking they can outdo God imho. You don't need to agree, I am entitled to my hypothesis. But according to Darwin we should be the healthiest people in existence, yet here we are.
@@iknowwhatsup2880 The true origins of the C-BSE epidemic in Europe was caused by them buying bones from India. Go watch the origins of BSE. Cattle were eating HUMAN remains. Human bones collected from the Ganges River and pulverized to be sold for bone protein meal.
@@truthxposed8975 in the 90s when this first started there was no understood origins. I haven't revisited, so I'm not aware of this, thanks. I'll go look up current theories. The main point is the cow is made to eat grass and man in is infantile wisdom decided to go against this. This resulted in disease. Making vaccines in my mind is the same flawed principle. Or cancer treatment that hasn't changed much in 50 years and somehow believes injecting you with chemicals is the answer. Most people have cancer return within 5 years. All that money and research and zero results. Insanity!
The best explanation of prion ever--thank you so much!!
Thank you so much for your explanation! First video I have found that was specific enough and yet comprehensible
You literally have a simplified version of my comment. Lol!
thanks. I finally understand the basics of prions. You are a good teacher.
thank yoou! I have a biochemistry homework about BSE, I am a visual learner so this video helped me a lot, thanks.
Thanks ! A good complement to my Biochemistry class.
Crystal clear.. thanks
Timestamp 9:11 was that just coincidence it seems very apt for this subject. Thanks for the video, very interesting area.
Excellent explanation!
THANK YOU
I very much expected to be confused by this video because how you started talking about the structure of the PrPc. Thought you were going to go deep into sodium channels and all that hard to grasp stuff. This made perfect sense actually. Thank you for this!
What is the playlist called? I cant find anymore prion videos on your channel
Hi! I love this video, so much more informative than my textbook, which glossed over prion diseases. Would you mind listing some sources? I'd love to be able to do more in depth research from what you have already presented.
There are 7 prion-like domains in the S1 part of the spike protein in the vaccines.
The abstract from the paper "A Potential Role of the Spike Protein in Neurodegenerative Diseases: A Narrative Review" goes into detail.
No kidding!
Sounds bad.
And thanks for sharing that information!
Is the spike protein (which also has the “w” configuration) suspected of causing this? I’ve researched that it’s consistent with the other prion like proteins that cause vCJD.
The Japanese have done a study of over 500,000 people which appears to show Dementia at double the rate amongst the vaccinated versus the unvaccinated control group. Whether or not that supports your point I don't know as it could just simply be micro clotting causing the problem rather than Prions. You raise a good point however.
Great video!! Thanks 🙏
So, prions are not chemically degraded through the digestion system, but what about heat degradation? (Cook process)
The reason of non degradation during the digestion is, I guess, because of the stability that the molecule prion cluster gets during aggregation… if my idea is correct… then, a simple and sole prion protein could be chemically degraded by the digestion process?
Can we generate enzymes that can naturally be generated to degrade some type of prion once we get exposed to a low dose?
Why do prions/clusters get attached to neurons and not other kind of cells? I used to believe it was some kind of biologic approach, but now it seems to me that it is also a mechanical reason (prion aggregation clusters)
This topic is so interesting
@Catalyst University , are these prions +positively charged?
Are those mechanisms of protein misfolding and aggregation known to occur and affect other types of cells beside neuron cells?
maybe, but i would assume the neuron death is so rapid and lethal that its the only one that is talked about (neuron death being worse than the death of other cells a prion would affect). again its just an assumption.
So when these proteins misfold, why do other neighboring proteins aggregate instead of just bouncing off? Using your chair analogy, if i have an auditorium full of open, unfolded chairs and then toss in a single folded chair, the rest of the chairs dont spontaneously fold and stack.
Is there some kind of "stickiness" that accompanies the prions causing the surrounding proteins to be more susceptible to aggregation?
Is there some kind of chemical relationship that causes the surrounding proteins to be weaker in structure, causing them to not properly resist the aggregation?
Im a mechanical engineer, and biology is the furthest from my specialty, so i apologize if my questions are poorly worded or nonsensical.
Some kind of signaling.
The documentary NO ACCIDENT is the briefing of 30 years of my personal search BUT WELL EXPLAINED BY that video made by scientific pros.
Glyphosate causing
Gondii Pseudomonas aeruginosa as well
Prions been around since the 1700s.
activation - has NOT
Formulated Glyphosate Activates the DNA-Response
What is the reason or trigger for conversion of PrPc to PrPsc??
Unknown.
Some times when its familiar its a mutation in genes.
Protein: folds the wrong way
Me: dies
hello I'm jay canillo, can I use your pictures as an illustration for educational purposes. Thank and God Bless
probably the most scary patogene
Prions is in everything we have and eat, a single wheat plant in a lab of 1996 GMO had 7 new gluten proteins never ever seen before, and it had prion proteins, I ma just left wondering how many Frankenstein plants are sold in the market and marketed healthy, and how many sick animals who are being fed this shit.
All of this because we mass-produce food and deplete nutrients in the soil, manure only replenishes some of it not all in particular when it comes to minerals. and that means weak, sick plants who get eaten by humans and animals alike and position the whole food chain and all that.
So scientists and researchers come in with chemicals to protect the plants and making new GMO plants at that with so many unpredictable effects on a living organism as life on earth has yet to be exposed or evolved mechanism to properly digest these modern Frankenstein foods new nutrients profile.
The plack builds up in the brain in Alzheimer's case is a natural prion that the body produces by its very own metabolism when we sleep the brain shrinks and expand like a sponge to circulate lymphatic fluid and brain fluid and flush away the prions for the body to digest/metabolize away and make the brain ready for a new day of living and learning and staying sharp.
This does not happen in alzheimers patient as they have inflamed their body with toxins from food so long that genes in the nerve cells turn on and make it less capable to get glucose/energy in so the nerve cell dies of energy starvation and is unable to flush the brain and lymphatic fluid during the night when sleeping (only flushes when we do sleep)
@@DanielPembrink you seem knowledgeable and this greatly interests me. Where can I learn more?
@@ZahdShah tom bilyeu RUclips, it introduces you to many interesting things for you to pick apart and figure out. There is also Thomas delaurer s RUclips channel. I am huge fan of his recent stay lean all year around 4 part video series.
You can also watch Dr sten Ekbergs lectures videos about insulin resistance and artificial sweeteners and how safe they are. And all Extra
They are all very educational.
Вот именно, что это не патоген а твой собственный белок а ведёт себя хуже вируса
@@DanielPembrink it is not about GMO. It is about certain substances like aluminum,Mercury,lead compounds,lifestyle, genetics etc
Can I ask why you say Parkinson’s is caused by prions so confidently as if it’s accepted fact? Honestly want to know
Who else is here after watching that one guy eat cow brains from tiktok 😂
Tryptophan tyrosine phenylalanine p450 enzyme glycine calcium
manganese disfunction
ohhh they are basically zombie protines
im pretty sure its only hypothesised that huntingtons, parkinsons and alzheimers are prion diseases, with huntingtons being more shaky than the other two at this point.
No closer captioning.
This I just life something that you need to live can misfold and destroy and break you, causing you to die, it’s simply life, something you need can become wrong and kill you
I have burger for my tea
Who cam here after reading the nature of predators novel......😄😄😄😄😄😄
Do Not Watch this while eating lunch!
the lip smacking reminds me of a characteristic of HD
Alzheimer's is double prions
give me a thumb up if you’re here in 2021 and un jabbed...you’re my brothers and sisters! 🙌