Lecture 4c: T Cell Signaling + Activation
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- Опубликовано: 28 июл 2024
- UCSD Extension School: Applied Immunology (BIOL-40371)
Spring Quarter 2021
This lecture summarizes the signal transduction mechanisms that occur downstream of T cell receptor binding to a cognate antigen:MHC complex, and how these contribute to the cellular state known as T cell activation.
All figures are either from Janeway's Immunobiology (9th ed.) where noted, or my own original figures.
I have been looking for a video explanation of the T Cell activation processes as clear as this for the last 7 years. My son was born with ORAI1 deficiency and passed away in 2017. I knew what went wrong and could explain to someone who had no idea, but i wanted to know exactly where in the activation process it went wrong. Thank you. Amazing that through all the genetic coding that goes in to one human being, all it takes is the substitution of 1 letter twice in one gene to catastrophically collapse it all. . .
Thank you for your clear explanation! This is great :)
thank you from Chile!
Hi! Thank you for your videos. Just wanted to point out that kinases attach phosphate groups from ATP as opposed from free phosphate. Phosphorylases are the one that utilize free phosphate.
Will be interesting to see if TCR can detect difference in epitopes at subatomic levels like replacing the H with deuterium or changing the stereochemistry of amino acids. GPCR for olfaction in drosophila can do that. If TCR can do it, this opens up a new field of research for autoimmunity. Damn I need funding for this project.! Btw should have included kinetic segregation model.
That is an interesting thought but not likely to happen, since the criteria of the two receptors to interact with their respective ligands are quite different. Also, one must consider the huge difference in the size and nature of the ligands that these two receptors detect. And changing the epitopes on such subatomic levels may at best influence the TCR's affinity for the epitope itself but even that would require the change to be significant enough.
mam your seapking pluency is so fast thtas why we face diffeculties in geting your words can you make another vedio in liitle slow
You might find it helpful to watch her lectures at 0.75X speed. As a nonnative speaker, I find myself slowing down/pausing and re-watching it, but the quality of content is so good and easy to follow once you get used to her style of lecturing.
You can set the auto-subtitle option