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Thanks for sharing

Thank you, very clear explanation

Thanks ❤

where is lecture 1a?

Thank you!

Thank you very much 😊

Fantastic video!

thanks Annelise

I couldn't find an answer why even with perfect matched MHC there's chronic rejection of graft. Now I understand that besides major HCs there are also minor ones. Thank you so much

Nice lecture!

I have been looking for a video explanation of the T Cell activation processes as clear as this for the last 7 years. My son was born with ORAI1 deficiency and passed away in 2017. I knew what went wrong and could explain to someone who had no idea, but i wanted to know exactly where in the activation process it went wrong. Thank you. Amazing that through all the genetic coding that goes in to one human being, all it takes is the substitution of 1 letter twice in one gene to catastrophically collapse it all. . .

awesome lecture - phd student trying to better understand Tfh mechanisms. thanks so much!!

they dont require help. that's the whole point of being Tindependant antigens

thank you!

@Annelise, your presentation is clear, concise and very well presented. Thank you!

Thank you for the lecture. Helped me a lot to cleary understand the mouse model.

very clear, concise and helpful. thank you Prof. Snyder!

I am writing to express my deepest gratitude for the immunology videos you have created and shared with the world. As a learner, I have found them to be incredibly fundamental to my understanding and appreciation of immunology. Your ability to simplify complex concepts and engagingly present them has made a significant difference in my learning journey. The depth and breadth of your knowledge, as well as your passion for the subject, shine through in each video. Your work has not only enriched my knowledge but also sparked a deeper interest in immunology. It is individuals like you who make learning accessible and enjoyable for many of us, and for that, I am truly grateful. Please continue to share your expertise and passion with the world. Your contributions are making a difference in ways you may not even realize. Thank you once again for your invaluable work.

doctor Snyder, I'm so grateful to you for this comprehensive course , but I wish to learn about immune response and cascade reactions of it at both cell & humoral mediated immunity in more details .

Hi Annelise... wonderful video.. I finally understand, I think... but I have a question. If you have a mouse model with a floxed gene and a Cre under the K18 promoter... what is the proper control mouse to use? Is it a wildtype mouse? Or a heterozygote mouse that has the Cre under the K18 promoter and an empty LxP cassette? Not sure... please help..

thank you from Chile!

TCR:which ones are the difference between: alpha, beta, gamma and delta ?

Doc Cd3s+ with cd8+ and anti Tcr gamma delta + what does mean ? Same as Cd3s, cd4-,cd8- and anti Tcr gamma delta -?

Really impressive! Many thanks for sharing

why is there only one CDR primarly involved in antigen binding for TCRs whereas the CDRs in Antibodies are all equally equivalent in regards to antigen binding?

Amazing video!! So comprehensive, very detailed and has the perfect depth in this topic. Thank you so much for sharing this.

i appreciate you've made immunology simpler

this is so relevant to immunology researchers. a must watch for all graduate, PhDs and even postdocs!

Hi! Thank you for your videos. Just wanted to point out that kinases attach phosphate groups from ATP as opposed from free phosphate. Phosphorylases are the one that utilize free phosphate.

thank you, you explain clearly

Thank you Dear Annelise, super clear!, thanks again!

Amazing 👏 🙀

Thank you so much!

is it possible that excessive antigen exposure lead to the allergy epidemic? We think of our environment as "clean" but its not. Maybe the modern home is full of certain antigens like bed bug antigens, mold, and some microbiota that differs from a more "natural" habitat Could it be a matter of evolutionary imcompatibility?

wow, very good

best lecture series on youtube, great for non immunologist getting into it. Thank you

What an excellent lecture! Thank you very much!

Thank you. But please Correct the history. It was used in India before it spread to China

Great

Your lectures are helping me a lot with my exams. Thanks a lot for sharing 🙏❤

Great lecture! I feel better prepared now for tomorrow's in-course assessment!

Thank you so much!

Hi thank you for the lecture! It helped a lot 😊

Sorry, is the last slide correct? Ti antigens require T cell help and induce GC B-cell differentiation?

well explained , well done, thanks

Thank you for your clear explanation! This is great :)

I appreciate for your lectures Annelise Snyder. Would you please make a big playlist explaining Testosterone replacement therapy for men at molecular knowledge and how to come off of it

Will be interesting to see if TCR can detect difference in epitopes at subatomic levels like replacing the H with deuterium or changing the stereochemistry of amino acids. GPCR for olfaction in drosophila can do that. If TCR can do it, this opens up a new field of research for autoimmunity. Damn I need funding for this project.! Btw should have included kinetic segregation model.

Wow thanks for such wonderful content

Thank you. I learned a lot