Sir what is your opinion about 1. Cidal vs static 2. Double coverage unless we aren’t on polymyxins . 3. Do we have any empirical role of aminoglycosides.. at AIIMS in my residency we wouldn’t use amino glycosides atleast empirically … but here in Punjab it is used right and left … I don’t have data and antibiogram here … what u say sir about .. 4. What are their irreplaceable indications .
Sir , Colistin is prodrug which activates in renal parenchyma so preferred choice of urosepsis and poly B is active molecule preferred for bacteremia In CNS infection due to carbapenem resistant GNB , intrathecal colistin preferred over poly B? And what is funda of nebulized colistin if it is a prodrug It's need to be activated in kidney then why don't we use poly B in place of colistin for local effect?
@Rajput CMS conversion to colistin occurs at other sites also ,not only bloodstream Thus it generates colistin in csf and resp tract as well The other advantages of colistin over poly b are there is more data and experience with its use..poly by was used much after colistin, then poly b is more irritable to meninges and airways and third colistin penetration into meninges is more After all that said, can use poly b as well ,there are no proper data comparing the two in such situations ,to the best of my knowledge
@ahmad ... ruclips.net/video/-aqWpeeJ6GU/видео.htmlsi=k8glsPthKrorUofO pl see @ 00:12:45 specific test requires testing to cefoxitin if not done in the c/s
Absolutely sensational... ❤️❤️❤️
Sir what is your opinion about
1. Cidal vs static
2. Double coverage unless we aren’t on polymyxins .
3. Do we have any empirical role of aminoglycosides.. at AIIMS in my residency we wouldn’t use amino glycosides atleast empirically … but here in Punjab it is used right and left … I don’t have data and antibiogram here … what u say sir about ..
4. What are their irreplaceable indications .
Sir ,
Colistin is prodrug which activates in renal parenchyma so preferred choice of urosepsis
and poly B is active molecule preferred for bacteremia
In CNS infection due to carbapenem resistant GNB , intrathecal colistin preferred over poly B?
And what is funda of nebulized colistin if it is a prodrug
It's need to be activated in kidney
then why don't we use poly B in place of colistin for local effect?
@Rajput
CMS conversion to colistin occurs at other sites also ,not only bloodstream
Thus it generates colistin in csf and resp tract as well
The other advantages of colistin over poly b are there is more data and experience with its use..poly by was used much after colistin, then poly b is more irritable to meninges and airways and third colistin penetration into meninges is more
After all that said, can use poly b as well ,there are no proper data comparing the two in such situations ,to the best of my knowledge
How can we identify inducible ampC on antibiograms??
@ahmad ... ruclips.net/video/-aqWpeeJ6GU/видео.htmlsi=k8glsPthKrorUofO
pl see @ 00:12:45
specific test requires testing to cefoxitin if not done in the c/s