This meta-analysis actually found that ribose was likely safe at up to 1g/kg/day for mice which is about 80mg/kg/day for humans which is 2.5x more than the max safe dose for humans according to European FSA. I would say if it makes you feel healthy then keep taking it. If it will cause memory problems you should notice them within weeks.
Thanks very much for sharing that. Just trying to work out the maths of it..... I'm 70 kg. 80 mg x 70 = 5600mg = 5.6 grams Most ME/CFS patients are told to have 10-15 grams daily. As for memory problems, maybe you are right but I've no idea how long they might take to show up. My brain already is foggy enough with my chronic illness - so it can be hard to know what is causing what. Theses days I take Ribose only as a rescue remedy.
@@me-cfs-strategiesforhealing according to Healthline, ribose has been shown safe in humans up to 60g daily. Idk why mice have an issue with it. The 36mg/kg/day limit set by EFSA was based not on NOAEL but rather just average of what people consume in their diet. I think prob no need to worry but if you do have brain fog then you should try detoxing metals, parasites, mold, pesticides, forever chems, etc. Sniffing dmso vapors can help. High dose niacin can help. Activated charcoal ozone steam also may be excellent.
Hi, came here by chance after searching. Thank you for picking up this important topic. I have post covid and had a thiamine deficiency too. My doctor gave me a Q10 supplement which contains d-ribose and also carnitin. With the recommended Dose i was taking approx 10 g d ribose and 500mg ubichinon a day. It helped me a lot. After 3 months i have reduced the dosage. After all reading i think i will quit ribose. I have had also sometimes the feeling After a while that my memory is a Bit slow but this could have to do with the thiamine topic too. I am also taking benfothiamine i think i have read anywhere this should be good against AGEs also.
My husband is prone to hypo glicemia and after taking this supplement a couple of times (with no remarkable effects), he had some hypo episodes so he stopped its consumption (he is an ME/CFS patient by the way). Thanks for this video
I took D Ribose for 3 months . I felt like it helped me feel 25% better .. I stopped taking it only because I ran out and never bought any more . Now I feel like I would have to research it again .
Yeah, ribose definitely has potential risks because of AGE formation (advanced glycation end products) in the brain and kidneys . But you can balance that with a carnosine supplement (a cheaper but not so well studied alternative is beta alanine). I think it's worth the risk if you keep the side effects under control. There are pros and cons with pretty much everything.
Fantastic summary, thank you for sharing. I am trying d ribose as my last resort before going back to a carnivore diet, as the diet works but I hate doing it and it has some side effects.
And thank you for the kind words! I've actually been struggling more recently since giving up Ribose altogether so I've decided to take 5 grams a day for a while. It is making a helpful difference and, at that dosage, I think it is more likely to be okay. Hope so anyway! I'm not carnivore at the moment (was for 5 months) but hope to go back to it next month. Hope Ribose works out for you.
Very interesting video, thank you Patrick. I believe this could potentially help me as well, but am now thinking it might be better not even trying it, as to prevent alzheimer etc... this is a new dilemma you just presented me with! 😮 I am taking Nad+ daily, which is really called "nicotinamide riboside". So, I was worried this was the same thing as D-ribose. But when doing a quick Google search it seems to be different things but with a similar name. Nicotinamide riboside being more closer to Niacin, vit b3, while D-ribose is closer to a sugar. I just wanted to write this in case any other viewer might wonder the same thing.
Oh, I know - it is quite the dilemma! I feel great on Ribose but after 3 years on it, I just don't want to run the potential risk of ending up with something worse down the line. The joys of supplements, eh? How do you find NAD+? I've never tried it.
@@me-cfs-strategiesforhealing I see. Yeah the joys of supplements... I am not sure about NAD+ yet, if it helps me or not. I am only taking half a capsule per day, otherwise I have trouble falling asleep at night. However, I really do feel that ALC is helping me (Acetyl-L-Carnitine). My mood is generally better, feel a bit happier while taking it. 400mg daily. In your case Patrick, you already eat lots of meat, so it might not make a big difference for you, but in my case (I have trouble eating red meat), it does help. I have listened to several ME doctors that are recommending this supplement to their patients.
That's great the ALC is helping you. Yes, it wouldn't make sense for me to take that or CoQ10. My CoQ10 level recently tested above range thanks to all the meat.
Yes but the context of my remark is about Ribose specifically. I find it hard to believe that women would only produce 2 grams of Ribose daily and men 18 grams, given how crucial ribose is in creating ATP, the body's energy currency molecule. So I'm not sure that the Norwegian booklet I read can be right.
This is a real balancing video on the subject. This is what people should know FIRST.
Thank you Kathy
This meta-analysis actually found that ribose was likely safe at up to 1g/kg/day for mice which is about 80mg/kg/day for humans which is 2.5x more than the max safe dose for humans according to European FSA.
I would say if it makes you feel healthy then keep taking it. If it will cause memory problems you should notice them within weeks.
Thanks very much for sharing that.
Just trying to work out the maths of it.....
I'm 70 kg. 80 mg x 70 = 5600mg = 5.6 grams
Most ME/CFS patients are told to have 10-15 grams daily.
As for memory problems, maybe you are right but I've no idea how long they might take to show up. My brain already is foggy enough with my chronic illness - so it can be hard to know what is causing what.
Theses days I take Ribose only as a rescue remedy.
@@me-cfs-strategiesforhealing according to Healthline, ribose has been shown safe in humans up to 60g daily. Idk why mice have an issue with it. The 36mg/kg/day limit set by EFSA was based not on NOAEL but rather just average of what people consume in their diet.
I think prob no need to worry but if you do have brain fog then you should try detoxing metals, parasites, mold, pesticides, forever chems, etc. Sniffing dmso vapors can help. High dose niacin can help. Activated charcoal ozone steam also may be excellent.
@@me-cfs-strategiesforhealinghave your energy levels sustained from precious 15g/day dosing? IE: did it fix something?
Hi, came here by chance after searching. Thank you for picking up this important topic. I have post covid and had a thiamine deficiency too. My doctor gave me a Q10 supplement which contains d-ribose and also carnitin. With the recommended Dose i was taking approx 10 g d ribose and 500mg ubichinon a day. It helped me a lot. After 3 months i have reduced the dosage. After all reading i think i will quit ribose. I have had also sometimes the feeling After a while that my memory is a Bit slow but this could have to do with the thiamine topic too. I am also taking benfothiamine i think i have read anywhere this should be good against AGEs also.
My husband is prone to hypo glicemia and after taking this supplement a couple of times (with no remarkable effects), he had some hypo episodes so he stopped its consumption (he is an ME/CFS patient by the way). Thanks for this video
You are welcome, thanks for sharing.
I took D Ribose for 3 months . I felt like it helped me feel 25% better .. I stopped taking it only because I ran out and never bought any more . Now I feel like I would have to research it again .
Yeah, ribose definitely has potential risks because of AGE formation (advanced glycation end products) in the brain and kidneys . But you can balance that with a carnosine supplement (a cheaper but not so well studied alternative is beta alanine). I think it's worth the risk if you keep the side effects under control. There are pros and cons with pretty much everything.
Oh, that's very interesting, thank you. Why does carnosine balance the risk?
@me-cfs-strategiesforhealing it breaks down AGE molecules
Thank you
@me-cfs-strategiesforhealing have you tried creatine? I think that could be a safer alternative than D-ribose.
Apologies for slow response. Only so this now. I have not tried it yet though it is on my list.
Get a MRI and see if anything is going on with your brain, if not...keep taking it
My regulat blood pressure is 170 over 90 sometimes higher
Fantastic summary, thank you for sharing. I am trying d ribose as my last resort before going back to a carnivore diet, as the diet works but I hate doing it and it has some side effects.
And thank you for the kind words!
I've actually been struggling more recently since giving up Ribose altogether so I've decided to take 5 grams a day for a while. It is making a helpful difference and, at that dosage, I think it is more likely to be okay. Hope so anyway! I'm not carnivore at the moment (was for 5 months) but hope to go back to it next month.
Hope Ribose works out for you.
Very interesting video, thank you Patrick.
I believe this could potentially help me as well, but am now thinking it might be better not even trying it, as to prevent alzheimer etc... this is a new dilemma you just presented me with! 😮
I am taking Nad+ daily, which is really called "nicotinamide riboside". So, I was worried this was the same thing as D-ribose. But when doing a quick Google search it seems to be different things but with a similar name. Nicotinamide riboside being more closer to Niacin, vit b3, while D-ribose is closer to a sugar. I just wanted to write this in case any other viewer might wonder the same thing.
Oh, I know - it is quite the dilemma! I feel great on Ribose but after 3 years on it, I just don't want to run the potential risk of ending up with something worse down the line. The joys of supplements, eh?
How do you find NAD+? I've never tried it.
@@me-cfs-strategiesforhealing I see. Yeah the joys of supplements...
I am not sure about NAD+ yet, if it helps me or not. I am only taking half a capsule per day, otherwise I have trouble falling asleep at night.
However, I really do feel that ALC is helping me (Acetyl-L-Carnitine). My mood is generally better, feel a bit happier while taking it. 400mg daily. In your case Patrick, you already eat lots of meat, so it might not make a big difference for you, but in my case (I have trouble eating red meat), it does help. I have listened to several ME doctors that are recommending this supplement to their patients.
That's great the ALC is helping you. Yes, it wouldn't make sense for me to take that or CoQ10. My CoQ10 level recently tested above range thanks to all the meat.
@@me-cfs-strategiesforhealing I am on 800mg Q10 a day... it has been a lifesaver for me.
That's great it so helpful - it is a brilliant supplement for a lot of ME/CFS people.
Short dry fast clear(desolve) glycated proteins in the body
Thank you for sharing.
Yes , men and women are the same species. However bodies are obviously different. Hormones , testosterone levels, menses etc .
Yes but the context of my remark is about Ribose specifically. I find it hard to believe that women would only produce 2 grams of Ribose daily and men 18 grams, given how crucial ribose is in creating ATP, the body's energy currency molecule. So I'm not sure that the Norwegian booklet I read can be right.
L-Ribose is the synthetic form
Thank you for letting me know.
Pickles from the store break through the blood brain barrier read your labels!