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I have indeed but I haven't studied it in detail

@@me-cfs-strategiesforhealing thankyou for your reply. I have m.e and fibromyalgia and autoimmune hepatitis. Is fibromyalgia and m.e an autoimmune disease!! It's been an horrendous 10 years with these 3 diseases ....I absolutely pray for some treatment 🙏 I'm so glad I found your channel

Hi Christine. ME/CFS autoimmunity is different from other illnesses. The body is not attacking itself but the autoantibodies are instead blocking various functions to further heighten ME/CFS pathomechanisms. Not everybody with ME/CFS has the autoantibodies and, among those that do have them, the degree will be different. Testing can be done via cell trend lab (see my video on testing) though that is a little tricky if outside of Germany (though not impossible). So in ME/CFS, autoimmunity is best thought of as a secondary dysfunction that can be brought on by the illness and make the overall situation additionally worse, but the degree to which it does this will depend on person to person.

Hi Christine. ME/CFS autoimmunity is different from other illnesses. The body is not attacking itself but the autoantibodies are instead blocking various functions to further heighten ME/CFS pathomechanisms. Not everybody with ME/CFS has the autoantibodies and, among those that do have them, the degree will be different. Testing can be done via cell trend lab (see my video on testing) though that is a little tricky if outside of Germany (though not impossible). So in ME/CFS, autoimmunity is best thought of as a secondary dysfunction that can be brought on by the illness and make the overall situation additionally worse, but the degree to which it does this will depend on person to person.

That's a great question, Danielle. It's not definitively proved yet. In fact, as Wirth's pill would be correcting the dysfunction, it the response to the pill that can ultimately prove the theory one way or the other. What we do know however is that high intracellular sodium is an issue in ME/CFS and a dysfunctional sodium-potassium pump will be the reason for that. If we have have intracellular sodium, then you tend to get high intracellular calcium as well and that makes the cells even more dysfunctional and the muscles more painful. So the pill would potentially correct the high intracellular sodium and resulting high intracellular calcium.

@me-cfs-strategiesforhealing okay, gotcha. My understanding was that the muscle burning was caused by acidosis. Ron Davis' crew believes the problem is a shunted Krebs cycle. They say the resulting anaerobic metabolism is to blame for the acidosis. Is the mitodicure group's theory opposed to Ron Davis' research, or do they believe this potassium/sodium pump issue is just adding to the muscle pain? Thanks so much for the response!

Indeed, Wirth includes the acidosis part. The sodium-potassium pump issue is just one part of the cycle of dysfunctions at a cellular level but, for Wirth, the most important one to target. There is a RUclips channel for The Irish ME Trust (channel is called 'ME Ireland'). There you can find a talk I gave in January of this year (titled something like 'ME/CFS and hypoperfusion'). That outlines a bigger picture view of Wirth's research and where the cellular issues fit in. Interestingly Davis also suggested the excessive cellular stress of ME cells in response to a hypertonic solution as a biomarker for ME/CFS. That ties in with the idea of high intracellular sodium being at play.

Hi Danielle. It needs to be funded first and then there may be some announcement about trials. However Wirth is connected to Charite University Berlin which has a lot of ME/CFS patients. My guess is that that would be the cohort used (but I don't know)

You're welcome

More the muscle PEM and aches in my experience.

Thank you very much! Likewise, this is the pill is what gives me the greatest hope. But, as always, ME/CFS and money for funding is tricky to come by. But let's indeed manifest it and if you happen know of any billionaires, maybe mention it to them!

Unfortunately not

@@me-cfs-strategiesforhealing They're going to give their results in November in a Long Covid Conference. Seems unlikely to have completely negative results if they're going to present their findings in a Conference?

That seems likely

I've looked at it a bit before Angel. Might do a video on it some day but my feeling is that it is one just one dysfunction among many inter-related dysfunctions

Thank you for sharing.

Best of luck! I'd be interested to hear how you get on.

Yes but the context of my remark is about Ribose specifically. I find it hard to believe that women would only produce 2 grams of Ribose daily and men 18 grams, given how crucial ribose is in creating ATP, the body's energy currency molecule. So I'm not sure that the Norwegian booklet I read can be right.

I plan to do that video in the future but hard at work on a book at the moment. I'll be getting my full thyroid labs (and cortisol) this autumn and I'll include those. I think I'm doing okay thyroid wise. I might be a bit hypo but I don't think anywhere near as bad as I was some years ago. And I think I am doing well with my cortisol again, pending labs.

@@me-cfs-strategiesforhealing Thanks for the reply. Glad to hear you're better than you were before. Hopefully your labs reflect the changes. Look forward to your future video. I hope you can include dietary, supplement and meds that helped you.

You are welcome and thank you. I'm a carnivore these days which I find helpful (have a couple of videos on that).

Unfortunately, Klaus Wirth still needs funding for a trial. Keep an eye on Mitodicure's website for updates.

Around two weeks. And then again a few months in.

@@me-cfs-strategiesforhealing how many months exactly would you say? After the 2 weeks in what way did you feel better? More energy? Less waves of feeling ill and tired?

3 months. After the two weeks, my legs felt lighter. I could do 8,000 steps per day rather than 6.000. Crashes lasted half as long.

Thank you Mark for the kind words. I'm sorry to hear about your son having Long Covid. The vegan mindset is hard to break free from. There is a RUclipsr - Ribeye Rach - who was very severe with POTS and who is doing very well now thanks to a mixture of brain retraining and carnivory. Also someone called Rebekah Heishman whose story of recovery is very powerful (I'm pretty sure she had ME amongst everything else) I'm giving a talk to the Irish ME Trust in a few days - which should be posted on their YT after (channel is called 'ME Ireland') - about why carnivory might help ME/CFS. I don't know if your son might be open to looking at those resources or not but just thought I'd mention in case. Positive examples of people improving can be more inspiring than anything else.

Thank you JP, that's kind of you! Yes, I'm fine. I haven't posted any videos in a while as I am working on a book about ME/CFS. I hope it will be out by November and - after a bit of a break - I'll be back on RUclips

@@me-cfs-strategiesforhealing oh that's great to hear! Wishing you goodluck with the writing! 👍

Thank you JP!

That's exactly the problem - the funding. Perhaps in any other illness, it would be a different story, but it is just hard to get the money in ME/CFS. It would help with post-Covid ME/CFS as well (and of course post 'poke in the arm' ME/CFS) so perhaps emphasising the Long Covid aspect more would help him in trying to find the funding.

No. My diastolic BP goes higher when I stand up though but that can happen in ME/CFS.

@@me-cfs-strategiesforhealing Heart rate remains normal?

Glad you found it of interest, Simon. Yes, it is a different take on a pacing monitor alright. Personally, I think Scheibenbogen and Wirth have worked it out. It takes a bit of effort to get your head around their ideas but, once you do, I think that is what ME/CFS basically is (though there will be variations around the edges in people). You might find my 'drug to cure ME/CFS' video interesting if you have not seen it already.

@@me-cfs-strategiesforhealing thanks for the heads up, I’ll take a look

Ah thank you, I'm touched by those kinds words! Do you think you ever might like to chat about your own personal story on my channel by the way? With the Stoicism angle as well as how challenging your journey has been, I think it could be a very interesting chat for people. No worries though if it is not something you want to be out in the public domain about, but just thought I'd suggest it. I'm hoping to do interviews of people later in the year. My head is down at the moment on working on a book about ME/CFS

And thank you for the kind words! I've actually been struggling more recently since giving up Ribose altogether so I've decided to take 5 grams a day for a while. It is making a helpful difference and, at that dosage, I think it is more likely to be okay. Hope so anyway! I'm not carnivore at the moment (was for 5 months) but hope to go back to it next month. Hope Ribose works out for you.

I was carnivore for five and a half months (until five weeks ago). I hope to go back onto it in October.

How much would you say it helped?

@@me-cfs-strategiesforhealing also did you still drink coffee or eat anything else?

I had much more stable energy throughout the day, maybe only needing to rest 15 minutes after lunch (unless in PEM). My stamina was noticeably better and PEM lifted more quickly. Mood was better though still low at times. I've definitely noticed a drop off in my functionality since I stopped doing it. I was 95% carnivore. I still had one cup decaf coffee and four squares dark chocolate per day. The chocolate messed things up a fair bit and I want to cut that out too.

Thank you for letting me know.

I'm so sorry for your suffering and for so long. It is a very cruel illness. I hope there can yet be better days ahead for you.

Thank you, I am glad you find it helpful. I'll continue to do my best.

You are very welcome! Well, I don't know about what exactly the measured protein is but the streasure4health website states it also has implications for type 1 diabetes. I don't know whether it will have implications beyond type 1 diabetes and ME/CFS and Long Covid, but those are the two indications it is being developed for.

@@me-cfs-strategiesforhealing Thank you. It'd be great if Peter Deen might clarify this in the interview you're planning (-:

Noted! :)

By that you mean that you have excessive thirst?

@@me-cfs-strategiesforhealing Yes

Look up the RUclips channel 'ME Ireland' and my talk there titled 'ME/CFS and thirst' in which I describe my whole awful experience with that symptom and how I resolved it. Or look up the health rising blog I wrote 'Why are some ME/CFS patients so thirsty? Have they been historically misdiagnosed as psychogenic water drinkers?' I hope those resources can help you. It's a horrid symptom.

@@me-cfs-strategiesforhealing Thank you so much; I will look up the information!

You are very welcome. It's a ghastly symptom but - although this can seem impossible when you are in it - it can be fixed.

That's brilliant. Write to me directly (via the contact form on my website which is just my name - Patrick Ussher) and I will put you in touch with Klaus. I'm in contact with him often.

@@me-cfs-strategiesforhealing hey there, I will reach out over the weekend. Thanks!

Cool, look forward to hearing from you

An ESR of 8 would seem to rule out microclotting.

@@me-cfs-strategiesforhealing Really? Then why do I have POTS and constant fatigue?😅😭😭.

Well, an ESR of less than 3 would suggest thick blood and microclotting pathology. There are plenty of other pathologies that contribute to POTS and ME/CFS - low blood volume, autoantibodies, mitochondrial issues, etc. Not everyone has all pathologies equally. I have a good friend with ME/CFS who has no signs of microclots at all but for me my microclots were through the roof.

Correct. The most severe form of Long Covid is ME/CFS (aka 'Post Covid ME/CFS') but others have more mild forms of persistent of illness.

@@me-cfs-strategiesforhealing Would you consider constant fatigue part of ME/CFS or is that applicable to normal POTS also? What is the differentiation point? Also, is BC007 for POTS specifically or ME/CFS? It seems you're an person who has had to gotten ME/CFS some time ago. I'm a realist and I see no way that anything actual comes up for ME/CFS or Long Covid for atleast another 15 years and that also if research momentum remains there and we're lucky. But since you must know better (I hope), have you seen any change in atitude among the researchers and medical community at large? And I mean actual change not just tweets or writing some papers for social studies.

BC007 will work for ME/CFS, POTS and Long Covid as the autoantibodies against G-Protein Coupled Receptors (which BC007 targets) are common to all of these illnesses. I understand your frustration with the system. The truth is I don't know. I like to stay optimistic but, let's face it, we've received hardly any real support from the medical powers that be. That said, I do think Long Covid has definitely led to increased interest and research. And I do think a treatment like BC007 - which isn't far off - could change things majorly (doctors love treatments that actually make patients feel better - and if the treatment makes someone feel better, well they probably aren't suffering from a psychosomatic complaint). Also in the UK the government is talking about more change. So I do think things are happening that we should be grateful for, just not quite as much as one would hope for.

@@me-cfs-strategiesforhealing I also have internal vibrations mostly at night ... Is that related to these? I never had these things😭😭.

This isn't medical advice but that could be part of autonomic nervous system dysfunction.

All good points. We can only hope.

@@me-cfs-strategiesforhealing As patients, we really do :)

Sorry about that, I'll look into why that was. It's called 'How I Boost Blood Volume in ME/CFS' and it was released back in March.

Hi, never tested though my understanding is that D-Dimer won't indicate microclotting.

From one 'crazy' person to another, thank you.

Wow, that's very interesting!

Not to my knowledge.

Thanks very much and, I have indeed heard about it. I keep an open mind and maybe I'll experiment with it but I didn't find it a particularly convincing theory. I wonder if people do well on a low vitamin A diet because it also means they are cutting out a lot of other crap. What do you think about the idea though?

@@me-cfs-strategiesforhealing fair enough, for me I at least found out about it from accidentally overdosing on it when I took vitamin C supplements (they added alot of Vitamin A to it that I didn't read on the ingredients beforehand). Got pretty much incapacitated and had to take 3 days off work getting over the migraine, nausea and eye strain. Started cutting out cod liver oil and other high vitamin a things to try it out and it has helped with symptoms alot. Seems because it's fat soluble it's harder to get rid of, so builds up in the body (liver and fat) over time and once you reach the threshold it spills over and causes symptoms every time you eat something with vit A or if the liver gets an injury from a virus or stressor, vit A apparently spills out from the liver where it's stored. Anyway, hope that helps

Thank you that does help a lot. Well you can't argue with success so it is definitely something I'll look into. I just love eggs though ;)