Oxygen Hemoglobin Dissociation Curve during Exercise

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Video Summary:
During exercise oxygen consumption is increased to provide energy to working muscles. The body's response to fulfil this demand can be explained by two changes in oxygen hemoglobin dissociation curve. One is decreased partial pressure of oxygen at the muscle. This allows equilibrium to be achieved at lower point in saturation of hemoglobin. Second is increased carbon dioxide, hydrogen ion concentration and temperature at the exercising tissues. All these factors shift the oxygen hemoglobin dissociation curve to right. This shift further increases release of oxygen. Thus oxygen delivery is increased at exercising tissue.
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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.

[@jordanpeters3746]

I read somewhere that during exercise plasma fluids move into the cells reducing the blood volume and hence increasing the haemoglobin in a sample of blood. Thus a person who had a blood sample taken after arriving at a hospital or surgery after having travelled there in a way that required them to exercise will have a higher Hb than a person who travelled there by car or who is a sedentary patient in a hospital. The difference could be as much as 20 g/l. The lab results can also vary by as much as plus or minus 3 g/l. I'm an active person attending for dialysis 3 times a week. My weekly bloods sample is sometimes taken as soon as I arrive, after a brisk 15 minute walk from the bus station, and sometimes the sample is taken mid-way through my dialysis. I've had to be firm with my nephrologist and tell her what dosage of medication I need for my kidney-caused anemia ... she doesn't understand what is going on. She also doesn't know how to differentiate between anemia of inflammation and the kidney-caused anemia. I keep having to request a CRP test to avoid being given an excessive does of an EPO that can have negative effects on my health. 10 mcg (the minmum dose) of Aranesp (Darbepoetin alfa) sends my Hb shooting up by up to 10 g/l in a few days when I've no inflammation but has hardly any effect when there's inflammation. The drug dosage should not be increased to counter Hb loss caused by inflammation (or, has happened recently, to counter blood loss caused by hematuria caused by my ureteral stents prior to them being changed). She also wants to raise my Ferritin way above 100 (with IV iron .. as she does with most other patients) despite the fact that the EPO works perfectly well at 40 when there's no inflammation ...when there's infammation the Ferritin shoots up into the hundreds... but she still wants me to have weekly IV iron. My Iron level is above the lower limit of the normal range .. as is my transferritin. As I get no treatment for the inflammation I use a herbal anti-inflammatory ... which works ... but I have to keep requesting a CRP test when I susoect there's inflammation that needs a higher dose. By taling control of my treatment (including insisting on a higher pump speed during dialysis) I've dramatically improved my fitness and quality of life (from:"Oh God, I'm gonna die soon!" to "bouncing around like a teenager"... I'm 78, slim and athletic ... most of the other patients are overweight/obese and "not in good shape" ... and some of the nurses could lose a bit of weight!)

[@rushdakhan]

Very well explained Sir🙌

[@SonuSHARMA-vc3om]

Woow sir ji

[@NonstopNeuron]

😊😊😊