Amazing explanation! One tip to remember the factors affecting the dissociation curve is "CADET, face RIGHT!" C - CO2 A - Acidity D - DPG E - Exercise T - Temperature Rise in all these shifts the curve to right. I hope it helps to all the readers!
I remember this because patients who "Leave" the OR...They often have a shift to the Left...Low Temp, Usually being Ventilated with Ambu Bag leading to Low CO2 and Alkalosis, and often times having received Transfusions. I always think of an OR patient having a Shift to the Left. Great Video by the way!
You having an amazing way of explaining the systems separately i have a test tomorrow and my science teacher has a false way of explaining things so thank you very much
Thanks sir this lecture is very useful and informative Another key points Left shift:show an increase HB affinity to oxygen.lt easier to loaded oxygen but diffcult to unload it. Right shift: show decrease HB affinity to oxygen , it is difficult to loaded the oxygen but easy to unload the oxygen.
In other words, in the lungs, the haemoglobin must be "selfish" taking and holding the oxygen. In the tissue, the haemoglobin must not be "selfish" releasing the oxygen! Tks 4 sharing the video.
You literally have the best video's ever !!! i recommended this channel to all of my classmates lol. I love the drawings. I wish there was a way for us to print them off.
Well done👍👍👍 I think it would be nice to put a link to a HD picture of the whole drawings of every video of yours so that we can use them as flashcards
From my understanding the oxyhaemglobin dissosociation curve or oxygen dissociation curve plots the relationship between two variables; oxygen partial pressure in arterial blood (horizontal) and haemoglobin bound with oxygen (vertical axis) expressed as a curve. Higher SpO2 (or other measures of bound haemoglobin/ vertical axis) increases the bohr effect, which causes more of the oxygen to detach and it becomes more selective for CO2 instead; thus as you go right on the curve, the higher spO2 = higher deposition in arterial blood of O2, therefore producing increased partial pressure of oxygen (ie more of it in the blood).
Important to remember that only a relatively small amount of CO2 is exhaled. Most CO2 stays in the blood. Venous blood CO2 is 45mmHg. arterial blood CO2 is 40mmHg. So only 5mmHg is exhaled.
The fact that arteries maintain such *high* partial pressure of CO2 compared to atmosphere makes one wonder if CO2 is really just a "waste product" of metabolism as claimed in mainstream.
You learning, study and even have experience still cannot beat person through the situations ☺️☺️☺️.... The effect and the pain will not made you scared with see person's Infront you die.... Before I sick I am little bit scary and unclaim when see patients nearly me struggle before DIE..
Thanks for that video which is sure clear. Can you confirm that the ppO2 you are speaking about is arterial pressure? I'm still trying to fully understand the big picture of it due to the different ppO2 depending on body locations (alveorus, arterial, veins)
DPG or BPG ....bi phospho glyceric acid ... It comes in GLYCOLYSIS. 2,3DPG bings to only beta chain of hemoglobin by displacing the oxygen ...that is the reason it causes right curve.
It's a substance found in RBC's, it decreases the affinity of hemoglobin for O2 and thus aids in the unloading of O2 from hemoglobin. So the greater the level of DPG/BPG, the more O2 is unloaded from Hemoglobin.
🎥 DON'T JUST WATCH, LEARN ACTIVELY! TRY THE QUIZ! 🤓
youmakr.ai/test-playground/questionnaire/673d3bec859b9c170836eccc
Amazing explanation!
One tip to remember the factors affecting the dissociation curve is "CADET, face RIGHT!"
C - CO2
A - Acidity
D - DPG
E - Exercise
T - Temperature
Rise in all these shifts the curve to right.
I hope it helps to all the readers!
Thanks!!
S F
You're welcome! :)
Thank you!!
Thanks for the tip
Kadak
Sir I am quite impressed how much hard work you have to put behind each video. Lots of love from this Indian student.
👍
studying for my CCRN exam and this was a huge help (especially because I'm a visual learner). Thanks so much!
hi
I'm also a visual one😊
I am also visual learner
@@ziauddin7583 Who asked ?
armando! we just went over hemoglobin-dissociation curves in a&p lecture today so the timing on this upload was perfect
Have my exam in next 15 minutes
This is why u have 1.2 million subscribers
You don't know how thankful I am for this video! Respect!
I remember this because patients who "Leave" the OR...They often have a shift to the Left...Low Temp, Usually being Ventilated with Ambu Bag leading to Low CO2 and Alkalosis, and often times having received Transfusions. I always think of an OR patient having a Shift to the Left. Great Video by the way!
My biology teacher couldn’t explain this properly! Thank you so much for this video you just saved my alevel
When you want to be an artist but couldn't be an artist😂
Stfu and be grateful to him.
That cute handwriting and those doodles were breathing life into me...
Amazing explanation! 💞
You having an amazing way of explaining the systems separately i have a test tomorrow and my science teacher has a false way of explaining things so thank you very much
Thanks sir this lecture is very useful and informative
Another key points
Left shift:show an increase HB affinity to oxygen.lt easier to loaded oxygen but diffcult to unload it.
Right shift: show decrease HB affinity to oxygen , it is difficult to loaded the oxygen but easy to unload the oxygen.
In other words, in the lungs, the haemoglobin must be "selfish" taking and holding the oxygen. In the tissue, the haemoglobin must not be "selfish" releasing the oxygen! Tks 4 sharing the video.
I appreciate the efforts you put into making these videos. Much respect!
You literally have the best video's ever !!! i recommended this channel to all of my classmates lol. I love the drawings. I wish there was a way for us to print them off.
I watched your video yesterday and I got the same question for the essay question today in my finals! Thanks a lot for such a crisp explanation!
thank you so much! I found my lecture extremely confusing when it came to this bit, but you've cleared out my questions
You deserve an award for these videos, if you do not have one already.
Armando is the best at explaining biochemistry I watched lot of his videos ! And his diagrams are so precise!
I have exam within next two hours, this really helped me to brush up my knowledge 🩺❤
this was amazing! my favorite video on the subject, thank you!
Well done👍👍👍
I think it would be nice to put a link to a HD picture of the whole drawings of every video of yours so that we can use them as flashcards
U will get most of them from Facebook page of him
👍
Entire unit completed in an hour thanks to your vids
Thanks for this amazing explanation ❤
This is so very helpful 😍 Would it be possible for you to zoom out at the end and show the whole picture?
Ufff ur handwriting and diagram and color choice is soo good it makes me to watch ur video on and on and on......
Excellent presentation of an intimidating topic!
Beautifully explained, this helped a lot
Always love your drawing and your explanation. Thank you. So much helping.
Such an amazing explanation 💞
Highly appreciable
THANKYOU SO MUCCHHHHHHHHHHHHHHHHHHHHHH FOR THIS KIND OF CLEAR EXPLANATION
Teaching is a gift
Great Explanation , Please make a video to show what is the role of water in our body , thanks in advance
Marvelous video, of great help to explain such complex mechanism to my colledge❤
Excellent work sir! Your explanations are simple and easy to understand
U deserve 10million subscribers
Amazing 😮.... The pictures are so clear and easier to understand
Another great video Armando!
Omg!! Ami living like a rock...how i missed all ur videos . thank god i find this channel..🙏🙏🙏
Unbelievable drawing !
Sir, I am in 10th standard and i was having few doubts regarding the exchange of gases...this video was really helpful to clear my concepts 💪
From my understanding the oxyhaemglobin dissosociation curve or oxygen dissociation curve plots the relationship between two variables; oxygen partial pressure in arterial blood (horizontal) and haemoglobin bound with oxygen (vertical axis) expressed as a curve. Higher SpO2 (or other measures of bound haemoglobin/ vertical axis) increases the bohr effect, which causes more of the oxygen to detach and it becomes more selective for CO2 instead; thus as you go right on the curve, the higher spO2 = higher deposition in arterial blood of O2, therefore producing increased partial pressure of oxygen (ie more of it in the blood).
Thank you for this comprehensive explanation
I'm glad I've discovered you
Thank you so much this videos Armando, clear and concise. You graphic skills are amazing. You should consider making some workbooks.
Important to remember that only a relatively small amount of CO2 is exhaled. Most CO2 stays in the blood. Venous blood CO2 is 45mmHg. arterial blood CO2 is 40mmHg. So only 5mmHg is exhaled.
The fact that arteries maintain such *high* partial pressure of CO2 compared to atmosphere makes one wonder if CO2 is really just a "waste product" of metabolism as claimed in mainstream.
@@dante911ify Exactly! Blood pH, the Bohr effect, numerous chemical processes in the body require CO2. There is no 'waste' in nature.
Incredibly easy to understand! Thank you so much!!! I love your videos!
Thanks for this video I understand that topic and prepared for my exam! 😊
Armando...you the best!
Loved it! Thank you!
finally i understand after three different explanations thanks!
😆😆😆😆
9:45 the colour changed from otange to violet. Who noticed that
Such a nice video thank you so much sir ❤❤❤
This helped a lot
Amazing explaination
I've learned bout THIS... It's important for place we stay
This gave me the clear cut understanding. Thank u so much.
always make me happy
Just Mesmerizing.....I adore on this video,Thank you so much ...oxygen dissociation curve was fantastic,i understood clearly.....
I have a quiz this week and this video helps a lot thanks to you and keep going 😄
Thank-you Sir... 💖💖💖
you teach so amazingly dude i love all your vedioss
You learning, study and even have experience still cannot beat person through the situations ☺️☺️☺️.... The effect and the pain will not made you scared with see person's Infront you die.... Before I sick I am little bit scary and unclaim when see patients nearly me struggle before DIE..
Thank you.I am glad I found you online
Thank you so much sir.
High quality explanation! The best video about this topic. Thank you
Such a good video👌👌👌
Very informative and well explained video. I also love your drawings. Thank you!
Thank you sir! your teaching is always amazing
Your work is amazing ! Thanks you ! from France :)
Awesome man. Thanks 🙏
Timestamps for myself:
05:22 pO2 is 95 mm Hg as per ncert
Yes even i was confused
Thanks for that video which is sure clear.
Can you confirm that the ppO2 you are speaking about is arterial pressure? I'm still trying to fully understand the big picture of it due to the different ppO2 depending on body locations (alveorus, arterial, veins)
You are just awesome sir thank you so much
I love okkkkksygen *(O²)*
Excellent and clear content. Thank you!
Great video! Thanks
Thanks for wonderful explanation 👍
Hi ! French student here thanking you a lot for all your videos ! Just one question though, what does DPG means ?
Chebhouni Yasmine DPG = diphosphoglyceric acid
good luck ! 🌸🌸
DPG or BPG ....bi phospho glyceric acid ... It comes in GLYCOLYSIS. 2,3DPG bings to only beta chain of hemoglobin by displacing the oxygen ...that is the reason it causes right curve.
It's a substance found in RBC's, it decreases the affinity of hemoglobin for O2 and thus aids in the unloading of O2 from hemoglobin. So the greater the level of DPG/BPG, the more O2 is unloaded from Hemoglobin.
Many thanks , you're the best 👌
thank you so much! you helped me so much!
Thank you so much! 💁
😊 loved it!
It made a lot of sense.
Thank you sir! Great video :)
Thank you for the great video's... love your work
THANK YOU VERY CLEAR
Very very helpful... Thank you so much for this amazing video... ♥♥♥
You're amazing. Thank you.
At the end plz show complete diagram.....
thank u for the clear cut explanation sir
AMAZING VIDEO!!!! THANK YOUUUU!!! finally makes sense to me
Very helpiful...
Thankz & keep it up.
This is so very helpful 💛
Thank you so much 😊
Awesome man..
Thanku so much.
Sir, could you explain little bit about temperature changes and the circumstances that affect this curve
Helped me so much for my final! Thanks!
A perfect video! Thank you so much!
Rock solid explaination!!!