Amazing explanation! One tip to remember the factors affecting the dissociation curve is "CADET, face RIGHT!" C - CO2 A - Acidity D - DPG E - Exercise T - Temperature Rise in all these shifts the curve to right. I hope it helps to all the readers!
Thanks sir this lecture is very useful and informative Another key points Left shift:show an increase HB affinity to oxygen.lt easier to loaded oxygen but diffcult to unload it. Right shift: show decrease HB affinity to oxygen , it is difficult to loaded the oxygen but easy to unload the oxygen.
I remember this because patients who "Leave" the OR...They often have a shift to the Left...Low Temp, Usually being Ventilated with Ambu Bag leading to Low CO2 and Alkalosis, and often times having received Transfusions. I always think of an OR patient having a Shift to the Left. Great Video by the way!
You having an amazing way of explaining the systems separately i have a test tomorrow and my science teacher has a false way of explaining things so thank you very much
In other words, in the lungs, the haemoglobin must be "selfish" taking and holding the oxygen. In the tissue, the haemoglobin must not be "selfish" releasing the oxygen! Tks 4 sharing the video.
Well done👍👍👍 I think it would be nice to put a link to a HD picture of the whole drawings of every video of yours so that we can use them as flashcards
Correct breathing will improve the oxygenation of blood and improve circulation. The breath can also be utilised to combat stress and improve mental wellness. This is a valuable guide to improving both physical and mental wellness. The Full Breath by James Francis.
Important to remember that only a relatively small amount of CO2 is exhaled. Most CO2 stays in the blood. Venous blood CO2 is 45mmHg. arterial blood CO2 is 40mmHg. So only 5mmHg is exhaled.
The fact that arteries maintain such *high* partial pressure of CO2 compared to atmosphere makes one wonder if CO2 is really just a "waste product" of metabolism as claimed in mainstream.
You literally have the best video's ever !!! i recommended this channel to all of my classmates lol. I love the drawings. I wish there was a way for us to print them off.
From my understanding the oxyhaemglobin dissosociation curve or oxygen dissociation curve plots the relationship between two variables; oxygen partial pressure in arterial blood (horizontal) and haemoglobin bound with oxygen (vertical axis) expressed as a curve. Higher SpO2 (or other measures of bound haemoglobin/ vertical axis) increases the bohr effect, which causes more of the oxygen to detach and it becomes more selective for CO2 instead; thus as you go right on the curve, the higher spO2 = higher deposition in arterial blood of O2, therefore producing increased partial pressure of oxygen (ie more of it in the blood).
So if there is a shift to the right does that mean that oxygen is more likely to be released from the hemoglobin to the tissues, and a shift to the left means the hemoglobin is more likely to hold onto the oxygen? And with that, does that also mean a right shift=less O2 pick up in lungs; left shift=less O2 to tissues?
The right shift means that oxygen is readily being dissociated from the Hemoglobin (before it even reaches the tissue) which means that the tissue is not receiving enough O2. Indicating that the right shift of O2 dissociation curve is bad for the health. Another explanation for it is that, observe the curve at 11:29 In the right shift (blue line) more pressure of O2 i.e. 50% pO2 is required to cause saturation of say 70%. Now observe the left shift (red line). It shows that less amount of partial pressure of O2 (less pO2 - say 20%) is required to fulfill the same amount of saturation level i.e. 70%. Which says that even if you have an environment with less pO2, ( say you're in a mountainous region) you will be able to fullfill your saturation levels. While a man with right side shift of the dissociation curve won't be able to do that. He will require a higher level of pO2 in his lungs and that's why he will pant. Hope this helps!
The first bit, definitely: YES - If there is a shift to the right the oxygen is more likely to be released from the hemoglobin to the tissues, and a shift to the left means the hemoglobin is more likely to hold onto the oxygen. A right shift happens with myoglobin of the muscles and also fetal hemoglobin. Neither of these are near adult lungs. Myoglobin needs a release of oxygen from the haemoglobin of the blood. Fetal haemoglobin needs a higher affinity than the mother's blood to grab hold of oxygen from the mother's blood. A left shift happens in normal haemoglobin of animals that live in high altitudes or low oxygen environments such as the tapeworm inside a human. They need to grab more Oxygen from their environment which has a low partial pressure of Oxygen. When the red blood cells reach the respiring tissues, the reason they give up their oxygen to the tissues is because of the high levels of CO2 at the tissues. The CO2 diffuses into the blood plasma and into the red blood cells. Inside the red blood cells are many molecules of an enzyme called carbonic anhydrase. It catalyses the reaction between CO2 and H2O. The resulting carbonic acid then dissociates into HCO3− + H+. An acidic environment causes HbO2 to dissociate (unload) to release the O2 to the tissues. Just a small decrease in the pH results in a large decrease in the percentage saturation of the blood with O2. Acidity depends on the concentration of hydrogen ions. H+ displaces O2 from the HbO2, thus increasing the O2 available to the respiring tissues. H+ + HbO2 → HHb + O2 HHb is called haemoglobinic acid. This means that the Hb mops up free H+. That way the Hb helps to maintain the almost neutral pH of the blood. Hb acts as a buffer. This release of O2 when the pH is low (even if the pO2 is relatively high) is called the Bohr effect
Tamara White just a quick question but isn’t fetal heamoglobin more to the left of the normal oxygen dissociation curve? In order to get the O2 from the mother they need to have a higher affinity for 02 correct? Therefore by being further to the left they’d be able to associate with oxygen more easily yet you mentioned (with fetal haemoglobin being on the right) that it has a lower association for O2.
Thanks for that video which is sure clear. Can you confirm that the ppO2 you are speaking about is arterial pressure? I'm still trying to fully understand the big picture of it due to the different ppO2 depending on body locations (alveorus, arterial, veins)
You learning, study and even have experience still cannot beat person through the situations ☺️☺️☺️.... The effect and the pain will not made you scared with see person's Infront you die.... Before I sick I am little bit scary and unclaim when see patients nearly me struggle before DIE..
DPG or BPG ....bi phospho glyceric acid ... It comes in GLYCOLYSIS. 2,3DPG bings to only beta chain of hemoglobin by displacing the oxygen ...that is the reason it causes right curve.
It's a substance found in RBC's, it decreases the affinity of hemoglobin for O2 and thus aids in the unloading of O2 from hemoglobin. So the greater the level of DPG/BPG, the more O2 is unloaded from Hemoglobin.
![Megan Thee Stallion - Roc Steady (feat. Flo Milli) [Official Video]](http://i.ytimg.com/vi/HozPPyqW0dY/mqdefault.jpg)
🎥 DON'T JUST WATCH, LEARN ACTIVELY! TRY THE QUIZ! 🤓
youmakr.ai/test-playground/questionnaire/673d3bec859b9c170836eccc
Amazing explanation!
One tip to remember the factors affecting the dissociation curve is "CADET, face RIGHT!"
C - CO2
A - Acidity
D - DPG
E - Exercise
T - Temperature
Rise in all these shifts the curve to right.
I hope it helps to all the readers!
Thanks!!
S F
You're welcome! :)
Thank you!!
Thanks for the tip
Kadak
studying for my CCRN exam and this was a huge help (especially because I'm a visual learner). Thanks so much!
hi
I'm also a visual one😊
I am also visual learner
Sir I am quite impressed how much hard work you have to put behind each video. Lots of love from this Indian student.
👍
Thanks sir this lecture is very useful and informative
Another key points
Left shift:show an increase HB affinity to oxygen.lt easier to loaded oxygen but diffcult to unload it.
Right shift: show decrease HB affinity to oxygen , it is difficult to loaded the oxygen but easy to unload the oxygen.
I remember this because patients who "Leave" the OR...They often have a shift to the Left...Low Temp, Usually being Ventilated with Ambu Bag leading to Low CO2 and Alkalosis, and often times having received Transfusions. I always think of an OR patient having a Shift to the Left. Great Video by the way!
armando! we just went over hemoglobin-dissociation curves in a&p lecture today so the timing on this upload was perfect
My biology teacher couldn’t explain this properly! Thank you so much for this video you just saved my alevel
Have my exam in next 15 minutes
This is why u have 1.2 million subscribers
You having an amazing way of explaining the systems separately i have a test tomorrow and my science teacher has a false way of explaining things so thank you very much
You don't know how thankful I am for this video! Respect!
In other words, in the lungs, the haemoglobin must be "selfish" taking and holding the oxygen. In the tissue, the haemoglobin must not be "selfish" releasing the oxygen! Tks 4 sharing the video.
That cute handwriting and those doodles were breathing life into me...
Amazing explanation! 💞
thank you so much! I found my lecture extremely confusing when it came to this bit, but you've cleared out my questions
I have exam within next two hours, this really helped me to brush up my knowledge 🩺❤
I watched your video yesterday and I got the same question for the essay question today in my finals! Thanks a lot for such a crisp explanation!
When you want to be an artist but couldn't be an artist😂
Stfu and be grateful to him.
I appreciate the efforts you put into making these videos. Much respect!
You deserve an award for these videos, if you do not have one already.
this was amazing! my favorite video on the subject, thank you!
Entire unit completed in an hour thanks to your vids
Well done👍👍👍
I think it would be nice to put a link to a HD picture of the whole drawings of every video of yours so that we can use them as flashcards
U will get most of them from Facebook page of him
👍
Beautifully explained, this helped a lot
Correct breathing will improve the oxygenation of blood and improve circulation. The breath can also be utilised to combat stress and improve mental wellness. This is a valuable guide to improving both physical and mental wellness.
The Full Breath by James Francis.
Important to remember that only a relatively small amount of CO2 is exhaled. Most CO2 stays in the blood. Venous blood CO2 is 45mmHg. arterial blood CO2 is 40mmHg. So only 5mmHg is exhaled.
The fact that arteries maintain such *high* partial pressure of CO2 compared to atmosphere makes one wonder if CO2 is really just a "waste product" of metabolism as claimed in mainstream.
@@dante911ify Exactly! Blood pH, the Bohr effect, numerous chemical processes in the body require CO2. There is no 'waste' in nature.
Armando is the best at explaining biochemistry I watched lot of his videos ! And his diagrams are so precise!
This is so very helpful 😍 Would it be possible for you to zoom out at the end and show the whole picture?
Great Explanation , Please make a video to show what is the role of water in our body , thanks in advance
Excellent presentation of an intimidating topic!
You literally have the best video's ever !!! i recommended this channel to all of my classmates lol. I love the drawings. I wish there was a way for us to print them off.
Teaching is a gift
I love okkkkksygen *(O²)*
Such an amazing explanation 💞
Highly appreciable
THANKYOU SO MUCCHHHHHHHHHHHHHHHHHHHHHH FOR THIS KIND OF CLEAR EXPLANATION
Thanks for this amazing explanation ❤
I've learned bout THIS... It's important for place we stay
I'm glad I've discovered you
Omg!! Ami living like a rock...how i missed all ur videos . thank god i find this channel..🙏🙏🙏
Ufff ur handwriting and diagram and color choice is soo good it makes me to watch ur video on and on and on......
Always love your drawing and your explanation. Thank you. So much helping.
This gave me the clear cut understanding. Thank u so much.
From my understanding the oxyhaemglobin dissosociation curve or oxygen dissociation curve plots the relationship between two variables; oxygen partial pressure in arterial blood (horizontal) and haemoglobin bound with oxygen (vertical axis) expressed as a curve. Higher SpO2 (or other measures of bound haemoglobin/ vertical axis) increases the bohr effect, which causes more of the oxygen to detach and it becomes more selective for CO2 instead; thus as you go right on the curve, the higher spO2 = higher deposition in arterial blood of O2, therefore producing increased partial pressure of oxygen (ie more of it in the blood).
U deserve 10million subscribers
Sir, I am in 10th standard and i was having few doubts regarding the exchange of gases...this video was really helpful to clear my concepts 💪
Thank you sir! your teaching is always amazing
Unbelievable drawing !
Incredibly easy to understand! Thank you so much!!! I love your videos!
Thank you for this comprehensive explanation
Thank you so much this videos Armando, clear and concise. You graphic skills are amazing. You should consider making some workbooks.
finally i understand after three different explanations thanks!
😆😆😆😆
Thanks for this video I understand that topic and prepared for my exam! 😊
So if there is a shift to the right does that mean that oxygen is more likely to be released from the hemoglobin to the tissues, and a shift to the left means the hemoglobin is more likely to hold onto the oxygen? And with that, does that also mean a right shift=less O2 pick up in lungs; left shift=less O2 to tissues?
The right shift means that oxygen is readily being dissociated from the Hemoglobin (before it even reaches the tissue) which means that the tissue is not receiving enough O2. Indicating that the right shift of O2 dissociation curve is bad for the health.
Another explanation for it is that, observe the curve at 11:29
In the right shift (blue line) more pressure of O2 i.e. 50% pO2 is required to cause saturation of say 70%.
Now observe the left shift (red line).
It shows that less amount of partial pressure of O2 (less pO2 - say 20%) is required to fulfill the same amount of saturation level i.e. 70%.
Which says that even if you have an environment with less pO2, ( say you're in a mountainous region) you will be able to fullfill your saturation levels. While a man with right side shift of the dissociation curve won't be able to do that. He will require a higher level of pO2 in his lungs and that's why he will pant.
Hope this helps!
The first bit, definitely:
YES - If there is a shift to the right the oxygen is more likely to be released from the hemoglobin to the tissues, and a shift to the left means the hemoglobin is more likely to hold onto the oxygen.
A right shift happens with myoglobin of the muscles and also fetal hemoglobin. Neither of these are near adult lungs. Myoglobin needs a release of oxygen from the haemoglobin of the blood. Fetal haemoglobin needs a higher affinity than the mother's blood to grab hold of oxygen from the mother's blood.
A left shift happens in normal haemoglobin of animals that live in high altitudes or low oxygen environments such as the tapeworm inside a human. They need to grab more Oxygen from their environment which has a low partial pressure of Oxygen. When the red blood cells reach the respiring tissues, the reason they give up their oxygen to the tissues is because of the high levels of CO2 at the tissues.
The CO2 diffuses into the blood plasma and into the red blood cells. Inside the red blood cells are many molecules of an enzyme called carbonic anhydrase. It catalyses the reaction between CO2 and H2O. The resulting carbonic acid then dissociates into HCO3− + H+.
An acidic environment causes HbO2 to dissociate (unload) to release the O2 to the tissues. Just a small decrease in the pH results in a large decrease in the percentage saturation of the blood with O2.
Acidity depends on the concentration of hydrogen ions.
H+ displaces O2 from the HbO2, thus increasing the O2 available to the respiring tissues.
H+ + HbO2 → HHb + O2
HHb is called haemoglobinic acid.
This means that the Hb mops up free H+. That way the Hb helps to maintain the almost neutral pH of the blood. Hb acts as a buffer.
This release of O2 when the pH is low (even if the pO2 is relatively high) is called the Bohr effect
Tamara White just a quick question but isn’t fetal heamoglobin more to the left of the normal oxygen dissociation curve? In order to get the O2 from the mother they need to have a higher affinity for 02 correct? Therefore by being further to the left they’d be able to associate with oxygen more easily yet you mentioned (with fetal haemoglobin being on the right) that it has a lower association for O2.
Amazing 😮.... The pictures are so clear and easier to understand
Excellent work sir! Your explanations are simple and easy to understand
Thank you.I am glad I found you online
Timestamps for myself:
05:22 pO2 is 95 mm Hg as per ncert
Yes even i was confused
High quality explanation! The best video about this topic. Thank you
This helped a lot
I have a quiz this week and this video helps a lot thanks to you and keep going 😄
thank u for the clear cut explanation sir
Thanks for that video which is sure clear.
Can you confirm that the ppO2 you are speaking about is arterial pressure? I'm still trying to fully understand the big picture of it due to the different ppO2 depending on body locations (alveorus, arterial, veins)
Marvelous video, of great help to explain such complex mechanism to my colledge❤
Sir, could you explain little bit about temperature changes and the circumstances that affect this curve
Just Mesmerizing.....I adore on this video,Thank you so much ...oxygen dissociation curve was fantastic,i understood clearly.....
Very helpiful...
Thankz & keep it up.
Thank you for the great video's... love your work
Loved it! Thank you!
always make me happy
At the end plz show complete diagram.....
Amazing explaination
Very informative and well explained video. I also love your drawings. Thank you!
Advertising was superrrrr
Helped me so much for my final! Thanks!
Armando...you the best!
Thank you so much! 💁
Another great video Armando!
Great explanation
It made a lot of sense.
You learning, study and even have experience still cannot beat person through the situations ☺️☺️☺️.... The effect and the pain will not made you scared with see person's Infront you die.... Before I sick I am little bit scary and unclaim when see patients nearly me struggle before DIE..
Thank you so much sir.
Thank you
Excellent and clear content. Thank you!
AMAZING VIDEO!!!! THANK YOUUUU!!! finally makes sense to me
Your work is amazing ! Thanks you ! from France :)
THANK YOU VERY CLEAR
Nice explanation ever
Thank you Armando!
Well done sir
Very very helpful... Thank you so much for this amazing video... ♥♥♥
Hi ! French student here thanking you a lot for all your videos ! Just one question though, what does DPG means ?
Chebhouni Yasmine DPG = diphosphoglyceric acid
good luck ! 🌸🌸
DPG or BPG ....bi phospho glyceric acid ... It comes in GLYCOLYSIS. 2,3DPG bings to only beta chain of hemoglobin by displacing the oxygen ...that is the reason it causes right curve.
It's a substance found in RBC's, it decreases the affinity of hemoglobin for O2 and thus aids in the unloading of O2 from hemoglobin. So the greater the level of DPG/BPG, the more O2 is unloaded from Hemoglobin.
Thank you for this video! It was a great explanation.
you teach so amazingly dude i love all your vedioss
Go to 6:03 if you need Just the explanation on the Dissociation Curve. Otherwise great background prior
Thank-you Sir... 💖💖💖
Sir your digramatic representation is better than digital representation. ..
really helpful bro
thank you so much! you helped me so much!
Very nice explanation sir
Great lecture
Thank you so much ❤
Thanks for wonderful explanation 👍