Oxygen - Haemoglobin Dissociation Curve - Physiology

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[@nachiketpargaonkar8646]

Amazing explanation!
One tip to remember the factors affecting the dissociation curve is "CADET, face RIGHT!"
C - CO2
A - Acidity
D - DPG
E - Exercise
T - Temperature
Rise in all these shifts the curve to right.
I hope it helps to all the readers!

[@sanxxxx]

Thanks!!

[@nachiketpargaonkar8646]

S F
You're welcome! :)

[@jessicamccauley7620]

Thank you!!

[@onyapidi5174]

Thanks for the tip

[@arjunmahajan757]

Kadak

[@briannarodriguez94]

studying for my CCRN exam and this was a huge help (especially because I'm a visual learner). Thanks so much!

[@godhelpme8977]

hi

[@ziauddin7583]

I'm also a visual one😊

[@goodboy6259]

I am also visual learner

[@souravdutta1487]

Sir I am quite impressed how much hard work you have to put behind each video. Lots of love from this Indian student.

[@Dragon-Slay3r]

👍

[@elliwilson3349]

armando! we just went over hemoglobin-dissociation curves in a&p lecture today so the timing on this upload was perfect

[@ruerue0066]

When you want to be an artist but couldn't be an artist😂

[@Nongthoi9344]

Stfu and be grateful to him.

[@ayseoz1068]

My biology teacher couldn’t explain this properly! Thank you so much for this video you just saved my alevel

[@debashrita77]

Have my exam in next 15 minutes
This is why u have 1.2 million subscribers

[@samikshakemwal664]

That cute handwriting and those doodles were breathing life into me...
Amazing explanation! 💞

[@anotacoesdeculinaria]

In other words, in the lungs, the haemoglobin must be "selfish" taking and holding the oxygen. In the tissue, the haemoglobin must not be "selfish" releasing the oxygen! Tks 4 sharing the video.

[@ericarosales7727]

this was amazing! my favorite video on the subject, thank you!

[@sarahm8997]

I watched your video yesterday and I got the same question for the essay question today in my finals! Thanks a lot for such a crisp explanation!

[@Autumn._.99_0]

At the end plz show complete diagram.....

[@FOREST-9351]

Thanks for this amazing explanation ❤

[@defichandrawati1199]

Always love your drawing and your explanation. Thank you. So much helping.

[@Mr.RimeGo]

Such an amazing explanation 💞
Highly appreciable

[@MrCEPPaulT]

Excellent presentation of an intimidating topic!

[@nirgunkaur3161]

thank you so much! I found my lecture extremely confusing when it came to this bit, but you've cleared out my questions

[@safinaiqbal9260]

You deserve an award for these videos, if you do not have one already.

[@user_error404_]

I have exam within next two hours, this really helped me to brush up my knowledge 🩺❤

[@NiyonzimaNesio]

Thank you for this comprehensive explanation

[@marxiewasalittlegirl]

Entire unit completed in an hour thanks to your vids

[@sovanpatro1228]

Ufff ur handwriting and diagram and color choice is soo good it makes me to watch ur video on and on and on......

[@youngjuyoon1325]

I'm glad I've discovered you

[@useyournoodle100]

Thank you so much this videos Armando, clear and concise. You graphic skills are amazing. You should consider making some workbooks.

[@yoanntux]

Thanks for that video which is sure clear.
Can you confirm that the ppO2 you are speaking about is arterial pressure? I'm still trying to fully understand the big picture of it due to the different ppO2 depending on body locations (alveorus, arterial, veins)

[@kritichhetri63]

Amazing 😮.... The pictures are so clear and easier to understand

[@joshaa9361]

Teaching is a gift

[@geopk4731]

Sir, could you explain little bit about temperature changes and the circumstances that affect this curve

[@strictlyroots7343]

Important to remember that only a relatively small amount of CO2 is exhaled. Most CO2 stays in the blood. Venous blood CO2 is 45mmHg. arterial blood CO2 is 40mmHg. So only 5mmHg is exhaled.

[@dante911ify]

The fact that arteries maintain such *high* partial pressure of CO2 compared to atmosphere makes one wonder if CO2 is really just a "waste product" of metabolism as claimed in mainstream.

[@strictlyroots7343]

@@dante911ify Exactly! Blood pH, the Bohr effect, numerous chemical processes in the body require CO2. There is no 'waste' in nature.

[@tasleemaakter4337]

THANKYOU SO MUCCHHHHHHHHHHHHHHHHHHHHHH FOR THIS KIND OF CLEAR EXPLANATION

[@karanveersingh1139]

Lovely explanation

[@lilysal8858]

why increased temp, co2, H and 2,3dpg cause a right shifting and the decreasing of them cause a left shifting, what is the explanation of each one and how do they effect the shifting ? please!

[@soumenmandi940]

This gave me the clear cut understanding. Thank u so much.

[@bakumansi9049]

Amazing explaination

[@sherparyu9994]

Thank you sir! your teaching is always amazing

[@vinosri264]

Just Mesmerizing.....I adore on this video,Thank you so much ...oxygen dissociation curve was fantastic,i understood clearly.....

[@avivayash4857]

always make me happy

[@SnoopyRC124]

So if there is a shift to the right does that mean that oxygen is more likely to be released from the hemoglobin to the tissues, and a shift to the left means the hemoglobin is more likely to hold onto the oxygen? And with that, does that also mean a right shift=less O2 pick up in lungs; left shift=less O2 to tissues?

[@mihika6730]

The right shift means that oxygen is readily being dissociated from the Hemoglobin (before it even reaches the tissue) which means that the tissue is not receiving enough O2. Indicating that the right shift of O2 dissociation curve is bad for the health.
Another explanation for it is that, observe the curve at 11:29
In the right shift (blue line) more pressure of O2 i.e. 50% pO2 is required to cause saturation of say 70%.
Now observe the left shift (red line).
It shows that less amount of partial pressure of O2 (less pO2 - say 20%) is required to fulfill the same amount of saturation level i.e. 70%.
Which says that even if you have an environment with less pO2, ( say you're in a mountainous region) you will be able to fullfill your saturation levels. While a man with right side shift of the dissociation curve won't be able to do that. He will require a higher level of pO2 in his lungs and that's why he will pant.
Hope this helps!

[@learnbiology2023]

The first bit, definitely:
YES - If there is a shift to the right the oxygen is more likely to be released from the hemoglobin to the tissues, and a shift to the left means the hemoglobin is more likely to hold onto the oxygen.
A right shift happens with myoglobin of the muscles and also fetal hemoglobin. Neither of these are near adult lungs. Myoglobin needs a release of oxygen from the haemoglobin of the blood. Fetal haemoglobin needs a higher affinity than the mother's blood to grab hold of oxygen from the mother's blood.
A left shift happens in normal haemoglobin of animals that live in high altitudes or low oxygen environments such as the tapeworm inside a human. They need to grab more Oxygen from their environment which has a low partial pressure of Oxygen. When the red blood cells reach the respiring tissues, the reason they give up their oxygen to the tissues is because of the high levels of CO2 at the tissues.
The CO2 diffuses into the blood plasma and into the red blood cells. Inside the red blood cells are many molecules of an enzyme called carbonic anhydrase. It catalyses the reaction between CO2 and H2O. The resulting carbonic acid then dissociates into HCO3− + H+.
An acidic environment causes HbO2 to dissociate (unload) to release the O2 to the tissues. Just a small decrease in the pH results in a large decrease in the percentage saturation of the blood with O2.
Acidity depends on the concentration of hydrogen ions.
H+ displaces O2 from the HbO2, thus increasing the O2 available to the respiring tissues.
H+ + HbO2 → HHb + O2
HHb is called haemoglobinic acid.
This means that the Hb mops up free H+. That way the Hb helps to maintain the almost neutral pH of the blood. Hb acts as a buffer.
This release of O2 when the pH is low (even if the pO2 is relatively high) is called the Bohr effect

[@normalisboring2831]

Tamara White just a quick question but isn’t fetal heamoglobin more to the left of the normal oxygen dissociation curve? In order to get the O2 from the mother they need to have a higher affinity for 02 correct? Therefore by being further to the left they’d be able to associate with oxygen more easily yet you mentioned (with fetal haemoglobin being on the right) that it has a lower association for O2.

[@FrenchImperialist]

I love okkkkksygen *(O²)*

[@Aliamsb]

Unbelievable drawing !

[@FATIMA-rj2fu]

you teach so amazingly dude i love all your vedioss

[@anandtechknow2129]

Omg!! Ami living like a rock...how i missed all ur videos . thank god i find this channel..🙏🙏🙏

[@krutinairlines22]

Thanks for this video I understand that topic and prepared for my exam! 😊

[@crit-ic]

Another great video Armando!

[@zarinaz9967]

THANK YOU VERY CLEAR

[@kimienick6721]

I've learned bout THIS... It's important for place we stay

[@LilianMgbe-cc6it]

Such a nice video thank you so much sir ❤❤❤

[@Aquilariaable]

Very informative and well explained video. I also love your drawings. Thank you!

[@RigoStar1931]

High quality explanation! The best video about this topic. Thank you

[@dreamyCat9615]

Thank-you Sir... 💖💖💖

[@yasminechebhouni7247]

Hi ! French student here thanking you a lot for all your videos ! Just one question though, what does DPG means ?

[@dimasaleem8411]

Chebhouni Yasmine DPG = diphosphoglyceric acid
good luck ! 🌸🌸

[@Dr-up3qm]

DPG or BPG ....bi phospho glyceric acid ... It comes in GLYCOLYSIS. 2,3DPG bings to only beta chain of hemoglobin by displacing the oxygen ...that is the reason it causes right curve.

[@45trlu]

It's a substance found in RBC's, it decreases the affinity of hemoglobin for O2 and thus aids in the unloading of O2 from hemoglobin. So the greater the level of DPG/BPG, the more O2 is unloaded from Hemoglobin.

[@medusablack5092]

Great video! Thanks

[@moonblume5688]

Your work is amazing ! Thanks you ! from France :)

[@dr.shandhanchowdhury3955]

Awesome man. Thanks 🙏

[@NehaSharma-up3gd]

thank you

[@Itz_2077]

It made a lot of sense.

[@immank2102]

Thank you.I am glad I found you online

[@mohamedabdihafidissak4759]

Very helpiful...
Thankz & keep it up.

[@debikaray6312]

😊 loved it!

[@217snehanayak3]

thank u for the clear cut explanation sir

[@temadyn4757]

I have a quiz this week and this video helps a lot thanks to you and keep going 😄

[@devinflore5798]

Excellent and clear content. Thank you!

[@manya.2509]

Thanks for wonderful explanation 👍

[@dr.dibbyajyotidutta8304]

Thãnks a lot doc

[@sunilkumarahri9384]

DPG means

[@sirajsirchemistry4875]

Thank You very mush.

[@salmanmajeed5303]

Thanks

[@onyapidi5174]

Go to 6:03 if you need Just the explanation on the Dissociation Curve. Otherwise great background prior

[@amanbhatt88]

Bro please provide the PDF of you that page on which you draw...
It will help a lot

[@UnYin99]

facebook.com/ArmandoHasudungan/photos/a.452356094808683/1480313528679596/?type=3&theater

[@arazmokari6192]

oKKKKKKKKSYgenated blood

[@max-px2lf]

where are u in life rn?

[@max-px2lf]

because its been 5 years, i mean 😅

[@pierrengo3731]

I bet he still breathing oKKKKsygenated air

[@dancewithdiksha7607]

Thanks😊

[@fatematuzzohora7628]

Please clarify P02 in alveoli or blood? Like when we say the flat part represents oxygenation im lungs then due to max saturation of Hb with 02 no matter how much P02 we increase the Hb wont carry any more 02 then which P02 that means the one that s dissolved or the one in alveoli? And the arterial P02 is 95 mm Hg not 100. Thanks.

[@laurenkromminga3043]

Thank you for this video! It was a great explanation.

[@anesutatenda4460]

You're amazing. Thank you.

[@angieportes5599]

thank you so much! you helped me so much!

[@sairatariq9710]

You didnt explain the 2,3 bis phosphoglycerate role
How it shifts
Is that so that in tissues glycolysis yields 2,3 bisphosphoglycerate.so affinity of HB decreases for oxygen hence it is delieverd to site
Please clarify me

[@gabriellerizzo8278]

Helped me so much for my final! Thanks!

[@lucasherr3828]

A perfect video! Thank you so much!

[@padmajasawant8240]

Thank you so much! 💁

[@thakkarghanshyam2450]

Thank u so much..👍👍

[@allthebest9620]

This is so very helpful 💛
Thank you so much 😊

[@saranya6199]

Rock solid explaination!!!

Great Work!

[@saidyayoub4795]

Nice explanation ever

[@balan3438]

Oxygen dissociation curve 6:09

[@austinsolak]

Thank you sir! Great video :)

[@ShahzadKhan-rp9xr]

Sir u r awesome.. Hats off u

[@supriya2711]

Sir will I please explain the topic about invertebrates and vetertebrates plz sir

[@kolarchildrenshomekolar2397]

Nice waiting for more videos on bio

[@norathalji2755]

thanks, you're greaaaaat!

[@estergarciapolanco]

Thank you Armando!

[@shelyaliz]

My hero

[@playmaan3783]

Thank you so muchhhh

[@larasons9443]

This video is very helpful! Thank you so much!

[@niyatisolanki5881]

Very nice

[@haindhavil4238]

Advertising was superrrrr

[@ashiestella7099]

Perfect

[@abhilashds7138]

If right shift occurs in tissues and left in lungs ,where does normal curve occurs ??

[@reemadas2760]

Really nice video. Amazing exploration ❤

[@anandparimal8812]

it is so comprehensive.!