AKT Signaling Pathway: Regulation by the Insulin Signaling Cascade

Lesson on the Insulin Signaling Pathway and its Regulation of the AKT Pathway. The insulin signaling cascade is activated upon binding of insulin to the insulin receptor. Afterwards, downstream targets, including IRS1/2, become activated, eventually leading to activation of AKT via two distinct mechanisms and two important phosphorylation sites on AKT. These AKT phosphorylation are important for AKT activation. These two sites also are regulated by two phosphatase enzymes as well. Eventually, activation of AKT will lead to particular effects within the insulin-stimulated cell, which we also discuss in this lesson.
I hope you find this lesson helpful. If you do, please like, subscribe and click the notification bell to stay up-to-date on future lessons.
Subscribe for more free medical lessons / @jjmedicine
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
www.amazon.com...
Support future lessons (and get other cool stuff) ➜ / jjmedicine
Follow me on Twitter! ➜ / jj_medicine
Come join me on Facebook! ➜ / jj-medicine-1006426481...
Start your own website with BlueHost ➜ www.bluehost.c...
Check out the best tool to help grow your RUclips channel (it’s helped me!)
www.tubebuddy....
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
• Medical Terminology - ...
Fatty Acid Synthesis Pathway:
• Fatty Acid Synthesis P...
Wnt/B Catenin Signaling Pathway:
• Wnt/β-Catenin Signalin...
Upper vs. Lower Motor Neuron Lesions:
• Upper and Lower Motor ...
Lesson on the Purine Synthesis and Salvage Pathway:
• Purine Synthesis and S...
Gastrulation | Formation of Germ Layers:
• Gastrulation | Formati...
Introductory lesson on Autophagy (Macroautophagy):
• Autophagy | Macroautop...
Infectious Disease Playlist
• Infectious Diseases
Dermatology Playlist
• Dermatology
Pharmacology Playlist
• Pharmacology
Hematology Playlist
• Hematology
Rheumatology Playlist
• Rheumatology
Endocrinology Playlist
• Endocrinology
Nephrology Playlist
• Nephrology
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[@hope5746]

PDK is not pyruvate dehydrogenase kinase ....it's phosphoinositide dependent protein kinase

[@timblackburn1593]

Actually 3-phosphoinositide-dependent protein kinase 1

[@АрсенКонд]

Thsnks, I waited this video for a long time.

[@misbahnaaz9794]

Thank you sir
it was really confusing before

[@bernardojunqueira2392]

Thank you! So, P70S6K inhibiting IRS1/2 phosphorylation would have any relation to insulin resistance?

[@hunter_69_69]

A bit late to reply, but my 2 cents is that is possibly could be the case.
We know that obesity often happens in concert with insulin resistance. Theoretically, when one is in a chronic calorie surplus (gains weight), that would happen in concert with a lot of insulin secretion (either one is on a high-carbohydrate diet, or their high fat/protein diet would spare carbohydrates from oxidation, allowing for them to induce insulin secretion in the pancreas). A lot of insulin secretion would, in theory, lead to more of the insulin signaling cascade, would could theoretically lead to a lot of p70s6 kinase inhibiting IRS 1/2, serving as the "feedback mechanism" of the insulin signaling cascade, decreasing the "potency" of insulin's metabolic effects (such as clearing glucose from the bloodstream).
I think the "potency" of insulin may possibly be inversely proportional to the activity of p70s6 kinase (which would make theoretical sense, since p70s6 kinase inhibits IRS 1/2), and I think it makes practical sense since weight loss (which would, in theory, lead to less insulin secretion) is generally prescribed to help with insulin resistance.
Just my 2 cents, but hope this helps.

[@bennguyen1313]

Saw an interesting video from Robert Lustig... is it possible that the liver's insulin receptors can be knocked out / resistant (and disrupt the FOXO pathway), yet *NOT* affect the SREBP-1c pathway?

[@shbangash437]

Hello sir . I need your help sir from where I can get the theory of these pathways

[@montadermajed9456]

Yeah these things are really complicated 😅😅

[@marafernandagalindoromero2496]

thank you so much