Ketogenic diets promote cellular senescence and systemic inflammation | Prof Luigi Fontana
HTML-код
- Опубликовано: 13 июн 2024
- High-fat, low-carbohydrate (ketogenic) diets have gained huge popularity over recent decades for weight loss. In a recent paper, David Gius's research group demonstrated that two different types of ketogenic diets (KDs) induce a significant increase in cellular senescence in various organs, including the heart and kidney, in experimental Black 6 mice. The researchers observed several markers of cell senescence, such as beta-galactosidase, p21, and p53, as well as an increase in pro-inflammatory markers typical of the senescence-associated phenotype. These effects were not only evident in mice but also in humans who consumed a ketogenic diet for six months.
The mechanism behind these changes involves AMPK and the inactivation of MDM2 by caspase-2, leading to the accumulation of p53 and the induction of p21. The robustness of these KD-induced activation of cell senescence was corroborated by other experiments using p53 and caspase-2 knockout mice, along with inhibitors of AMPK, p21, and caspase-2. Additionally, as I have already said, inflammatory biomarkers associated with the senescence-associated secretory phenotype were elevated in the serum of mice on a KD and in plasma samples from patients participating in a 6 months KD clinical trial.
Given that these changes were observed in key organs such as the heart and kidneys, where the accumulation of senescent cells can contribute to systemic inflammation and toxicity, the findings have important clinical implications.
Therefore, my friends, it is crucial to be mindful of the foods you consume and to avoid following fad diets indiscriminately. While such diets, including ketogenic diets, might offer short-term benefits like weight loss, they can potentially cause lasting damage to vital organs such as the heart and kidneys.
The research by David Gius's group underscores the risks associated with ketogenic diets, demonstrating that they can lead to increased cellular senescence and chronic inflammation in critical organs. These changes are not merely theoretical but have been observed in both experimental mice and humans adhering to ketogenic diets over several months. The accumulation of senescent cells and the associated inflammatory response can have severe implications for organ function and overall health.
Long-term adherence to ketogenic diets has been linked to cardiac fibrosis and impaired mitochondrial function, both of which contribute to chronic inflammation and long-term organ damage. The heart and kidneys are particularly vulnerable to these effects, which can lead to systemic toxicity and increased risk of chronic diseases.
In light of these findings, it is essential to approach diet and nutrition with caution and to seek guidance from healthcare professionals. Focusing on balanced, nutritionally rich diets that promote overall health and well-being is a safer and more sustainable approach. Prioritizing long-term health over quick fixes can help prevent the potential adverse effects associated with fad diets and ensure the maintenance of healthy organs and systems throughout your life.
Great video
Great : cellular senescence is the bloody point. Its what you want to replace old cells. It's part of autophagy.
You have no idea or what you are talking about. Can you share with us what is your profession and expertise in this field? Any scientific publication of yours that you can share to support your claims?
🙏🌷
So what? Our food is not the same as food for 100 or 200 years. There is a lot of chemicals in it. In addition, our life style is sedentary. Add excessive stress to the bill. All those negative factors accumulate and cause permanent damage to the organs. The ketogenic diet is not a universal diet. This diet will be applied in some special medical situation, such as cancer or obesity in order to enhance autophagy (cancer) or to keep insulin at the low concentrations. Otherwise than those cases, a low carb diet would be recommended under the assumption that all rectified products will be omitted.
???
00:52 A minute in and already there is a severely debillitating detail in this study. The first line “The primary source of fat in this [Keto Diet] was *hydrogenated vegetable shortening* (crisco)…” That is either a very sneaky trick by the research team or a severe undersight since that is just about the worst source of fat you can find. To compare, my human-sustaining keto diet revolves around fats of EVOlive Oil, Avocado Oil, Wild Caught Fish oils, Organic coconut oil/cream/MCT oils, Grass Fed Butter and Beef, and Pasture Raised Eggs. Does it seem possible I would poison that with a drop of a chemically overprocessed “vegetable” oil better used in the auto shop? The problem isn’t from ketosis, its from the source of the fat.
If you say so! Can you share with us what is your profession and expertise in this field? Any scientific publication of yours that you can share to support your claims?