Ketamine Gets Controversial FDA Approval for Depression Treatment | SciShow News
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- Опубликовано: 14 мар 2019
- The FDA has approved a whole new class of antidepressant, and ultrasounds might be far more useful than we thought.
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Sources:
Ketamine:
www.fda.gov/NewsEvents/Newsro...
www.nytimes.com/2019/03/05/he...
www.nytimes.com/2019/03/08/he...
www.livescience.com/64937-ket...
www.nimh.nih.gov/health/stati...
www.ncbi.nlm.nih.gov/pubmed/2...
www.nature.com/articles/tp201733
www.bap.org.uk/pdfs/Veterinar...
journals.sagepub.com/doi/10.1...
www.ncbi.nlm.nih.gov/pmc/arti...
www.ncbi.nlm.nih.gov/pmc/arti...
www.janssenlabels.com/package-...
Ultrasound:
www.nature.com/articles/s4146...
www.nature.com/articles/s4146...
jem.rupress.org/content/jem/20...
clinicaltrials.gov/ct2/show/N...
Images:
www.videoblocks.com/video/ult...
www.bartleby.com/107/illus793...
www.istockphoto.com/vector/hu...
commons.wikimedia.org/wiki/Fi...
Sure, why not make it expensive. Nothing cures depression like debt !
It's such BS because normal ketamine is $10 per dose... S-Ketamine should be more expensive (it requires some extra steps to separate it from the R-Ketamine in normal ketamine), but not _that_ much more
@fontagra That's not fully true. Big pharma lobbied and the FDA is staffed with pharma friendly people. They WANT it to cost this much. That way you can protect your investor money because it's so expensive to get approval. It doesn't have to cost so much. Also the true costs for drug development are also often overinflated with costs for marketing.
It costs so much BECAUSE they don't want new drugs on the market.
It's a good thing. For investors who invested in the old drugs.
And all the time costs for development are socialized. Some researchers at universities find something, apply for a patent, the patent is sold for pharma to make insane profits off of it. Socialized costs, privatized profits.
I can't back up this claim and the truth will lie in between your view and mine, there are lots of people working in pharma who want to do good. But if I ask my psychopathic self, it's exactly how I would optimized my profits and protect my market.
Some one put their own money into developing this drug, so it will be pricey for a few years. You may not like it but you will get a cheap drug faster by letting a company develop it then milk it for a few years, then by some other means with out the add cost befits.
@fontagra That is only an explanation on how bad the system works! These companies have a duty and they can't and won't do what they should do because of shareholders and stock prices! We're talking about LIVES bekng lost and destroyed by the thousands here and profit or margins can not be the answer here if we consider ourselves advanced and progressive !
@@Almost3331 what if I don't habe time to wait?
What if it's still too expensive in 5 years when my cancer goes for the kill?
Sorry but "they gotta make a buck" is a silly excuse for a morally disastrous industry !!
3000$ a month?
That's depressing.
this cost will be absorbed by insurance companies (mostly)
This can be a major adverse effect.
@@Huebo_ And covered by other people's premiums. The only place "free money" exists is in the minds of Bernie Sanders voters.
@@johnjriggsarchery2457 One Archer to another; real Archer's don't troll...
The price is a complete joke. This is the same chemical already being used for anesthetics. The anesthetic doses are of course heavier than therapeutic ones. Sure there is going to be an excuse that this is a special kind of ketamine. And of course it's total bs.
drug companies just pull those prices out of their asses.
ain't that the truth
Lot cheaper if you buy it on the street. Of course your never sure what you r getting. 😊
@@rogerschrager3589 test kits man
Nah they calculate what will earn them maximum profit
actually no.
When it says "We don't fully understand how ketamine works" keep in mind the same applies to all antidepressant drugs on the market for the past 4 decades. There might be theories but not a concrete answer to that question.
Edit: I want to make clear that even if a drug is not fully understood (e.g. anesthetics) doesn't mean it can't be used as medicine. The point of this post is to not discourage people looking for other options of treatment, quite the contrary.
That's exactly what I was thinking while watching this... (and the reason I stopped taking mine three times before and haven't taken them again since the last time)
Why are things whose workings are not understood approved?
Yet they still won't legalize or De-regulate psilocybin, which does everything the ket is supposed to do.
Not really though lol SSRIs regulate serotonin receptors in order to create a new baseline level in the brain.
Yeah, we don't even know why pot does what it does. All we know is that it acts on cannabinoid receptors.
And 20 euro for a gram off a dealer...
Who are the real criminals again?
Depends on who you ask.
Poor people = Rich people are criminals.
Rich people = Poor people are criminals.
@@welshzecorgi7903 stereotype much?
@@emerson-sheaapril8555 All the time! It's cool, fun, has what plants crave and great sound quality!
@@welshzecorgi7903 let's look at who hoards the money
WelshZeCorgi That’s way too generalizing and both sides are not equal.
Yeah, that's too expensive. People will long term medication resistant depression have a very very high probability of being low income.
Don't, Jim only two solutions, get out of the situation ur in, or change the way you look at life.
xboxfellatio1000 only one solution, get your undergrad, pass the mcat, go to med school, get a degree, finish residency, then get your license before giving false medical advice so at least somebody can sue you and get something worthwhile out of the waste of time spent listening to your baseless nonsense.
@@xboxfullauto1000 the neckbeard gamer is an oracle now
I'm a neckbeard? You can see through monitors? xDDD
I'm not allowed to comment about anything that I don't have a degree in. Love your logic, you're a bright guy!
My mom got a compassionate release for Ketamine, as an IV though. She’s had depression for decades and this is the first treatment that has actually helped. She even tried TMS (transcranial magnetic stimulation) and this has helped her the most BY FAR. I’m really excited for this to be a treatment option. My sister will probably end up doing this treatment too.
MrsSaxophonegirl I’m so happy for your family! People in my fam have dealt with mental health struggles and it’s great to hear your mom had success with it.
my mom's doing the reverse, actually! Been doing the IV ket for like 2 yrs and it's decent, but super cost prohibitive (even with discount, can only afford one treatment every 6+ weeks, instead of the recommended 2-3 per dose) and so over time it's gotten less helpful for her. we've convinced her to give the magnets a chance though. if all else fails, back to the ket. :p
best of luck to you guys!
Esketamine, a form of Ketamine in the same family as Bisketamine, Spaghetamine, and Regretamine.
I have a lot of regretamine...
Esketit
I regretamine how much this treatment costs.
Holy shetamine
*Me:* "This sounds promising! Nothing else has worked..."
*Hank:* "$4,500 to $6,500"
*Me:* "...nevermind, guess I'll just stay depressed"
Self Treatments are always very risky but you could theoretically try DXM and every Source I know says once a month is without risk of neurotoxicity
It's really stupid and unfair that it's illegal, but I recommend you try to find real ketamine. Magic Mushrooms also show promise in curing depression and are probably easier to find.
a gram costs between 20 and 40 euro when you get it your self. a dose would be max 10mg/20mg so that is like a month of 2 times a week. WTF with the legal prices
or just microdose lsd, its cheaper and helps a lot of people with depression too and is in active research for a medical use :)
That price is depressing...
What!? A hallucinogen helping with depression!? WHO KNEW!?
Oh wait, loads of people did. Thanks US govt for finally coming to the same conclusion many of us did years ago.
Yeah next they're going to discover that mushrooms have real medical property and the sky is blue.
@@1992ilikepie
They already have! Psilocybin will be on the market, soon! Probably for seizure medicine or one of the other things there's an active medical study being done on them for, but as long as it's on the market, doctors will be able to start prescribing it!
It's a dissociative. Hallucinogen is an unbrella term, like "upper" or
"downer".
@@mycelia_ow no
Pshycedelic means mind expanding in Greek Roman
Pshyce is mind
And delic comes from delos to expand
They are tools not drug.
A drug force's the brain to regulate chemical flow to neurons
Pshycedelics open all floodgates and expand the bandwidth you perceive the world on...its not a upper or downer lmao
@@mycelia_ow muscimol is a dissociative used by the reindeer people in Siberia
Also known for the story of Santa claus
Google amanita muscaria and you will find out
4500 dollars? For Ketamine? U WOT M8
ShamaticWow somehow america has to get money for the war on drugs you know, as we all know every drug on this planet is pure evil, and what better way to do so than denying poor people treatment(involving drugs with much worse side effects and less effective actual use) by making the prices so ridiculous that no normal working person can afford it?
You think that they would've legalised it if they couldn't make insane profits off it?
You need to pay extra for your trip sitter I guess
John Doe yeah no wonder it “somehow” got special treatment by the FDA.
This has to do a lot with how medical patents in the US is handled, which is apparently done by the FDA. How is changing colors and/or appearance of medication an improvement that warrants patents to be renewed? Yet it has happened over and over again; so much, countries has actually rebelled regarding some patents and just flat out ignored it (India and a certain cancer medication that is several decades old)!
So a short answer, corruption! Laws needs to be changed or enforced; which is often hindered by a corruption some fail to see as corruption; lobbying, that is only beneficial for the group they represent usually!
FDA has been instrumental to food safety in the US if not safety in general; but now, at least the part of FDA that deal with medicine, is corrupt and/or incompetent...
Can’t believe lil pump got his own anti-depressant
I was just about to comment Esketitamine as well, dammit!
ESSSKETIT
Maybe he Was test piggie and tried to tell us without getting suspiciouse... But we too dumb to get it....
Just a theory
Benzodiazepines are not anesthetics. Don't take drugs if you don't know their classification and the dangers that come with it.
@@argoneonoble what are you about?? You think ketamin is a benzo?
Or?
What I used to feel for a few days after taking K was a sense of reconciliation. A feeling of "ah, world, you're insane but I can't stay mad at you". Not yer average hangover.
Waking up the Next Morning always feels refreshing
@@YellowPenetrator Ah, your use of the present tense broke my old heart a little :)
@@Tautolonaut Why? It's less addictive than alcohol, so they're probably not an addict or anything.
Edit: I read that you can overdose on ketamine, but it's hard to do and doesn't happen very often. Ketamine is fine as long as you're safe and responsible so I don't get sad that someone is using ketamine unless I think they're an irresponsible dumbass, lol.
@@thingamabitch lol. I meant "I wish I could still get hold of it" ;)
I'm considering just going to a vet and ask for one! If I'm asking for less than what is used for recreational use, perhaps it can work? Or is the ketamine vets use not certified for human use?
Special K is great, especially for depression (and breakfast)
Fresh keta salad
Esketit
Abbieq11 I love special K cereal!
Chocolatey delight
But I'm allergic to corn :(
So glad to live in Sweden where you never have to pay more than approx. €250/year for prescription medication.
@Ronnyqt land of free
Jealous.
I really hope we can elect Bernie Sanders, he’s currently the front runner and supports single payer and universal healthcare. I would be proud of my country if we can do that
Great, now stop bragging. We're depressed enough.
Sorry how much? I’ll stick with horse tranq from the stables next door thx
It's not the same type. ...
Because nothing soothes depression quite like crippling medical debt
I sexually identify as a horse can I get some ket for my depression? ruclips.net/video/l75NcBXz0fw/видео.html
@@papperdakVG: Taking the horse medicine might not be so bad if you rmember how much larger horses are than people. The average thoroughbred weighs 1100 lbs, or 500 kg. So just divide your own weight by the horse's weight, and that's the percentage of the horse tablet that is scaled down for you. If you weight 160lbs, then 160/1100 = 0.145, or one seventh. If you try it and end up dead or living as a turnip in an institution, I don't know nuttin'.
PS: The above is intended as satire and should not be considered actual medical advice.
Ketamine has long been used as a sedative / tranq on both humans and horses, hamsters, dogs and many animals inbetween.
Even as a vetranary anaesthetic though once as a human anaesthetic if I remember correctly.
Saw docos on organised crime in NE USA NY/IL/NJ using it to fix horse and greyhound races.
All I know is thay it's great sometimes.
Once it knocked me out longer than GHB or roofies on a long toad trip, another I couldn't contain the new felt energy, built two computers from my parts bin, cleanes my flat both inside and outside overnight and still found time to shave all my body hair off @ 5am.
I wish the "upper" chance didn't exist though.
Why depression is so complicated it’s so depressing
Nafrost not enough research into yet and the whole mental illness thing is still pretty foreign. Just think about it, mental illness wasnt even a concept back in the 60s
That’s a sign of depression...
It really isnt for most people!
FryRiceLover wooosh
That's because of the shortcomings of the industry in general, we've had an extremely effective treatment for depression for many years, but because of stigma and moral authoritarianism, people are not allowed to use them: opiates. Jist google "treatment resistant depression and opiates" and you will find numerous studies where individuals with treatment resistant depression where every prescribable antidepressant has failed them, and then they're giving an opiate...several of these studies report "complete remission of depression in as little as 1 hour after the first dose" and efficacy reaching 80-90% , whereas typicql SSRI's and SNRIs at best achieve 40%-50%. FYI, every consenting adult should be allowed to consume whatever medication they want if it makes their life worth living again, and anyone who believes that they should have the authority to tell another adult what they can or cant do with their own body (especially considering that people getting high has no effect on anyone's life but their own) is a fascist and is completely antithetical to freedom. "I should be able to tell another adult what they can do with their own body, even though whatever they do with their own body is of absolutely no consequence to my own life"....that thinking is the definition of irrational and insane
My wife started getting Ketamine infusions in December and in her own words “it saved my life”. We were both extremely skeptical but when used right, Ketamine can be an amazing tool in fighting treatment resistant depression!
How long has she had relief? I am looking to get this soon.
I'm also curious about the same Jennifer Free is. Also in which form was it administered, IV or tablet form?
I'm curious. Does your insurance cover the cost? Or do you live in a country that lets it's people get medications at reasonable prices?
@@rainydaylady6596 I live in a country that get medications at a reasonable cost. Healthcare that is not cosmetic etc, will max cost me $277 USD a year, then everything is free. So if this were to cost $1000 here, I would get $723 in return etc :)
I wonder when people will pay attention to psilocybin to treat depression and MDMA to treat (along with a therapy) post traumatic stress disorder
Maybe they will if this esketamine sells well.
Blame the public as well as war on drugs BS. Anything that is considered in the illegal family that was famous, like LSD, mushrooms, molly etc is gonna be really tough.
Even though all of them have proven to help with depression with little side effects when used medically, especially molly since it doesn't even cause a bad drug trip in its street form.
Any and all substances should be able to be used in medicine. We already use opioids constantly, but most people don't know about it since it usually goes under a different name.
“Because that’s so much more affordable” 3:06 lol
As someone with severe treatment-resistant depression this is actually really promising. No joke I was thinking earlier today that I thought I didn’t respond well to things like Prozac and lexapro because it takes such a long time to take effect that I often get unmotivated and will occasionally miss a dose. This quick-acting ketamine sounds very promising.
@@HerbaMachina psilocybin would need to be taken with a very experienced sitter because things can get super intense and scary and if a trip goes south can make someone's depression get worse or turn into something existential
@@jacobrael9872 the details are in the dosages
You have to actually take them if you want them to work bro
It will go to hell.
@@jacobrael9872 Egodeath is actually like having a weight lifted off your shoulders when you come around. I had a hellish trip years ago and the introspection helped my anxiety. Every day since I thank my lucky stars for the still ground beneath my feet.
Shrooms are no gateway drug. I'll never touch them again.
If anyone wants to read further about this there is information in the March issue of Nature journal.
My doctor was talking about this at my last visit, now I'm seeing it everywhere. The biggest issue is insurance isn't covering it yet. Which is disconcerting.
$4,500? Your healthcare system is so backwards!
A quick Google search and I find that on the street the average price is around $30 per gram. (UK)
Tell me about it. It’s disgusting watching family members suffer for the profit of large corporations
It's just sad how rare ketamine is here in finland :s
Yea but YOUR healthcare system doesn’t cover it, either. Not to say that it isn’t *insane and extremely infuriating* that it makes more sense just to go buy it (illegally but justifiably) off the street and that $4000 PER TREATMENT (prescribed twice a week at this point) isn’t egregious and nauseating. It’s just that you can’t live in a heathcare glass house and throw stones like that without being somewhat disingenuous.
Out of the 33 developed countries in the world, 32 of them have universal healthcare.
And America has $3000 nasal spray
Hey don't talk about Sprix like that. It's a hard working little spray :(
How does that comment make sense? Do any countries cover this NEW nasal spray under their healthcare? Which country develops such new treatments? (I do not accept such statistics -33 and 32- without accountable sources.)
@@youmaycallmeken Countries with universal health-care (2018): www.worldatlas.com/articles/countries-with-universal-health-care.html
Granted no country's health-care system covers NEW things immediately, that's near impossible, but most will add health and life-saving benefits eventually.
@@youmaycallmeken ketamine is so extensively used for anesthesia and can be literally found anywhere in the world for dirt cheap. Just because they approved a drug for another use and remarketed it doesn't make it better.
Rad, any ruling that is anti drug war is a good ruling. And if it’s helping people then thats even better.
It's not street ketamine is still illegal, it's just this specific isotomer
lemonman93
Obviously.
But just the fact that an illegal drug got approved by the government for testing is a big move against the drug war.
@@Bolt99K Not if it's beneficial for people to get it off the street even if they actually need it to cure depression.
Lil pump won't be happy about this esketamine
Explain this reference to me. He's a rapper right?
@@TheCorrectionist1984 yes sir and his uses the adlib esketee in his music
I want the undisputed right to explore my own conciousness and the limits therein.
Really the only true "AMEN"
$6,000 LMAO. Just go to your dealer
It works so well that big pharma needs to make it profitable
$5000 a month for something that did no better than a placebo in 2 of 3 trials?
Now I'm just remembering that once scene from _Armageddon_ (the Bruce Willis michalbaysplosion movie) about how some of the oil rig guys tested positive for ketamine.
"Sedatives are used all the time, doc."
"Well this one's USED ON HORSES!"
xD
ESKEEETTTAAAAAMINE
Was really hoping someone else caught on 😂
Esketit!
it's barbaric that we take people's freedom away for peacefully enjoying a substance
Thank you! So many doctors think im being dramatic when I say how bad I reacted to antidepressants and they have never helped me!
As someone battling a UC flare right now, the ultrasound therapy is super interesting!
I don't see why the testing is going to take soooo long since ultrasound seems like a safe and non-invasive treatment.
Tried CBD?
"We don't know what the long term effects are" Well if drugs weren't virtually banned from research we might.
And who would buy it for 100x the street price even if it's legal?
I don’t know what will depress me more, depression itself or not being able to pay for the treatment 🤔
This is very encouraging.
I know someone who got an IV infusion and it got rid of their fibromyalgia symptoms for a whole year. As a fibromyalgia sufferer, the future of ketamine is really exciting to me. I hope they keep working with it!
Ketamine treatment for depression would give me a newfound sense of hope, if it didn’t cost as much as a car...
Very interesting news about Ketamine and Depression.
Very interesting Comment about very interesting News.
Are you like......a robot?
@@Danny-jl2sd I think their point was, why even comment then?
I wonder if the ultrasound can help with chronic back pain
This is a LITTLE extrapolated, but my French Bulldog has had two major events where she suffered from severely ruptured discs in her spinal column (both of which were so significant that they caused her to almost immediately become paralyzed in her back legs and lower half 😢) after the two intensive surgical procedures intended to restore the function in her lower extremities and relieve the pressure and unbelievable pain (which thank goodness they both did and with much physical therapy and rehab afterwards she is nearly back to “close to normal” lol) the vet recommended that we do several treatments of laser therapy for her to help with the repair/ healing and inflammatory reaction in the injured/post-surgical area of her back- and even though it was with much incredulity ON HER PART (she hated the “doggles” lol! but they were hilarious) it really provided a very significantly intervening assistance to her recovery and it was noticeable how much it clearly helped with the relief of her inflammation just from how much better she clearly felt and how much more active she was able to be afterwards. It might be that the ultrasound therapy could work in a similarly restorative way for sufferers of chronic back pain. 🤷🏻♀️💕
As a person who has tried this at a state of emergency in my life concerning depression, THIS WORKS SO WELL. It started worked immediately and for two weeks I just felt so normal like my depression was cured idk how to explain it but this works so well and I’m so happy that people are paying more attention to it
*sigh* and eskatmine is really just ketamine... Stupid purification steps getting companies all their money...
So what you’re saying is i should probably just get the non prescription version
Lololol I love that “non-prescription” title that you gave it- not at all untrue and honestly, I’m not mad at it. 😉💕
woooooooooooooooooooow. As someone with treatment resistant depression, this is fascinating, but at the same time, I think I'm gonna wait before trying this out. Excellent episode; thank you for doing the research.
Need this
When my 4 year old broke his arm katamine was used as an anesthetic so he wouldn't feel the pain it's interesting to hear its going to be used for depression
Lmao you euthanized your kid!?
@@SquirrelASMR lol I can should have reworded that haha I get it
@@SquirrelASMR Hey, he couldn't race anymore! Had to send 'im to the glue factory!
@@ClandestineMerkaba lolol
Welcome to the US, where feeling hopeless puts you in astronomical debt!
Nathan “damn, why is there so much drug related crime?”
Ketamine is a generic drug, but to get it into non-generic status they flipped the molecule 180 degrees to make esketamine for which they can charge ANYTHING THEY WANT FOR 7 YEARS. This is what they did with citalopram (Celexa) an SSRI antidepressant. When its patent ran out they flipped it into escitalopram (Lexapro) and bang the price went up and the patent was good for another 7 years, so in total, they got 14 years of patent protection.
Do you mean they made a chiral change in the molecule to make it mirror image but not superimposable onto the original molecule?
Makes sense to me. Way back in the way back I used to keep a little Ketamine powder in stock for when I was doing a coke and it ran out. Instead of lapsing into craving more coke the K took the edge off the come down, it also seemed to markedly reduce the subsequent depression the next day while my dopamine production was on the fritz.
Oh great. Special K repackaged at original brand name Abilify prices. The street value of this just shot up.
Lol, all the concerns "doctors" had for this new drug are the exact things that they either ignore or don't bother finding out about all the ordinarily prescribed anti depressants.
Super awesome!
The ultrasound part is so interesting! Very much needed too.. sure, there are lots of drugs for inflammatory diseases, but none of them work well. When the results are released, please do a follow-up video!!
A dear friend of mine suffers from both arthritis and an auto-immune disorder as she have psoriatic arthritis. She have been diagnoses for few years now. She's only 27, and she needs a cane.
The ultrasound may be useful for her. I hope so.
She needs CBD.
If these treatments are a solution, imagine the millions of lives that would improve
If they work AND don't cost the thousands that Spravato does right now. Was worried about that
John Doe
Yeah, that’s why There’s something called insurance.
@@phoenixrising9352 Insurance can only cover so much, $6500 a month for medication is much more than most companies will be willing to cover
John Doe
Yeah agreed, still a step in the right direction, this is for people who have already tried many drugs with no success.
@@phoenixrising9352 Oh it absolutely is, both for psychiatric medication and the FDA honestly. It's a massive step. And I know, I actually have treatment resistant depression myself. Currently trying my fifth medication
General PSA on medications - if you have insurance (in the US) and your doctor prescribes new to market meds, make sure you contact your insurance to determine if its covered before going to a pharmacy and especially before paying for it and taking it home. New medications are rarely covered right away. If they're going to be covered, it will often take several months for the plan to ok it to be added to the formulary. HOWEVER! You may be able to get an exception. So don't be afraid to check with them and see what your options are. (This is true for completely new meds to the market, like this one, as well as when a generic finally comes to market for brand name meds.)
I really hope it reaches here in Australia and helps me
Finally, a cure for my crippling depression
Lol party monster
It shrinks parts of your brain, and they haven't figured out what doses to give, so it's arbitrary at this point. You're better off with MDMA therapy and psilocybin afterwards.
Medication wont solve but only numb your depression, im sorry :'(
@@xboxfullauto1000 That's why I reject my medication.
@@fuzinonzlot don't forget cannabis!
If I have $6500 to spare every month, I won't be having depression in the first place :P
Haha
Supposedly there are doctors out there that will prescribe generic ketamine "off-label". I'm trying to find one right now....
I've now known two people who have taken ketamine for depression. Watching how it seemed to affect them has made me very wary of it. One had a psychotic episode, the other also seemed less in touch with reality but not full blown psychosis. It did seem to help their depression though.
if it grows new brain connections, then would it help with alzheimers? as a work around to
the plaqued-compromised connections?
I would love to see *properly conducted* clinical trials and research on that. Peer reviewed and all that
Memantine blocks NMDA receptors in a different way than Ketamine and is used for Alzheimer's. I've never heard of the use of Ketamine on dementia though.
Strangely, a chemical found in apples and their juice has been shown to reduce plaque.
Further, compounds in certain mushrooms, like *Lion's mane Mushroom*, have been clinically proven to cue neurogenesis. Same with some of the psychedelic fungi variants, though the MOA and effect is a bit different.
Pure organic apple cider, lion's mane extract, psylocibin microdosing as well as cannabis(cbd emphasis) supplementation would undoubtedly have demonstrable effects and I wish I could conduct the tests and studies to unequivocally prove it.
*Correction, or rather addition- the antioxidants in apples and similar food items can alleviate, or help the brain to compensate, for some of the oxidative stress caused by beta amyloid plaques.
Also, perhaps most strange of all(to some), music therapy has been shown to be extremely effective in some cases at helping severe Dementia patients recover lucidity for brief periods. It quite literally triggers memory pathways connected to when the person heard or enjoyed the music earlier in their lives.
"Sonic time-capsule"
But the REAL Q is..... What happens when you stop using Keta????????
FMR depression and The government will cause worse depression and worse anxiety 🥴
@@dainaburk8204 only if you let it in
More pharmacy/medical videos please!
I remember this one from college (no, I didn’t go to medical school). Good times.
I’m really confused on my existence rn.. just recently got out the hospital.. had surgery.. and I have no way to get my medicine.. so I’m stressing out honestly might just go back to the hospital honestly bout to just walk in traffic.. I’m so confused
Same
gregory house has entered the chat
I have been getting intravenous ketamine infusions for more than two years through my doctor. It really works. I only pay $350 per treatment (about once every three months) and $85 per month on the intranasal maintenance drug.
!!!!!! I have rheumatoid arthritis, I am VERY interested in this study with the spleen...!
👍 I agree, now I can tie my purring cats to my hands so their purring can heal me. 👍
Interesting especially since cats purr at a frequency known to heal.
@@darkshadowstorm7056
That's the point.
That's Catamine
Ahoy Spongebob, I overdosed on ketamine and I'm going to die arghargharghargh
I feel special for understanding this reference 😂😂
What's with all these restrictions, something like oxycodone and hydrocodone are way more dangerous but are far easier to get your hands on.
I was given ketamine when they inserted a tube in my chest for a collapsed lung. It was the wildest disassociated three weeks of my life. I woke up 25 minutes later. I've been confused how it could be a party drug ever since.
The brand name should have been 'esketiiit'
I didn't know Lil Pump worked at the FDA
Can you please do a video on metal foam and/or Amorphous metal
Can I pre-order them?
The price is disgusting thank god for the NHS
balthiers girl up downhyihydrocodoneoooooioooooooo
Germany technically has a multilayer system and we only pay 2-10% more than you Britts and wait 4 weeks more if we send in the bill (because we were impatient).
:( Can you come and slap some sense into my fellow countrymen who think socialized medicine is evil because how dare we have to help other people who live in a society with us if we don't want to? If everyone I know and love didn't live here, I'd definitely consider moving somewhere better (though probably Norway, not the UK... sorry, Brits!).
Was Esketamine named after lil pump?
Yup
(S)-Ketamine
Esketamine
マインドPFKNT 0:40
No it has to with the absolute configuration of S ketamine and R ketamine it has to do with sterochemostry
lemonman93 ok, but the drug you physically buy from Spravato is Esketamine
Very true that we don't know what ketamine does. Always considered an glutamate receptor antagonist only, however in the second half of last year a paper was published showing that in depression ketamine acts as an opioid agonist (small scale cross over double blind study using naloxone to block opioid receptors in one trial and not another)
About the ketamine trials cited in the vídeo, could you guys post the links to them?
A full vile of normal ketamine is produced wholesale for less than $3. Drug company is just slightly changing the compound with no added benefits to normal ketamine and charging extortionate prices for it. Someone high up is getting a pay off in the FDA. Hopefully the EU don't follow suit.
It takes a surprisingly high amount of money to bring a drug to market, with all of the stability testing/clinical trials etc. that needs to be done thus the high price of the drug
@@viktoryegorov2721 I completely understand that. At the end of the day, most of the drugs we have is due to companies wanting to make money and they have to invest huge amounts of money and need to make it back. So we should be greatfull that these drugs do come to market. What I find sad though is that an available affordable drug already exists (normal ketamine). However, it is not approved despite much research proving its efficacy. Most of the population would simply not be able to afford this treatment. Probably won't happen but a better balance from pharmaceutical companies of ethics over profit would be nice. Even with something such as insulin price hikes in the USA (up to $130) for a drug that been on the market for a long time. The HSE in the UK pays up to £15 pounds for the same drug. No rational behind the increase in the US but increased profits.
It's not just "slightly changing the compound with no added benefits to normal ketamine". Enantiomers often have very different effects on the body. For a concrete example, look no further than thalidomide. One enantiomer of it is a decent sedative, the other causes severe birth defects. In the case of ketamine, esketamine metabolizes faster than arketamine (so any side effects don't last as long), it is up to 8 times more effective at inhibiting dopamine transporters (so quite a bit more effective at boosting dopamine levels), and doesn't bind to PCP-associated receptors like arketamine does (so fewer PCP-style side effects overall).
There IS a benefit to doing this. It's still being way overpriced, I agree, but it's not the same as the $3 vial of racemic ketamine and it's not just changed "with no benefits".
@@IceMetalPunk could you link me to a paper with those results for the efficacy of esketamine over ketamine. I would be quite interested to see that. Thank you
@@IceMetalPunk However, the high cost will lead to mass self administration of the cheaper alternative for desperate people.
Next in line to get approved: *MDMA*
This is what I'm most excited about for people suffering from PTSD, depression, and other mental health disorders.
@@fuzinonzlot MDMA taken in a therapy session could be a breakthrough for ptsd treatment
Demitri first plz
And the price 1000$ a pill xD
@@ThatThing1675 I could get it for 20/25$ a pop on the street.
Dear Hank, could you explain more about the cholinergic pathway and the vagus nerve stimulation. I think it deserves more visibility the fact thAt this kind of therapy has a great potential, in the same way that microbiome studies are changing our view of therapeutic use of specific meals with probiotics and prebiotics. For more info there is a MD (Kevin Tracey) in charge of open this field, and his presentations in RUclips are great, besides its implications of this therapy. I'm a Physical Therapist from Chile and also diagnosed with UC, and this neural circuit could be also stimulated transcutaneous, to lower TNF and other inflammatory cytokines (IL1, IL6, IL10) and also promote antiinflammatory ones (IL10). They are proving the mechanisms of how it happens and even a group is doing research with infrared stimulation.
Great video!
Consider CBD for inflammation, and a stack of Choline Bitartrate and Alpha GPC for a comprehensive predrug supplement to aid your body's own acetycholine production.
Perhaps only semi-related, but also if you're a large indulger of sweets and dairy- particularly high fructose corn syrup products(soda) and Milk, try laying off those for a while, as they both directly cause, and worsen inflammation- which is now suspected too be the underlying cause of almost all chronic illnesses. More veggies may sound cliche, but truly tis the way to go.
This means so much to me. 💖
My husband has severe, treatment-resistant depression, and he had a 6-week course of ketamine infusions last November, which we're still working on paying off. If the FDA has approved it for this use, do you think that means we could submit the bill to his insurance for reimbursement? :D
The ultrasound thing could potentially help me, too. I have both an inflammatory disorder AND metabolic issues. I wonder if they've tested doing both on the same person. Also, do you think there'd be a way to do the inflammation treatment on someone who doesn't have a spleen? I have mine, but my mom's was removed before I was even under construction.
a nice new way for companies to make money. ridiculous price. No way it costs them near that much to produce.
The production of the drug is not where the company spent most of the money to bring it to market...
Pharma is the real cartel.
yeah if you ever need ketamine you can definitely get cheaper somewhere else
@@glowingone1774 I agree it's overpriced, but regulated, enantiopure esketamine is not the same drug as the racemic, unregulated stuff you get on the streets.
WERE’RE MY WOOKS AT! I KNOW YOU FOOLS LOVE YOUR K 😂😂🍄
Jolak Zmtag wook?
What!? You forgot to mention the creator of this miracle drug that is esketamine
Dr Lil Pump!
An alternative way to stimulate the vagus nerve and reduce inflammation would be the Wim Hoff breathing method, sounds much easier than surgical implants
Better off buying ketamine at the stables, goddamn
In small doses, yeah I can get that
My dad got this for chronic back pain after surgery. Said he could only feel his skeleton and it burned the whole time. Was sick for days after said he never reccomend it.
This is anecdotal of course, but when I was younger I took a lot of party drugs. I noticed that mdma would make me feel really low for days afterwards, but ketamin would almost completely negate this effect, helping me feel much less low in the days after. I used to consider it a viable counter to an mdma come-down.
Drug use doesn’t cause mental health, people with poor mental health are more likely to use drugs.
We should study what they find that helps.
Overusing drugs clearly decrease mental health (especially hardcore ones). Even perfectly healthy people will see a decline over time. Imo the issue with this kind of treatment is than it creates the illusion than all drugs are actually safe, while there is always a risk
blue smurff no it doesn’t. It creates the reality that people who are appropriately prescribed and especially in need of this type of drug therapy based on their chronic treatment resistant depression should take it, not EVERYBODY. 🙅🏻♀️🤦🏻♀️
welp... TIME TO DO KETAMINE. SORRY, MOM!
2:51 well with prices like that only the rich or those with amazing health insurance can afford it, the rest of us will have to go to the black market for regular ketamine even if it becomes a mainstream treatment method
4:50 Isn't that image kind of half way between a mouse and a rat, also the study performed some experiments on rats, some on mice