The Paternal Age Effect: Identifying reproductive risks

Research from the University of Oxford's Clinical Genetics Laboratory initiated the introduction of an upper age limit of 40 years for sperm donors in the UK and internationally, and led to increased public awareness of the effect of paternal age in the transmission of inherited disease.
Oxford researchers, led by Professor Andrew Wilkie, were the first to describe the exclusively paternal transmission of genetic mutations in a rare craniofacial disorder called Apert Syndrome; they also showed that the accumulation of such mutations leads to a disproportionate risk of disease transmission with age.
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