The Mary Lyon Centre, MRC Harwell | Gaining Insight into Human Conditions from Mice DNA

Mark Gardiner is Facilities Resource and Training Manager at MRC Harwell in Oxfordshire, an international centre for mouse genetics.
In this video Mark goes through a tour of the Mary Lyon Centre, which houses over 55,000 mice with different genetic mutations. Scientists worldwide are studying these mice to gain insight into human diseases like #diabetes and #deafness.
Most human diseases have a significant #genetic component. Many variants in human #DNA predispose individuals to disease, yet the knowledge of these changes in DNA, and how they cause disease, is limited.
Although outwardly a mouse looks very different to a human, its development, physiology and biochemistry are very similar. Studying genes in mice can therefore reveal important insights into the functions of genes in humans and mouse models of disease can be remarkably similar to their human equivalent, helping to investigate how a disease develops and possible ways to treat or prevent it.
The Mary Lyon Centre at MRC Harwell offers a wide range of services to researchers around the world. Services include free archiving of mouse lines to protect them for future use, distribution of mouse lines from the Archive, breeding and phenotyping of genetically altered mice, and genome engineering services to generate new mouse models.
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