Methylene Blue is Neuroprotective After Ischemic Injury (Mouse Study)
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- Опубликовано: 14 окт 2024
- Methylene Blue is Neuroprotective After Ischemic Injury
A quick review of the mechanisms demonstrated by methylene blue studies for MB's neuroprotective role in animal models.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Thursday, Dec. 1 2022
Contraindications: www.rxlist.com...
The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core | PLOS ONE
journals.plos....
AMPK - Legere Pharmaceuticals
www.legerephar...
Schematic illustration of the mTOR signaling pathway. AMPK indicates... | Download Scientific Diagram
www.researchga...
Model of the AMPK and mTOR signaling network in mammalian cells. AMPK... | Download Scientific Diagram
www.researchga...
Frontiers | Protection against neurodegeneration with low-dose methylene blue and near-infrared light
www.frontiersi...
Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation | Translational Neurodegeneration | Full Text
translationaln...
I started taking Methylene Blue on May 1, and my multiple sclerosis bout that I have been going through for two years disappeared. I’m walking and bending my legs. It’s been a miracle for me.
This is fantastic news !!! So pleased for you.
What brand did you get. And what dosages did you take
I take nine drops a day
I tried to insert a picture of the brands of methylene blue, but it's not working. You must buy USP grade.
Nine drops a day.
I ordered MB based on this video (been watching this channel for 2 years and greatly appreciate all your content!). Today is day 2 and I am blown away at how much better I feel. I was diagnosed with fibro, asthma, etc decades ago...I can think clearly without coffee jitters, my pain level has dropped dramatically and I finally don't feel like I have the flu 24/7. This is amazing! Thank you so much for sharing this information. I would never have learned about MB if you hadn't discussed it! You are greatly appreciated.
@Ahmed N Keep in touch with your progress. Thanks.
@Ahmed N I am on 360 mg daily and perfectly fine I reversed my chronic fatigue syndrome, ibs, fibro I am now restored after approxiemntly 3 months I did feel the effects within a week and gradually it went better and better I have so much more energy in gym also as before I was slammed like by a bus!
@@kusamagaming7375 that's a monster dose without getting a herx reaction. You're a champ!
@Ahmed N if liquid start with 2 drops twice a day then build up based on how you feel
@@kusamagaming7375no sideeffects?
I’m 76 now and also vary healthy but 6 years ago I was a metabolic disaster. Now I have even started driving again I stopped 5 years ago to be safe. Been doing low dose MB and my mood and cognitive function is vary improved. There’s more but Mb matters.
Great ❤ I'm really impressed ❤
Would you please tell more?
What dosage did you take?
What else did you do?
❤ from Germany
If you don't mind me asking, how long after starting the MB did you really start feeling great. I just started taking 5 mg a couple weeks ago
it's working!!! I started taking one 25 mg capsule daily three weeks ago. I've had CFS, brain fog, nerve pain (and many other symptoms post vax) for three years. within a week of taking MB, I began to feel more energetic. I can feel my brain coming back online! I have no nerve pain. I feel better than I have in years. I'm super emotional as I write this; so many people, suffering so badly, finally getting help...it's overwhelming. I love you, dr. been. I feel so much for the people who commented and shared their stories here. thank you all. ❤
miracle molecule,,,, glad its helping you heal the horrid vax rubbish x (biggest scam that was) thank goodness for MB, ive just started taking also,feel a lot more energy
What kind of pill / brand??
I’m very glad that this is helping with the symptoms from side effects of the Covid vaccine. I’m glad that people are finding cures… and I know that some people had no choice but to be vaccinated. But I’ve been called a conspiracy theorist, when I knew that this is what people were going to be dealing with! I myself never got the vaccine. I’ve never gotten Covid. Therefore don’t even have the antibodies! Which I’m thrilled about! Because I also don’t believe that Covid is still around! Take another shot, lol. Much love
I'm here just re-researching methylene blue. I thought I remembered that this is the compound to give quickly after having a brain injury to keep the brains ability to recover. I was right, this is the compound every soldier in war should have on hand for his fellow man/ or woman.
Agree for acute brain injury. Dr Been did not give suggested dose for that- only for continuous low dose (5mg once or twice a day). Could you suggest for immediate ischemic stroke?
Good question. That was one of questions I had myself. I never finished my research to find out dosage immediately after a stroke or tromatic brain injury. I would suggest researching this question on the internet, I'd ask for nih (national institute of health) sources.
Great idea
@@KimMachotka Yes, I believe so. Methylene blue is also good for lots of things at all times. Mitochondrial biogenesis comes to mind. Adenine tryphosphate, AMPK pathways also comes to mind. My mind is a bit foggy right now. You might want to research the drug Etanercept for stroke recovery as well. For microglial and Neuron Neuro genesis look into polygala tenuifolia (he shou wu), polygonum multiflorum (yuan zhi) , passion fruit seeds, cats claw, etc. Their are a few.
Their is research that showed a dosage of 16mg everyday helped patients with Alzheimer’s show cognitive impairments per Mark Sloan.
As I understand it, one can have a lot of underperforming neurons. If one takes MB , it can 'recharge' those cells, resulting in increased ATP output. Hence reconditioning old brain cells. As I have been suffering from Lyme disease and probably missing a lot of mitochondrial function, I have just ordered some Methylene Blue to experiment. Wish me luck people.
So.. how it works on your body? getting better?
Yes. So far, so good. I am experiencing improvements. Unfortunately, I have been knocked back by a fall, resulting in a broken arm. Therefore I am in a lot of pain which sort of muddies the effect of the MB. I'll know better when my arm heals. Basically I am hoping that my balance will be improved. I think that I fell due to poor balance due to the neurological damage to my system, caused by Lyme disease.@@sansanmatahari36
Hi, also have Lyme disease and was wondering how MB was working for you?
Hi Laura,
Yes definitely helping. Not sure how things will work out. I need to recover from a broken arm that I encountered at the start of July. Lot of pain you understand. However I think I will be a lot better after recovering from this. I won't know until afterwards, obviously but have high hopes. I am also taking Ivermectin which I know is helping me. I could not walk properly, two years ago, now I can. Lyme is a horrible horrible thing that I have suffered from all my life. People cannot appreciate what we have to endure. I think MB is a help.
@@lauraa2877
It will bypass a dysfunctional component of energy production in mitochondria. However, it doesn't fix this issue. Lyme is a microbial issue of which MB will kill.
CELEBRATING!! Thanks to people like DrBeen, the commenter's input, the doctors and researchers that have kept open minds, and other high quality youtubers exercising freedom of thought and speech.... MY DAUGHTER'S BLOOD PRESSURE AND HEART RATE ARE NORMAL UPON STANDING THIS MORDING!!!!! I couldn't have figured out what to try or who to work with if it hadn't been for all of you. We will probably never meet, but I am thanking God for each one of you. This horrible thing may not be over, but we are getting there! THANK YOU AL! Thank you especially, DrBeen, for info about FLCCC, Dr. Patterson. Just responding to me helped me not give up even in my worst moments of a heart broken mom.
Xan you elaborate? Did methelene blue help with your daughters blood pressure?
She might also benefit from vitamin B1 as well. Watch Elliott Overton eonutrictio on the benefits of B1.
@@micaonyx5301 Your reply is such a confirmation! I have a milder case of long covid and heard about B1 by reading a comment on a DrBeen video. I researched a bit more, especially EO Nutrition, and tried it myself with very good results. My daughter's recovery has had several significant crashes and she is going backwards fast at this moment. I just saw an FLCCC video about sepsis and post sepsis. The protocol includes IV vitamin C and THIAMIN to fix a disregulated immune system and to help the mitochondria. Over the last two days I have deep dived into thiamin research again, and watched newer EO Nutrition videos. Now I have to help my daughter see and understand. She is so discouraged and fatalistic at this point. It is hard to help her without getting into weird relationship zone. She must take ownership of her recovery. Thank you so much for your reply.
@@micaonyx5301Allithiame B1 is awesome.
I almost stopped taking MB as l have read that it is direct NO blocker. After watching this l have learned it is actually the the opposite!! U are so knowledgeable! I love the way u explain everything in a way l can absorb the amazing knowledge and information that u share! Thank u! Xxx 😊💖 xxx
It does block nitric oxide synthesis. If this guy says it does the opposite he doesn't know what he is talking about. You don't want excess nitric oxide it's harmful. So methylene blue is helpful in that regard
Impressive: prevents neural apoptosis, protects mitocondria, and activates neural autophagy (perhaps in other cells too)! (May the force be with you. ;^)
I know this is my third comment, and I apologise if it’s annoying, but another really important thing to take into account is the purity of the MB:
There are three different grades of methylene blue:
Industrial grade - used to dye fabric
Chemical grade - used in laboratory experiments
Pharmaceutical grade - used to treat methemoglobinemia, urinary tract infections, overdoses, and considered safe for human use.
By the way, the methionine blue that you will find in fish shops for treating fish diseases is not pharmaceutical grade.
Do you have link to correct MB?
DrB covered pharmacy grade options at the beginning of this video. He’s the best!
Would you recommend a good quality pharma brand MB?
@@tzvetadaskalova9257 I think Dr B showed them at the start of the video. I live in the U.K. I didn’t get mine online
I use Biopharm Inc out of Arkansas. 1% USP grade and purchased through Amazon. I’m sure the also have a website directly but haven’t looked.
Can't recommend this enough ❤i give it to my dog in her water (micro dosing) and her health is back to being like a puppy. She's hipermobile and her joints and bones are very fragile, and since taking it,she not showing signs of any pain or discomfort, and her coat condition has improved. She also has teeth issues and bad breath which has almost disappeared
Can you tell me how you add it? Approximately the amount of water and MB per day? :)
@@lindamalee7902 I was just dabbing my finger on it and putting it in the bowl,so the water was just a pale blue and every second refresh was pure water. We also have a mesquito problem and birds drinking from the bowls so it's good for keeping still water clean
@@donnafraenkel7852 Very helpful, thank you! I’m only starting to research, and yours is the first comment I’ve seen about it benefitting your dog.
@@lindamalee7902 it's pretty amazing because we have so many parasites and worms which affect dogs on the street and it's rotated because of wildlife and nature so I found that animal sanctuaries and places housing animals should also treat their waters, especially ground water and still water that's sitting
I love your sense of humor in selling access to your lectures. 1/2 the price of a bottle of MB!!!!
Your videos are priceless, like a Stradivarius. Your drawings make your comments understandable to non-physicians. I, therefore, bought your lifetime membership and I bought pharmaceutical grade MB. I addition, I bought one for each vehicle in my family.
Thank you for this fantastic explanation of the mechanism of methylene blue! I agree that every emergency medical professional needs to have a vial of this ready to go. It's not a questionable treatment! And as long as the doses are low enough there would be very small number of times when it wouldn't be safe.
I started out in healthcare in 1982 and have learned that mainstream medicine has its benefits, but it certainly has many limitations. I'm not aware of any pharmaceutical that can do this. We all know why that is. I'm talking about there being no profits in it. But that doesn't translate into meaning that there is no use for it because it is astonishing what it can do!
I recently stumbled on it looking for something else, as often happens. I decided to use myself as a guinea pig because I have some conditions that I felt it might improve. I don't believe it was wishful thinking when I say that's after one dose got my thinking felt much clearer. As I continue to just take small doses my clear-thinking has persisted! That's saying a lot because I have had depression and anxiety for about as long as I have been a healthcare professional. And I have been willing to try almost anything including clinical ketamine IV treatments which didn't help me at all. That should tell you how desperate I've been.
I'm going to kiss my bottle of methylene blue as you jokingly mentioned! Thank goodness it's not a joke. 🎉
We have been researching MB for Lupus and auto immune anxiety .. started a low dose once and sometimes twice a day .. no side effects . But noticeable clarity from Lupus brain fog... I am excited. Multiple Dr's and medications..
I do feel a difference .. as we keep exploring
I plan to get my Dr's on board to help monitor dosage & bloodwook ..
Effects don't seem to last long.. I guess because using such a low dose..
I am pleased .. I want off all pharma medications
This MB seems to make this a possibility and no Dr ever mentioned .. I will receive healing
Thank you Dr Been
I have ME/CFS and started Methylene blue 2 weeks ago. I have more energy, less brain fog. I take 3 drops =1 1/2mg in morning, 2 drops at noon and 1 or 2 drops in the evening. I'm sleeping better than I have for years.
whıch MB you buy.ay want to buy MB ,but whıch one correct form
This is such a beautiful video! I've watched SO MANY MB videos, and this one is easily the best. Thank you!
I have ME and normally get sick all the time. I've been on methylene blue for about 3 months and haven't been sick once.
What is ME and thank you fir your comment
@@user-mn1ql6ky4x ME/CFS, a debilitating disease. Myalgic encephalomyelitis/Chronic Fatigue Syndrome. It makes people so weak, to the point of feeling paralyzed and feeling very ill; and unable to stand or sit up. Many neurologic symptoms such as dysautonomia, extreme sensory over-stimulation (signt, sounds, etc) any sound (even whispers) or movement can cause severe illness. Their symptoms are so varied, numerous, and overwhelming. Many are so severe that they are left bed-ridden and housebound and possibly even unable to interact with people.
That's awesome!
@@user-mn1ql6ky4x It's also called Chronic Fatigue Syndrome.
Hello Dr Been, I love your teaching style. I’ve been taking MB for two weeks now after having a suspected tia/Bell’s palsy last year. I sleep do my well and I feel so much clearer in my mind. Thank you ❤
I have just discovered Dr Ben’s channel and he is one of the best presenters that have come across in RUclips or elsewhere. Fantastic way of explaining how MB works in action and other mechanisms in and around mitochondria. Thank you for your work
🎯 Key Takeaways for quick navigation:
00:13 ⚠️ Dr. Mobeen discusses methylene blue side effects, contraindications, and cautions - important to review before considering use.
05:14 🧠 In ischemic brain injury, methylene blue interferes with p53 activation which reduces apoptosis, providing neuroprotection.
08:58 🧹 It also enhances autophagy, helping clean up cellular debris in injured neurons.
15:08 🩺 The study authors suggest emergency responders could administer methylene blue on-site to protect more acute stroke patients.
23:16 🔋 As an electron cycler, methylene blue can kickstart dysfunctional mitochondria in ischemic tissues by donating and accepting electrons.
29:32 💊 This makes it an antioxidant, anti-inflammatory, energy enhancer, and nitric oxide producer, conferring neuroprotection through multiple mechanisms.
36:13 📝 In summary, low dose methylene blue may help rehabilitate mitochondria, reduce apoptosis, trigger autophagy, and protect tissues in various conditions.
You know all channels should have this sort of summary. I would subscribe to them just because they added this kind of thing!!!
It does not produce nitric oxide it inhibits its synthesis which you want.
I’ve been talking 4mg … 8x 0.5ml drops in a 1/2 a glass of water in the morning on a empty stomach
In the morning just before I walk my dogs
It most definitely works .
It’s quite amazing, energy and focus. A subtle yet undeniable effect.
It takes 25-30 for me to notice that it is working
If you need a burst of energy and focus… then this is it ❤
I made a post that I am taking methylene blue and finding it very helpful.
There is something that I don’t think was mentioned strongly, apparently from what I have read taking overly high doses can be dangerous even fatal.
The low dose, therapeutic affect are exactly that they are found in low-dose.
“Methylene blue exhibits very different effects at low doses than it does at high doses. They call this a ‘hormetic dose response,’ where the effects of a low dose are the opposite than at a high dose. “Methylene blue is a safe drug when used in therapeutic doses (
Was there any data on how long someone would take at a low dose?
Been taking low dose (20 drops per day) and higher dose (100 drops per day), I might as well be taking water. No benefit at all. I hav major inflammation & it doesnt touch it at all. I have CFS, IBS & asthma too- nothing. If anything my breathing worsened on MB. I even bot the powder & mixed it myself thinking the prev (USP) MB i bot mite hav been
Mixed wrong altho it stated 1%. High dose herbs do wonders for my inflammation so I was hoping MB was everything these YT drs say it is. Nope.
What substance exactly is NOT fatal when taking in overly high doses? That applies to everything.
@@Userxyz-z2dwhich herbs do you take?
Excellent!
Thank you 💚 I am starting this today with my flccc protocol for my v. Injury 🤞🤞🤞🤞
And what hav your results been?
How has it worked for you?
Ive been using MB for over a month & hav not noticed any changes.
I’ve been taking it for a couple of months every day and it’s really made me feel wide-awake and in a happy mood.
I did a lot of research, and you have to be careful that you’re taking pharmaceutical grade.
I also did a lot of listening and reading around the research of Dr Gonzalez-Lima, one of the main researchers in this area and he has published many of the papers.
I heard him mention that when they use it in research, they mix it with ascorbic acid. This helps the absorption because before the body can absorb it, it has to reduce it to leucomethylene blue, and ascorbic acid will reduce it. I wrote to him and he confirmed this to me. (Kind)
The other benefit of adding ascorbic acid is that it takes out the dark blue colour which can make your tongue and mouth and teeth go blue. And it takes away a lot of the bitter taste methylene blue is extremely bitter.
It does make your urine range from very blue to very green. At first this is disconcerting.
Thank you! I just took my first drop today, will for sure be adding some ascorbic acid!
@@ms_amanda2714 great, as a clarification, the body will do the reduction process itself, apparently so you don’t have to add the ascorbic acid, but by adding it, it makes it much more easily absorbable and has the benefits I mentioned.
@@GoldenBlaisdale
Always good to hear a positive testimonial of MB.
What dosage have you taken over the last 2 months?…a drop a day?
@@GoldenBlaisdale thank you! I was wondering how many months I would have to have a blue tongue for, very timely info
@@reliableandrew actually no. I ‘discovered’ MB a while ago but was a bit afraid so did a lot of reading.
I’m not suggesting that you do this by the way, but from my reading a very safe, starting dose is actually 10 drops twice a day, and that is what I did, mixed with ascorbic acid.
I am now taking as we speak, 25 drops in one dose.
I think Dr been mentioned something different, and I have not looked this up again but my understanding is the half life of methylene blue is 12 hours.
Therefore if you want to keep the same amount in you should dose it twice a day I have to say it appears true because at about the 12 hour point my urine is becoming more normal coloured.
PS the drops are based on 1% solution so each drop contains 0.5mg of methylene blue.
Thank you! Today is day 2. Brain fog lifting, it's wonderful!
Glad you took four days off. Glad to see you again love this lecture. Thank you Dr. Mobeen.
26:15 love the way he explains complex things!!
Brilliant Dr Been miracle molecule , it's literally the OG 'Magic Bullet' the phrase was first coined to describe this very molecule a hundred odd year ago, i just started low dose and feel good for it x
I totally agree with others I felt much better, better focus and good mood although even medical grade has trace heavy metals (just barely measurable). When I'm on this stuff even talking to my ex-wife would not piss me off but look at the research on L-threonate (type of magnesium that can pass the blood-brain barrier). This stuff is legal? Gives me a overwhelming feeling of well-being and focus.
Fantastic painting and brilliant info thanks very much.
Always been interested in methylene blue as a preventative for acute vasospasm post aneurysm repair.
Methelyne Blue could be used in Sepsis. It works with Alzheimer’s and has probably the capability to help in Parkinson’s like Michael J. Fox.
It did as I used it this way and it worked
@@donnafraenkel7852hi. Can you explain details of how it helped you.
@@donnafraenkel7852did you take it for Parkinson’s or Alzheimer’s?
@@donnafraenkel7852and at what daily doses & after how log before you found results? My friend’s mother 73yrs old has Parkinson’s & want to help.
@@nobodynothing2594 I used it for a torn Auric field.i noticed significant improvement in overall health but I don't have either
I have autism so it greatly improved my memory, physical improvement and consciousness awareness, without a doubt
I bought clear, empty 00 keratin pill shells and found a small lid to turn upside down to use as a pill stand.
I put 10 drops of USP MB into the long side of the opened empty pill shell and then carefully put the shorter side over the long side to close it up and make a pill out of it so that it won't stain my tongue.
The pill case is a keratin substance and will quickly dissolve, so I only made one pill at the time of dosing.
This is my first pass at MB. I'm praying for healing. 🕊️
I always thought that MB inhibited NO which is why it is protective in ischemic stroke due to vasoconstriction and increasing BP? Here is an paragraph from a study I found.
Nitric oxide generation during ischemia and reperfusion plays a significant role in ischemic and reperfusion injury.[56] There is evidence that MB decreases or inhibits nitric oxide generation that might have the potential effect of neuroprotection in ischemia/reperfusion injury. In order to prove that the endocardial endothelium of Rana esculenta produces an amount of nitric oxide that is sufficient to modulate ventricular performance, Sys et al. measured the changes of stroke volume (as a measure of performance in paced frog hearts) and stroke work (as an index of systolic function) after using MB-induced inhibition of nitric oxide synthase.[43] This reminded us that MB could inhibit nitric oxide generation. Evgenov et al. found that continuous infusion of MB counteracted the early myocardial dysfunction and derangement of hemodynamics and gas exchange by the inhibition of nitric oxide pathway in ovine endotoxemia model.
I'm so confused so is it increasing or decreasing 🤦♂️
According to “ The Ultimate Guide To Methylene Blue” by Mark Sloan, methylene blue is the nitric oxide inhibitor. I was in shock that the informations about nitric oxide are focusing on vasodilation, but not on paradox involved with this phenomenon. In small amounts, the vasodilatory effects of nitric oxide can be beneficial. In excess, it can be causative of a whole host of disorders and pathologies. I am glad I purchased the book. Nitric oxide is the body’s backup mechanism for dilating blood vessels during stress.
If it helps after a TIA stroke , wouldn’t it be preventative if taken regularly?
thank you so much, dr. been. I'm beginning a protocol that includes methylene blue - to see if I can finally overcome the CFS I've been living with since the spike protein entered our lives. feeling a bit of hope...again.
Can dogs take it? My dog just had a stroke. Would it help her?
Methylene Blue stops mtor? I didn't know that. That concerns me, particularly for older folks for whom sarcopenia (muscle loss) is an issue. Mtor is what builds muscle. There has to be a balance where mtor is activated. Knowing this, I think I'm going to change the way I take MB. Instead of taking it every day, i think I'm going to take it intermittently, perhaps 3 days every two weeks to kick myself into increased autophagy for a period of time. Then stop so mtor can resume normally for the next 10 days.
good idea.
Dr Been - FLCCC recommends to take one day off every six days. Prob good for kidneys to give a break as well.
It leaves the body in 5 hours but accumulate as well with the half-life. What is accumulating? What does accumulating mean? Are there any harmful substances in it that accumulate? Where may this accumulation occur in the body?
40% excreted through urine. Please detail the remaining 60%.
Great informative talk! Thank You.
be more mindful about this 40% going through kidneys I guess
well 60% are used up by the body i guess
I'm amazed... Thank you 😊
I love your channel.
Wonderful information. The more I know the less I know. Thank you Dr. Been.
Dr. bean, you are an amazing artist!!! This is also a very interesting topic, thank you.❤
Thank you, Dr. Been - you are the best! Methylene Blue Forever in my pocket!
I listened to the video - judging by the mechanism proposed in this video, wouldn't methylene blue also help the heart during ischemic lesions? That could be, in principle, the same pathway.
Wow! That would be amazing.
Good point. Anything that helps the cell use oxygen protects against heart attack. Great deduction!
I have been using methylene Blue during my niacin and infrared sauna detox (30 days) My urine was not green but before and since the detox my urine is a lovely green/blue. So something about the high dose niacin and an infrared sauna was making my body utilize all the methylene Blue. Usually 40% of methylene Blue is excreted in the urine.
But my urine was not the slightest bit green.
Now this is a real eye opener!!..love it..i'm getting some!
Thanks Mobeen. It seems that this applies to neurons through the body and not just the brain. It seems long term use of methylene blue can cause problems with inappropriate prevention of cell deaths, such as during infections. Thanks again for the fine video and teaching.
If taken in high doses, right? If you take lower doses long-term, it doesn't cause problems I guess.
I disagree my friend is sucessful businessman and it was he who introduced me to it, he used to suffer with cfs/me but found that MB, cordyceps, sulbutiamine and ozone terapy did wonders for him to recover, MB is on he's number one list since, he's been on it for years without side effects, if you suffer with CFS your life is hell!
How do I get ozone therapy and how much MB?
@@valeriecuan4189 depends where you live normally in us and Canada is around 200 for s session in EU is anything between 50/150
@@valeriecuan4189 do an internet search for functional medicine doctors that offer ozone therapy
Very important there can be serious side affects with MB and anti-depressants be careful check with yr doctor firdt
I take fish grande methylene blue it is safe for wounded fish, their delicate eggs, and baby fish.
So it is safe enough for me take.
I find it cheaper than human marketed methylene blue.
And I do feel good after taking it.
No, it has heavy metals & other contaminates. Use only 99% purity pharmaceutical grade.
It's only advice for humans to take the pharmaceutical grade. That form of methylene blue is not suitable for human consumption.
Would it be safe to combine low-dose MB with other autophagy-promoting mechanisms (such as intermittent fasting and/or low-dose rapamycin and/or fisetin)? Would it render any of these superfluous?
Idk about rapamycin, fisetin, but MB both accepts and donates electrons. Do they also do that?
@@Grace-Upon-Grace Rapamycin seems to do its thing through mTor inhibition; I'm not sure what the mechanism is for fisetin. Generally, there seem to be multiple paths and dependencies, so causes and effects are difficult to understand or predict.
Started using MB as strips just put on tongue and absorbed
So it sounds like this should only be used when having a TIA or outright stroke? Does it make sense to take it just due to aging, and if so, how much? Would it be useful during a heart attack or only stroke? Did he say at the end that this would help all cells, not just neurons? Why does he say to use 5 mg per day, whereas most advocates say that a small dose is actually 5 mg. per Kg, which would mean 77 mg. per day for a 170 pound man? That is considered a low dose by Dr. Gonzalez-Lima, one of the foremost researchers on MB? Are we sating that MB helps only when the electron chain is dysfunctional (say, due to TIA), or that it is helpful even in the absence of cellular, electron-chain insult?
Jazz Dr Gonzalez says 0.5 to 1 mg per kg. Not 5 mg/kg. He said 4mg/kg would be highest for low dose use.
Doctor it would be great if you would lend your support to some brands or options for MB as amazon options have both "saved me" and "this is not for humans it hurt me" reviews on so many things!
My colon ruptured in March and only after getting out of the hospital did I realize that the sepsis that came with it, caused some mild brain issues. My vision became worse and my coordination was off. I had some of the MB before this happen that I was trying out and going to start back. I was afraid of trying anything because of the meds I was on and the issues I was still having with my digestive system. I will try to remember to come back and update my results.
Update?
@@barbarapenner2581 I ended up not trying it as I learned the product I had was not considered pharmaceutical grade and I need someone to rx it to access that quality.
19:00 how cell autophagy works, role of insulin etc
Does adding vitamin C to the water to counteract the staining decrease or modify the efficacy of the methylene blue?
Vitamin C is removing the blue colour. Supposedly works just as well. I don't know studies that prove this though.
My same question. 🤔
I’m currently taking 3mg or 6 drops of .05% twice a day. Total 6mg daily. A relatively low dose, or average from the video. I am 64 and weigh 160lbs. How will this affect nitric oxide levels, since those are supposed to be good for dilation of blood vessels? Is this considered a negative effect? Thank you.
Love your info Dr. Been
Maybe I missed something. The study says MB was given by IV to the animals at 1mg/kg. What would the dosage be if given orally instead of by IV to achieve the same blood concentration?
Start low first 5 days then move up gradually. We're using:. 0.5 ml of 1% solution twice a day
Spike protein will likely be causing a dementia explosion in elderly, which we already can see signs of. Can Methylene Blue help with detoxification of SP and restoration of circulation and mitochondrial function in the brain?
Not sure, but a lady in the comment section said it cured her MS.
Nattokinase and ivm destroy sp ,either and both
@@jsanders9975which one?
Is not cellular apotposis beneficial some of the time? I though this is why people recommend fasting (ie 24-48 hours) -- in order to get rid of poorly functioning cells.
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Would that protect other ischemic events like acute myocardial ischemia for example?
Of course it would, from better use of oxygen.
Don't forget to earth with Methylene Blue.
What is earth
I just fell in love with you. Very very informative wonderful video, thank you
Would this be useful for a brain bleed as well, or just ischemia?
Brain bleed causes cell damage, no? The pressure from the blood, i.e., hematoma, exerts pressure on blood vessels, restricting blood flow, i.e., ischemia, as well, does it not? So, wouldn’t MB be helpful in brain bleed as well?
@@musimedmusi8736 I don't think MB is okay if the bleed is active, because the nitric oxide release would dilate vessels and increase bleeding. If the bleed has stopped it should be okay. In an emergency situation it is hard to know if a stroke is just a TIA, a larger blockage, or a bleed. So maybe a scan is needed first, but of course that causes a delay in treatment. Maybe if blood pressure is not high you can assume it's ischemia and give MB, but I'm not sure.
I read an article that BM is killing E-Colie bacteria In UTI. I have suffered for years from UTI . I am going to try. I will let you know the result.
How did it work out
Omg your painting is amazing.
You’re saying methylene blue increases nitric oxide however, the book I’m reading by Mark Sloan “The Ultimate Guide to Methylene Blue” states the opposite?
Apparently if NO is too high it lowers and if too low it's increasing NO
What is the role of diertary organic sulfur substrates such as onions, garlic, turmeric in supporting MB activity? ( I prepare leuco-MB and dose fasting at 2 mg/kg of gross body weight). I noticed on a day adding back those items to my diet, among others, reduced overnight water productuon and improved sleep
Namasté & Ho’Oponopono everything 🕊️❤️
Thanks Dr.Been.
Why do so many doctors claim MB blocks nitric oxide thus causing loss of libido for men?
JazakAllahuKhayr
Thank you Dr. Been
I'm wondering if MB should be taken with or without food?
Take it with a tea spoon of olive oil as it absorbs better with fats!
I remember reading many years ago that...cannabis that contains THC was also known to be neuron sparing in situations that involved a disruption in oxygen.
There was a study done by an Israeli university on cannabis for protection following a stroke. That was late 90s so I’m sure there are many others since.
Is it better than triggering autophagy through fasting?
You could do both.
The notion that our cells ,so complex created themselves from muck is absurd!
I use drops of MB for depression. It helps a lot but I never know how many drops is best. I’m 120 lbs.
Hi DR Been,I'm a doctor from TURKEY,Ilisten your videos always and want to listen your lectures .what must I do for this
Mrb hocam
If MB cleansing cells, is it helpful to clear our gout crystals?
Is this the same stuff given for UTI’s? I’m just a lowly CCMA but is that the same stuff?
Yes.
It gav me a vag infection. Other than that has not helped any of my conditions.
@@Userxyz-z2dwell it destroys your natural bacterial composition of your skin. so makes sense
Hi Dr been.
Thank you so much for all the incredible information you give.
About the low dose orally, it's 5ml of 1% solution?
5mg
5ml of solution would provide 50mg of MB
Dr Been, I dont understand the mechanism at the point of apoptosis. I understood that MB causes apotosis in cancer cells. Your mechanism seems to say that MB stops apoptosis. Is that correct?
Thanks!
Thank you Dr Been....I keep reading that MB is suppose to limit or stop NO production or keeps NO from being produced too much or something like that. Is that true?
C Holman methylene blue helps with needed nitric oxide (donates electron to Cytochrome C oxidase 4), BUT it also accepts an electron if inducible nitric oxide synthase is too high (self induced -iNOS). I may not be explaining it the best, but it helps if not enough and if too much in our cells.
I've been trying to find information (that I can understand) about taking NADH and MB? I'm reluctant to take them on the same day. I haven't come across anything that states a negative interaction with NADH, however, there are medical papers on the effects of MB and NAD/NADH. Just wondering if anyone has an answer for me. Thanks.
I still haven’t gotten any information, even after writing to doctors promoting MB and companies that sell NADH. Disappointing.
Ask an AI for a well formatted reply.
Great presentation !
Thank you for this info.
Is this part 2? Did I miss something? How about a short explanation of what it's for before discussing side effects.
Dr. Been please report on that fact that only 10% of Americans with stroke are treated within the window for TPA. Lots of unnecessary paralysis and devastation. Both my parents were not appropriately treated, mom still paralyzed 9 years later.
My question is, would someone still recover if they got MB but no TPA?
What about MB depleting nitric oxide?
If I missed it , how and why methylphenidate blue helps with epilepsy ?
Dr I have a spinal cord injury between T2-T5 as a lesion caused by one acute attack known as Transverse Myelitis. I'm in chronic pain and constant fatigue. My doctors got me on Gabapentin and then Duloxetine (SRNI) all for pain. It is not working. I'd like to ween off of them, and I'm curious about the mechanism of Methylene Blue versus my current cocktail.
The impact of methylene blue on neurotransmitter levels is multifaceted. While it can inhibit the breakdown of serotonin and norepinephrine by inhibiting MAO, it can also have other effects that modulate neurotransmitter activity. For example, methylene blue has been shown to interact with various receptors and enzymes involved in neurotransmitter regulation, which can influence their overall levels and activity. Do you think it is fair to extrapolate that MB use, while reducing my fatigue, MIGHT also reduce this false pain signal I'm getting from my lesion site?
Try it. It is very safe and effective. Let us know.
@@geoattoronto Been taking 15 drops for a little over a week with some fatigue relief, but no noticable pain reduction. But overall, I cannot see any reason not to keep taking it as long as it does not mess with my gut biome.
MB same initials as MoBeen 🤠I’m so excited bc now the inflammation on my brain can be reduced in a natural way thank you Dr. Been. This will also help the biotoxin mold exsposure illness and the chronic fatigue syndrome caused by mold not being eliminated from the body, suppressing the mitochondria uptake of the atp molecule; bc of the gene in the 6th chromosome which doesn’t detox mold in 1/4 ppl! Thanks thank you thank you. You’re the best doctor ever. 🤍🌺 you’re saving lives doctor I’m so happy to be alive this is an answer to my prayer. Love and light to your soul.
Any ideas or links to where to purchase a LLLT IR device?
Great lecture Doc!
Great info!
Thank you again ❤
Thank You !!!
What grade of Methylene Blue to you sale?
Do you offer Reagent grade or ACS grade?
Thank you for your time.
Does methylene blue help treat panic attacks and extreme fear?