How THIS Natural Ingredients Supplement Addresses All Hallmarks & Reverse Aging?
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- Опубликовано: 16 апр 2024
- Why do we age? What are the hallmarks of aging? What we can do to target the hallmarks of aging? In this video, Dr. Nichola Conlon explains what are the hallmarks of aging in details and how we can address multiple hallmarks of aging to slow down or even reverse cellular aging.
Dr. Colon Recent Paper:
A systems-approach to NAD+ restoration
www.sciencedirect.com/science...
Dr Nichola Conlon is a molecular biologist specialising in the study of cellular ageing. After a career in drug development with a leading biotech firm, Dr Nichola founded Nuchido Laboratories driven by her belief that cutting-edge science should not lie hidden.
Dr Nichola is on a mission to democratise science and is an expert in cellular health, with particular focus on the science of ageing well, helping people to reverse their biological age and improve their healthspan. Dr Nichola’s work to translate recent scientific discoveries into interventions to increase healthspan and vitality recognizes that while great progress has been made in treating age-related ailments, the focus now must be placed on reducing the burden of these diseases as we live longer lives.
Along with leading scientists at Nuchido, Dr Conlon has identified the optimum combination of targets to restore cellular NAD+ production back to youthful levels, leading to the development of a breakthrough NAD+ booster called Nuchido TIME+.
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DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.
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I like David sinclair
@@joshlocher71 ds = con artist - had to step down from his post
Niacin boosts NAD+ levels
And it has decades of research behind
Consume sulforaphane ( frozen broccoli sprouts ) and be sure to take TMG (AKA betaine anhydrous) to counter the increase in homocysteine.
Nicotinic Acid > Niacinamide
Also not as expensive as NMN
@@slobodanfuletic9465some recent study suggested negative result in cardiovascular health😮
You have realty done it this time Dr. Colon! This video is the best overall summary we have seen on Human Bio Science covering Lifespan and Healthspan as directed to ordinally people. Please put it into a book and embellished it with your insights on stem cells, diet. and maybe a brief discussion on Rapamycin. It would be a great book I am sure. You do a wonderful job explaining the status of this exciting leading edge science. Congratulations.
While I take some of this already, I find already for myself that my energy level has come up. As of now I am 52 years. I don't feel like bad now. I'm also losing weight which is good. I used to weigh 502 pounds. I'm now in the 360 range, so I've come down quite a bit.
George Davis
That's a great achievement....well done and I hope you continue to get such good results
@@marknel3863 This is the rest of my life. However long it ends up being. Thank you, man.
George Davis
What do you take?
@@King311___ Collagen, Creatine monohydrate, Pomegranate extract, Taurine, Calcium Pyruvate, Niacinamide...There's my list. I hope it helps.
George Davis
You're doing a fantastic job! 🎉🎉
The research on NAD has generally showed that NAD supplementation has minimum effect on aging. One person who has pushed NAD is David Sinclair but he is a bit of a cowboy. So I would certainly not take NAD boosting supplements. They are more or less useless. Another thing should be mentioned it is not necessary to target all the Hallmarks of Aging. Targeting one or two will affect the other hallmarks of aging, because they are interconnected
by far one of the best most comprehensive videos regarding these processes in the body and how they relate to one another that i have seen.
NAD doesn't prevent aging. All it does is provide energy for the cells to use. Cells function better and you feel younger because of the energy. As soon as you stop taking it, you feel exactly how you felt before. You can say it temporarily reverses the depletion and lack of NAD from ageing. But the ageing is not reversed in itself.
NAD does reverse some symptoms of aging. I got intravenous NAD+ (WAY more powerful than NAD in pill form) for a prescription drug addiction, and it literally rebuilt the exhausted receptors in my brain that were why I couldn't quit the medication.
I noticed all these other changes too. My back pain improved, my knotted-up muscles loosened, my joint pain improved, and my guts 'purified' (wink). I am gluten intolerant and didn't know it at the time. My body also felt very uncomfortable at the beginning of the therapy and after the 14 days that were required to get clean (with no withdrawal symptoms), the discomfort was much reduced.
So yeah, my body was purifying a bunch of crap. That crap had to have been doing a lot of damage that I wasn't aware of i.e. it was causing some symptoms of aging.
I take NAD pills every day, and still get intravenous NAD every three or four months for maintenance, which is all you need.
similarly, if you stop ingesting enough XYZ, you feel exactly like being without it.
As long as NAD levels are in a good range, the aging process is much slower. why? because energy is everything on the cellular level
@@monnoo8221where can I buy nad?
Bingo! 🙌
@@squamish4244so I have to get a drug addiction before I can get all these longevity injections and pills?
I would like to add a comment to this brilliant presentation: SIRTUINS are a family of so called "Silent Regulator Genes". If they are active they express certain proteins which act as enzymes. These enzymes are also called "Sirtuins" but they are written in small letters. The genes are expressed in capital letters instead in order to distinguish wheather the subject is about genes (SIRTUINS) or their enzymatic deriatives (Sirtuins).
Detailed and concise presentation, thank you! definitely don't want to spend 20 years suffering from age-related diseases!!!
I took Nuchido Time for about 2 months. . . didn't feel anything but it did make me gain a lot of weight. . . . I didn't want to get fat so I stopped taking it and lost all of that weight.
Ok. Do you have any evidence of functional improvement after taking this product? Part of the way the NAD levels are being increase is by inhibiting it's use, which may not be net beneficial. For instance the product includes rutin and quercetin which inhibit PARP. Because of its role in DNA repair, PARP inhibition results in genomic instability and accumulation of damaged cells in cell cycle arrest. So good for treating some cancers but doesn't sound ideal to be taking on a regular basis. You highlight how interrelated all these things are so without evidence you don't know the net effect of increasing NAD at the expense of other things.
Curious to hear your thoughts on the matter.
Totally agree. No point in spending a lot of money on these kinds of supplements without strong evidence that they will produce the desired long-term effect on the aging process itself, rather than just affecting the level of an intermediate biomarker in the overall system.
She is here to sell her companys product, dont trust them, Simclair is another cheat all in it for money these nad supplements are.made dirt cheap in china and sold to dumb westerners who have more money than sense wherever there is a need you'll find conmen/women and products to be offered to us at a profit of course
💖💖Love her explanation! I just started nuchido a month ago and stopped all my other supplements to see how it goes, 2 months later will test my NAD level.
I'd love to hear the result.
Word. Results would be sweet. Thanks, jcyume.
Current at home tests aren’t accurate as NAD is unstable and degrades quickly out of the body. Nichola talks about that in her other interviews. Hope that changes!
I'm of the opinion that the majority of aging indicators stem from a central cause, which sets off a domino effect of other issues. Although I lack scientific expertise, it seems plausible that this could clarify why certain shorter-lived mammals, like dogs, age more rapidly than humans
Oh it is an ad for their product…cool
Exactlty plus she never mentioned a recent study on niacin that may negatively impact heart health
What I find weird is, exercise may activate AMPK, but actually by doing exercise, my intention is mainly to gain or maintain muscle strength, so I want to activate the growth path, so MTOR
I think that while doing exercise you strain your body and activates your mitochondria to produce more ATP using stored energy, glucose and fats, once these are used up you are in a depleted state stimulating AMPK. That's why it's best to exercise in a fasted state. After you eat protein your body switches to growth and repair. Makes sense?
how do we know that cells has or have been repaired and zombie cells are killed?? can one test them .--
I think maybe they need to describe possible disruption of hormones from all these ingredients.
We take charge of the nutrients that go in us every day, but once you learn and start applying then when we start taking charge. Health problems go away when we find our body type and start eating right. Revolutionary Health changes come your way. Keto, carnivore, are changing lines
Yeah....I take all of these...
NAD sounds great, but can we still take our NACglycine with it??
Yes
Nope. The police will put you in prison if you do that.
@@joebartles3986 lol
So what if you could increase NAD. No one has proven that that has any functional benefit. I want a functional benefit not an NAD increase
New studies out now
@@nutech1810 Link?
Great video. I wonder if R-Lipoic Acid accomplishes the same as Alpha Lipoic Acid.
Better
YES, IT IS THE PREFERD FORM.
Yes, it does, but the racemate mixture is way cheaper and has a better cost performance ratio
Actually, the two of them works synergistically together. Together, they are more than sum of their parts. I have experience with them as they fixed my neuropathy after chemotherapy. That was 23 years ago.
NAD
I don't agree the reason is the food we eat the chemical pesticides
250 mg of niacinamide in Nuchido will likely raise your homocysteine a fair amount. Homocysteine, a hallmark of aging, raises with age and is linked to increased mortality. So does Nuchido cause you to age faster?
This is easily addressed by taking TMG, which provides a methyl donor, alongside. This should be done with niacin, NMM, NR..or any NAD booster.
@@Livelovelaugh684 I don't think it's easily addressed because your raise in homocysteine will only likely only be offset by TMG to a small degree. Of course, this is all testable. There appear to be many people taking NMN, NR, or Niacin alongside TMG with Homocysteine levels over 10. I don't think it's an easily solved problem.
@@Livelovelaugh684 There is 250Mg of Niacinamide in Nuchido. There is no way this problem is easily addressed with TMG with a 61% increase in Homocysteine.
See excerpt from study below.
Methods: Thirty adult subjects were randomly divided into three groups of equal size, and orally received purified water (C group), nicotinic acid (300 mg, NA group) or nicotinamide (300 mg, NM group).
Results: The level of 3-h plasma nicotinamide, N1-methylnicotinamide, homocysteine, the urinary excretion of N1-methyl-2-pyridone-5-carboxamide and pulse pressure (PP) in the NM group was 221%, 3972%, 61%, 1728% and 21.2% higher than that of the control group
Sun WP, Zhai MZ, Li D, Zhou Y, Chen NN, Guo M, Zhou SS. Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels. Clin Nutr. 2017
Just 300mg of Niacinamide caused a 61% increase in homocysteine compared to controls in a study. Nuchido has 250mg of Niacinamide. There is no way TMG is going to offset a more than 50% increase in homocysteine. You would be lucky to get a 10% offset. In all likelihood, Nuchido worsens a hallmark of aging.
Just like Niacin will raise NAD+homocysteine. This idea to megadose minerals and vitamins is a very juvenile understanding of the body. But ofcourse commercial forces love this idea. Make 100 forms of B3 to patent and sell it for 100x price. First, test your biomarkers. Why take something you're not even deficient in. Makes no sense to me. Also get this idea out of your head, that if something is good for me, more is better! Everything is about balance and homeostasis. Look for foods high in B3. Diet is always the best way. Also there are many more ways to raise your NAD levels without side effects like exercise and fasting.
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And you must start taking this by 25 years old.
One active good ingredient increase more by another good ingredient but at some point a god mix of people or substance can do way more than alone and in the right activity, like fasting plus good supplements can increase the benefits of fasting even way more.... so a mix of antioxidants and fasting and powerful minerals like zinc, citrate magnesium, resveratrol and omega 3 and the benefits of fasting increase by 10x?? only yoga do that increase cuality of sleep that is so important.
Low vitamin d level over a long time will take its toll on your body!!
Is there a difference in quality of vit d brands? 😢
@@garydownes1594Absolutely! Supplements aren’t regulated. Look for a reputable company that does third party testing on the purity of their supplement and one that contains olive or avocado oil. Also, look at the source. Is it derived from plants or animals. From my research, animal based is the better option.
Lol at "age-n", "track-n", "evra-thin", "sit-n", damage-n", "sleep-n", have-n"
"Paa-ern" swallow those double TTs!
So much for spell-n and speak-n English...
Oh well….
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I thought niacin was bad for the heart?
the Opposite - Nicotinic Acid will reduce ApoB & Lp(a) in the blood
Sorry we still talk a lot about it but we dont have any HARD data tomsupport the hype. I am still waiting.
Proeins?
My wife is British, I've learned to translate.😂
and stabili-ee 😄
The Northerns in England lose letters.like "g' from the end of words 😊
Needs a better narrator. Sounds like she’s just reading.
I don't think it is useful. Bye.