The Hydrophobic Effect | Reason of Protein Folding | Dr. Nagendra Singh | PENS#10
HTML-код
- Опубликовано: 9 сен 2024
- #ugcnetpreparation #UGCNETLifeSciences #CSIRJRFPreparation
The Hydrophobic Effect | Reason of protein folding | Dr. Nagendra Singh | PENS#10
UGC NET preparation | UGC NET preparation online | UGC NET preparation tips | UGC NET Life Sciences | CSIR JRF Preparation
1. The main reason for a protein to fold into globular shape is hydrophobic forces, which resulted due to hydrophobic effect. That is tendency of non polar compounds to aggregate in aqueous / water medium.
2. Biochemistry of protein folding
3. Basics of protein folding
4. Hydrophobic effects dives protein folding
Video Lecture given by Dr. Nagendra Singh, Assistant Professor, Gautam Buddha University, Greater Noida, INDIA
UGC NET preparation | UGC NET preparation online | UGC NET preparation tips | UGC NET Life Sciences
Related links:
Experimental Vs Theoretical PI of proteins | Isoelectric focusing | Dr. Nagendra Singh
• Experimental Vs Theor...
Calculation of Theoretical PI of Peptides | proteins |Dr. Nagendra Singh | PENS#24
• Calculation of Theoret...
Calculation of Theoretical PI of Amino acids | Glycine & Aspartic acid |Dr. Nagendra Singh | PENS#23
• Calculation of Theoret...
Peptide bond | Peptide bond Biochemistry | Peptide bond formation | PENS#16 Dr. Nagendra Singh
• Peptide bond | Peptide...
Henderson Hasselbach Equation |applications| Numerical Solutions | Dr. Nagendra Singh | PENS#15
• Henderson Hasselbach E...
Gene v/s Protein | Which is bigger in size | Nagendra Singh | PENS#14
• Gene v/s Protein | Wh...
Molecular weight calculation of polypeptide | Proteins | Dr. Nagendra Singh | PENS#13
• Molecular weight calcu...
Amino acids and Proteins | Basic Idea | Definition | Structure | Dr. Nagendra Singh | PENS#12
• Amino acids and Protei...
Thank you sir for this video 🙏🙏🙏
Nicely explained
thanks @Subham karmakar
Awesome explanation, thank you
My pleasure @Alissa
Very nice explanation
Thank you @medical world
Sir I am Ritesh sharma
And sir I watched this video
Wow miracle
I clearly understood the concept of hydrophobic interactions
Your way explaining is brilliant ☺☺
Sir please reply my feedback
I will wait for your correspondence
Thank you sir
Thanks @Ryker Never Stop
I am happy that you find it useful.
👏👏👍👍
Thank you so much sir
my pleasure @Sravani Pakki
👌😊😘
What is the role of hydrophobic interactions in protein structure and What elements influence protein folding?
hydrophobic portions of protein create hydrophobic effect..
Why mostly, hydrophobic effects are the main driving force behind protein folding instead of h-bonds or ionic interactions?
(Narendra Vikram Singh)
because polar interactions dont contribute much change in enthalpy during folding..
What happens if the nonpolar protein is mixed in a nonpolar solvent? Does the protein degrade or maintain the native structure?
@Rachana Vanjare .... Like dissolves Like rule is always applicable in solubility....But in case of non polar or hydrophobic proteins, these are not completely nonpolar molecules. Such proteins have only some segments which are hydrophobic....for example a membrane receptor is an example of non polar protein that contain at least 1 stretch of totally non polar amino acids....if u keep that receptor in non polar solvent it wont be soluble as it contain polar regions as well....in order to solubilize hydrophobic proteins u add detergents which can stabilize non polar regions and solubilize protein.
Hypothetically, if u have a protein with all non polar residues, that wont exist in aqueous cytosol... and may be soluble only in non polar solvent.
Also to keep in mind protein degradation means peptide bong hydrolysis and that can not happen just by keeping a protein in a nonpolar solvent....to break peptide bond 1 need to give heat + acid or use Proteases
What is the role of hydrophobic interactions in protein structure?
it helps in folding of protein by folding the protein in such a way that the hydrophobic part forms the core.
What drives the hydrophobic effect and What is the difference between van der Waals and hydrophobic interactions ?
VDW forces occur between nonpolar molecules...whereas hydrophobic effects is due to water
Ab toh
paper top
🤯😎😎
What methods used for quantifying hydrophobicity in Proteins?
hydropathy index
How significant are hydrophobic interactions in protein-ligand complexes?
very crucial...thats why most drugs have hydrophobic group so that diffuse faster to target site in aqueous medium
sir but how is hydrophobic effect responsible for protein folding
Polypeptide chain adopt 3d shape after translation, in the cytosole is because it contains stretches of non polar residues. non polar stretches tend to stick together to avoid water contacts. so acquire a shape. @19IBT034 Prakhar
@@proteinengineering007 ok sir
How hydrophobic interaction occurs in any molecule?
vander walls forces u call them
What happens when a hydrophobic molecule is exposed to water?
it aggregates due to hydrophobic effect..
Do hydrophobic molecules attracted to each other?
ofcourse yes
Do hydrophobic interaction are bonded together?
sliding interactions...very weak in nature
How does urea diminishes the hydrophobic effect ?
non polar side chains prefer urea over water so help in denaturation @Ms Apaarna
What if a person with strong will drinks water while having this deadly disease,, what would have happen?
water will behave as per will of the drinker... @Scent Of Kashi
Ganta kuch sunai ni de raha be