Its more ordered(the water ) *pre/before* hydrophobic effect and aggregation. Afterwards however you have less ordered water molecules. Which is why the less ordered environment of water, is favored because more disorder is more favorable
I have often thought about hydrophobic interactions in drug design but never considered entropy's contribution to the energetic unfavorability of lipophilic functional groups being surrounded by water. This really well introduced that facet to me, thanks!
Thank you so much! This brought together many of the topics I learned during my lecture but I was having a hard time combining it all... Now it's clear :)
so the hydrophobic effects decreases the solvation layer of a protein? it makes protein folding make some more sense as to why it's energetically favorable
finally. a short precise explanation that actually makes sense. I think the pictures really helped. I read through jack westin, shem, and reddit and still couldn't understand it as well until I watched this. I knew all of the concepts but I just couldn't make it make sense.
You're better than my lecturer thank you so much!!!!! I remember hearing that the bonding of hydrophillic ligands to proteins was mainly because that is entropically favourable too becuase the hydrophillic ligands bond to many water molecules and bonding to a protein means more free molecules in solution, but the again I remember hearing the main driving force of binding is the decrease in enthalpy instead, do you have any idea which one the truth is
OK so the water gets disordered through the aggregation of the non-polar molecules, doesn't the opposite effect occur with the hydrophobic peptides? They go from infinite number of states to a small number of states?
theres a total net increased possible conformations when hydrophobic amino acids aggregate.. so the increased number of conformations of water outweighs the number of possible conformations lost by amino acids
Thanks for explaining this concept clearly. It helped me to understand the forces stabilising self assembly of amphiphiles. For lay person to follow it could have been better if you explained bit more slowly.
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I really appreciate this method of teaching, sometimes you just gotta beat the concept into your head
The amount of times he says orderly makes it hard to forget the concept XDD
ORDERLY
This video should be used as a drinking game!
great job though. thank you man!
Teachers just said "disorder" but that means nothing unless we see it. You did an excellent job at helping us visualize it.
Thanks, demonstrating this with the phenylalanine made the concept so much clearer
I was having such a hard time understanding this concept. Thank you for the clarification! :)
wait so is it ... orderly?
literally the only thing i take away is that things have been orderly in this video. This video is the very definition of orderly.
Its more ordered(the water ) *pre/before* hydrophobic effect and aggregation. Afterwards however you have less ordered water molecules. Which is why the less ordered environment of water, is favored because more disorder is more favorable
@@tammyclairs166 I read in a biochem book that before the hydrophobic effect happen , the entropy is more favorable… that’s weird
Explained absolutely PERFECTLY, and in such a short video! Thanks so much
Great concept but.. this video is giving me a stroke.
samee
In an orderly fashion, very orderarily
Lmao!
I have often thought about hydrophobic interactions in drug design but never considered entropy's contribution to the energetic unfavorability of lipophilic functional groups being surrounded by water. This really well introduced that facet to me, thanks!
This is how I explain things when I don't get them for a long time and then suddenly it clicks because i understood a fundamental thing (ORDERLY)
TL;DR HYDROPHOBIC EFFECT, ENTROPICALLY FAVORED, ORDERLY
this is the best way I've ever heard this explained. thank you so much!!
amazing teaching, making my life easier omg tysmmmm, and the video is so comprehensive
Thank you so much! This brought together many of the topics I learned during my lecture but I was having a hard time combining it all... Now it's clear :)
Realize this is five years old but it was exactly what I needed because my notes on this were soooo confusing smh
i swear bro has a video for everything
I love how everything comes back to physics
Greatly explained a tough topic! ❤
I rarely comment on RUclips, but I'm really grateful for your clarification!
Thank you for your nice explanation. I would ask, why water molecules ordered on the surface of non polar molecules?
I’m wondering the same thing!
so the hydrophobic effects decreases the solvation layer of a protein? it makes protein folding make some more sense as to why it's energetically favorable
finally. a short precise explanation that actually makes sense. I think the pictures really helped. I read through jack westin, shem, and reddit and still couldn't understand it as well until I watched this. I knew all of the concepts but I just couldn't make it make sense.
Great video. I totally understand this concept now!
Thank you for making this so simple!
A lot of passion, man, that's great! Make sure to not have unrelated flashing or moving elements in the video, because it's very distracting.
Finally, a video that explains it all!!!
Thank you for helping me with my biophysics exam, you’re the best!!!!!🙏🙏🙏
This explanation was magnificent!
drink everytime he says orderly
it was tremendously great explained. Thank you very much!!
this was really freaking good
You're better than my lecturer thank you so much!!!!! I remember hearing that the bonding of hydrophillic ligands to proteins was mainly because that is entropically favourable too becuase the hydrophillic ligands bond to many water molecules and bonding to a protein means more free molecules in solution, but the again I remember hearing the main driving force of binding is the decrease in enthalpy instead, do you have any idea which one the truth is
Very clear explanation. Thank you!
Thank you for this♥️ read the passage in an mcat book, and was a little confused until I saw this
Answered my exact question, thanks!
interesting! is there a non entrophic explaination?
Very well explained thank you ❤
So what are the new L17 A21 street lights supposed to be? Anything to do with fibril growth?
Great Job bro.. u cleared my doubt. Keep Going as such bro 👍
Perfect. Made sense.
OK so the water gets disordered through the aggregation of the non-polar molecules, doesn't the opposite effect occur with the hydrophobic peptides? They go from infinite number of states to a small number of states?
theres a total net increased possible conformations when hydrophobic amino acids aggregate.. so the increased number of conformations of water outweighs the number of possible conformations lost by amino acids
@@sciencesimplified3890 Thanks. A complex problem then.
Great Video
Thanks for explaining this concept clearly. It helped me to understand the forces stabilising self assembly of amphiphiles. For lay person to follow it could have been better if you explained bit more slowly.
wait, it's all orderly?
Great didactic, thanks!
I couldn’t watch past 49 seconds. Oh lord. My heart
Now this... this. Makes sense
Great explanation!
take a shot every time he says orderly
Just dropped dead from alcohol poisoning, would recommend
Awesome video I really appreciate this, slow down a bit that's my only critique, nice work!
Thank you!
To reduce surface area. That's it.
guys i think it’s because the water is orderly
amazing
u sir... r AMAZING.. THANK U
The amount of times he said "orderly" makes me cringe but I learned the concept well.
Passionate orderly
THANK U!!! finally
Amazing thank u I have my exam in two weeks I’m so nervous
Great!
DAMN SIR STOP YELLING AT MEE💀💀
why you are saying ORDERLY many timessssss
O R D E R L Y
couldnt miss the point here
Why do u sound like the one from nicki minaj livestream
but why WHY
It's a little bit more complex than that, it relates to the number of possibilities.
If any one is interested I would reconsider explaining it
i love you
Definitely not everything i need to know
You sounds like Morty lol
W explanation ty